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Circadian rhythms and inflammatory diseases of the liver and gut

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Liver Research 2023年第3期7卷 196-206页

作者： jessica M.Ferrell Department of Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Circadian rhythms play a central role in maintaining metabolic homeostasis and orchestrating interorgan *** evidence indicates that disruption to rhythms,which occurs through shift work,chronic sleep disruption,molecular clock polymorphisms,or the consumption of alcohol or highfat diets,can influence inflammatory status and disrupt timing between the brain and periphery or between the body and the external *** the liver and gut,circadian rhythms direct the timing of glucose and lipid homeostasis,bile acid and xenobiotic metabolism,and nutrient absorption,making these systems particularly susceptible to the effects of disrupted *** this review,the impacts of circadian disruption will be discussed with emphasis on inflammatory conditions affecting the liver and gut,and the potential for chronotherapy for these conditions will be explored.

关键词： Circadian rhythm Liver Gut Inflammation Non-alcoholic fatty liver disease(NAFLD) Alcohol-associated liver disease(AALD)

A low-cost PDGNSS-based sensor network for landslide monitoringchallenges,possibilities,and prospects

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International Journal of Digital Earth 2010年第4期3卷 365-383页

作者： jessica Glabsch Otto Heunecke Stefan Schuhbäck Institute of Geodesy University of the Federal Armed Forces of Germany in MunichWerner-Heisenberg-Weg 39D-85577 NeubibergGermany

Simple navigation receivers can be used for positioning with sub-centimeter accuracy in a wireless sensor network if the read-out of the carrier phase(CP)data is possible and all data are permanently broadcast to a central processing *** this base station an automated near real-time processing takes place and a precise differential GNSS-based positioning of the involved sensor nodes is *** paper describes the technical principles of such a system with its essential demands for the sensing,the communication,and the computing *** experiences in a research project related to landslide monitoring are *** course the developed system can also be embedded for location finding in a widespread multifunctional geo sensor *** quality of the obtained result is restricted due to the fact that the CP measurements must be recorded over a certain time span,usually a few minutes for every independent position *** far as possible a modular structure with commercial off-theshelf components,*** wireless local area network for communication,and in cooperation of existing proofed and powerful program tools is *** interfaces are used as far as possible.

关键词： low-cost precise differential GNSS(LC PDGNSS) near real-time processing(NRTP) wireless sensor networks(WSNs) geo sensor networks(GSNs) landslide monitoring data acquisition 1.Introduction Geodetic monitoring of building structures and

Putative nicotinic acetylcholine receptor subunits express differentially through the life cycle of codling moth, Cydia pomonella （Lepidoptera： Tortricidae）

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Insect Science 2016年第2期23卷 277-287页

作者： jessica A. Martin Stephen F. Garczynski USDA-ARS Yakima Agricultural Research Laboratory Wapato WA 98951 USA

Nicotinic acetylcholine receptors （nAChRs） are the targets of neonicotinoids and spinosads, two insecticides used in orchards to effectively control codling moth, Cydia pomonella （L.）（Lepidoptera： Tortricidae）. Orchardists in Washington State are concerned about the possibility of codling moth field populations developing resistance to these two insecticides. In an effort to help mitigate this issue, we initiated a project to identify and characterize codling moth nAChR subunits expressed in heads. This study had two main goals; （i） identify transcripts from a codling moth head transcriptome that encode for nAChR subunits, and （ii） determine nAChR subunit expression profiles in various life stages of codling moth. From a codling moth head transcriptome, 24 transcripts encoding for 12 putative nAChR subunit classes were identified and verified by PCR amplification, cloning, and sequence determination. Characterization of the deduced protein sequences encoded by putative nAChR transcripts revealed that they share the distinguishing features of the cys-loop ligand-gated ion channel superfamily with 9 α-type subunits and 3 β- type subunits identified. Phylogenetic analysis comparing these protein sequences to those of other insect nAChR subunits supports the identification of these proteins as nAChR subunits. Stage expression studies determined that there is clear differential expression of many of these subunits throughout the codling moth life cycle. The information from this study will be used in the future to monitor for potential target-site resistance mechanisms to neonicotinoids and spinosads in tolerant codling moth populations.

关键词： codling moth nAChR expression nicotinic acetylcholine receptor subunits

Comparison of L-band and X-band differential interferometric synthetic aperture radar for mine subsidence monitoring in central Utah

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International Journal of Mining Science and Technology 2017年第1期27卷 159-163页

作者： jessica M.Wempen Michael K.McCarter Department of Mining Engineering University of UtahSalt Lake City 84112USA

Differential interferometric synthetic aperture radar(DIn SAR), a satellite-based remote sensing technique, has potential application for measuring mine subsidence on a regional scale with high spatial and temporal resolutions. However, the characteristics of synthetic aperture radar(SAR) data and the effectiveness of DIn SAR for subsidence monitoring depend on the radar band(wavelength). This study evaluates the effectiveness of DIn SAR for monitoring subsidence due to longwall mining in central Utah using L-band(24 cm wavelength) SAR data from the advanced land observing satellite(ALOS)and X-band(3 cm wavelength) SAR data from the Terra SAR-X mission. In the Wasatch Plateau region of central Utah, which is characterized by steep terrain and variable ground cover conditions, areas affected by longwall mine subsidence are identifiable using both L-band and X-band DIn ***, using L-band data, subsidence magnitudes are measurable. Compared to X-band, L-band data are less affected by signal saturation due to large deformation gradients and by temporal decorrelation due to changes in the surface conditions over time. The L-band data tend to be stable over relatively long periods(months). Short wavelength X-band data are strongly affected by signal saturation and temporal decorrelation, but regions of subsidence are typically identifiable over short periods(days). Additionally,though subsidence magnitudes are difficult to precisely measure in the central Utah region using X-band data, they can often be reasonably estimated.

关键词： Mine subsidence DInSAR Terra SAR-X ALOS Interferometry

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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer J.Allen Stephanie M.Ntoukas Gordon J.Bell jessica McNeil Qinggang Wang Margaret L.McNeely Jeff K.Vallance Lin Yang S.Nicole Culos-Reed Leanne Dickau John R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(p<0.001),poor sleep quality(p=0.009),significant fatigue(p=0.008),any symptom(p<0.001),and multiple symptoms(p<0.001).VO_(2peak)demonstrated threshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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Restoring the gut microbiome for the treatment of inflammatory bowel diseases

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World Journal of Gastroenterology 2014年第13期20卷 3468-3474页

作者： jessica R Allegretti Matthew J Hamilton Division of Gastroenterology Brigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02115United States

Fecal microbiota transplantation (FMT) is considered to be a highly successful therapy for recurrent and refractory Clostridium difficile infection (CDI) based on recent clinical trials. The pathogenesis of inflammatory bowel diseases (IBD) is thought to be due in part to perturbations in the gut microflora that disrupt homeostasis. FMT restores essential components of the microflora which could reverse the inflammatory processes observed in IBD. Case reports and series for the treatment of IBD by FMT have shown promise with regards to treatment success and safety despite the limitations of the reporting. Future studies will determine the optimal delivery and preparation of stool as well as the conditions under which the recipient will derive maximal benefit. The long term consequences of FMT with regards to infection, cancer, auto-immune, and metabolic diseases are not known and will require continued regulation and study. Despite these limitations, FMT may be beneficial for the treatment of ulcerative colitis and Crohn’s disease, particularly those with concurrent CDI or with pouchitis.

关键词： Crohn’ s, Ulcerative colitis, Microbiota, Fecal transplantation, Dysbiosis, Pouchitis, Clostridium difficile, Probiotic

Effects of environmental stressors on stem cells

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World Journal of Stem Cells 2019年第9期11卷 565-577页

作者： jessica R Worley Graham C Parker Department of Pediatrics Wayne State University School of Medicine

Environmental toxicants are ubiquitous,and many are known to cause harmful health ***,much of what we know or think we know concerning the targets and long-term effects of exposure to environmental stressors is sadly *** exposure may have health effects that are currently mischaracterized or at least mechanistically incompletely *** much of the recent excitement about stem cells(SCs)focuses on their potential as therapeutic agents,they also offer a valuable resource to give us insight into the mechanisms and risks of toxicant *** only as a response to the increasing ethical pressure to reduce animal testing,SC studies allow us valuable insight into the true effects of human exposure to environmental stressors under controlled *** present a review of the history of publications on the effects of environmental stressors on SCs,followed by a consolidation of the literature over the past five years on a subset of key environmental stressors of importance to human health and their effects on both embryonic and tissue *** review will make constructive suggestions as to areas of toxicant research where further studies are needed,as well as making indications of the potential utility for advancing knowledge and directing research on environmental toxicology.

关键词： Environmental substances Toxic Stem cells Endocrine disruptors Alcohols Tobacco smoking Metals Heavy Particulate matter Volatile organic compounds Ozone

可扭转骨支架提高物质传输效率及细胞剪切应力响应水平的数值研究

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医用生物力学 2024年第S1期 606-606页

作者：王路平王嘉秋陈强李奇维 jessica Benitez Mendieta 李志勇中国计量大学机电工程学院东南大学生物科学与医学工程学院昆士兰科技大学机械医学与过程工程学院伦敦南岸大学工程学院宁波大学体育学院

目的骨支架内部营养物质的提供与废物的排出对骨组织再生至关重要,细胞受到的流体剪切应力被认为是重要的机械调控信号。扭转结构元素存在于天然骨骼的多个分级结构中,搅拌是日常生活中加速流体中物质均匀的常用手段。受此启发,本研究...

目的骨支架内部营养物质的提供与废物的排出对骨组织再生至关重要,细胞受到的流体剪切应力被认为是重要的机械调控信号。扭转结构元素存在于天然骨骼的多个分级结构中,搅拌是日常生活中加速流体中物质均匀的常用手段。受此启发,本研究将扭转效应融入支架构型设计,提出了一种可扭转的骨支架结构构型,并进一步研究其在生理荷载作用下的物质传输行为和流体剪切应力水平。方法采用数值分析的手段,对支架施加循环荷载以模拟所受到的生理振荡荷载,对支架结构及周围流体进行流固耦合分析,并评估可扭转支架内部的物质传输效率及壁面剪切应力水平。结果研究结果显示,无论是物质传输能力,还是细胞剪切应力响应水平,扭转支架均相对传统支架展示出优越性;对荷载作用下支架-流体的流固耦合效应的考虑能够更为真实反映支架微环境,更为真实探讨支架的成骨效应。结论将扭转效应融入新型支架构型设计及优化,具备辅助提高成骨效率的潜力;结合数值分析,有助于开发新型的可加载器官芯片模型。

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Use of the stepwise progression return-to-play protocol following concussion among practicing athletic trainers

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Journal of Sport and Health Science 2018年第2期7卷 204-209页

作者： jessica Wallace Tracey Covassin Meghan Lafevor Department of Kinesiology Michigan State University Human Performance & Exercise Science Department Youngstown State University

Purpose: The purpose of this study was to determine whether practicing athletic trainers(ATs) were using the stepwise progression to make return-to-play(RTP) decisions after concussion and to determine what factors influenced their decision to use the stepwise ***: A total of 166 ATs(response rate = 16.6%) completed a 21-item questionnaire that evaluated participant demographics, methods of concussion management, and RTP decision-making using the stepwise progression. Descriptive statistics and a logistic regression were completed to analyze ***: Factors such as education level(p = 0.05) and number of concussions treated(p = 0.05) predicted use of the stepwise progression,whereas sex(p = 0.17), employment setting(p = 0.17), state law(p = 0.86), and years practicing(p = 0.17) did not predict whether ATs were following the stepwise ***: The majority of the ATs from this study are employing the stepwise progression to safely return athletes to play after sustaining a concussion. This demonstrates that ATs are providing a standard of care for concussed athletes across various athletic training settings; however,having a graduate degree and treating more concussions per year are predictors of whether an AT follows all steps of the stepwise progression.

关键词： Athletic trainers Concussion Concussion management Graduate degree Return to play Sports medicine Stepwise progression

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