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Over-ground walking in Parkinson’s disease: A pilot study utilizing a portable metabolic analyzer

Health 2012年第11期4卷 1127-1132页

作者： Alyssa D. Stookey Frederick M. Ivey jessica e. Hammers Lisa M. Shulman Karen Anderson Leslie I. Katzel Department of Neurology University of Maryland School of Medicine Baltimore USA Department of Psychiatry University of Maryland School of Medicine Baltimore USA Division of Gerontology and Geriatric Medicine Department of Medicine University of Maryland School of Medicine Baltimore USA VA Maryland exercise and Robotics Center of excellence Baltimore USA

Alterations in gait biomechanics are common during early stages of Parkinson’s disease (PD), potentially elevating energy requirements of walking and leading to impaired economy of gait. Although gait economy is traditionally assessed during treadmill walking with simultaneous ox-ygen consumption (VO2) monitoring, treadmill gait mechanics, particularly in PD, may be different from over-ground walking mechanics, possibly providing a distorted picture of true gait economy. Currently, no studies have directly examined the energy cost of over-ground walking in PD patients. The purpose of this study was to test the feasibility of measuring energy expenditure during over-ground walking in mild to moderate PD using portable gas exchange monitoring technology. Additionally, we sought to determine whether energy expenditure, as assessed through VO2 measures, related to disease severity for PD. Seventeen PD patients underwent separate 6-minute walk (6MW) tests both with and without the COSMeD K4b2 portable oxygen monitoring system. Gait economy was calculated as measured VO2 during 6MW divided by the predicted VO2 for non-PD age-matched subjects, according to a standard estimation equation utilizing ground speed. Distance covered during the 6MW with the portable system (420 ± 12 meters) was highly correlated (r = 0.96, p 2 peak for normal floor walking, and show impaired gait economy relative to prediction equations. Interestingly, the degree of elevated energy expenditure during gait did not relate to disease severity.

关键词： Gait economy Oxygen Consumption K4b2

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exercise training and antioxidant supplementation independently improve cognitive function in adult male and female GFAP-APOe mice

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Journal of Sport and Health Science 2014年第3期3卷 196-205页

作者： Kiran Chaudhari jessica M.Wong Philip H.Vann Nathalie Sumien Department of Pharmacology and Neuroscience and Institute for Aging and Alzheimer's Disease Research University of North Texas Health Science Center at Fort Worth

Purpose： The purpose of this study was to determine if antioxidant supplementation, moderate exercise, and the combination of both treatments could ameliorate cognitive performance in adult mice and whether the apolipoprotein e （APOe） genotype as well as sex could influence the functional outcomes of the treatments. Methods： For a period of 16 weeks, separate groups of male and female mice expressing either the human APOe3 or APOe4 isoforms were fed either a control diet （NIH-31） or the control diet supplemented with vitamins e and C （1.12 IU/g diet a-tocopheryl acetate and 1.65 mg/g ascorbic acid）. The mice were further separated into a sedentary group or a group that followed a daily exercise regimen. After 8 weeks on the treatments, the mice were administered a battery of functional tests including tests to measure cognitive and affective function. Results： There was no effect of genotype or treatment on the learning performance in the Morris water maze. In the discriminated avoidance task, APOe4 mice performed better in learning the discrimination component of the task. Overall, exercise improved performance of APOe4 and APOe3 mice on various aspects of the active avoidance task. Antioxidant supplementation improved performance only in the APOe4 mice. On the test for anxiety, APOe4 mice spent more time in the open arms and supplementation with antioxidant reversed that effect. Conclusion： exercise was the most effective treatment at improving cognitive function in both genotypes and sex, while antioxidants seemed to be effective only in the APOe4. In young adult mice only non-spatial learning and memory were improved. The combination of the two treatments did not yield further improvement in cognition, and there was no antagonistic action of the antioxidant supplementation on the beneficial effects of exercise.

关键词： Alzheimer's disease Antioxidant Apolipoprotein e Cognition exercise Vitamin C Vitamin e Water maze

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Infectious etiopathogenesis of Crohn's disease

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World Journal of Gastroenterology 2014年第34期20卷 12102-12117页

作者： jessica Carriere Arlette Darfeuille-Michaud Hang Thi Thu Nguyen Clermont Universite M2iSHUMR 1071 Inserm University of Auvergne 63001 Clermont-FerrandFrance INRA USC 2018 63000 Clermont-FerrandFrance Centre Hospitalier Universitaire 63000 Clermont-FerrandFrance

Important advances during the last decade have been made in understanding the complex etiopathogenesis of Crohn’s disease(CD).While many gaps in our knowledge still exist,it has been suggested that the etiology of CD is multifactorial including genetic,environmental and infectious *** most widely accepted theory states that CD is caused by an aggressive immune response to infectious agents in genetically predisposed *** rise of genome-wide association studies allowed the identification of loci and genetic variants in several components of host innate and adaptive immune responses to microorganisms in the gut,highlighting an implication of intestinal microbiota in CD ***,numerous independent studies reported a dysbiosis,i.e.,a modification of intestinal microbiota composition,with an imbalance between the abundance of beneficial and harmful *** microorganisms including viruses,yeasts,fungi and bacteria have been postulated as potential CD pathogens,based on epidemiological,clinicopathological,genetic and experimental evidence,their precise role in this disease is not clearly *** review summarizes the current knowledge of the infectious agents associated with an increased risk of developing *** approaches to modulate the intestinal dysbiosis and to target the putative CD-associated pathogens,as well as their potential mechanisms of action are also discussed.

关键词： Crohn's disease Intestinal microbiota Dysbiosis Adherent-invasive escherichia coli Probiotics Antibiotics Fecal microbiota transplantation

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Presence of blaOXA-48-carrying IncF plasmid in an escherichia fergusonii strain isolated from a sugarcane soil

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Pedosphere 2020年第2期30卷 293-294页

作者： jessica Aparecida Silva MOReTTO Joao Pedro Rueda FURLAN Vania Santos BRAZ Tamires Aparecida BITeNCOURT eliana Guedes STeHLING Departamento de Analises Clinicas Toxicologicas e BromatologicasFaculdade de Ciencias Farmaceuticas de Ribeirao PretoUniversidade de Sao PauloRibeirao Preto SP 14040-903(Brazil Departamento de Genetica Faculdade de Medicina de Ribeirao PretoUniversidade de Sao PauloRibeirao Preto SP 14040-903(Brazil

Dear editor,A large number of antimicrobial agents used for the treatment of humans and animals reach water sources and agricultural soils in different ways,including animal ***,antimicrobial-resistant bacteria,carrying important antimicrobial resistance genes(ARGs),circulate between humans,animals,and the environment,giving attention to the concept of One Health(Topp,2017;Tiedje et al.,2019).

关键词： soil soils sugarcane

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海洋资源的利用和海洋公园的建立:坦桑尼亚马菲亚岛

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人类环境杂志 1995年第7期24卷 475-481页

作者： jessica e.C.Andersson Zainab Ngazi 刘美敏王欣哥德堡大学环境经济系达累斯萨拉姆大学

近年来,由本地海洋资源使用者参与海洋保护区的规划和管理已经倍受关注。虽然许多项目考虑到了这个方面,但是在实地研究中却很少考虑上述做法会如何影响保护区。人们已经看出,由于缺乏对本地资源使用者在社会经济意义上如何与环境相关... 详细信息

近年来,由本地海洋资源使用者参与海洋保护区的规划和管理已经倍受关注。虽然许多项目考虑到了这个方面,但是在实地研究中却很少考虑上述做法会如何影响保护区。人们已经看出,由于缺乏对本地资源使用者在社会经济意义上如何与环境相关联的了解,很多保护项目都已宣告失败了。本文研究了新建的坦桑尼亚马菲亚岛海洋公园内沿海各社区之间的相互关系。从对这一地区海洋资源使用者的广泛调查来看,要确定和定量分析现行的资源使用格局以及调查各个社区对海洋公园和保护问题的认识和期望还是可能的。本研究还证明,当地人参与规划和管理会很有价值,有助于找到解决诸如经济刺激、取代破坏性活动的方法、教育和补偿等问题的可行办法。此外,据发现,不同形式的补偿会是一种成本效益和执行法规的可持续性手段,但先决条件是,这种补偿应该是合理的,并且由本地资源使用者直接参与。

关键词：海洋资源海洋公园坦桑尼亚

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Mind on statistics jessica M. Utts, Robert F. Heckard 2nd ed.

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2004年

作者： jessica M. Utts Robert F. Heckard

来源：畅想之星图书光盘版（南... 评论

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Beam control for indoor FSO and dynamic dual-use VLC lighting systems

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Journal of Communications and Information Networks 2017年第4期2卷 11-27页

作者： Michael B.Rahaim jessica Morrison Thomas D.C.Little electrical and Computer engineering Department Boston UniversityBostonMA02215USA

Practical VLC(Visible Light Communication)systems are expected to leverage the lighting infrastructure in order to deliver data to devices in a lighting *** devices can be static or quasistatic(e.g.,laptops or IoT devices);however,it is becoming clear that the preponderance of wireless data consumption is dominated by handheld mobile devices which will exhibit varying physical orientations and 3D *** free-space optical and visible light communications are primarily line of sight,transmitter radiation patterns and receiver field of view are very important for predicting the data *** dynamic emission characteristics,there is an opportunity to adapt to the *** caveat of dynamic VLC systems is that the quality and distribution of the resulting illumination must be considered as part of the dual goal of providing high quality *** this paper we investigate the impact of device orientation and mobility on static and then dynamic lighting emission under a multi-cell lighting *** a source standpoint we consider the performance of beam control through angular control and beam focus for one or more sources in a lighting *** and simulation demonstrate that dynamic beam and luminaire control can increase the AP coverage range by 12.8X under a 1.67 m ceiling ***,the use of multiple sources tracking device orientation and position can mitigate off-angle performance degradation by increasing redundancy in the number of available *** proposed techniques,when applied in concert,successfully mitigate common concerns about the viability of VLC and indoor FSO(Free Space Optical Communication)methods related to signal occlusion and device dynamics.

关键词： VLC ultra-dense wireless networks beam steering MeMS dynamic wireless networks

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New Copper (II), Palladium (II), and Platinum (II) 2-Acetylpyrazine Tert-Butylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells

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Open Journal of Medicinal Chemistry 2022年第1期12卷 1-13页

作者： edward C. Lisic Sarah N. Grossarth Sarah B. Bowman jessica L. Hill Michael W. Beck Joseph e. Deweese Xiaohua Jiang Department of Chemistry Tennessee Technological University Cookeville TN USA Department of Biological Physical and Human Sciences Freed Hardeman University Henderson TN USA

The new ligand, 2-acetylpyrazine-tertbutylthiosemicarbazone (APZ-tBTSC), and its Cu(II), Pd(II) and Pt(II) complexes have been synthesized. This ligand coordinates to the metal ions in a tridentate monoanionic fashion forming monometallic complexes with the formula [M(APZ-tBTSC)Cl]. The ligand and the three metal complexes [Cu(APZ-tBTSC)Cl], [Pd(APZ-tBTSC)Cl], and [Pt(APZ-tBTSC)Cl] were tested for anti-proliferative biological behavior with a panel of seven microbes, and the copper and palladium complexes were found to be highly active against Gram positive bacteria. The 4 compounds were also tested in human topoisomerase IIα DNA relaxation assays and all three metal complexes had topoisomerase inhibition at a concentration between 4 - 6 micro-molar. The 4 compounds were also tested for activity with the HeK293T cell line and also the breast cell cancer line, MDA-MB-231. The most effective compound for activity against the HeK293T cell line was the [Cu(APZ-tBTSC)Cl] complex, and the MDA-MB-231 breast cancer cell line was the [Pt(APZ-tBTSC)Cl] complex.

关键词： Topoisomerase Breast Cancer α-(N)-Heterocyclic Thiosemicarbazones

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“互联网+”时代中国成人学习变革

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开放教育研究 2015年第5期21卷 112-120页

作者：吴峰李杰北京大学教育学院北京100871 伊利诺伊大学香槟分校教育学院美国伊利诺州il61801

中国劳动力数量巨大,但平均受教育程度较低。中国经济正处于从粗放式增长向集约式增长转变之中,人力资源质量是其中的关键性因素,因此,中国对成人学习的需求比其它国家强烈得多。互联网技术的进步给中国成人学习带来新机遇,中国成人学... 详细信息

中国劳动力数量巨大,但平均受教育程度较低。中国经济正处于从粗放式增长向集约式增长转变之中,人力资源质量是其中的关键性因素,因此,中国对成人学习的需求比其它国家强烈得多。互联网技术的进步给中国成人学习带来新机遇,中国成人学习也迫切需要拥抱互联网技术。本研究分析了互联网技术对中国成人学习带来的变革,认为互联网技术的进步给中国成人学习带来了两次重大机遇:一是e-learning的出现,使中国成人学习得以全面普及,突破性地拓展了中国成人学习的广度,至少理论上中国成人学习可以实现全覆盖;二是MOOC的冲击,极大地提高了成人学习的自主性,增强了成人学习的深度。在两次机遇中,高校与企业都扮演着重要角色。本研究在具体分析两次机遇下高校e-learning及企业e-learning、高校MOOC及企业MOOC对成人学习变革的基础上认为,移动学习技术未来将给中国成人学习带来第三次新机遇,使得成人学习加速,大规模促进成人社会化学习。本文提出成人学习的技术变革模型,认为技术变革的环境要素有经济、信息化、人群三个方面,技术变革的路径选择有接受性学习、探究性学习、社会化学习。

关键词：互联网成人学习在线学习中国

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Two mitochondrial phosphatases,PP2c63 and Sal2,are required for posttranslational regulation of the TCA cycle in Arabidopsis

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Molecular Plant 2021年第7期14卷 1104-1118页

作者： Youjun Zhang Jonas Giese Sandra M.Kerbler Beata Siemiatkowska Leonardo Perez de Souza jessica Alpers David Barbosa Medeiros Dirk K.Hincha Danilo M.Daloso Mark Stitt Iris Finkemeier Alisdair R.Fernie Max-Planck-lnstitut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany Center of Plant Systems Biology and Biotechnology 4000 PlovdivBulgaria lnstitute of Plant Biology and Biotechnology University of MuensterSchlossplatz 748149 MuensterGermany Departamento de Bioquimica e Biologia Molecular Universidade Federal do CearaFortalezaCearaBrasil

Protein phosphorylation is a well-established post-translational mechanism that regulates protein functions and metabolic *** is known that several plant mitochondrial proteins are phosphorylated in a reversible ***,the identities of the protein kinases/phosphatases involved in this mech-anism and their roles in the regulation of the tricarboxylic acid(TCA)cycle remain *** this study,we isolated and characterized plants lacking two mitochondrially targeted phosphatases(Sal2 and PP2c63)along with pyruvate dehydrogenase kinase(PDK),Protein-protein interaction analysis,quantitative phos-phoproteomics,and enzymatic analyses revealed that PDK specifically regulates pyruvate dehydrogenase complex(PDC),while PP2c63 nonspecifically regulates *** recombinant PP2c63 and Sal2 proteins were added to mitochondria isolated from mutant plants,protein-protein interaction and enzymatic analyses showed that PP2c63 directly phosphorylates and modulates the activity of PDC,while Sal2 only indirectly affects TCA cycle *** of steady-state metabolite levels and fluxes in the mutant lines further revealed that these phosphatases regulate flux through the TCA cycle,and that altered metabolism in the sa/2 pp2c63 double mutant compromises plant *** results are discussed in the context of current models of the control of respiration in plants.

关键词： TCA cycle pyruvate dehydrogenase phosphorylation mitochondrial protein phosphatase TCA cycle enzymes phosphorylation

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