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The function of floral orientation in bluebells:interactions with pollinators and rain in two species of Mertensia(Boraginaceae)

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Journal of Plant Ecology 2019年第1期12卷 113-123页

作者： Shang-Yao Lin jessica R.K.Forrest Department of Biology University of Ottawa30 Marie CurieOttawaOntario K1N 6N5Canada Rocky Mountain Biological Laboratory P.O.Box 519Crested ButteColorado 81224USA

Aims Pollinators are traditionally considered to be the primary agent of selection on floral ***,floral traits may also be under selection from abiotic agents(***),which makes considering the relative importance of pollinators and abiotic selective agents on floral traits *** functional significance of floral orien-tation is often ascribed to pollinator attraction,but orientation can also protect reproductive structures from ***,a study that incorporates both factors will enhance our understanding of the ecological roles of floral orientation in plant *** brevistyla and *** are herbaceous species that differ in their floral orientations.A series of field and laboratory experi-ments was used to investigate the adaptive function of floral orien-tation in these species,particularly with respect to pollinators and *** We measured and compared floral orientation and visitor assem-blages between *** and *** populations in west-ern Colorado,*** manipulated floral stems and conducted a choice experiment with floral visitors,and also compared orienta-tions of pollinator-visited stems with those of unvisited stems in a natural *** examined pollinator-and rain-mediated selec-tion on floral orientation by manipulating orientation,conducting supplemental pollinations,applying watering treatments and meas-uring subsequent seed *** also experimentally tested the like-lihood of rain contact with anthers,and the effect of rainwater on pollen *** Findings Mertensia brevistyla had a significantly more upright floral orienta-tion than ***,and seed set was highest in upright ***-vistyla and in horizontal/pendant *** stems,supporting an adaptive function(via female fitness)of the interspecific difference in ***,floral visitor assemblages did not differ significantly between the two species;visitors did not exhibit sig-nificant prefere

关键词： floral orientation male and female fitness Mertensia pollinators rain

Scalable Methods for Device Patterning as an Outstanding Challenge in Translating Paper-Based Microfluidics from the Academic Benchtop to the Point-of-Care

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Journal of Analysis and Testing 2019年第1期3卷 50-60页

作者： jessica C.Brooks Charles R.Mace Department of Chemistry Tufts UniversityMedfordMA 02155USA

Paper-based microfluidic devices offer unparalleled adaptability for the development of low-cost,point-of-care analytical *** potential for these devices to drastically improve access to healthcare around the globe is obvious,but very few tests have found success in clinical ***,we identify manufacturing-specifically,methods to pattern paper devices at large scales-as a major barrier to translating prototype paper-based devices from the academic benchtop to the *** introduce current methods used to pattern papers and discuss their utility as means to prototype and manufacture paper-based devices.

关键词： Paper-based microfluidics μPAD Point-of-care Diagnostics Manufacturing

Single organ hepatic artery vasculitis as an unusual cause of epigastric pain:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9384-9389页

作者： Rojin Kaviani jessica Farrell Natasha Dehghan Sarvee Moosavi Internal Medicine University of British ColumbiaVancouver V5Z 1M9British ColumbiaCanada Division of Radiology Providence Health CareVancouver V5T 3N4British ColumbiaCanada Division of Rheumatology Providence Health CareVancouver V5T 3N4British ColumbiaCanada Division of Gastroenterology University of British ColumbiaVancouver V6Z 2K5British ColumbiaCanada

BACKGROUND Single-organ vasculitis(SOV)is characterized by inflammation of a blood vessel,affecting one organ,such as the skin,genitourinary system,or the aorta without systemic *** SOV is rare,with hepatic artery involvement reported only in two prior published ***,we presented a case of isolated hepatic artery vasculitis presenting after Pfizer-BioNTech mRNA corona virus disease 2019(COVID-19)*** SUMMARY A 50-year-old woman with hypertension presented to our Emergency Department with recurrent diffuse abdominal pain that localized to the epigastrium and emesis without diarrhea that began eight days after the second dose of the PfizerBioNTech COVID-19 *** work revealed an elevated C-reactive protein(CRP)of 19 mg/L(normal<4.8 mg/L),alkaline phosphatase 150 U/L(normal 25-105 U/L),gamma-glutamyl transferase(GGT)45 U/L(normal<43 U/L)and elevated immunoglobulins(Ig)G 18.4 g/L(normal 7-16 g/L)and IgA 4.4 g/L(normal 0.7-4 g/L).An abdominal computed tomography revealed findings in keeping with hepatic artery vasculitis.A detailed review of her history and examination did not reveal infectious or systemic autoimmune causes of her *** extensive autoimmune panel was ***-19polymerase chain reaction nasopharyngeal swab,human immunodeficiency virus,viral hepatitis and Heliobacter pylori serology were *** six months,the patient’s symptoms,and blood work spontaneously *** High clinical suspicion of SOV is required for diagnosis in patients with acute abdominal pain and dyspepsia.

关键词： Single organ vasculitis Hepatic artery gastrointestinal vasculitis COVID-19 vaccine Hepatic artery vasculitis Case report

Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients

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World Journal of Gastroenterology 2010年第31期16卷 3888-3896页

作者： jessica Mwinyi Christa Wenger Jyrki J Eloranta Gerd A Kullak-Ublick Division of Clinical Pharmacology and Toxicol-ogy University Hospital Zurich

AIM: To study whether the glucocorticoid receptor (GR/ NR3C1) gene haplotypes influence the steroid therapy outcome in inflammatory bowel disease (IBD). METHODS: We sequenced all coding exons and flanking intronic sequences of the NR3C1 gene in 181 IBD patients, determined the single nucleotide polymorphisms, and predicted the NR3C1 haplotypes. Furthermore, we investigated whether certain NR3C1 haplotypes are significantly associated with steroid therapy outcomes. RESULTS: We detected 13 NR3C1 variants, which led to the formation of 17 different haplotypes with a certainty of > 95% in 173 individuals. The three most commonly occurring haplotypes were included in the association analysis of the influence of haplotype on steroid therapy outcome or IBD activity. None of the NR3C1 haplotypes showed statistically signifi cant association with glucocorticoid therapy success. CONCLUSION: NR3C1 haplotypes are not related to steroid therapy outcome.

关键词： Inflammatory bowel disease Steroid therapy Glucocorticoid receptor Pharmacogenetics Haplotype analysis

Waders(Scolopacidae)surviving despite malaligned leg fractures in the wild:kinematics of bipedal locomotion

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Avian Research 2017年第3期8卷 168-175页

作者： jessica Reichert Gerald Mayr Thomas Wilke Winfried S.Peters Department of Animal Ecology and Systematics Justus Liebig UniversityHeinrich-Buff-Ring 26-32(IFZ)35392 GiessenGermany Ornithology Section Senckenberg Research Institute and Natural History MuseumSenckenberganlage 2560325 FrankfurtGermany School of Biological Science Washington State UniversityPullmanWA 99164USA

Background: Bone fracture frequencies and survival rates are essential parameters in skeleton evolution, but information on the functional consequences of naturally healed fractures is scarce. No leg bone fracture healing in the wild has been reported so far from long-legged Charadriiformes(waders), which depend on bipedal locomotion for ***: We documented a healed but malaligned tarsometatarsus fracture in a wild Willet(Tringa [Catoptrophorus]semipalmata), and a malaligned tibiotarsus fracture in a Curlew(Numenius arquata) skeleton from a museum collection. Functional consequences of the malalignments were evaluated by kinematic analyses of videos(Willet) and in silico 3D modeling(Curlew).Results: The Willet's left tarsometatarsus exhibited an angular malalignment of 70°, resulting in a limping gait that was less pronounced at high than at low walking speed. The bird seemed unable to club the toes of the left foot together, apparently a secondary effect of the deformity. The Curlew's tibiotarsus showed an angular and an axial malalignment, causing the foot to rotate outwards when the intertarsal joint was flexed. Despite the severe effects of their injuries, the birds had survived at least long enough for the fractures to heal ***: Somewhat unexpectedly, leg fractures are not necessarily fatal in long-legged waders, even if deformities occur in the healing process. Bipedal locomotion on vegetated grounds must have been impeded due to the bone malalignments in both analyzed cases. The birds probably alleviated the impact of their handicaps by shifting a larger proportion of their activities to vegetation-free habitats.

关键词： 3D modeling Bone fracture healing Tringa(Catoptrophorus) semipalmata Kinematic gait analysis Long bone malalignment Numenius arquata Scolopacidae

Perspectives for the association between olfactory disturbances and depression in Parkinson's disease

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Neural Regeneration Research 2019年第4期14卷 591-592页

作者： jessica L.Ilkiw Marcelo M.S.Lima Neurophysiology Laboratory Department of PhysiologyFederal University of Paraná

Non-motor disturbances in Parkinson’s disease:Globally,population aged 60 or over is growing and considering the World Bank predictions for the next 20 years it is expected that the number of Parkinson’s disease(PD)cases will double at the end of this period thus,reaching an impressive 13–39 million patients *** scenario is potentially associated with a significant global negative impact on public health systems particularly in countries with increased ageing populations such as the European countries,Asia and *** pathophysiology of PD involves the progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta(SNpc)that triggers denervation of the nigrostriatal pathway and consequent significant reduction of dopamine in the dorsal *** process leads to a critical motor impairment scenario characterized by bradykinesia,rigidity,resting tremor,and postural instability(Emamzadeh and Surguchov,2018).However,several other non-motor disturbances develop earlier,thus,being considered as prodromal signs of the *** this sense,the literature is increasingly emphasizing the importance of investigating mood and olfactory disruptions as high sensitive benchmarks of the early-phase *** fact,the need for innovative early-phase diagnostic tools,as well as the elucidation of the pathophysiological mechanisms of such disturbances,is essential priority in the field of investigation of ***,in the year of 2015,a woman was known for an intriguing ability of“smell PD”.Her husband had lived with the disease for twenty years and during this process she noticed that his odor slowly changed to a musky ***,this woman could associate this particular smell with PD after meeting different people with this distinct odor in a charity for PD *** fact,this clever observation is aligned with studies showing that hyposmia is found decades before the motor *** type of anecdotal story,

关键词： Parkinson olfactory disturbances association

Comparison of closure measurements with finite element model results in an underground coal mine in central Utah

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International Journal of Mining Science and Technology 2019年第1期29卷 9-15页

作者： William G.Pariseau Michael K.McCarter jessica M.Wempen Department of Mining Engineering University of Utah

Quantitative analysis of mine-wide subsidence at the kilometer scale and details of stress distribution about an advancing longwall face are estimated using an adaptation of the finite element method. The method is well suited to the tasks at hand. For greater realism, variability of strata properties is taken into account as are the effects of joints and cleats on elastic moduli and strengths. Evolution of pillar stress and entry closure remote from the face is readily quantified in a series of analyses that simulate face advance. Computed results compare favorably with the evolution of closure measurements about an instrumented pillar in a two-entry headgate. The appropriateness of the finite element method is confirmed. This method is based on first principles that avoid empirical schemes of uncertain applicability and numerical models ‘‘calibrated" by fitting computer output to mine measurements.

关键词： Finite element modeling Longwall mining Mine subsidence Stress modeling

Harvesting of forest products and implications for Afrotemperate bird communities in a montane forest of the Eastern Cape, South Africa

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Forest Ecosystems 2019年第4期6卷 352-366页

作者： jessica Leaver Johann C.Carstens Michael I.Cherry Department of Botany and Zoology Stellenbosch University

Background: Harvesting of forest products is a widespread driver of disturbance in developing nations, where policies are increasingly aimed at managing natural forests for sustainable use. There is thus need for research aimed at understanding the impact of resource use on forest habitats and concomitant effects on *** forests in the Eastern Cape, South Africa are harvested informally for poles and medicinal bark and occur along elevational gradients of 800–1600 m above sea level. Patterns of spatial diversity and human disturbance are expected to be affected by elevation. Furthermore, species’ responses to disturbance are expected to vary depending on their level of habitat specialisation. Understanding harvest impacts on forest biodiversity thus requires disentangling the separate effects of elevation and disturbance, and considering forest-specialist and forest-generalist species separately. This study comprises two components. First, harvest activities, resultant harvestmediated habitat heterogeneity, and avifaunal species richness, composition and beta-diversity were compared across two elevational zones in a harvested forest. Second, the role of harvest-mediated habitat heterogeneity in driving patterns of avifaunal diversity were assessed, while controlling for elevation, and considering forest-specialist and forest-generalist species ***: Harvest rates were higher, and activities more varied in the lower elevation zone, with significant impacts of harvesting on habitat features resulting in higher harvest-mediated habitat heterogeneity at lower ***-mediated increases in habitat heterogeneity positively affected forest-generalist species richness, while forest-specialist richness was negatively affected. While species composition of both groups differed across elevational zones, variation in harvest-mediated habitat heterogeneity did not fully account for this, suggesting that factors other than disturbance

关键词： Human disturbance Habitat heterogeneity Habitat modification Beta-diversity Elevation Generalist species Forest-specialist species

Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms

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Journal of Environmental Sciences 2017年第12期29卷 133-137页

作者： Renate Kopp Irene Ozáez Martínez jessica Legradi Juliette Legler Institute for Environmental Studies(IVM) VU University Amsterdam1081HVThe Netherlands. Biology and Environmental Toxicology Group Faculty of SciencesNational Distance Education University28015 MadridSpain Institute for Environment Health and SocietiesCollege of Health and Life SciencesBrunel University LondonUxbridgeUB8 3PHUnited Kingdom

A growing body of evidence indicates that exposure to environmental chemicals can contribute to the etiology of obesity by inappropriately stimulating adipogenesis as well as perturbing lipid metabolism and energy balance. One potential mechanism by which chemical exposure can influence lipid metabolism is through disturbance of circadian rhythms, endogenously-driven cycles of roughly 24 hr in length that coordinate biochemical, physiological, and behavioral processes in all organisms. Here we show for the first time that exposure to endocrine disrupting compounds（EDCs）, including the pesticide tributyltin, two commercial flame retardants, and a UV-filter chemical found in sunscreens,can perturb both circadian clocks and lipid metabolism in vertebrates. Exposure of developing zebrafish to EDCs affects core clock activity and leads to a remarkable increase in lipid accumulation that is reminiscent of the effects observed for longdaysin, a known disruptor of circadian rhythms. Our data reveal a novel obesogenic mechanism of action for environmental chemicals, an observation which warrants further research. Because circadian clocks regulate a wide variety of physiological processes, identification of environmental chemicals capable of perturbing these systems may provide important insights into the development of environmentally-induced metabolic disease.

关键词： zebrafish adiposity tributyltin flame retardants clock genes