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Perspectives for the association between olfactory disturbances and depression in Parkinson's disease

Neural Regeneration Research 2019年第4期14卷 591-592页

作者： jessica l.Ilkiw Marcelo M.S.lima Neurophysiology laboratory Department of PhysiologyFederal University of Paraná

Non-motor disturbances in Parkinson’s disease:Globally,population aged 60 or over is growing and considering the World Bank predictions for the next 20 years it is expected that the number of Parkinson’s disease(PD)cases will double at the end of this period thus,reaching an impressive 13–39 million patients *** scenario is potentially associated with a significant global negative impact on public health systems particularly in countries with increased ageing populations such as the European countries,Asia and *** pathophysiology of PD involves the progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta(SNpc)that triggers denervation of the nigrostriatal pathway and consequent significant reduction of dopamine in the dorsal *** process leads to a critical motor impairment scenario characterized by bradykinesia,rigidity,resting tremor,and postural instability(Emamzadeh and Surguchov,2018).However,several other non-motor disturbances develop earlier,thus,being considered as prodromal signs of the *** this sense,the literature is increasingly emphasizing the importance of investigating mood and olfactory disruptions as high sensitive benchmarks of the early-phase *** fact,the need for innovative early-phase diagnostic tools,as well as the elucidation of the pathophysiological mechanisms of such disturbances,is essential priority in the field of investigation of ***,in the year of 2015,a woman was known for an intriguing ability of“smell PD”.Her husband had lived with the disease for twenty years and during this process she noticed that his odor slowly changed to a musky ***,this woman could associate this particular smell with PD after meeting different people with this distinct odor in a charity for PD *** fact,this clever observation is aligned with studies showing that hyposmia is found decades before the motor *** type of anecdotal story,

关键词： Parkinson olfactory disturbances association

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Reducing psychiatric illness in the perinatal period:A review and commentary

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World Journal of Psychiatry 2023年第4期13卷 149-160页

作者： jessica Rohr Farhaan S Vahidy Nicole Bartek Katelynn A Bourassa Namrata R Nanavaty Danielle D Antosh Konrad P Harms Jennifer l Stanley Alok Madan Department of Psychiatry and Behavioral Health Houston MethodistHoustonTX 77030United States Department of Neurosurgery Houston MethodistHoustonTX 77030United States Department of Obstetrics and Gynecology Houston MethodistHoustonTX 77030United States

This brief overview highlights the global crisis of perinatal psychiatric illness(PPI).PPI is a major contributor to many adverse pregnancy,childbirth,and childhood development *** contributes to billions of dollars in spending worldwide each year and has a significant impact on the individual,their family,and their *** is also highly *** recommendations for intervention and management of PPI are limited and vary considerably from country to ***,there are several significant challenges associated with implementation of these *** challenges are magnified in number and consequence among women of color and/or minority populations,who experience persistent and negative health disparities during pregnancy and the postpartum *** paper aims to provide a broad overview of the current state of recommendations and implementation challenges for PPI and layout a framework for overcoming these *** equityinformed model of care that provides universal intervention for pregnant women may be one solution to address the preventable consequences of PPI on child and maternal ***,this model emphasizes the importance of managing and eliminating known barriers to traditional health care *** and contextually specific challenges must be overcome to fully realize the impact of improved management of PPI.

关键词： Perinatal psychiatric illness Postpartum depression Equity-oriented care Minority populations Maternal mortality Pregnancy

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Analysis of PFAAs in American alligators part 2： Potential dietary exposure of South Carolina hunters from recreationally harvested alligator meat

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Journal of Environmental Sciences 2017年第11期29卷 31-38页

作者： jessica J.Tipton louis J.Guillette Jr Susan lovelace Benjamin B.Parrott Thomas R.Rainwater jessica l.Reiner College of Charleston Charleston SC 29724 USA Medical University of South Carolina Department of Obstetrics and Gynecology Charleston SC 29425 USA University of Georgia Odum School of Ecology Savannah River Ecology Laboratory Jackson SC 29831 USA Torn Yawkey Wildlife Center & Belle W. Baruch Institute of Coastal Ecology and Forest Science Clemson University P.O. Box 59(5 Georgetown SC 29442 USA National Institute of Standards and Technology Chemical Sciences Division Hollings Marine Laboratory Charleston SC 29412 USA

Exposure to perfluorinated alkyl acids（PFAAs） has been linked to many harmful health effects including reproductive disorders, developmental delays, and altered liver and kidney function. Most human exposure to environmental contaminants, including PFAAs,occurs through consumption of contaminated food or drinking water. This study uses PFAA data from meat samples collected from recreationally harvested American alligators（Alligator mississippiensis） in South Carolina to assess potential dietary exposure of hunters and their families to PFAAs. Consumption patterns were investigated using intercept surveys of 23 hunters at a wild game meat processor. An exposure scenario using the average consumption frequency, portion size, and median perfluorooctane sulfonic acid（PFOS） concentration in alligator meat from all hunt units found the daily dietary exposure to be 2.11 ng/kg body weight per day for an adult human. Dietary PFOS exposure scenarios based on location of harvest suggested the highest daily exposure occurs with alligator meat from the Middle Coastal hunt unit in South Carolina. Although no samples were found to exceed the recommended threshold for no consumption of PFOS found in Minnesota state guidelines, exposure to a mixture of PFAAs found in alligator meat and site-specific exposures based on harvest location should be considered in determining an appropriate guideline for vulnerable populations potentially exposed to PFAAs through consumption of wild alligator meat.

关键词： Public hunt American alligator Dietary exposure PFOS Consumption advisory Contaminant consumption

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Analysis of PFAAs in American alligators part 1： Concentrations in alligators harvested for consumption during South Carolina public hunts

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Journal of Environmental Sciences 2017年第11期29卷 24-30页

作者： jessica J.Tipton louis J.Guillette Jr Susan lovelace Benjamin B.Parrott Thomas R.Rainwater jessica l.Reiner College of Charleston Charleston SC 29424 USA Medical University of South Carolina Department of Obstetrics and Gynecology Charleston SC 29425 USA University of Georgia Odum School of Ecology Savannah River Ecology Laboratory Jackson SC 29831 USA Tom Yawkey Wildlife Center & Belle W. Baruch Institute of Coastal Ecology and Forest Science Clemson University P.O. Box 596 Georgetown SC 29442 USA National Institute of Standards and Technology Chemical Sciences Division Hollings Marine Laboratory Charleston SC 29412 USA

Environmental contamination resulting from the production or release of harmful chemicals can lead to negative consequences for wildlife and human health. Perfluorinated alkyl acids（PFAAs） were historically produced as protective coatings for many household items and currently persist in the environment, wildlife, and humans. PFAAs have been linked to immune suppression, endocrine disruption, and developmental toxicity in wildlife and laboratory studies. This study examines the American alligator, Alligator mississippiensis,as an important indicator of ecosystem contamination and a potential pathway for PFAA exposure in humans. Alligator meat harvested in the 2015 South Carolina（SC） public hunt season and prepared for human consumption was collected and analyzed for PFAAs to determine meat concentrations and relationships with animal body size（total length）, sex, and location of harvest. Of the 15 PFAAs analyzed, perfluorooctane sulfonate（PFOS） was found in all alligator meat samples and at the highest concentrations（median 6.73 ng/g）. No relationship was found between PFAA concentrations and total length or *** of one or all compounds varied significantly across sampling locations, with alligators harvested in the Middle Coastal hunt unit having the highest PFOS concentrations（median 16.0 ng/g; p = 0.0001）. Alligators harvested specifically from Berkley County, SC（located in the Middle Coastal hunt unit） had the highest PFOS concentrations and the greatest number of PFAAs detected（p 〈 0.0001）. The site-specific nature of PFAA concentrations in alligator meat observed in this study suggests a source of PFAA contamination in Berkley County, SC.

关键词： Perfluorinated alkyl acids American alligators South Carolina Perfluorooctane sulfonate(PFOS) Dietary exposure

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Hepatic pseudotumor associated with Strongyloides infection:A case report

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World Journal of Hepatology 2023年第12期15卷 1338-1343页

作者： jessica P Gialanella Tyler Steidl Kokkola Korpela Miral S Grandhi Russell C langan H Richard Alexander Rachel M Hudacko Brett l Ecker Department of Surgical Oncology Rutgers Cancer Institute of New JerseyNew BrunswickNJ 08901United States Rutgers New Jersey Medical School NewarkNJ 07103United States Department of Infectious Disease Cooperman Barnabas Medical CenterLivingstonNJ 07039United States Department of Pathology and labratory Medicine Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States

BACKGROUND Strongyloides sterocoralis is a parasitic infection caused by a roundworm that is transmitted through soil contaminated with *** can infrequently cause hepatic abscesses in immunocompromised patients and is rarely reported to form hepatic lesions in immunocompetent *** SUMMARY We present a case study of a 45-year-old female who presented with right upper quadrant abdominal pain and constitutional symptoms for several *** imaging identified several malignant-appearing liver *** investigation,including serological testing and histopathologic examination,revealed the presence of serum Strongyloides antibodies and hepatic granulomas with extensive *** treatment with ivermectin for 2 wk,there was complete resolution of the liver lesions and associated *** This case highlights the importance of considering parasitic infections,such as Strongyloides,in the differential diagnosis of hepatic *** recognition and appropriate treatment can lead to a favorable outcome and prevent unnecessary invasive *** awareness among clinicians is crucial to ensure the timely diagnosis and management of such cases.

关键词： Hepatic tumor liver mass Strongyloides sterocoralis Parasitology Case report

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Bile acid receptors and signaling crosstalk in the liver, gut and brain

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liver Research 2021年第3期5卷 105-118页

作者： jessica M.Ferrell John Y.l.Chiang Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Bile acids are physiological detergents derived from cholesterol that aid in digestion and nutrient ab-sorption,and they play roles in glucose,lipid,and energy metabolism and in gut microbiome and metabolic *** acids mediate crosstalk between the liver and gut through bactericidal modulation of the gut microbiome,while gut microbes influence the composition of the circulating bile acid *** research indicates bile acids may also be important mediators of neurological disease by acting as peripheral signaling molecules that activate bile acid receptors in the blood-brain barrier and in the brain *** review highlights the role of bile acids in maintaining liver and gut microbe homeostasis,as well as their function as mediators of cellular signaling in the liver-gut-brain axis.

关键词： Bile acid metabolism Farnesoid X receptor(FXR) Gut-brain axis Microbiome Neurodegenerative disease Takeda G protein-coupled receptor(TGR5)

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Removal and desorption of chromium in synthetic effluent by a mixed culture in a bioreactor with a magnetic field

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Journal of Environmental Sciences 2020年第5期32卷 151-159页

作者： Roseli MDias jessica GSilva Vicelma lCardoso Miriam Mde Resende Faculty of Civil Engineering Federal University of UberlandiaMinas GeraisBrazil Faculty of Chemical Engineering Federal University of UberlandiaMinas GeraisBrazil

Two chromium removal experiments were performed in bioreactors with and without a magnetic field under the same *** release of the chromium present in the biomass was tested in two experiments one with the initial pH of the medium and one with pH *** objective was to remove Cr(Ⅵ)and total Cr from the effluent,this was carried out by placing biological treatments of synthetic effluent contaminated with 100 mg/l of Cr(Ⅵ)in a bioreactor with neodymium magnets that applied a magnetic field(intensity85.4 mT)to the mixed *** removal of Cr(Ⅵ)was approximately 100.0%for the bioreactor with a magnetic field and 93,3%for the bioreactor without a magnetic field for9 hr of recirculation of the synthetic effluent by the *** removal of total Cr was61.6%and 48.4%,with and without a magnetic field,respectively;for 24 *** desorption of Cr(VI)in the synthetic effluent was 0.05 mg/l,which is below the limit established by Brazilian legislation(0.1 mg/l)for the discharge of effluent containing Cr(Ⅵ)into bodies of *** results obtained for the removal of chromium in synthetic effluent suggested that there was no significant influence on the viable cell count of the mixed *** desorption of Cr(Ⅵ)in synthetic effluent after bioadsorption of chromium by the mixed culture in the process of removal of chromium in bioreactors with and without a magnetic field was not significant in either of the experiments with different initial pHs.

关键词： Chromium removal Mixed culture Magnetic field Desorption Effluent treatment

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Visual classification of feral cat Felis silvestris catus vocalizations

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Current Zoology 2017年第3期63卷 331-339页

作者： jessica l. OWENS Mariana OlSEN Amy FONTAINE Christopher KlOTH Arik KERSHENBAUM Sara WAllER Cooperative Predator Vocalization Consortium South Daytona FL 32119 Department of Philosophy Montana State University Bozeman MT 59717 Department of Wildlife Humboldt State University Arcata CA 95521 Department of Philosophy University of Nevada Reno NV 89503 USA Department of Zoology University of Cambridge Cambridge CB2 3E J UK

Cat vocal behavior, in particular, the vocal and social behavior of feral cats, is poorly understood, as are the differences between feral and fully domestic cats. The relationship between feral cat social and vocal behavior is important because of the markedly different ecology of feral and domestic cats, and enhanced comprehension of the repertoire and potential information content of feral cat calls can provide both better understanding of the domestication and socialization process, and improved welfare for feral cats undergoing adoption. Previous studies have used conflicting classification schemes for cat vocalizations, often relying on onomatopoeic or popular descriptions of call types (e.g., “miow”). We studied the vocalizations of 13 unaltered domestic cats that complied with our behavioral definition used to distinguish feral cats from domestic. A total of 71 acoustic units were extracted and visually analyzed for the construction of a hierarchical classification of vocal sounds, based on acoustic properties. We identified 3 major categories (tonal, pulse, and broadband) that further breakdown into 8 subcategories, and show a high degree of reliability when sounds are classified blindly by independent observers (Fleiss’ KappaK= 0.863). Due to the limited behavioral contexts in this study, additional subcategories of cat vocalizations may be identified in the future, but our hierarchical classification system allows for the addition of new categories and new subcategories as they are described. This study shows that cat vocalizations are diverse and complex, and provides an objective and reliable classification system that can be used in future studies.

关键词：发声行为分类技术视觉分析野猫野生社会行为声学特性分类系统

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Genetic architecture of quantitative trait loci(QTl)for FHB resistance and agronomic traits in a hard winter wheat population

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The Crop Journal 2023年第6期11卷 1836-1845页

作者： Yuzhou Xu Yaoguang li Ruolin Bian Guorong Zhang Allan K.Fritz Yanhong Dong lanfei Zhao Yunfeng Xu Nida Ghori Amy Bernardo Paul StAmand jessica l.Shoup Rupp Myron Bruce Wei Wang Eduard Akhunov Brett Carver Guihua Bai Department of Agronomy Kansas State UniversityManhattanKS 66506USA Department of Plant Pathology University of MinnesotaSt.PaulMN 55108USA Hard Winter Wheat Genetics Research Unit USDAManhattanKS 66506USA Department of Plant Pathology Kansas State UniversityManhattanKS 66506USA Department of Plant and Soil Sciences Oklahoma State UniversityStillwaterOK 74078USA

Wheat resistance to Fusarium head blight(FHB)has often been associated with some undesirable agronomic *** study the relationship between wheat FHB resistance and agronomic traits,we constructed a linkage map of single nucleotide polymorphisms(SNPs)using an F6:8 population from G97252W*** two hard winter wheat parents showed contrasts in FHB resistance,plant height(HT),heading date(HD),spike length(Sl),spike compactness(SC),kernel number per spike(KNS),spikelet number per spike(SNS),thousand-grain weight(TGW)and grain size(length and width).Quantitative trait locus(QTl)mapping identified one major QTl(***-2DS)on chromosome arm 2DS for the percentage of symptomatic spikelets(PSS)in the spike,deoxynivalenol(DON)content and Fusarium damaged kernel(FDK).This QTl explained up to 71.8%of the phenotypic variation for the three FHB-related traits and overlapped with the major QTl for HT,HD,Sl,KNS,SNS,TGW,and grain *** on chromosome arms 2Al,2DS,3Al and 4BS were significant for the spike and grain traits measured.G97252W contributed FHB resistance and high SNS alleles at ***-2DS,high KNS alleles at the QTl on 2Al and 2DS,and high TGW and grain size alleles at QTl on 3Al;whereas G97380A contributed high TGW and grain size alleles at the QTl on 2Al and 2DS,respectively,and the high KNS allele at the 4BS *** ***-2DS with positive alleles for spike and grain traits from other chromosomes may simultaneously improve FHB resistance and grain yield in new cultivars.

关键词： Wheat Fusarium head blight FHB resistance Developmental and yield traits Pleiotropic QTl

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Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis

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liver Research 2020年第2期4卷 47-63页

作者： John Y.l.Chiang jessica M.Ferrell Department of Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Cholesterol 7 alpha-hydroxylase(CYP7A1,EC1.14)is the first and rate-limiting enzyme in the classic bile acid synthesis *** progress has been made in understanding the transcriptional regulation of CYP7A1 gene expression and the underlying molecular mechanisms of bile acid feedback regulation of CYP7A1 and bile acid synthesis in the last three *** of bile acid-activated receptors and their roles in the regulation of lipid,glucose and energy metabolism have been translated to the development of bile acid-based drug therapies for the treatment of liver-related metabolic diseases such as alcoholic and non-alcoholic fatty liver diseases,liver cirrhosis,diabetes,obesity and hepatocellular *** review will provide an update on the advances in our understanding of the molecular biology and mechanistic insights of the regulation of CYP7A1 in bile acid synthesis in the last 40 years.

关键词： Cholesterol 7 alpha-hydroxylase(CYP7A1) Bile acid metabolism Farnesoid X receptor(FXR) Takeda G protein-coupled receptor 5(TGR5) Bile acid receptors liver metabolism

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