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贝莱斯·卢比奥幼儿园

景观设计 2011年第5期 36-45页

作者： Los del Desierto jesus granada（图） David Frutos（图）谷晓瑞（翻译）

该项目是为3岁以下的孩子们而设计．目的是要培养孩子们的心智以及社交能力。在孩子们的世界里．房子的屋顶都是倾斜的。先画一个屋顶．下面画个方框．再添上门和窗户．一个房子就画好了。孩子们的童年大部分时间是在托儿所这所大房子... 详细信息

该项目是为3岁以下的孩子们而设计．目的是要培养孩子们的心智以及社交能力。在孩子们的世界里．房子的屋顶都是倾斜的。先画一个屋顶．下面画个方框．再添上门和窗户．一个房子就画好了。孩子们的童年大部分时间是在托儿所这所大房子里面度过的。

关键词：幼儿园莱斯孩子房子托儿所屋顶窗户

Survival effects of antibiotic exposure during the larval and adult stages in the West Nile virus vector Culex pipiens

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Insect Science 2024年第2期31卷 542-550页

作者： Marta Garrigos Mario Garrido Manuel Morales-Yuste JosuéMartinez-de la Puente jesus Veiga Faculty of Pharmacy Department of ParasitologyUniversity of GranadaGranadaSpain CIBER de Epidemiologia y Salud Publica(CIBERESP) MadridSpain

The ability of mosquitoes to transmit a pathogen is affected,among other factors,by their survival rate,which is partly modulated by their *** microbiota is acquired during the larval phase and modified during their development and adult feeding behavior,being highly dependent on environmental *** residues including antibiotics are widespread pollutants potentially being present in mosquito breeding waters likely affecting their ***,we used Culex pipiens mosquitoes to assess the impact of antibiotic exposure during the larval and adult stages on the survival rate of adult ***-collected larvae were randomly assigned to two treatments:larvae maintained in water supplemented with antibiotics and control *** adults were subsequently assigned to each of two treatments,fed with sugar solution with antibiotics and fed only with sugar solution(controls).Larval exposure to antibiotics significantly increased the survival rate of adult females that received a control *** addition,the effect of adult exposure to antibiotics on the survival rate of both male and female mosquitoes depended on the number of days that larvae fed ad libitum in the laboratory before *** particular,shorter larval ad libitum feeding periods reduced the survival rate of antibiotic-treated adult mosquitoes compared with those that emerged after a longer larval feeding *** differences were not found in control adult *** results extend the current understanding of the impact of antibiotic exposure of mosquitoes on a key component of vectorial capacity,that is the vector survival rate.

关键词： antibiotics avian malaria microbiota mosquitoes vector competence vector survival

Life cycle and nymphal feeding of Besdolus ravizzarum （Plecoptera： Perlodidae）, a threatened stonefly

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Insect Science 2010年第2期17卷 149-153页

作者： Stefano Fenoglio Tiziano Bo Manuel jesus Lepez-Rodriguez Jose Manuel Tierno de Figueroa Dipartimento di Scienze dell'Ambiente e della Vita Universita del Piemonte Orientale Alessandria Italy Departamento de Biologia Animal Facultad de Ciencias Universidad de Granada Granada Spain

We have studied some aspects of Besdolus ravizzarum biology in the Apen- nines. This stonefly has a very localized distribution in southeastern France and northern Italy. This species is considered threatened. For this reason it is especially relevant to improve knowledge about its natural history, previously unknown. Despite the large size of nymphs, this species shows a univoltine life cycle. The growth is slow but uniform from October to April or May when the short flight period occurs. The analysis of the gut con- tents indicates this species is a predator, feeding mainly on Baetidae and Chironomidae. It is notable that the development of this carnivorous species through cold periods coincides with the season with higher richness and density of potential prey in Apennine streams. Further studies are needed to improve knowledge of the distribution of the species and to start planning effective conservation efforts.

关键词： conservation life history northern Italy stonefly threatened species trophic role

Impact of socioeconomic and health-related factors on consumption of homeopathic and natural remedies in Spain in 2006, 2011 and 2017

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Journal of Integrative Medicine 2022年第1期20卷 52-56页

作者： Jose Antonio Castilla-Jimena Isabel Ruiz-Perez jesus Henares-Montiel Andalusian School of Public Health 1801J GranadaSpain Unit of Clinical Management of Preventive Medicine and Public Health and Occupational Medicine Puerto del Mar University Hospital11009 CadizSpain Consortium for Networked Biomedical Research in Epidemiology and Public Health 28029 MadridSpain Institute for Biosanitary Research(ibs.granada) 18012 GranadaSpain

Objective: Complementary and alternative medicine use and type of use may be influenced by sociodemographic and economic determinants through which we could identify characteristics of patients with greater trend to use it. This paper aims to describe the changes in the consumption of homeopathic and natural remedies in Spain for three time points in order to discern changes in rate of consumption, associated factors and whether their use has been affected by a period of economic ***: This study utilized 2006, 2011 and 2017 cross-sectional data from the Spanish National Health Survey, a nationally representative survey of the population aged more than 15 years old and resident in Spain. Independent bivariate and multivariate descriptive analyses for each of the 3 years studied were ***: The rate of consumption of both homeopathic and natural remedies has decreased over the periods studied. In spite of this decrease, the consumer profile appears to remain stable over the three periods. The sociodemographic factors associated with their consumption were being female, being 30–64 years old, being separated/divorced, having higher education qualifications, being employed and belonging to a higher social class. Psychiatric morbidity, chronic health problems such as pain, mental health problems or malignant tumors, and absence of major cardiovascular events were the clinical factors ***: It can be concluded that beyond the economic situation, the use of homeopathic and natural remedies obeys to the needs of the patients related to their state of health and the response they receive from the health system. It may be that women have different needs and expectations of the healthcare system and, given this breach of expectations, seek remedy to alleviate their needs outside the system and conventional medicine.

关键词： Complementary and alternative medicine Homeopathic remedies Natural remedies Economic recession Gender differences

Megacryometeors:Distribution on Earth and Current Research

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AMBIO－人类环境杂志 2006年第6期35卷 314-316页

作者： jesus Martinez-Frias Antonio Delgado Huertas Planetary Geology Laboratory Centro de Astrobiologia Ctra de Ajalvirkm.4 28850 Torrejón de Ardoz MadridSpain Department of Earth Sciences and Environmental Chemistry Estación Experimental del Zaidín CSIC Prof.Albareda 1 18008 GranadaSpain

研究有关陨冰（ice falls）的历史记录，我们可以发现许多非常类似的事例。实际上，还没有任何关于晴天坠落的冰的适当研究，这些现象往往未经证实就被简单地归为飞机在高空的结冰现象、飞机卫生间产生的污水（蓝冰）或飞机水箱漏水而... 详细信息

研究有关陨冰（ice falls）的历史记录，我们可以发现许多非常类似的事例。实际上，还没有任何关于晴天坠落的冰的适当研究，这些现象往往未经证实就被简单地归为飞机在高空的结冰现象、飞机卫生间产生的污水（蓝冰）或飞机水箱漏水而结成的冰。然而，有必要重新考虑以下两个问题：首先，记载这些事件的历史文献可以追溯到19世纪上半叶，在飞机发明之前已经有了大量的记载。其次，如果在科学数据库（Webof Science，GeoRef）中，仔细检索众所周知的飞机结冰过程的有关案例，所得到的结论相悖于前文中简单的解释——在飞机任何部位都无法形成长达1m、重达几百公斤的冰。

关键词：陨冰地球结冰过程科学数据库历史记录历史文献飞机卫生间

Modifications of sexual activity during uncomplicated pregnancy: A prospective investigation of Spanish women

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Health 2013年第8期5卷 1289-1294页

作者： Raquel Escudero-Rivas Pilar Carretero Africa Cano Milagros Cruz jesus Florido Department of Obstetrics and Gynecology San Cecilio University Hospital(HUSC)GranadaSpain Department of Obstetrics and Gynecology University of GranadaGranadaSpain

Introduction: Pregnancy is a time of profound changes in a woman’s life. These changes can influence her sexual behaviour and the relationship with her partner. The purpose of this article is to study sexual behaviour modification before and during pregnancy in a cohort of healthy Spanish pregnant women. Methods: This is a prospective cohort study in which 111 pregnant women took part. They completed a questionnaire about their sexual habits before pregnancy and at 20, 30 and 38 weeks (frequency of intercourse and orgasm, satisfaction with their relationships and pain or discomfort). Results: Intercourse frequency decreased progressively during pregnancy at all times studied relative to pre-regnancy periods, to a significant degree (p < 0.0001), accompanied by a reduction in sexual satisfaction. The incidence of orgasm was lightly modified, except in the weeks before parturition in which it underwent a notable decrease (p < 0.0001) with an increase in the rate of hypoorgasmia/ anorgasmia from 19% pre-pregnancy to 43% at 38th week. Conclusions: The longitudinal monitoring of this cohort permits the conclusion that during pregnancy, sexual behaviour undergoes a general decline with respect to prepregnancy levels. The differences vary depending on the sexual parameter considered, with intercourse frequency being the most affected variable in contrast to dyspareunia, which is the least affected.

关键词： Sexuality Frequency of Intercourse Satisfaction Orgasm

Context-dependent insect predation pressure on an avian ectoparasite

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Insect Science 2023年第6期30卷 1784-1797页

作者： Angela Salido Jesús Veiga Joaquín Luis Reyes-López Francisco Valera Department of Botany Ecology and Plant PhysiologyUniversity of CórdobaCórdobaSpain Departamento de Ecología Funcional y Evolutiva Estación Experimental de ZonasÁridas(EEZA-CSIC)AlmeríaSpain Department of Parasitology University of GranadaGranadaSpain MEMEG Department of BiologyLund UniversityLundSweden

Context dependence arises when ecological relationships vary with the conditions under which they are observed. Context dependence of interactions involving parasites is poorly known, even if it is key to understanding host–parasite relationships and food web dynamics. This paper investigates to which extent predation pressure on an avian ectoparasite (Carnus hemapterus) is context-dependent. Based on a predator-exclusion experiment, predation pressure on C. hemapterus pupae in the host's nest for 3 years, and its variation between habitat types are quantified. Variation in precipitation and normalized difference vegetation index (NDVI) is also explored as a likely cause of context dependency. We hypothesize that predation pressure should fluctuate with such surrogates of food availability, so that inter-annual and intra-annual differences may emerge. The number of nests with significant reduction of pupae varied widely among years ranging from 24% to 75%. However, average pupae reduction in nests where a significant reduction occurred did not vary between years. No differences in predation rates between habitat types were detected. Precipitation and NDVI varied widely between years and NDVI was consistently lower around nests on cliffs than around nests on trees and farmhouses. Parallels were found between variation in predation pressure and precipitation/NDVI at a wide scale (highest predation the driest year, and much lower the 2 rainier ones), but not at the nest scale. This paper shows clear context-dependent insect predation pressure on an ectoparasite under natural conditions, and that such interaction changes in signs rather than magnitude between years. The causes for these variations require longer-term studies and/or well-designed, large-scale experiments.

关键词： ants arid areas Carnus hemapterus consumer-resource interaction ecosys-tem productivity predator-parasite rainfall

Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

Determination of Polyphenolic Compounds by Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry and Antioxidant Capacity of Spanish Subtropical Fruits

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Agricultural Sciences 2018年第2期9卷 180-199页

作者： Adelaida Esteban Munoz Montserrat Barea Alvarez Maria-jesus Oliveras-Lopez Rafael Gimenez Martinez Jose Angel Rufian Henares Manuel Olalla Herrera Department of Nutrition and Bromatology School of PharmacyUniversity of GranadaGranadaSpain Nutrition and Food Science University of GranadaGranadaSpain Department of Molecular Biology and Biochemical Engineering Area of Nutrition and Food ScienceUniversity Pablo de Olavide of SevillaSevilleSpain

In an analysis of the seven types of subtropical fruits most consumed and produced in southern Spain, UPLC-ESI-MS/MS was used to quantify 14 phenolic species: five hydroxycinnamic acids, seven hydroxybenzoic acids and two flavonoids (quercetin and naringenin). In each case, in addition, antioxidant capacity was determined by FRAP, ABTS and DPPH. Of these fruits, carambola (or starfruit) presented the highest levels of phenolic compounds, cherimoya (custard apple) and kiwi were the richest in non-flavonoid phenolic compounds and papaya had the highest levels of the flavonoids studied. Higher mean values were recorded in home-grown fruits than in imported varieties by ABTS and DPPH methods. Persimmon’s antioxidant capacity was well above that of the other fruits, according to our analyses.

关键词： Phenolic Compounds Spanish Subtropical Fruits Antioxidant Activity UPLC-ESI-MS/MS Q-TOF