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Associ.ti.ns between Avocado i.take and Lower Rates of i.ci.ent Type 2 Di.betes i. US Adults wi.h Hi.pani./Lati.o Ancestry

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Journal of Di.betes Melli.us 2023年第2期13卷 116-129页

作者： Alexi. C. Wood Mackenzi. K. Senn jerome i. rotter USDA/ARS Chi.dren’s Nutri.i.n Research Center Baylor College of Medicine Houston USA The i.sti.ute for Translati.nal Genomi.s and Populati.n Sci.nces Department of Pediatrics The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance USA

Background/Purpose: Hi.pani./Lati.os i. the US are at i.creased ri.k for type 2 di.betes (T2D). Data suggest that avocado i.take i. associ.ted wi.h better glycemi. control, but whether thi. translates to protecti.n from T2D has not been studi.d. The goal of the current analyses was to exami.e whether consumi.g avocados at baseli.e i. associ.ted wi.h lower i.ci.ent T2D over a si.-year peri.d, compared to not consumi.g avocados at baseli.e. Subjects/Methods: Usi.g data from a large populati.n of US adults wi.h Hi.pani. ancestry, wi.hout known or unknown T2D at baseli.e (N = 6159), parti.i.ants were classi.i.d as avocado consumers (N = 983) or non-consumers (N = 5176) based on the mean of two 24-hour di.tary recalls. Cox proporti.nal hazard models esti.ated the associ.ti.n of avocado consumpti.n wi.h i.ci.ent T2D (N = 656 cases) over a si.-year follow-up peri.d, i. the populati.n as a whole, and separately i. those wi.h normoglycemi. vs. predi.betes at baseli.e. A set of three sequenti.l models were run: the fi.st controlli.g only for soci.demographi. factors (“mi.i.ally adjusted” models), the second for these and health behavi.rs (“fully adjusted” models), and a thi.d for both sets of covari.tes and also body mass i.dex (BMi.“fully adjusted + BMi. models). Results: i. the populati.n as a whole, avocado i.take at baseli.e was associ.ted wi.h reduced i.ci.ent T2D i. both the mi.i.ally adjusted (hazard rati. [HR] (±95% confi.ence i.tervals [Ci.]): 0.70 (0.52 - 0.94), P = 0.04) and the fully adjusted models (HR: 0.72 (0.54 - 0.97), P = 0.03). Thi. associ.ti.n was observed i. both those wi.h predi.betes and wi.h normoglycemi. at baseli.e, but only reached si.ni.i.ance i. those wi.h predi.betes (mi.i.ally adjusted model: HR: 0.68 (0.48 - 0.97), P = 0.03;fully adjusted model: HR: 0.69 (0.48 - 0.98), P = 0.04), not i. those wi.h normoglycemi. (mi.i.ally adjusted model: HR: 0.86 (0.45 - 1.65), P = 0.65;fully adjusted model: HR: 0.80 (0.41 - 1.55), P = 0.50). i. models whi.h ad

关键词： Avocado Di.t Type 2 Di.betes Dysglycemi. Monounsaturated Fats

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Di.ferenti.lly expressed genes i. adi.ocytoki.e si.nali.g pathway of adi.ose ti.sue i. pregnancy

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Journal of Di.betes Melli.us 2013年第2期3卷 86-95页

作者： Dotun Ogunyemi.Jun Xu Arnold M. Mahesan Steve Rad Eri. Ki. Jacqueli.e Yano Carolyn Alexander jerome i. rotter Y.-D. i.a Chen Department of Endocri.ology Cedars-Sinai Medical Center Los Angeles USA Department of Medi.al Educati.n David Geffen School of Medicine at UCLA Los Angeles USA Department of Medi.al Geneti.s Cedars-Sinai Medical Center Los Angeles USA Department of Obstetri.s and Gynecology Cedars-Sinai Medical Center Los Angeles USA

Objecti.e: To profi.e the di.ferenti.l gene expressi.n of the KEGG Adi.ocytoki.e Si.nali.g pathway i. omental compared to subcutaneous ti.sue i. normal pregnancy. Study Desi.n: Subjects i.cluded 14 nonobese, normal glucose tolerant, healthy pregnant women. Matched omental and subcutaneous ti.sue were obtai.ed at electi.e cesarean deli.ery. Gene expressi.n was evaluated usi.g mi.roarray and vali.ated by RT-PCR. Di.ferenti.l gene expressi.n was defi.ed as ≥1.5 fold i.crease at p i. genes were si.ni.i.antly downregulated wi.h two upregulated genes i. omental ti.sue. Downregulati.n of Adi.onecti. and i.suli. Receptor substrate, key genes medi.ti.g i.suli. sensi.i.i.y, were observed wi.h borderli.e upregulati.n of GLUT-1. There were downregulati.ns of CD36 and acyl-CoA Synthetase Long-chai. Fami.y Member 1whi.h are genes i.volved i. fatty aci. uptake and acti.ati.n. There was a novel expressi.n of Carni.i.e palmi.oyltransferase 1C. Conclusi.n: Di.ferenti.l gene expressi.n of Adi.ocytoki.e Si.nali.g Pathway i. omental relati.e to subcutaneous adi.ose ti.sue i. normal pregnancy suggests a pattern of i.suli. resi.tance, hyperli.i.emi., and i.flammati.n.

关键词： Adi.ose Ti.sue Pregnancy Adi.ocytoki.e Pathway i.suli. Resi.tance

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A passi.e,reusable,and resonati.g wearable sensi.g system for ondemand,non-i.vasi.e,and wi.eless molecular stress bi.marker detecti.n

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Nano Research 2024年第8期17卷 7542-7556页

作者： Shi.gi.i.ai.Chakoma Xi.ochang Pei.Hui.i.g Qi. Ani.a Ghandehari.Sahar Najafi.hoshnoo jerome Rajendran Rahi. Esfandyarpour Department of Electri.al Engi.eeri.g and Computer Sci.nce University of CaliforniaIrvineCA 92697USA Laboratory for i.tegrated Nano Bi.Electroni.s i.novati.n The Henry Samueli School of EngineeringUniversity of CaliforniaIrvineCA 92697USA Henry Samueli.School of Engi.eeri.g University of CaliforniaIrvineCA 92697USA

The si.ni.i.ant i.pact of stress on health necessi.ates accurate assessment methods,where tradi.i.nal questi.nnai.es lack reli.bi.i.y and *** advancements li.e wearables wi.h electrocardi.gram(ECG)and galvani. ski. response(GSR)sensors face accuracy and arti.act *** bi.sensors detecti.g corti.ol,a cri.i.al stress hormone,present a promi.i.g ***,exi.ti.g corti.ol assays,requi.i.g sali.a,uri.e,or blood,are complex,expensi.e,and unsui.able for conti.uous *** study i.troduces a passi.e,molecularly i.pri.ted polymer-radi.-frequency(Mi.-RF)wearable sensi.g system for real-ti.e,non-i.vasi.e sweat corti.ol *** system i. wi.eless,flexi.le,battery-free,reusable,envi.onmentally stable,and desi.ned for long-term moni.ori.g,usi.g an i.ductance-capaci.ance *** transducer translates corti.ol concentrati.ns i.to resonant frequency shi.ts wi.h hi.h sensi.i.i.y(~160 kHz/(log(μM)))across a physi.logi.al range of 0.025–1μ*** wi.h near-fi.ld communi.ati.n(NFC)for wi.eless and battery-free operati.n,and threedi.ensi.nal(3D)-pri.ted mi.roflui.i. channel for i.-si.u sweat collecti.n,i. enables dai.y acti.i.y corti.ol level *** of corti.ol ci.cadi.n rhythm through morni.g and eveni.g measurements demonstrates i.s effecti.eness i. tracki.g and moni.ori.g sweat corti.ol levels.A 28-day stabi.i.y test and the use of cost-effecti.e 3D nanomateri.ls pri.ti.g enhance i.s economi. vi.bi.i.y and *** i.novati.n paves the way for a new era i. reali.ti.,on-demand health moni.ori.g outsi.e the laboratory,leveragi.g wearable technology for molecular stress bi.marker detecti.n.

关键词： corti.ol wearable flexi.le sensors three-di.ensi.nal(3D)nanomateri.ls pri.ti.g reusable envi.onmentally stable

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Lax-Olei.i.-Type Formulas and Effi.i.nt Algori.hms for Certai. Hi.h-Di.ensi.nal Opti.al Control Problems

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Communi.ati.ns on Appli.d Mathemati.s and Computati.n 2024年第2期6卷 1428-1471页

作者： Paula Chen jerome Darbon Ti.gwei.Meng Di.i.i.n of Appli.d Mathemati.s Brown UniversityProvidenceRIUSA Department of Mathemati.s UCLALos AngelesCAUSA

Two of the mai. challenges i. opti.al control are solvi.g problems wi.h state-dependent runni.g costs and developi.g effi.i.nt numeri.al solvers that are computati.nally tractable i. hi.h *** thi. paper,we provi.e analyti.al soluti.ns to certai. opti.al control problems whose runni.g cost depends on the state vari.ble and wi.h constrai.ts on the *** also provi.e Lax-Olei.i.-type representati.n formulas for the correspondi.g Hami.ton-Jacobi.parti.l di.ferenti.l equati.ns wi.h state-dependent ***,we present an effi.i.nt,gri.-free numeri.al solver based on our representati.n formulas,whi.h i. shown to scale li.early wi.h the state di.ensi.n,and thus,to overcome the curse of *** exi.ti.g opti.i.ati.n methods and the mi.-plus techni.ue,we extend our numeri.al solvers to address more general classes of convex and nonconvex i.i.i.l *** demonstrate the capabi.i.i.s of our numeri.al solvers usi.g i.plementati.ns on a central processi.g uni.(CPU)and a fi.ld-programmable gate array(FPGA).i. several cases,our FPGA i.plementati.n obtai.s over a 10 ti.es speedup compared to the CPU,whi.h demonstrates the promi.i.g performance boosts FPGAs can *** numeri.al results show that our solvers have the potenti.l to serve as a bui.di.g block for solvi.g broader classes of hi.h-di.ensi.nal opti.al control problems i. real-ti.e.

关键词： Opti.al control Hami.ton-Jacobi.parti.l di.ferenti.l equati.ns Gri.-free numeri.al methods Hi.h di.ensi.ns Fi.ld-programmable gate arrays(FPGAs)

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Structural engi.eeri.g of anti.i.robi.ls for opti.al broad-spectrum acti.i.y

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Green Chemi.al Engi.eeri.g 2024年第4期5卷 473-482页

作者： Arunmozhi.rasi.Armugam Di.ne S.W.Li. Si.i.Nurhanna Ri.uan Shook Pui.Chan jerome Asugan Yugen Zhang i.sti.ute of Bi.engi.eeri.g and Bi.i.agi.g i.sti.ute of Sustai.abi.i.y for Chemi.als Energy and Environment(ISCE2) Agency for Science Technology and Research (A*STAR) Di.loma i. Bi.medi.al Sci.nce School of Chemical and Life SciencesSingapore Polytechnic

Anti.i.robi.l materi.ls are a cruci.l component i. eradi.ati.g and managi.g the spread of i.fecti.us *** are expected to act on a broad-spectrum of mi.robes, i.cludi.g emergi.g pathogens whi.h could cause the next Di.ease X. Herei., we reassessed a seri.s of anti.i.robi.l i.i.azoli.m polymers on our shelves and uncovered extended functi.nali.y through dual modes of acti.n. By redesi.ni.g thei. structures, a truly broadspectrum anti.i.robi.l materi.l wi.h opti.i.ed acti.i.y agai.st bacteri.(G +ve, G-ve) and fungi. as well as enveloped and non-enveloped vi.uses was developed. We demonstrated that the i.i.azoli.m polymer exhi.i.s dual modes of functi.n agai.st mi.robes: targeti.g the mi.robi.l membrane and bi.di.g DNA. The latter DNA bi.di.g affi.i.y was found to be key agai.st non-enveloped vi.uses. Wi.h thi. i.si.ht, we desi.ned small molecule compounds that exhi.i.ed opti.um broad-spectrum anti.i.robi.l acti.i.y and excellent effi.acy agai.st ESKAPE group of pathogens that are responsi.le for some of the deadli.st nosocomi.l i.fecti.ns worldwi.e. Our results could also shed li.ht on the desi.n of broad-spectrum anti.i.robi.l compounds agai.st Di.ease X.

关键词： Broad-spectrum Anti.i.robi.l Polyi.i.azoli.m Structure-functi.n Membrane acti.e

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i.munogeneti. phenotypes i. i.flammatory bowel di.ease

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World Journal of Gastroenterology 2006年第23期12卷 3645-3650页

作者： Mari. C Dubi.sky Kent Taylor Stephan R Targan jerome i.rotter Departments of Pedi.tri.s Medicine and Medical Genetics InstituteCedars-Sinai Medical CenterLos Angeles CAUnited States

The currently accepted eti.pathogeni. hypothesi. suggests that the chroni. i.testi.al i.flammati.n and related systemi. mani.estati.ns characteri.ti. of i.flammatory bowel di.ease （i.D） are due to an overly aggressi.e or pathologi. i.mune response to resi.ent lumi.al bacteri.l consti.uents. Predi.posi.g factors are geneti. dysregulati.n of mucosal i.mune responses and/ or barri.r functi.n, wi.h onset tri.gered by envi.onmental sti.uli. These factors and thei. i.teracti.ns may also be i.portant determi.ants of di.ease phenotype and di.ease progressi.n. The emergence of i.munogeneti. phenotypes lends support to the proposed hypothesi. that suscepti.i.i.y genes regulate di.ti.ct i.mune processes, dri.en by lumi.al anti.ens, expressed as speci.i. i.mune phenotypes whi.h i. turn i.fluence cli.i.al phenotypes i. i.D pati.nt.

关键词： i.flammatory bowel di.ease i.munereacti.i.y Di.ease phenotype

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Predi.tors of the placebo response i. a nutraceuti.al randomi.ed controlled tri.l for depressi.n

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Journal of i.tegrati.e Medi.i.e 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jeni.er Murphy-Smi.h Chee H.Ng Davi. Mi.choulon Gerard J.Byrne Chad A.Bousman Con Stough Mi.hael Berk jerome Sarri. Professori.l Uni. the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depressi.n Cli.i.al and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medi.i.e Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medi.al Geneti.s PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychi.try the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The i.sti.ute for Mental and Physi.al Health and Cli.i.al Translati.n School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence i. Youth Mental Health the University of MelbourneParkville 3052Australia Florey i.sti.ute of Neurosci.nce and Mental Health the University of MelbourneParkville 3052Australia Ni.M Health Research i.sti.ute Western Sydney UniversityWestmeadNSW 2145Australia

Objecti.e The placebo response i. depressi.n studi.s i. the change i. symptoms amongst those who recei.e an i.acti.e *** well-desi.ned randomi.ed controlled tri.ls(RCTs)of depressi.n have a hi.h proporti.n of placebo responders,wi.h li.tle understandi.g as to *** present study assesses characteri.ti.s associ.ted wi.h the placebo response i. a nutraceuti.al tri.l wi.h a large proporti.n of placebo *** Thi. i. a secondary analysi. of a nutraceuti.al depressi.n RCT whi.h i.enti.i.d no overall treatment benefi. relati.e to placebo(n=69 i. placebo group).We i.vesti.ated parti.i.ant characteri.ti.s such as soci.-demographi.s,cli.i.al features,and recrui.ment methods,and thei. associ.ti.n wi.h the placebo *** geneti. polymorphi.ms were also *** response was measured based on change i. Montgomery-Asberg Depressi.n Rati.g Scale *** associ.ti.n of these hypothesi.-dri.en vari.bles of i.terest and the placebo response was exami.ed usi.g li.ear mi.ed effects *** Greater levels of educati.n,parti.ularly pursui.g post-hi.h school educati.n,better self-reported general health,marri.ge/de facto,greater i.provement i. the fi.st tri.l week,and more fai.ed anti.epressant therapi.s i. the current depressi.e epi.ode were associ.ted wi.h greater placebo *** i.creased placebo response was not found i. those recrui.ed vi. soci.l medi. nor i. those wi.h concomi.ant anti.epressant *** nucleoti.e polymorphi.ms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associ.ted wi.h greater placebo response,although the evi.ence was attenuated after accounti.g for multi.le *** Thi. i.,to our knowledge,the fi.st study wi.hi. nutraceuti.al research for depressi.n to assess the associ.ti.n between parti.i.ant characteri.ti.s and vari.ti.n i. the placebo *** vari.bles appeared to predi.t the placebo *** fi.di.gs may encourage future tri.l desi.n

关键词： Randomi.ed controlled tri.l Placebo Depressi.n Nutraceuti.al Psychi.try

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Magneti. hydroxyapati.e nanobelt-stem cell hybri. spheroi.s for remotely patterni.g bone ti.sues

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BMEMat(Bi.Medi.al Engi.eeri.g Materi.ls) 2024年第1期2卷 146-159页

作者： Mi. Hao Wenhan Wang Ani. Kumar Wan Hai.ul Anuar Kamaruddi. Syafi.ah Sai.i. Ni. Ahmad Ni.am Ni. Malek jerome Claveri. Hong Li. State Key Laboratory of Crystal Materi.ls Shandong UniversityJinanChina The Wallace H.Coulter Department of Bi.medi.al Engi.eeri.g Georgia Institute of TechnologyAtlantaGeorgiaUSA Department of Chemi.try University of GeorgiaAthensGeorgiaUSA Uni.ersi.i.Teknologi.Malaysi. Johor BahruJohorMalaysia Department of Chemi.try Universitéde SherbrookeSherbrookeQuebecCanada

The low survi.al rate and poor di.ferenti.ti.n effi.i.ncy of stem cells,as well as the i.suffi.i.nt i.tegrati.n of i.planted stem cells,li.i. the regenerati.n of bone ***,we have developed magneti. ferroferri. oxi.ehydroxyapati.epolydopami.e(Fe3O4-HAp-PDA)nanobelts to assemble mesenchymal stem cells(MSCs)i.to a three-di.ensi.nal hybri. spheroi. for patterni.g bone *** nanobelts,whi.h are featured by thei. hi.haspect rati. and contai. Fe3O4 nanospheres wi.h a PDA coati.g,can be mani.ulated by a magneti. fi.ld and foster enhanced cell-nanobelt *** strategy has been demonstrated to be effecti.e for both bone marrow mesenchymal stem cells and adi.ose-deri.ed mesenchymal stem cells,enabli.g remote mani.ulati.n of stem cell spheroi.s and effi.i.nt spheroi. fusi.n,whi.h i. turn accelerates osteogeni. ***,thi. methodology serves as an effi.i.nt and general tool for bone ti.sue pri.ti.g and can potenti.lly overcome the low survi.al rate and poor di.ferenti.ti.n effi.i.ncy of stem cells,as well as mi.matched i.terface fusi.n i.sues.

关键词： hybri. spheroi. hydroxyapati.e nanobelt mesenchymal stem cells osteogenesi. di.ferenti.ti.n ti.sue pri.ti.g

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来到牛津

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疯狂英语（新悦读） 2024年第5期 40-42,75页

作者： jerome K.jerome 不详

We left Streatley early the next morn⁃*** were goi.g to Culham,and we wanted to spend the ni.ht *** Streatley and Walli.gford the ri.er i. not very *** from Cleeve,there i. qui.e a long pi.ce of the ri.er whi.h has no *** people are pleased about thi. because i. makes everythi.g much easi.r,but i.qui.e li.e locks,myself.i.remember that George and i.nearly had an acci.ent i. a lock once...

关键词： qui.e has remember

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Plei.tropi. attenuati.g effect of Gi.kgo bi.oba agai.st i.oprenali.ei.duced myocardi.l i.farcti.n vi. i.provi.g Bcl-2/mTOR/ERK1/2/Na^(+) , K^(+) -ATPase acti.i.i.s

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Chi.ese Herbal Medi.i.es 2024年第2期16卷 282-292页

作者： jerome Ndudi.Asi.e Abodunri. Adebayo Ojetola Nwoke Enekabokom Ekene Esthi.sheen Osi.i. Anthony Chi.uzor Nnamudi.Benjami. Ori.semuelebi.Jackson Erozueme Onuelu Ni.holas Asi.e Harri.on Ogheneochuko Eruotor Savi.ur i.egbenehi Department of Physi.logy Delta State UniversityAbraka 1Nigeria Department of Physi.logy University of IbadanIbadan 3017Nigeria Department of Physi.logy Adeleke UniversityEde 250Nigeria Department of Pharmacology Rivers State UniversityNkpolu-Oroworukwo 5080Nigeria Department of Physi.logy Redeemer’s UniversityEde 230Nigeria Department of Bi.chemi.try PAMO University of Medical SciencesPort Harcourt 500211Nigeria Department of Pharmacology Delta State UniversityAbraka 1Nigeria Department of Anatomy University of Port HarcourtChoba 5323Nigeria Department of Medi.al Laboratory Sci.nces University of Port HarcourtChoba 5323Nigeria

Objecti.e:Myocardi.l i.farcti.n(Mi.i. li.ked to an i.balance i. the supply and demand of blood oxygen i. the heart ***-blockers and calci.m antagoni.ts are just two of the common medi.ati.ns used to treat ***,these have reportedly been shown to be ei.her i.effecti.e or to have undesi.able si.e *** of Gi.kgo bi.oba leaves(GBE),a Chi.ese herbal product offers speci.l compati.i.i.y benefi.s i. therapeuti. setti.gs relati.g to i.flammatory di.eases and oxi.ati.e *** order to better understand how GBE affects Mi.i. rats i.sulted by i.oprenali.e(i.O),the current study was ***:The heart wei.ht i.dex,serum li.i. profi.e,cardi.c marker enzymes,endogenous anti.xi.ants[catalase(CAT),superoxi.e di.mutase(SOD),glutathi.ne(GSH),ni.ri.es and malondi.ldehyde(MDA)],i.flammatory medi.tors[tumour necrosi. factor alpha(TNF-a)and i.terleuki.-6(i.-6)],i.munohi.tochemi.al expressi.ns of B-cell lymphoma factor-2(Bcl-2),extracellular si.nal-regulated ki.ase(ERK1/2),and mammali.n target of rapamyci.(mTOR)and hi.topathologi.al analysi. were used to assess the cardi.protecti.e properti.s of ***:The fi.di.gs showed that GBE effecti.ely attenuated myocardi.l i.farcti.n by boosti.g the body’s natural anti.xi.ant defense system and reduci.g the release of i.flammatory cytoki.es as well as heart i.jury marker *** expressi.n of Bcl-2,ERK1/2 and mTOR was i.creased whi.e the hi.tomorphologi.al alterati.ns were ***:The cardi.protecti.e effects of GBE may be due to a mechani.m i.volvi.g i.creased Bcl-2/mTOR/ERK1/2/Na^(+),K^(+)-ATPase acti.i.y.

关键词： anti.xi.ants extracellular si.nal-regulated ki.ase Gi.kgo bi.oba extract i.oprenali.e mammali.n target of rapamyci. myocardi.l i.farcti.n Na^(+),K^(+)-ATPase

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