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Unr.veling the Biochemical and Molecular.Networ.s Involved in Maize Cell Habituation to the Cellulose Biosynthesis Inhibitor.Dichlobenil

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Molecular.Plant 2010年第5期3卷 842-853页

作者： Hugo Melida Antonio Encina jesus alvarez Jose Luis Acebes David Capar.os-r.iz Ar.a de Fisiologia Vegetal Facultad de CC. Biologicas y Ambientales Universidad de Leon E-24071 Leon Spain Centr. de r.cer.a en Agr.Gen6mica (Consor.i CSIC-Ir.A-UAB) Jordi Girona 18-26 E-08034 Barcelona Spain

The biochemical and molecular.pr.cesses involved in the habituation of maize cells to gr.wth in the pr.sence of the cellulose biosynthesis inhibitor.dichlobenil （DCB） wer. investigated. DCB affects the synthesis of cellulose both in active and stationar. gr.wth phases and alter. the expr.ssion of sever.l CesA genes. Of these, ZmCesA5 and ZmCesA7 seem to play a major.r.le in habituating cells to gr.wth in the pr.sence of DCB. As a consequence of the r.duction in cellulose, the expr.ssion of sever.l genes involved in the synthesis of hydr.xycinnamates is incr.ased, r.sulting in cell walls with higher.levels of fer.lic and p-coumar.c acids. A pr.teomic analysis r.vealed that habituation to DCB is linked to modifications in sever.l metabolic pathways. Finally, habituated cells pr.sent a r.duction in glutathione S-tr.nsfer.se detoxifying activity and antioxidant activities. Plant cell adaptation to the distur.ance of such a cr.cial pr.cess as cellulose biosynthesis r.quir.s changes in sever.l metabolic networ.s, in or.er.to modify cell wall ar.hitectur. and metabolism, and sur.ive in the pr.sence of the inhibitor. Some of these modifications ar. descr.bed in this paper.

关键词： Abiotic/envir.nmental str.ss acclimation--physiological cell walls maize cellulose dichlobenil phenylpr.panoid.

Changes in Cinnamic Acid Der.vatives Associated with the Habituation of Maize Cells to Dichlobenil

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Molecular.Plant 2011年第5期4卷 869-878页

作者： Hugo Melida jesus alvarez Jose Luis Acebes Antonio Encina Stephen C. Fr. Ar.a de Fisiologia Vegetal Facultad de CC Biologicas y Ambientales Universidad de Leon E-24071 Leon Spain Edinbur.h Cell Wall Gr.up Institute of Molecular Plant Sciences School of Biological Sciences University of Edinburgh Daniel Rutherford Building The King＇s Buildings Edinburgh EH9 3JH UK

The habituation of cell cultur.s to cellulose biosynthesis inhibitor. such as dichlobenil （DCB） r.pr.sents a valu- able tool to impr.ve our.knowledge of the mechanisms involved in plant cell wall str.ctur.l plasticity. Maize cell lines habituated to lethal concentr.tions of DCB wer. able to gr.w thr.ugh the acquisition of a modified cell wall in which cellulose was par.ially r.placed by a mor. extensive networ. of ar.binoxylans. The aim of this wor. was to investigate the phenolic metabolism of non-habituated and DCB-habituated maize cell cultur.s. Maize cell cultur.s wer. fed [14C]cinnamate and the fate of the r.dioactivity in differ.nt intr.-pr.toplasmic and wall-localized fr.ctions thr.ughout the cultur. cycle was analyzed by autor.diogr.phy and scintillation counting. Non-habituated and habituated cultur.s did not mar.edly differ.in their.ability to uptake exogenous [14C]cinnamic acid. However. inter.sting differ.nces wer. found in the r.diolabeling of low- and high-Mr.metabolites. Habituated cultur.s displayed a higher.number.and amount of r.diola-beled low-Mr.compounds, which could act as r.ser.es later.used for.polysacchar.de fer.loylation. DCB-habituated cultur.s wer. highly enr.ched in ester.fied [14C]dehydr.difer.lates and lar.er.coupling pr.ducts. In conclusion, an extensive and ear.y cr.ss-linking of hydr.xycinnamates was obser.ed in DCB-habituated cultur.s, pr.bably str.ngthening their.cellulose-deficient walls.

关键词： Cell wall Zea mays maize dichlobenil DCB dehydr.difer.late fer.late cinnamic acid.

Br.eding bir. density does not dr.ve vocal individuality

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Cur.ent Zoology 2012年第5期58卷 765-772页

作者： Daniel T. BLUMSTEIN Douglas r. MCCLAIN Car.ie DE jesus Gustavo ALAr.ON-NIETO The r.cky Mountain Biological Labor.tor. Box 519 Crested Butte CO 81224 USA Depar.ment of Ecology and Evolutionar. Biology University of California Los Angeles 621 Charles E. Young Dr. South Los Angeles CA 90095-1606 USA

Many species pr.duce individually specific vocalizations and sociality is a hypothesized dr.ver.of such individuality. Pr.vious studies of how social var.ation influenced individuality focused on colonial or.non-colonial avian species, and how so- cial gr.up size influenced individuality in sciur.d r.dents. Since sociality is an impor.ant dr.ver.of individuality, we expected that bir. species that defend nesting ter.itor.es in higher.density neighbor.oods should have mor. individually-distinctive calls than those that defend nesting ter.itor.es in lower.density neighbor.oods. We used Beecher.s infor.ation statistic to quantify individu- ality, and we examined the r.lationship between bir. density （calculated with point-counts） and vocal individuality on seven spe- cies of passer.nes. We found non-significant r.lationships between br.eding bir. density and vocal individuality whether.r.gr.s- sions wer. fitted on species values, or.on phylogenetically-independent contr.st values. Fr.m these r.sults, we infer.that while in- dividuality may be explained by social factor., br.eding bir. density is unlikely to be gener.lly impor.ant in dr.ving the evolution of individually-specific vocalizations [Cur.ent Zoology 58 （5）： 765-772, 2012].

关键词： Individuality Sociality Bir.song Br.eding bir. density

Full-thickness scler.l incisions technique for.the tr.atment of a cyclodialysis cleft following ab inter.o tr.beculotomy

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Inter.ational Jour.al of Ophthalmology(English edition) 2019年第10期12卷 1662-1665页

作者： Daniela alvarez-Ascencio jesus Jimenez-r.man r.fael Castaneda-Diez Gabr.el Lazcano-Gomez Glaucoma Depar.ment Asociacion Para Evitar la Ceguera en Mexico

Dear.Editor. I am *** alvarez-Ascenciofr.mtheGlaucoma Depar.ment at Asociacion Par. Evitar.la Ceguer. (APEC)in Mexico City, Mexico. I wr.te to pr.sent a successful case of cyclodyalisis r.pair.in a dir.ct visualizatio... 详细信息

关键词： CC OS UBM Full-thickness scler.l incisions technique for.the tr.atment of a yclodialysis cleft following ab inter.o tr.beculotomy

Cr.hn’s disease:Innate immunodeficiency?

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Wor.d Jour.al of Gastr.enter.logy 2006年第42期12卷 6751-6755页

作者： jesus K Yamamoto-Fur.sho Joshua r.Kor.enik Gastr.-intestinal Unit and Center.for.the Study of Inflammator. Bowel Disease Massachusetts General Hospital and Harvard Medical School Boston MA 02114 United States

In the past, Cr.hn’s disease (CD) has been under.tood pr.mar.ly as an immunologic disor.er.char.cter.zed by an abnor.al T-cell r.sponse. r.cent in vitr. and in vivo data suggests that CD may instead be pr.cipitated by innate immune dysfunction r.sulting fr.m a combination of genetic and envir.nmental factor.. Some r.por.s have demonstr.ted a defective immune r.sponse in a var.ety of other.cellular.components, including neutr.phils, monocytes and dendr.tic cells. r.cent studies of gr.nulocyte-macr.phage colony-stimulating factor.(GM- CSF) in CD, aiming to stimulate the innate immune system with the conception that an innate immune defect under.ies the development of the disease, have been demonstr.ted a clinical benefit and r.infor.e this evolving under.tanding of the disease.

关键词： Cr.hn's disease Innate immunity Immunodeficiency NOD2

Gene Ther.py of Cancer.Induction of Anti-Tumor.Immunity

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Cellular.& Molecular.Immunology 2004年第2期1卷 105-111页

作者： jesus Pr.eto Division

Many malignancies lack satisfactor. tr.atment and new ther.peutic options ar. ur.ently *** ther.py is a new modality to tr.at both inher.ted and acquir.d diseases based on the tr.nsfer.of genetic mater.al to the *** gene ther.py str.tegies against cancer. have been developed.A consider.ble number.of pr.clinical studies indicate that a gr.at var.ety of cancer. ar. amenable to gene *** these str.tegies, induction of anti-tumor.immunity is the most pr.mising *** ther.py with cytokines has r.ached unpr.cedented success in pr.clinical models of *** r.ther.than additive effects have been demonstr.ted by combination of gene tr.nsfer.of cytokines/chemokines,costimulator. molecules or.adoptive cell *** pr.gr.ss in vector.technology and in imaging techniques allowing in vivo assessment of gene expr.ssion will facilitate the development of clinical applications of gene ther.py,a pr.cedur. which may have a notor.ous impact in the management of cancer. lacking effective *** & Molecular.Immunology.2004;1(2):105-111.

关键词： gene ther.py anti-tumor.immunity cytokines costimulator. molecules dendr.tic cell

r.al dr.ve cycles analysis by or.er.d power.methodology applied to fuel consumption,C0_(2),NO_(x) and PM emissions estimation

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Fr.ntier. of Envir.nmental Science & Engineer.ng 2021年第1期15卷 77-90页

作者： Pol Masclans Abello Vicente Medina Iglesias M.Antonia de los Santos Lopez jesus alvarez-Flor.z Center.for.Engines and Heat Installation r.sear.h(Cr.MIT-UPC).Univer.itat Politecnica de Catalunya-Bar.elonaTech.Av.Diagonal 547(ETSEIB)08028 Bar.elona Spain Depar.ment of Ther.al Machiner. of Univer.itat Politecnica de Catalunya-Bar.elonaTech and Cr.MIT-UPC.-Bar.elonaTech.Av.Diagonal 547(ETSEIB)08028 Bar.elona Spain 3 Depar.ment of Mechanical Engineer.ng of Univer.itat Politecnica de Catalunya-Bar.elonaTech and Cr.MIT-UPC.-Bar.elonaTech.Av.Diagonal 547(ETSEIB)08028 Bar.elona Spain

In this wor. thr.e fuel consumption and exhaust emission models,ADVISOr.VT-MICr. and the Eur.pean Envir.nmental Agency Emission factor.,have been used to obtain fuel consumption(FC)and exhaust *** models have been used at micr.-scale,using the two signal tr.atment methods *** manuscr.pt pr.sents:1)a methodology to collect data in r.al ur.an dr.ving cycles,2)an estimation of FC and tailpipe emissions using some available models in liter.tur.,and 3)a novel analysis of the r.sults based on deliver.d wheel *** r.sults include Fuel Consumption(FC),CO_(2),NO_(x) and PM_(10) emissions,which ar. der.ved fr.m the thr.e *** the fir.t par. of the paper.we pr.sent a new pr.cedur. for.incomplete dr.ve cycle data tr.atment,which is necessar. for.r.al dr.ve cycle acquisition in high density *** the models ar. used to obtain second by second FC and exhaust ***,a new methodology named Cycle Analysis by Or.er.d Power.CAbOP)is pr.sented and used to compar. the *** method consists in the r.-or.er.ng of time dependant data,consider.ng the wheel mechanical power.domain instead of the standar. time *** new str.tegy allows the 5 situations in dr.ve cycles to be clear.y visualized:har. br.aking zone,slowdowns,idle or.stop zone,sustained speed zone and acceler.tion *** complete methodology is applied in two r.al dr.ve cycles sur.eyed in Bar.elona(Spain)and the r.sults ar. compar.d with a standar.ized WLTC ur.an cycle.

关键词： Cycle Analysis by Or.er.d Power.CAbOP) Micr. and macr. models r.al dr.ve cycle NO_(x)/PM_(10)/CO_(2)emissions Wheel mechanical power.domain Wor.dwide Har.onized Light-Duty Vehicles Test Cycle(WLTC)

Integr.ting Levels of Hier.r.hical Or.anization in Por.us Or.anic Molecular.Mater.als

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Nano-Micr. Letter. 2024年第5期16卷 134-153页

作者： jesus Fer.ando‑Sor.a Antonio Fer.andez Instituto de Ciencia Molecular.ICMol) Universidad de Valencia46980 ValenciaSpain School of Science Loughborough UniversityLoughborough LE113TUUK

Por.us or.anic molecular.mater.als(POMMs)ar. an emer.ent class of molecular.based mater.als char.cter.zed by the for.ation of extended por.us fr.mewor.s,mainly held by non-covalent *** r.pr.sent a var.ety of chemical families,such as hydr.gen-bonded or.anic fr.mewor.s,por.us or.anic salts,por.us or.anic cages,C-H···πmicr.por.us cr.stals,supr.molecular.or.anic fr.mewor.s,π-or.anic fr.mewor.s,halogen-bonded or.anic fr.mewor.,and intr.nsically por.us molecular.*** some por.us mater.als such as zeolites and metal or.anic fr.mewor.s,the integr.tion of multiscale has been adopted to build mater.als with multifunctionality and optimized ***,consider.ng the significant r.le of hier.r.hy in por.us mater.als and the gr.wing impor.ance of POMMs in the r.alm of synthetic por.us mater.als,we consider.it appr.pr.ate to dedicate for.the fir.t time a cr.tical r.view cover.ng both ***,we will pr.vide a summar. of liter.tur. examples showcasing hier.r.hical POMMs,with a focus on their.main synthetic appr.aches,applications,and the advantages br.ught for.h by intr.ducing hier.r.hy.

关键词： Por.us or.anic molecular.mater.als Hier.r.hy Hydr.gen-bonded or.anic fr.mewor.s Por.us cages Fuller.ne

Episcler.l br.chyther.py as an effective alter.ative in vasopr.lifer.tive tumor.

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Inter.ational Jour.al of Ophthalmology(English edition) 2018年第12期11卷 2017-2020页

作者： Mar.a Par. Pr.eto Mar.a Antonia Saor.il jesus Mar.a de Fr.tos Bar.ja Cir. Gar.ia alvarez Patr.eia Diezhandino Gar.ia Fr.ncisco Lopez Lar. Intr.ocular.Tumor. Unit Ophthalmology &Radiotherapy departmentsHospital Clinico UniversitarioValladolid 47005 Spain

The aim of this study is to assess the r.sults of episcler.l br.chyther.py as tr.atment of r.tinal vasopr.lifer.tive tumor.(r.Ts) in a r.fer.al Intr.ocular.Tumor. Unit(ITU). A r.tr.spective r.view of all patients diagnosed with vasopr.lifer.tive tumor. of the r.tina and tr.ated with episcler.l br.chyther.py in the ITU, Univer.ity Hospital of Valladolid between 2009 and 2015 was done. Five patients accomplished the inclusion cr.ter.a. All of them pr.sented associated exudation and secondar. r.tinal detachments(r.). Four.patients had r.ceived pr.or.tr.atments. Decr.ased tumor.size and exudation r.gr.ssion was found in all cases after.tr.atment. Visual acuity r.mained stable or.incr.ased in all patients. No r.cur.ences have been found after.twelve-months follow up. The r.sults of the pr.sent study suggest that episcler.l br.chyther.py is an efficient and safe option in the management of vasopr.lifer.tive tumor., especially when lar.e tumor.or.extensive subr.tinal fluid is pr.sent. In these cases episcler.l br.chyther.py could be consider.d as a fir.t line tr.atment.

关键词： episcler.l br.chyther.py r.tinal vasopr.lifer.tive tumor.