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Disrupted Maturation of Prefrontal Layer 5 Neuronal Circuits in an Alzheimer’s Mouse Model of Amyloid Deposition

Neuroscience Bulletin 2023年第6期39卷 881-892页

作者： Chang Chen Jing Wei Xiaokuang Ma Baomei Xia Neha Shakir jessica k.zhang Le zhang Yuehua Cui Deveroux Ferguson Shenfeng Qiu Feng Bai Department of Neurology Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing210008China Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZ85004USA

Mutations in genes encoding amyloid precursor protein(APP)and presenilins(PSs)cause familial forms of Alzheimer’s disease(AD),a neurodegenerative disorder strongly associated with *** is currently unknown whether and how AD risks affect early brain development,and to what extent subtle synaptic pathology may occur prior to overt hallmark AD *** mutant APP/PS1 over-expression mouse lines are key tools for studying the molecular mechanisms of AD *** these lines,the 5XFAD mice rapidly develop key features of AD pathology and have proven utility in studying amyloid plaque formation and amyloidβ(Aβ)-induced *** reasoned that transgenic mutant APP/PS1 over-expression in 5XFAD mice may lead to neurodevelopmental defects in early cortical neurons,and performed detailed synaptic physiological characterization of layer 5(L5)neurons from the prefrontal cortex(PFC)of 5XFAD and wild-type littermate controls.L5 PFC neurons from 5XFAD mice show early APP/Aβ***-cell patch-clamp recording at an early post-weaning age(P22–30)revealed functional impairments;although 5XFAD PFC-L5 neurons exhibited similar membrane properties,they were intrinsically less *** addition,these neurons received smaller amplitude and frequency of miniature excitatory synaptic *** functional disturbances were further corroborated by decreased dendritic spine density and spine head volumes that indicated impaired synapse *** biotinylation followed by Western blot analysis of PFC-L5 tissue revealed that 5XFAD mice showed reduced synaptic AMPA receptor subunit GluA1 and decreased synaptic NMDA receptor subunit *** with this,patch-clamp recording of the evoked L23>L5 synaptic responses revealed a reduced AMPA/NMDA receptor current ratio,and an increased level of AMPAR-lacking silent *** results suggest that transgenic mutant forms of APP/PS1 overexpression in 5XFAD mice leads to early deve

关键词： Alzheimer’s disease Mouse model Synaptic plasticity Long-term potentiation Cortical circuit Electrophysiology Learning and memory

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Polygonal finite element-based content-aware image warping

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Computational Visual Media 2023年第2期9卷 367-383页

作者： Juan Cao Xiaoyi zhang Jiannan Huang Yongjie jessica zhang School of Mathematical Sciences Xiamen UniversityXiamen 361005China Fujian Provincial key Laboratory of Mathematical Modeling and High-Performance Scientific Computation Xiamen UniversityXiamen 361005China Department of Mechanical Engineering Carnegie Mellon UniversityPittsburghPA 15213USA

Mesh-based image warping techniques typically represent image deformation using linear functions on triangular meshes or bilinear functions on rectangular *** enables simple and efficient implementation,but in turn,restricts the representation capability of the deformation,often leading to unsatisfactory warping *** present a novel,flexible polygonal finite element(poly-FEM)method for content-aware image *** deformation is represented by high-order poly-FEMs on a content-aware polygonal mesh with a cell distribution adapted to saliency information in the source *** allows highly adaptive meshes and smoother warping with fewer degrees of freedom,thus significantly extending the flexibility and capability of the warping *** from the continuous formulation of image deformation,our polyFEM warping method is able to compute the optimal image deformation by minimizing existing or even newly designed warping energies consisting of penalty terms for specific *** demonstrate the versatility of the proposed poly-FEM warping method in representing different deformations and its superiority by comparing it to other existing state-ofthe-art methods.

关键词： image warping finite element method(FEM) polygonal element mesh generation

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Stick-slip nonuniform rotation distortion correction in distal scanning optical coherence tomography catheters

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Journal of Innovative Optical Health Sciences 2020年第6期3卷 94-101页

作者： jessica Mavadia-Shukla Jianlin zhang kaiyan Li Xingde Li Department of Biomedical Engineering Johns Hopkins University Baltimore MD 21205USA

We present a robust and fiducial-marker-free algorithm that can identify and correct stick-slip distortion caused by nonuniform rotation(or beam scanning)in distally scanned catheters for endoscopic optical coherence tomography(OCT)*** algorithm employs spatial fre-quency analysis to select and remove *** demonstrate the feasibility of this algorithm on images acquired from ex vivo rat colon with a distally scanned DC motor-based *** proposed algorithm can be applied to general endoscopic OCT images for correcting non-uniform rotation distortion.

关键词： Optical coherence tomography nonuniform rotation distortion correction endoscope distal-scanning

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Fluid-inspired field representation for risk assessment in road scenes

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Computational Visual Media 2020年第4期6卷 401-415页

作者： Xuanpeng Li Lifeng Zhu Qifan Xue Dong Wang Yongjie jessica zhang School of Instrument Science and Engineering Southeast UniversityNanjing 210096China Department of Mechanical Engineering Carnegie Mellon UniversityPittsburghPA 15213USA

Prediction of the likely evolution of traffic scenes is a challenging task because of high uncertainties from sensing technology and the dynamic *** leads to failure of motion planning for intelligent agents like autonomous *** this paper,we propose a fluid-inspired model to estimate collision risk in road ***-object states are detected and tracked,and then a stable fluid model is adopted to construct the risk ***’state spaces are used as the boundary conditions in the simulation of advection and diffusion *** have evaluated our approach on the public kITTI dataset;our model can provide predictions in the cases of misdetection and tracking error caused by *** proves a promising approach for collision risk assessment in road scenes.

关键词： fluid-inspired risk field multi-object tracking road scenes

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Corneal neurotization: a narrative review of techniques, outcomes, and surgical considerations

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Annals of Eye Science 2023年第2期8卷 1-13页

作者： jessica zhang Anne Barmettler Department of Ophthalmology and Visual Sciences Montefiore Medical CenterAlbert Einstein College of MedicineBronxNew YorkUSA

Background and Objective:Corneal neurotization is a novel surgical technique used to restore corneal sensation in patients with neurotrophic *** keratopathy is a disorder characterized by dysfunction of the ophthalmic division of the trigeminal nerve,which provides sensory innervation to the *** sensation,the cornea is at risk of infection,ulceration,perforation,and ultimately,vision *** neurotization has emerged as an innovative technique to reinnervate anesthetized corneas by transferring a healthy donor nerve to the affected eye around the corneoscleral *** the field of corneal neurotization rapidly grows,there is a need to synthesize the existing body of literature on corneal neurotization and identify important areas for further *** this review,we will discuss neurotrophic keratopathy and its current management strategies,followed by an overview of corneal neurotization techniques,outcomes,surgical considerations,and future ***:PubMed and Google Scholar searches were conducted to retrieve and analyze relevant original papers and reviews on neurotrophic keratopathy and corneal neurotization up until April *** Content and Findings:Currently,numerous techniques for corneal neurotization exist,including direct nerve transfers,as well as indirect neurotization via interposition nerve *** far,corneal neurotization has been shown to be highly successful in restoring corneal sensation,improving visual acuity,and improving corneal epithelial *** date,there have been no significant differences in outcomes between direct versus indirect neurotization techniques,different donor nerves,or autologous versus allogeneic interposition ***,there is some evidence that corneal neurotization procedures may be more successful in pediatric ***:Corneal neurotization shows great promise in treating neurotrophic corneas and represents the first management option to date tha

关键词： Corneal neurotization neurotrophic keratopathy corneal sensation neurotrophic cornea

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Efficient nanozyme engineering for antibacterial therapy

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Materials Futures 2022年第2期1卷 121-152页

作者： Yonghai Feng Funing Chen jessica M Rosenholm Lei Liu Hongbo zhang Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 202013People’s Republic of China Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringÅbo Akademi UniversityTurku 20520Finland Jiangsu Agrochem Laboratory Co. LtdChang Zhou 213022People’s Republic of China

Antimicrobial resistance(AMR)poses a huge threat to human *** is urgent to explore efficient ways to suppress the spread of *** nanozymes have become one of the powerful weapons to combat AMR due to their enzyme-like catalytic activity with a broad-spectrum antibacterial ***,the inherent low catalytic activity of nanozymes limits their expansion into antibacterial *** this regard,a variety of advanced chemical design strategies have been developed to improve the antimicrobial activity of *** this review,we have summarized the recent progress of advanced strategies to engineer efficient nanozymes for fighting against AMR,which can be mainly classified as catalytic activity improvement,external stimuli,bacterial affinity enhancement,and multifunctional platform construction according to the basic principles of engineering efficient nanocatalysts and the mechanism of nanozyme ***,the deep insights into the effects of these enhancing strategies on the nanozyme structures and properties are ***,current challenges and future perspectives of antibacterial nanozymes are discussed for their future clinical potential.

关键词： nanozymes antimicrobial resistance chemical design strategy enhanced antibacterial activity

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Molecular Dynamics Simulations for Anisotropic Thermal Conductivity of Borophene

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Computers, Materials & Continua 2020年第5期63卷 813-823页

作者： Yue Jia Chun Li Jinwu Jiang Ning Wei Yang Chen Yongjie jessica zhang School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710129China Shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai200433China School of Mechanical Engineering Jiangnan UniversityWuxi214122China College of Water Resources and Architectural Engineering Northwest A&F UniversityYangling712100China Department of Mechanical Engineering Carnegie Mellon UniversityPittsburgh15213USA

The present work carries out molecular dynamics simulations to compute the thermal conductivity of the borophene nanoribbon and the borophene nanotube using the Müller-Plathe *** investigate the thermal conductivity of the armchair and zigzag borophenes,and show the strong anisotropic thermal conductivity property of *** compare results of the borophene nanoribbon and the borophene nanotube,and find the thermal conductivity of the borophene is orientation *** thermal conductivity of the borophene does not vary as changing the width of the borophene nanoribbon and the perimeter of the borophene *** addition,the thermal conductivity of the borophene is not sensitive to the applied strains and the background temperatures.

关键词： Borophene molecular dynamics thermal conductivity

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Alternative Copper-Based Single-Atom Nanozyme with Superior Multienzyme Activities and NIR-II Responsiveness to Fight against Deep Tissue Infections

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Research 2023年第3期6卷 409-421页

作者： Jiaxiang Bai Yonghai Feng Wenming Li Zerui Cheng jessica MRosenholm Huilin Yang Guoqing Pan Hongbo zhang Dechun Geng Department of Orthopedic Surgery Orthopedic InstituteThe First Affiliated HospitalMedical CollegeSoochow UniversitySuzhouJiangsu 215006P.R.China Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiangJiangsu 212013P.R.China Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringÅbo Akademi UniversityTurku 20520Finland Turku Bioscience Centre University of Turku andÅbo Akademi UniversityTurku 20520Finland

Nanozymes are considered to represent a new era of antibacterial agents,while their antibacterial efficiency is limited by the increasing tissue depth of *** address this issue,here,we report a copper and silk fibroin(Cu-SF)complex strategy to synthesize alternative copper single-atom nanozymes(SAzymes)with atomically dispersed copper sites anchored on ultrathin 2D porous N-doped carbon nanosheets(CuN_(x)-CNS)and tunable N coordination numbers in the CuN_(x) sites(x=2 or 4).The CuN_(x)-CNS SAzymes inherently possess triple peroxidase(POD)-,catalase(CAT)-,and oxidase(OXD)-like activities,facilitating the conversion of H_(2)O_(2)and O_(2)into reactive oxygen species(ROS)through parallel POD-and OXD-like or cascaded CAT-and OXD-like *** to CuN_(2)-CNS,tailoring the N coordination number from 2 to 4 endows the SAzyme(CuN_(4)-CNS)with higher multienzyme activities due to its superior electron structure and lower energy ***,CuN_(x)-CNS display strong absorption in the second near-infrared(NIR-II)biowindow with deeper tissue penetration,offering NIR-II-responsive enhanced ROS generation and photothermal treatment in deep *** in vitro and in vivo results demonstrate that the optimal CuN_(4)-CNS can effectively inhibit multidrug-resistant bacteria and eliminate stubborn biofilms,thus exhibiting high therapeutic efficacy in both superficial skin wound and deep implant-related biofilm infections.

关键词： copper offering eliminate

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Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China

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Chinese Journal of Cancer Research 2019年第4期31卷 663-672页

作者： Shuang Zhao Xuelian Zhao Shangying Hu jessica Lu Xianzhi Duan Xun zhang Feng Chen Fanghui Zhao Department of Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China Biology University of ChicagoChicagoIL 60637USA Department of Gynecology and Obstetrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100176China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and middleincome countries(LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North ***: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction(PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus(HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting ***: A total of 22.2%(2,112/9,526) of women were HR-HPV positive and HPV52(21.7%) was the most common HR-HPV genotype, followed by HPV58(18.2%), HPV53(18.2%) and HPV16(16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia(CIN)1 were HPV16(36.7%), HPV58(20.4%), HPV56(15.3%). Among CIN2+, the most frequent genotypes were HPV16(75.6%), HPV52(17.8%),HPV58(16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions,and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ ***: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for scr

关键词： Human papillomavirus cervical intraepithelial neoplasia genotype distribution attribution proportion cervical cancer

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Helper T Cell(CD4^(+))Targeted Tacrolimus Delivery Mediates Precise Suppression of Allogeneic Humoral Immunity

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Research 2022年第3期2022卷 189-203页

作者： Jia Shen Chang Liu Pengpeng Yan Meifang Wang Luying Guo Shuaihui Liu Jianghua Chen jessica MRosenholm Hongfeng Huang Rending Wang Hongbo zhang kidney Disease Center The First Affiliated HospitalCollege of MedicineZhejiang UniversityKey Laboratory of Kidney Disease Prevention and Control TechnologyZhejiang ProvinceChina Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringÅbo Akademi UniversityTurku 20520Finland Turku Bioscience Centre University of Turku andÅbo Akademi UniversityTurku 20520Finland Organ Donation and Coordination Office The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Antibody-mediated rejection(ABMR)is a major cause of dysfunction and loss of transplanted *** current treatments for ABMR involve nonspecific inhibition and clearance of T/B cells or plasma ***,the prognosis of patients following current treatment is poor.T follicular helper cells(Tfh)play an important role in allograft-specific antibodies secreting plasma cell(PC)*** cells are therefore considered to be important therapeutic targets for the treatment of antibody hypersecretion disorders,such as transplant rejection and autoimmune ***(Tac),the primary immunosuppressant,prevents rejection by reducing T cell ***,its administration should be closely monitored to avoid serious side *** this study,we investigated whether Tac delivery to helper T(CD4^(+))cells using functionalized mesoporous nanoparticles can block Tfh cell differentiation after alloantigen *** showed that Tac delivery ameliorated humoral rejection injury in rodent kidney graft by suppressing Tfh cell development,PC,and donor-specific antibody(DSA)generation without causing severe side effects compared with delivery through the drug administration *** study provides a promising therapeutic strategy for preventing humoral rejection in solid organ *** specific and controllable drug delivery avoids multiple disorder risks and side effects observed in currently used clinical approaches.

关键词： Tacrolimus treatment donor

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