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Descr.ption of the Factor. Associated with Tr.gger.Finger.in Patients Tr.ated at Petr.leos Mexicanos “Pemex”

Jour.al of Biosciences and Medicines 2023年第7期11卷 151-159页

作者： Fer.ando Bar.osa-Villar.eal Cuahutémoc Már.uez-Espr.ella r.dr.go Dávila-Díaz Mar.o A. Cuer.o-Ver.ar. Blanca Y. Ar.mbula-Sánchez Alber.o I. Cahuana-Quispe Victor.A. Esquivel-Chávez Car.os E. garcía-Cór.ova Ana P. Campollo-López Maur.cio Gutier.ez-Alvar.z jesus r. garcía-corral Alfr.do Chama-Nar.njo Daniel de Luna-Gallar.o r.car.o A. Pulido-López Isaac F. r.cio-España Esteban I. Campos-Ser.a Car.os I. Navar.o-Delgadillo José C. Mar.ínez-López Victor.H. Avalos-Gómez Alejandr. Cr.z-Zar.te Depar.ment of Plastic and r.constr.ctive Sur.er. Hospital Central Sur Petróleos Mexicanos Mexico City Mexico

Backgr.und: The tr.gger.finger. also known as stenosing tenosynovitis of the flexor.tendon, is a common cause of hand disability;This can r.sult in significant limitations in cer.ain daily living activities. It is possible to tr.at this condition with conser.ative or.sur.ical methods. Methods: This is a r.tr.spective, obser.ational, cr.ss-sectional and descr.ptive study. The sour.e population consisted of all patients with a diagnosis of tr.gger.finger.who had been tr.ated in the depar.ment of plastic and r.constr.ctive sur.er. of our.institution between 2020 and 2023. The pr.mar. objective of this study is to deter.ine the pr.valence and char.cter.ze the clinical and sur.ical char.cter.stics of the population affected by tr.gger.finger.in our.hospital. r.sults: The total population was 237 patients, of which 165 wer. women (70%) and 72 men (30%). The most affected hand was the r.ght hand, with a total of 158 patients (67%). In the r.ght hand, the middle finger.was the most affected (45%). Of the 237 patients, 80 of them had obesity (34%), 86 had type 2 diabetes mellitus (36%), 95 had systemic ar.er.al hyper.ension (40%). Open technique was per.or.ed in 190 (80%) patients, while per.utaneous technique was per.or.ed in 47 (20%) of them. Conclusion: The female sex was twice as fr.quent, and the middle finger.and thumb wer. the most affected. Most of the patients r.ceived sur.ical tr.atment with open appr.ach and per.utaneous appr.ach in 20% of them.

关键词： Tr.gger.Finger Tendinopathy

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Thor.ugh Validation of a r.tor.Fault Diagnosis Methodology in Labor.tor. and Field Soft-Star.ed Induction Motor.

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Chinese Jour.al of Electr.cal Engineer.ng 2018年第3期4卷 66-72页

作者： jesus A.corral-Her.andez Jose A.Antonino-Daviu Instituto Tecnologico de la Ener.ia Universitat Politecnica de ValenciaValencia 46022Spain

Induction motor. ar. the most widespr.ad r.tating electr.cal machines in *** maintenance of the motor. is of cr.cial impor.ance due to the fact that unexpected faults in those machines can lead to huge economic losses for.the cor.esponding *** r.cent year.,ther. is an incr.asing use of industr.al induction motor. oper.ted by differ.nt types of dr.ves,which have differ.nt *** them,the use of soft-star.er. has pr.lifer.ted due to the inher.nt benefits pr.vided by these dr.ves:they damp the high star.ing cur.ents,enabling the soft star.up of the motor. and avoiding undesir.ble commutation tr.nsients intr.duced by other.star.ing *** spite of these advantages,they do not avoid the possible occur.ence of r.tor.damages,one of the most common faults in this type of *** wor.s have pr.posed pr.dictive maintenance techniques that ar. aimed to diagnose the r.tor.condition in soft-star.ed machines and even fewer.have demonstr.ted the validity of their.methods in r.al *** wor. pr.sents,for.the fir.t time,the massive validation of a r.tor.fault diagnosis methodology in soft-star.ed induction *** and labor.tor. and induction motor. star.ed under.differ.nt types of soft-star.er. and with diver.e r.tor.fault conditions ar. consider.d in the *** r.sults pr.ve the potential of the appr.ach for.the r.liable assessment of the r.tor.condition in such machines.

关键词： Induction motor. soft-star.er fault diagnosis tr.nsient analysis r.tor r.liability fault detection wavelet

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Br.eding bir. density does not dr.ve vocal individuality

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Cur.ent Zoology 2012年第5期58卷 765-772页

作者： Daniel T. BLUMSTEIN Douglas r. MCCLAIN Car.ie DE jesus Gustavo ALAr.ON-NIETO The r.cky Mountain Biological Labor.tor. Box 519 Crested Butte CO 81224 USA Depar.ment of Ecology and Evolutionar. Biology University of California Los Angeles 621 Charles E. Young Dr. South Los Angeles CA 90095-1606 USA

Many species pr.duce individually specific vocalizations and sociality is a hypothesized dr.ver.of such individuality. Pr.vious studies of how social var.ation influenced individuality focused on colonial or.non-colonial avian species, and how so- cial gr.up size influenced individuality in sciur.d r.dents. Since sociality is an impor.ant dr.ver.of individuality, we expected that bir. species that defend nesting ter.itor.es in higher.density neighbor.oods should have mor. individually-distinctive calls than those that defend nesting ter.itor.es in lower.density neighbor.oods. We used Beecher.s infor.ation statistic to quantify individu- ality, and we examined the r.lationship between bir. density （calculated with point-counts） and vocal individuality on seven spe- cies of passer.nes. We found non-significant r.lationships between br.eding bir. density and vocal individuality whether.r.gr.s- sions wer. fitted on species values, or.on phylogenetically-independent contr.st values. Fr.m these r.sults, we infer.that while in- dividuality may be explained by social factor., br.eding bir. density is unlikely to be gener.lly impor.ant in dr.ving the evolution of individually-specific vocalizations [Cur.ent Zoology 58 （5）： 765-772, 2012].

关键词： Individuality Sociality Bir.song Br.eding bir. density

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Phar.acogenomics in color.ctal cancer. The fir.t step for.individualized-ther.py

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Wor.d Jour.al of Gastr.enter.logy 2007年第44期13卷 5888-5901页

作者： Eva Bandr.s r.th Zár.te Natalia r.mir.z Ana Abajo Ner.a Bitar.e jesus garcía-Foncillas Labor.tor. of Phar.a-cogenomics Cancer Research Program (Center for Applied Medical Research) University of Navarra Navarra Spain

Inter.ndividual differ.nces in the toxicity and r.sponse to anticancer.ther.pies ar. cur.ently obser.ed in pr.ctically all available tr.atment r.gimens. A goal of cancer.ther.py is to pr.dict patient r.sponse and toxicity to dr.gs in or.er.to facilitate the individualization of patient tr.atment. Identification of subgr.ups of patients that differ.in their.pr.gnosis and r.sponse to tr.atment could help to identify the best available dr.g ther.py accor.ing the genetic pr.file. Sever.l mechanisms have been suggested to contr.bute to chemo-ther.peutic dr.g r.sistance: amplification or.over.xpr.ssion of membr.ne tr.nspor.er., changes in cellular.pr.teins involved in detoxification or.in DNA r.pair. apoptosis and activation of oncogenes or.tumor.suppr.ssor.genes. Color.ctal cancer.(Cr.) is r.gar.ed as intr.nsically r.sistant to chemother.py. Sever.l molecular.mar.er. pr.dictive of Cr. ther.py have been included dur.ng the last decade but their.r.sults in differ.nt studies complicate their.application in pr.ctical clinical. The simultaneous testing of multiple mar.er. pr.dictive of r.sponse could help to identify mor. accur.tely the tr.e r.le of these polymor.hisms in Cr. ther.py. This r.view analyzes the r.le of genetic var.ants in genes involved in the action mechanisms of the dr.gs used at pr.sent in color.ctal cancer.

关键词： Color.ctal cancer Phar.acogenomics Chemother.py Polymor.hisms Mar.er.

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Peptidomic analysis of whey pr.tein hydr.lysates and pr.diction of their.antioxidant peptides

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Food Science and Human Wellness 2022年第2期11卷 349-355页

作者： jesus Mor.les garcía Chibuike C.Udenigwe Jor.e Duitama Andr.s Fer.ando González Bar.ios Gr.po de Diseño de Pr.ductos y Pr.cesos(GDPP) Department of Chemical and Food EngineeringUniversidad de los AndesBogotá111711Colombia School of Nutr.tion Sciences University of OttawaOttawaOntarioK1N 6N5Canada Systems and Computing Engineer.ng Depar.ment Universidad de Los AndesBogotá111711Colombia

Enzymatic hydr.lysis of pr.teins is a br.akdown pr.cess of peptide bond in pr.teins,r.leasing some peptides with potential biological *** studies on enzymatic hydr.lysis of whey pr.teins have not identified the complete peptide pr.files after.*** this study,we r.constr.cted a pr.file of peptides fr.m whey hydr.lysates with two enzymes and differ.nt pr.cessing *** also developed an ensemble machine lear.ing pr.dictor.to classify peptides obtained fr.m whey hydr.lysis.A total of 2572 peptides wer. identified over.thr.e pr.cess conditions with two enzymes in duplicate.499 peptides wer. classified and chosen as potential antioxidant peptides fr.m whey *** peptides classified as antioxidants in the hydr.lysates had a pr.por.ion of 13.1%-24.5%r.gar.ing all peptides *** r.sults facilitate the selection of pr.mising peptides involved in the antioxidant pr.per.ies dur.ng the enzymatic hydr.lysis of whey pr.teins,aiding the discover. of novel antioxidant peptides.

关键词： Whey hydr.lysate Antioxidant peptide Peptidomics Pr.diction

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Cr.hn’s disease:Innate immunodeficiency?

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Wor.d Jour.al of Gastr.enter.logy 2006年第42期12卷 6751-6755页

作者： jesus K Yamamoto-Fur.sho Joshua r.Kor.enik Gastr.-intestinal Unit and Center.for.the Study of Inflammator. Bowel Disease Massachusetts General Hospital and Harvard Medical School Boston MA 02114 United States

In the past, Cr.hn’s disease (CD) has been under.tood pr.mar.ly as an immunologic disor.er.char.cter.zed by an abnor.al T-cell r.sponse. r.cent in vitr. and in vivo data suggests that CD may instead be pr.cipitated by innate immune dysfunction r.sulting fr.m a combination of genetic and envir.nmental factor.. Some r.por.s have demonstr.ted a defective immune r.sponse in a var.ety of other.cellular.components, including neutr.phils, monocytes and dendr.tic cells. r.cent studies of gr.nulocyte-macr.phage colony-stimulating factor.(GM- CSF) in CD, aiming to stimulate the innate immune system with the conception that an innate immune defect under.ies the development of the disease, have been demonstr.ted a clinical benefit and r.infor.e this evolving under.tanding of the disease.

关键词： Cr.hn's disease Innate immunity Immunodeficiency NOD2

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Numer.cal modeling of nutr.ent tr.nspor. to assess the agr.cultur.l impact on the tr.phic state of r.ser.oir.

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Inter.ational Soil and Water.Conser.ation r.sear.h 2023年第1期11卷 197-212页

作者： Fr.nklin Tor.es-Bejar.no Jesús garcía-Gallego Javier.Salcedo-Salgado Depar.ment of Envir.nmental Engineer.ng University of CordobaCarrera 6 No.77-305230002MonteriaColombia Envir.nmental Engineer.ng Pr.gr.m University of CordobaCarrera 6 No.77-305230002MonteriaColombia

A tr.phic state incr.ase r.lates to sur.ace water.bodies nutr.ent enr.chment,due to the chemical pr.ducts used such as fer.ilizer. in agr.cultur. and r.sidues fr.m cattle r.ising *** r.sear.h consists of nutr.ent tr.nspor. numer.cal modeling to analyze the Betancír.ser.oir.tr.phic state in Colombia;Water.samples wer. collected to analyze total nitr.gen,total phosphor.s,ammonia,nitr.tes,nitr.tes,phosphates,chlor.phyll-a,dissolved oxygen,BOD,COD,suspended solids,and water.*** water.quality model MOHID Studio was implemented and after.its calibr.tion,scenar.os of incr.ase and decr.ase of nutr.ents and inflows to the r.ser.oir.thr.ugh its main tr.butar.es wer. simulated to r.pr.duce the agr.cultur.l activity changes in the basin and the effects that would have on the r.ser.oir.s tr.phic state dynamics;Ther.for.,the Car.son Tr.phic Status Index was calculated for.each *** r.sults show that var.ations in total nitr.gen concentr.tion and incr.ased inflows pr.sent shor.-ter. consequences on the r.ser.oir.s tr.phic *** the incoming total nitr.gen con-centr.tions by 100%causes the r.ser.oir.to change fr.m a light eutr.phic to a hyper.utr.phic *** r.sults of this r.sear.h pr.vide a star.ing tool to water.r.sour.es integr.ted management in r.ser.oir..

关键词： Envir.nmental modeling Tr.phic state index Nutr.ent tr.nspor. Eutr.phication Water.pollution

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Mitochondr.al phylogeogr.phy and molecular.evolution of the r.odopsin visual pigment in tr.globitic populations of Astyanax mexicanus(De Filippi,1853)

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Zoological r.sear.h 2023年第4期44卷 761-775页

作者： Mar.o A.A.Gar.uño-Sánchez Vladimir.de jesus-Bonilla Silvia Per.a r.mses Mir.nda-Gamboa Andr.a Her.er.-garcía Maur.cio de la Maza Benignos Claudia Patr.cia Or.elas-garcía Colección Nacional de Peces Departamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoC.P.04510México Posgr.do en Ciencias Biológicas Colección Nacional de PecesDepartamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoC.P.04510México Licenciatur. en Ciencias For.nses Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCiudad UniversitariaCoyoacánMéxico CityC.P.04510México Instituto de Ener.ías r.novables Universidad Nacional Autónoma de MéxicoTemixcoMorelos C.P.62580Mexico Facultad de Ciencias Biológicas Universidad Autónoma de Nuevo LeónCiudad UniversitariaSan Nicolás de los GarzaNuevo LeónC.P.66450México

Cave-adapted animals pr.vide a unique oppor.unity to study the evolutionar. mechanisms under.ying phenotypic,metabolic,behavior.l,and genetic evolution in r.sponse to cave *** Mexican tetr.(Astyanax mexicanus)is consider.d a unique model system as it shows both sur.ace and cave-dwelling *** date,at least 33 differ.nt cave populations have been identified,with phylogenetic studies suggesting an or.gin fr.m at least two independent sur.ace lineages,ther.by pr.viding a unique oppor.unity to study par.llel *** the pr.sent study,we car.ied out the most exhaustive phylogeogr.phic study of *** to date,including cave and sur.ace localities,using two mitochondr.al mar.er.(cytochr.me b(cyt b)and cytochr.me c oxidase subunit I(COI))and nuclear.r.odopsin visual pigment(r.o).Additionally,we infer.ed the molecular.evolution of r.o within the two contr.sting envir.nments(cave and sur.ace)and acr.ss thr.e geogr.phic r.gions(Sier.a de El Abr.,Sier.a de Guatemala,and Micos).In total,267 individuals wer. sequenced for.the two mitochondr.al fr.gments and 268 individuals wer. sequenced for.the r.o visual pigment fr.m 22 cave and 46 sur.ace *** r.sults based on the mitochondr.al data suppor.ed the two-lineage hypothesis,except for.the Pachón and Chica caves,whose intr.gr.ssion has been lar.ely *** Sier.a de El Abr. r.gion depicted the lar.est genetic diver.ity,followed by the Sier.a de Guatemala *** the phylogeogr.phic patter.s of r.o,we r.cover.d exclusive haplogr.ups for.the Sier.a de El Abr.(Haplogr.up I)and Sier.a de Guatemala r.gions(Haplogr.up IV).Mor.over.a 544 bp deletion in the r.o gene was obser.ed in the Escondido cave population fr.m Sier.a de Guatemala,r.ducing the pr.tein fr.m seven to thr.e intr.membr.ne *** change may pr.duce a loss-of-function(LOF)but r.quir.s fur.her.*** nonsynonymous(dN)and synonymous(dS)substitution r.tes(omega valuesω),our.r.sults r.vealed

关键词： Visual pigments Selection Cavefish Vision loss Loss of function

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Commitment of human mesenchymal str.mal cells to skeletal lineages is independent of their.mor.hogenetic capacity

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Wor.d Jour.al of Stem Cells 2023年第7期15卷 701-712页

作者： Jessica Cr.stina Mar.n-Ller. Damián garcía-garcía Estefania Gar.y-Pacheco Victor.Adr.an Cor.es-Mor.les Juan Jose Montesinos-Montesinos jesus Chimal-Monr.y Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCoyoacan 04510Mexico Labor.tor.o de Células Tr.ncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Depar.amento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCoyoacan 04510Mexico

BACKGr.UND Mesenchymal str.mal cells(MSCs)ar. multipotent cell populations obtained fr.m fetal and adult *** shar. some char.cter.stics with limb bud mesoder.al cells such as differ.ntiation potential into osteogenic,chondr.genic,and tenogenic lineages and an embr.onic mesoder.al *** MSCs differ.ntiate into skeletal-r.lated lineages in vitr.,they have not been shown to selfor.anize into complex skeletal str.ctur.s or.connective tissues,as in the *** this wor.,we demonstr.te that the expr.ssion of molecular.mar.er. to commit MSCs to skeletal lineages is not sufficient to gener.te skeletal elements in *** To evaluate the potential of MSCs to differ.ntiate into skeletal lineages and gener.te complex skeletal str.ctur.s using the r.combinant limb(r.)*** We used the exper.mental system of r.s fr.m dissociated-r.aggr.gated human placenta(PL)and umbilical cor. blood(UCB)*** being har.ested and r.aggr.gated in a pellet,cultur.d cells wer. intr.duced into an ectoder.al cover.obtained fr.m an ear.y chicken limb ***,this filled ectoder. was gr.fted into the back of a donor.chick *** these conditions,the cells r.ceived and r.sponded to the ectoder.’s embr.onic signals in a spatiotempor.l manner.to differ.ntiate and patter. into skeletal *** r.sponse to differ.ntiation and mor.hogenetic signals was evaluated by quantitative poly-mer.se chain r.action,histology,immunofluor.scence,scanning electr.n micr.scopy,and in situ *** We found that human PL-MSCs and UCB-MSCs constituting the r.s expr.ssed chondr.genic,osteogenic,and tenogenic molecular.mar.er. while differ.ntially committing into limb lineages but could not gener.te complex str.ctur.s in ***-r. fr.m PL or.UCB wer. committed ear.y to chondr.genic ***,the UCB-r. osteogenic commitment was favor.d,although pr.fer.ntially to a tenogenic cell *** findings suggest that the commitment of MSCs to differ.ntiate int

关键词： Human mesenchymal str.mal cells r.combinant limbs Mesenchymal str.mal cell mor.hogene-sis Mesenchymal str.mal cell in vivo differ.ntiation Skeletal tissues

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r.sidents'per.eption of sustainable tour.sm in pr.tected mountain ar.as:the case of Astur.as

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Jour.al of Mountain Science 2022年第12期19卷 3597-3614页

作者： MAGADAN-DIAZ Mar.a r.VAS-garcIA jesus I. Faculty of Business and Communication Universidad Internacional de La RiojaAvda.de la Paz 137Logrono 26o06Spain

Spain is the countr. with the most Biospher. r.ser.es in the wor.d,52,and Astur.as,with 7,r.nks fir.t among the single-pr.vince Autonomous *** tour.st inter.st in these natur.l spaces is incr.asing,but little or.nothing is known about how the r.sidents of these natur.l spaces per.eive the tour.st *** main objective of this r.sear.h was to evaluate the r.sidents’per.eived changes in pr.tected mountain ar.as in Astur.as concer.ing the envir.nmental,sociocultur.l,and economic dimensions r.lated to tour.sm activity with sur.ey methods and var.ous quantitative *** findings obtained wer. the following:fir.tly,ther. wer. significant differ.nces between the r.sidents’sociodemogr.phic char.cter.stics and their.per.eptions of tour.sm impacts;secondly,ther. wer. positive r.lationships between the r.sidents’per.eived tour.sm economic,envir.nmental and sociocultur.l impacts and their.gener.l attitude towar.s tour.sm development;and thir.ly,the mor. positive the r.sidents’attitude towar.s tour.sm development,the mor. likely r.sidents actively suppor. its fur.her.*** findings indicate the willingness of r.sidents to get involved and par.icipate in the tour.sm activity,so policymaker. should implicate r.sidents in decisionmaking on local tour.sm *** conclusion,long-ter. monitor.ng of r.sidents’evolution of their.per.eptions and attitudes is necessar. to achieve sustainable tour.sm development.

关键词： Sustainable tour.sm Tour.sts’per.eption Sur.ey method r.gr.ssion analysis Astur.as

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