Corneal neurotization: a narrative review of techniques, outcomes, and surgical considerations
作者机构:Department of Ophthalmology and Visual SciencesMontefiore Medical CenterAlbert Einstein College of MedicineBronxNew YorkUSA
出 版 物:《Annals of Eye Science》 (眼科学年鉴(英文))
年 卷 期:2023年第8卷第2期
页 面:1-13页
学科分类:1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
主 题:Corneal neurotization neurotrophic keratopathy corneal sensation neurotrophic cornea
摘 要:Background and Objective:Corneal neurotization is a novel surgical technique used to restore corneal sensation in patients with neurotrophic *** keratopathy is a disorder characterized by dysfunction of the ophthalmic division of the trigeminal nerve,which provides sensory innervation to the *** sensation,the cornea is at risk of infection,ulceration,perforation,and ultimately,vision *** neurotization has emerged as an innovative technique to reinnervate anesthetized corneas by transferring a healthy donor nerve to the affected eye around the corneoscleral *** the field of corneal neurotization rapidly grows,there is a need to synthesize the existing body of literature on corneal neurotization and identify important areas for further *** this review,we will discuss neurotrophic keratopathy and its current management strategies,followed by an overview of corneal neurotization techniques,outcomes,surgical considerations,and future ***:PubMed and Google Scholar searches were conducted to retrieve and analyze relevant original papers and reviews on neurotrophic keratopathy and corneal neurotization up until April *** Content and Findings:Currently,numerous techniques for corneal neurotization exist,including direct nerve transfers,as well as indirect neurotization via interposition nerve *** far,corneal neurotization has been shown to be highly successful in restoring corneal sensation,improving visual acuity,and improving corneal epithelial *** date,there have been no significant differences in outcomes between direct versus indirect neurotization techniques,different donor nerves,or autologous versus allogeneic interposition ***,there is some evidence that corneal neurotization procedures may be more successful in pediatric ***:Corneal neurotization shows great promise in treating neurotrophic corneas and represents the first management option to date tha