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Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats

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World Journal of Gastroenterology 2005年第4期11卷 587-592页

作者： Tadeusz Sebzda Piotr Hanczyc Yousif Saleh Bernice F Akinpelumi Maciej Siewinski jerzy rudnicki Department of Pathophysiology Medical University of Wroclaw Poland Department of Obstetrics and Gynaecology Medical University of Wroclaw Poland Faculty of Public Health Medical University of Wroclaw Poland Clinical of Surgery and Oncology Medical University of Wroclaw Poland

AIM: To examine the effectiveness of human placental inhibitors, by injecting vitamin E to rats with transplanted Morris-5123 hepatoma, on the expression of cathepsins B and L in tumor, liver, lung and blood sera after transplantation of Morris 5123 hepatoma. METHODS: Animals were divided into 10 groups receiving three different concentrations of vitamin E and inhibitors along or in combination and compared with negative control (healthy rats) and positive control (tumor rats). Effectiveness of treatment was evaluated with regard to survival time, tumor response and determination of the activities of proteolytic enzymes and their inhibitors using flurogenic substrates. RESULTS: Cathepsins B and L activities were elevated by 16-fold in comparison with negative control tissues, and their endogenous inhibitor activity decreased by 1.2-fold before treatment. In several cases, tumors completely disappeared following vitamin E plus human placental cyteine protease inhibitor (CPI) compared with controls. The number of complete tumor responses was higher when 20 m/kg vitamin E plus 400 μg of CPI was used, i.e. 7/10 rats survived more than two mo. Cathepsins B and L were expressed significantly in tumor, liver, lung tissues and sera in parallel to the increasing of the endogenous inhibitor activity compared with the controls after treatment(P<0.0001) CONCLUSION: The data indicate formation of metastasis significantly reduced in treated rats, which might provide a therapeutic basis for anti-cancer therapy.

关键词： Morris-5123 hepatoma Vitamin E Human placenta cysteine peptidase inhibitor Cathepsin B Cathepsin L

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A preliminary study on selected methods of modeling the effect of shearer operation on methane propagation and ventilation at longwalls

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International Journal of Mining Science and Technology 2020年第5期30卷 675-682页

作者： jerzy Krawczyk Strata Mechanics Research Institute Polish Academy of SciencesReymonta 2730-059 KrakowPoland

Underground coal mining frequently uses *** occurrence of a potentially explosive mixture of methane and air is one of the most serious hazards.A large number of papers have applied numerical modeling of methane propagation in research aimed at this *** date,none of the CFD simulations has considered the movement of the shearer in the *** paper proposes an adaptation of a method used for the description of the movement of trains in tunnels to a specific geometry of a longwall *** flow of the air-methane mixture was calculated using the finite volume method,in particular the k-w SST and SAS turbulence *** to the movement of the shearer,moving and deforming meshes were used for simulation of unsteady *** of solutions for two hypothetical cases are ***,the drawbacks and advantages of presented methods are *** development with the application of either local mesh variability or overset meshes is outlined.

关键词： Longwall mining Mine ventilation Finite volume method Shearer Methane propagation

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When a smooth self-map of a semi-simple Lie group can realize the least number of periodic points

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Science China Mathematics 2017年第9期60卷 1579-1590页

作者： JEZIERSKI jerzy Institute of Applications of Informatics and Mathematics Warsaw University of Life Sciences(SGGW)Warsaw 00-757Poland

There are two algebraic lower bounds of the number of n-periodic points of a self-map f ： M →4 M of a compact smooth manifold of dimension at least 3： NFn（f） = min{#Fix（gn）;g - f; g continuous} and NJDn（f） = min{#Fix（gn）;g - f; g smooth}. In general, NJDn（f） may be much greater than NFn（f）. We show that for a self-map of a semi-simple Lie group, inducing the identity fundamental group homomorphism, the equality NFn（f） = NJDn（f） holds for all n →← all eigenvalues of a quotient cohomology homomorphism induced by f have moduli ≤ 1.

关键词： periodic points Nielsen number fixed point index smooth maps Lie group

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Self-maps of S2 Homotopic to a Smooth Map with a Single n-periodic Point

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Acta Mathematica Sinica,English Series 2017年第8期33卷 1073-1082页

作者： jerzy JEZIERSKI Department of Applied Informatics and Mathematics Warsaw University of Life SciencesNowoursynowska 15902757 WarszawaPoland

We show for which （d, n） ∈ Z × N there exists a smooth self-map f ： S2 → S2 so that deg（f） = d and Fix（fn） is a point.

关键词： Fixed point periodic point Nielsen fixed point theory Dold congruences least number of periodic points

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The abc-conjecture for Algebraic Numbers

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Acta Mathematica Sinica,English Series 2006年第1期22卷 211-222页

作者： jerzy BROWKIN Institute of Mathematics University of Warsaw ul. Banacha 2 PL-02-097 Warsaw Poland

The abe-conjecture for the ring of integers states that, for every ε 〉 0 and every triple of relatively prime nonzero integers （a, b, c） satisfying a ＋ b = c, we have max（｜a｜, ｜b｜, ｜c｜）〈 rad（abc）^1＋ε with a finite number of exceptions. Here the radical rad（m） is the product of all distinct prime factors of m. In the present paper we propose an abe-conjecture for the field of all algebraic numbers. It is based on the definition of the radical （in Section 1） and of the height （in Section 2） of an algebraic number. From this abc-conjecture we deduce some versions of Fermat＇s last theorem for the field of all algebraic numbers, and we discuss from this point of view known results on solutions of Fermat＇s equation in fields of small degrees over Q.

关键词： abc-conjecture Radical Height Fermat's last theorem for algebraic numbers

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Elements of Small Orders in K_2FⅡ

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Chinese Annals of Mathematics,Series B 2007年第5期28卷 507-520页

作者： jerzy BROWKIN Institute of Mathematics University of Warsaw ul.Banacha 2PL-02-097 WarsawPoland.

In ＂Elements of small orders in K2（F）＂（Algebraic K-Theory, Lecture Notes in Math., 966, 1982, 1-6.）, the author investigates elements of the form {α, Фn（α）} in the Milnor group K2F of a field F, where Фn（x） is the n-th cyclotomic polynomial. In this paper, these elements are generalized. Applying the explicit formulas of Rosset and Tate for the transfer homomorphism for K2, the author proves some new results on elements of small orders in K2F.

关键词： Cyclotomic elements in K2F Transfer in K-theory Milnor group

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CYCLOTOMIC ELEMENTS IN K_2F,REVISITED

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Acta Mathematica Scientia 2010年第1期30卷 19-26页

作者： jerzy Browkin Institute of Mathematics Polish Academy of Sciencesul.Sniadeckich 8PL-00-956 WarsawPoland

Basing on results of Xu and Qin [10], and Guo [12] on cyclotomic elements in K2F for local fields F, we prove that every element in K2Q is a finite or infinite product of cyclotomic elements. Next, we extend this resu... 详细信息

关键词： Milnor group cyclotomic elements

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Least Number of Periodic Points of Self-maps of Lie Groups

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Acta Mathematica Sinica,English Series 2014年第9期30卷 1477-1494页

作者： jerzy JEZIERSKI Department of Applied Informatics and Mathematics Warsaw University of Life Sciences

There are two algebraic lower bounds of the number of n-periodic points of a self-map f ： M → M of a compact smooth manifold of dimension at least 3： NFn（f） = min{#Fix（gn）;g - f; g is continuous} and NJDn（f） = min{#Fix（gn）; g - f; g is smooth}. In general, NJDn（f） may be much greater than NFn（f）. If M is a torus, then the invariants are equal. We show that for a self-map of a nonabelian compact Lie group, with free fundamental group, the equality holds 〈=〉 all eigenvalues of a quotient cohomology homomorphism induced by f have moduli ≤ 1.

关键词： Fixed point periodic point Nielsen fixed point theory Dold congruences least number of periodic points

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The Modern Applications of Surface Duplex Treatment Technology

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材料热处理学报 2004年第05B期25卷 866-869页

作者： jerzy Smolik Jan Walkowicz Adam Mazurkiewicz jerzy Tomaszewski Institute for Terotechnology Pulaskiego 6/10 Radom 26-600 PolandInstitute for Terotechnology Pulaskiego 6/10 Radom 26-600 PolandInstitute for Terotechnology Pulaskiego 6/10 Radom 26-600 PolandResearch and Development Center of Motoreducers and Reducers "REDOR " Piekarska 81 Bielsko-Biala 43-300 Poland

The paper presents results of the research carried out by the authors in different fields of plasma surface technologies applications. Three groups of different surface engineering technologies are shown in the paper. The first one concerns the possibility of using the duplex treatment technology for creation of biocompatible diamond-like a-C:H films. The paper presents research results concerning influence of the process parameters of the a-C:H coatings creation by means of the RF PACVD method in the pure methane atmosphere on their phase structure and mechanical properties. In the second case authors present the concept of a new special multilayer thermal barrier coatings with the PAPVD diffusion barrier layers based on aluminium oxide. As the last one the special application of plasma techniques for creation of composite materials characterized by the muffling of mechanical vibration was presented.

关键词：二相处理 PVD 等离子表面处理 RFPACVD a-C:H涂层

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Introduction to investigations of the negative corona and EHD flow in gaseous two-phase fluids

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Plasma Science and Technology 2018年第5期20卷 147-156页

作者： jerzy MIZERACZYK Artur BERENDT Department of Marine Electronics Gdynia Maritime University Institute of Fluid Flow Machinery Polish Academy of Sciences

Research interests have recently been directed towards electrical discharges in multi-phase *** electrical discharges,such as lightning and coronas,occur in the Earth＇s atmosphere,which is actually a mixture of gaseous phase（air） and suspended solid and liquid particulate matters（PMs）.An example of an anthropogenic gaseous multi-phase environment is the flow of flue gas through electrostatic precipitators（ESPs）,which are generally regarded as a mixture of a post-combustion gas with solid PM and microdroplets suspended in *** discharges in multi-phase environments,the knowledge of which is scarce,are becoming an attractive research subject,offering a wide variety of possible discharges and multi-phase environments to be *** paper is an introduction to electrical discharges in multi-phase *** is focused on DC negative coronas and accompanying electrohydrodynamic（EHD） flows in a gaseous two-phase fluid formed by air（a gaseous phase） and solid PM（a solid phase）,run under laboratory *** introduction is based on a review of the relevant *** cases will be considered：the first case is of a gaseous two-phase fluid,initially motionless in a closed chamber before being subjected to a negative corona（with the needle-toplate electrode arrangement）,which afterwards induces an EHD flow in the chamber,and the second,of a gaseous two-phase fluid flowing transversely with respect to the needle-to-plate electrode axis along a chamber with a corona discharge running between the *** review-based introductory paper should be of interest to theoretical researchers and modellers in the field of negative corona discharges in single-or two-phase fluids,and for engineers who work on designing EHD devices（such as ESPs,EHD pumps,and smoke detectors）.

关键词： DC negative corona discharge Trichel pulses gaseous two-phase flow air withsuspended particle flow ESP EHD

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