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Ursolic Acid derivatives Induced Apoptosis and Reduces the NF-κB in Human Lung Adenocarcinoma Cells

Journal of Cancer Therapy 2019年第10期10卷 863-876页

作者： Elaine Carlos Scherrer Ydia Mariele Valadares Caio Cesar souza Alves Gabriella Freitas Ferreira Marcela Pereira Leao jessica Aline Soares Fernando Sa Silva Alessandra Paula Carli Oswaldo Cardoso Jr. Fabiana Simao Machado Sandra Bertelli Ribeiro Castro Life Sciences Institute Federal University of Juiz de ForaGovernador ValadaresMGBrazil Faculty of Medicine Federal University of the Valleys of Jequitinhonha and MucuriTeofilo OtoniMGBrazil department of Biochemistry and Immunology Federal University of Minas GeraisBelo HorizonteMGBrazil

Lung cancer is the major cause of death in the neoplastic diseases. In spite of the advances in the chemotherapy, the lung cancer treatments are still complex and costly, being necessary the seeking of new drugs. In this context, the ursolic acid (UA) becomes the target of studies that investigate its antitumor potential and, thus, structural modifications can enhance its biological activities. Eight UA semisynthetic derivative compounds (UAD1-8) were synthesized and evaluated their cytotoxic activity against human alveolar adenocarcinoma cells (A549). UAD1, UAD3, UAD5, UAD6 and UAD8 were able to reduce the viability of the A549 cells. Only UAD1 and UAD6 reduced the viability at 24 h, and only UAD3 didn’t reduce the NF-κB expression. The compound UAD1 showed the greater apoptosis induction. Moreover, the compound UAD1 showed better results than UA in all assays. The present study shows, for the first time, the action of these compounds in the apoptotic effect, in the expression of NF-κB and in the A549 cell line. The ursolic acid derivatives showed substantial results in the apoptosis, cytotoxicity and NF-κB inhibition of A549 cells, and further studies are necessary for the development of possible new therapeutic drugs.

关键词： Ursolic Acid Apoptosis NF-κB A549 Cells Tumoral

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Primary Scientific Project in Evaluating the Quality of Life and Healthy Factors in Medical Students of a Private Brazilian University

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Journal of Pharmacy and Pharmacology 2018年第6期6卷 620-625页

作者： Gabriela Carvalho Monnerat Magalhaes Carolina Padilha Tavares Fernanda Tebaldi Henriques de Queiroz jessica Barone Sangineto Rocha Camilla Soares Moreira Mariana Montenegro Banharo Lilian Soares da Costa Liga Academica de Ciencias Cardiovasculares - LACCAV Fundacao Tecnico Educacional Souza Marques Medical School Rio de Janeiro 21310-310 Brazil

Introduction： Limited data are available regarding medical students’ habits related to long duration shifts and graduation classes that could negatively impact on their academic performance. The objective of this study is to identify the profile factors related to life quality and cardiovascular risk on medical students of a private university in Brazil. Methods： This study is based on a descriptive analysis of cross-sectional cohort of a sample of 490 students from the first to sixth year of medical school. The data were collected through an anonymous questionnaire. Results： Some of the data were： 81.6% of students reported alcohol ingestion, 5.9% are smokers and 13.9% reported use of illicit drugs, 27.9% informed adding salt to the food, 78.4% reported stress/anxiety. Conclusion： After observing all the collected data, a project was built for a longitudinal analysis of the influence of life style during the medical school years on mental and cardiovascular health, short and long term.

关键词： Medical students health cardiovascular risk stress.

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detection of Gram-Negative Bacteria Carrying the blaKPC-2 Gene from Mangrove Sediments

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Journal of Pharmacy and Pharmacology 2019年第8期7卷 485-492页

作者： Wallace Ribeiro Nunes Neto jessica Mayara Mendes Araujo Darlan Ferreira da Silva Joveliane de Melo Monteiro Wallace Borges Pachêco Jessflan Rafael Nascimento Santos Maria Raimunda Chagas Silva Maria Rosa Quaresma Bomfim Andrea de souza Monteiro Laboratory of Applied Microbiology CEUMA UniversitySao Luis Maranhao 65000-000Brazil Laboratory of Environmental Sciences CEUMA UniversitySao Luis Maranhao 65000-000Brazil Laboratory of Molecular Biology Sciences CEUMA UniversitySao Luis Maranhao 65000-000Brazil

Mangroves are environments that have fast cycles associated with high concentration of bacterial *** are impacted by anthropogenic pollution due to contamination of bacterial species carrying resistance *** study aims to evaluate the metabolic profile of the microbiota in mangrove sediments,and verify the presence of Gram-negative bacteria resistant to *** samples were obtained from location along the Anil river and were seeded in medium supplemented with the antibiotic meropenem in increasing *** DNA was analyzed by multiplex PCR for detecting resistance genes forβ-lactam *** bacteria were identified by Matrix-assisted laser desorption ionization–time of flight mass spectrometry(MALDI-TOF MS).The genes were sequenced by ABI PRISM 3100,analyzed by MEGA 6.0 program,and the sequence identified was assessed by GenBank using the BLAST ***■the kit was used to determine the metabolic profile of the *** results of the six bacterial isolates showed the blaKPC-2 gene and were identified as Stenotrophomonas maltophilia and Pseudomonas *** samples showed a greater diversity Shannon index,a rich substrate consumption and high *** was a metabolic richness such as carbon consumption profiles,being a factor of adaptation of pathogenic bacteria carrying resistance genes toβ-lactamics antibiotics.

关键词： Antibiotic resistant meropenem bacterial isolates

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