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Prevalence of Helicobacter pylori vacA,cagA,dupA and oipA Genotypes in Patients with Gastric Disease

Advances in Microbiology 2017年第1期7卷 1-9页

作者： Mayara Luciana Sallas jessica lima melchiades Luanna Munhoz Zabaglia Juliana Ribeiro do Prado Moreno Wilson Aparecido Orcini Elizabeth Suchi Chen Marilia de Arruda Cardoso Smith Spencer Luiz Marques Payao Lucas Trevizani Rasmussen Sagrado Coracao University(USC) BauruBrazil Federal University of Sao Paulo(UNIFESP) Sao PauloBrazil

Gastric diseases such as chronic gastritis and gastric cancer are most commonly caused by virulence factors of Helicobacter pylori (H. pylori), such as the vacA, cagA, dupA and oipA genes. Therefore, this study investigated the prevalence and the combination of these virulence factors from patients with gastric diseases. The endoscopic biopsies were obtained from 516 patients with gastric symptoms, 101 of which were from patients with normal gastric tissue, 365 of which were from patients with chronic gastritis, and 50 of which were from patients with gastric cancer. H. pylori and the virulence factors were detected by PCR. The oipA gene exhibited an increased risk for chronic gastritis (p = 0.0296), and the vacA gene demonstrated a risk for gastric cancer from chronic gastritis (p = 0.0002). Based on the combination of the virulence factors, cagA, vacA, dupA and oipA genes exhibited a high prevalence in patients with chronic gastritis and gastric cancer. The cagA+/dupA+ genotype demonstrated a significant correlation in patients with normal gastric mucosa (p = 0.0278). In the chronic gastritis group, a significant association was observed between the cagA+ and the vacA s1m1 genotypes (p cagA+/dupA+ genotypes (p = 0.0183), the dupA+/oipA+ genotypes (p cagA, vacA, dupA, and oipA genes, which contributed to the risk of developing gastroduodenal diseases. Furthermore, this is the first study to reveal a high prevalence of the oipA gene in H. pylori isolates in Brazil.

关键词： Helicobacter pylori Virulence Factors cagA dupA oipA vacA

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Perspectives for the association between olfactory disturbances and depression in Parkinson's disease

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Neural Regeneration Research 2019年第4期14卷 591-592页

作者： jessica L.Ilkiw Marcelo M.S.lima Neurophysiology Laboratory Department of PhysiologyFederal University of Paraná

Non-motor disturbances in Parkinson’s disease:Globally,population aged 60 or over is growing and considering the World Bank predictions for the next 20 years it is expected that the number of Parkinson’s disease(PD)cases will double at the end of this period thus,reaching an impressive 13–39 million patients *** scenario is potentially associated with a significant global negative impact on public health systems particularly in countries with increased ageing populations such as the European countries,Asia and *** pathophysiology of PD involves the progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta(SNpc)that triggers denervation of the nigrostriatal pathway and consequent significant reduction of dopamine in the dorsal *** process leads to a critical motor impairment scenario characterized by bradykinesia,rigidity,resting tremor,and postural instability(Emamzadeh and Surguchov,2018).However,several other non-motor disturbances develop earlier,thus,being considered as prodromal signs of the *** this sense,the literature is increasingly emphasizing the importance of investigating mood and olfactory disruptions as high sensitive benchmarks of the early-phase *** fact,the need for innovative early-phase diagnostic tools,as well as the elucidation of the pathophysiological mechanisms of such disturbances,is essential priority in the field of investigation of ***,in the year of 2015,a woman was known for an intriguing ability of“smell PD”.Her husband had lived with the disease for twenty years and during this process she noticed that his odor slowly changed to a musky ***,this woman could associate this particular smell with PD after meeting different people with this distinct odor in a charity for PD *** fact,this clever observation is aligned with studies showing that hyposmia is found decades before the motor *** type of anecdotal story,

关键词： Parkinson olfactory disturbances association

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Oxaliplatin induced disseminated intravascular coagulation: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2012年第7期4卷 181-183页

作者： Shweta Kurian jessica Macintyre Muzammil Mushtaq Caio Max Rocha-lima Yeon Ahn Division of Hematology Oncology Sylvester Comprehensive Cancer Center University of Miami Miami FL 33136 United States

Oxaliplatin in combination with a fluoropyrimide is a treatment option for colorectal cancer patients in the adjuvant and metastatic settings. Very few hematological emergencies have been reported associated with Oxaliplatin. These include autoimmune hemolytic anemia, thrombocytopenia and pancytopenia. We present a case report of a patient who developed hematuria and disseminated intravascular coagulation while receiving the second cycle of FOLFOX and bevacizumab for metastatic colon cancer.

关键词： Oxaliplatin Disseminated intravascular coagulation Hematological emergencies Metastatic colon cancer Platelet count

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Joannesia princeps： Evaluation of Aqueous Extracts Genotoxicity Utilizing Allium cepa Assay and Micronucleus Test

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Journal of Life Sciences 2013年第12期7卷 1249-1254页

作者： Viviane Moreira de lima jessica Tamara dos Santos Teixeira Jennifer Vieira Gomes Lelio Kallut Almeida Netto Leonardo Oliveira Bastos Hataanderson Luiz Cabral dos Santos Lenicio Gongalves Francisco de Assis da Silva Bruno Pereira Berto Helcio Resende Borba Department of Animal Biology Federal Rural University of Rio de Janeiro Seropddica Rio de Janeiro 23890000 Brazil

Evaluation of the genotoxic and cytotoxic potentials is a part of the analysis process where plant products with therapeutic properties must be submitted for being safely employed, mainly through long time points, doannesia princeps, also known as ＂cotieira＂ has been used on popular medicine as laxative and several diseases treatment. Aiming to analyze genotoxic potential ofd. princeps leaves extract, Allium cepa assay and micronucleus test were employed. No genotoxic activity presented J. princeps leaves extract; however, extracts cytotoxic activity over A. cepa meristematic cells and mice marrow cells was observed. J. princeps leaves extract presented antiproliferative activity at concentrations and systems employed indicating their therapeutic potential for cellular cycle inhibition. Moreover, results showed that in regard to its mutagenic effect, usage of J. princeps leaves tea on popular medicine has been a safe procedure, as well.

关键词： Cytotoxicity genotoxicity Allium cepa assay micronucleus Joannesia princeps.

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Prediction of Drought with Artificial Neural Networks and Genetic Algorithms Using Precipitation by Remote Perception

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Journal of Environmental Science and Engineering(B) 2018年第7期7卷 253-265页

作者： Iván Ayala Bizarro Miguel Zubiaur Alejos jessica Zuniga Mendoza Department of Civil Engineering National University of HuancavelicaHuancavelica 09001Peru Department of Civil Engineering National University of EngineeringLima 15333Peru AYZU Engineering Company Huancavelica 09001Peru

The aim of the study is to determine the performance of the regional agricultural drought prediction by the model of ANN(Artificial Neural Networks)type NARX,using the SPI(Standardized Precipitation Index),SPEI(Precipitation Index Standardized Evapotranspiration),VCI(Vegetation Condition Index)and GCI(Global Climate Indexes).There have been determined 10 homogeneous regions through RAF(regional frequency analysis)and L-moments,defining the most arid region and the index representing their respective time scale(SPEI 6 months)which responds to the growth and development of vegetation in the basin correlation Pearson equal to *** rainfall and temperatures correspond to PISCO data prepared by SENAMHI-Peru,with space resolution of 0.05 *** prediction,they have determined two groups,the first to build the model with 80% of the registration and validation of the model and the hypothesis with the remaining 20%.The results have been satisfactory prediction accepting the null hypothesis.

关键词： Drought ANN SPI-SPEI-VCI RAF L-Moments

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