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Asian Journal of Pharmaceutical Sciences 2016年第4期11卷 547-558页

作者： Elisabeth Peeters Ana Filipa Tavares da Silva Maunu Toiviainen jeroen van renterghem Jurgen Vercruysse Mikko Juuti Joao Almeida Lopes Thomas De Beer Chris Vervaet Jean-Paul Remon Laboratory of Pharmaceutical Technology Ghent UniversityOttergemsesteenweg 4609000GhentBelgium Laboratory of Pharmaceutical Process Analytical Technology Ghent UniversityOttergemsesteenweg 4609000GhentBelgium REQUIMTE Department of Chemical SciencesUniversity of PortoRua de Jorge Viterbo Ferreira2284050-313PortoPortugal VTT Technical Research Centre of Finland Optical Measurement TechnologiesKaitoväylä190570 OuluFinland

This study investigated whether Raman and Near Infrared(NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares(PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn’t be established. Principal component analysis(PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression(MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.

关键词： Continuous production PAT Granulation Tableting NIR Raman

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面向城市交通噪声控制的树种筛选与种植策略

应用声学 2024年第4期43卷 843-853页

作者：李朦朦 Timothy van renterghem 孟琪 Dick Botteldooren 康健哈尔滨工业大学建筑与设计学院寒地城乡人居环境科学与技术工业和信息化部重点实验室哈尔滨150001 比利时根特大学工程与建筑学院信息技术系Waves研究组根特9052 英国伦敦大学学院环境设计与工程学院伦敦WC1H 0NN

植物降噪是一种减碳且低成本的降噪方式,可有效改善城市声环境。然而现存植物降噪影响因素与预测模型主要集中在植物群落层面,忽略了树种间差异在不同频率噪声控制过程中的重要作用,难以满足城市交通噪声有效防控的需求。基于此,该研究... 详细信息

植物降噪是一种减碳且低成本的降噪方式,可有效改善城市声环境。然而现存植物降噪影响因素与预测模型主要集中在植物群落层面,忽略了树种间差异在不同频率噪声控制过程中的重要作用,难以满足城市交通噪声有效防控的需求。基于此,该研究以植物树干为切入点,提出一种量化树干与树皮粗糙度的方法,针对交通噪声频谱特征系统测量13种树种的吸收作用,并模拟降噪效果。研究首先测得树干吸声系数的频谱特征,确定了树干主要吸声频率范围与交通噪声频率分布具备较好的一致性;其次,从树种视角分析视觉因素与测试获取因素两个层面对树干吸声效果有影响的主要因素;最后,通过模拟对比分析15 m宽植物带种植不同树种的降噪效果,发现相差∼0.9 dBA,证明了种植吸声系数高的树种对交通噪声控制的有效性。以期从树形、树干吸声效果、树种生长速度以及种植方式等方面,提出应对城市交通噪声污染的树种筛选依据与设计策略。

关键词：噪声控制交通噪声吸声系数自然降噪途径

Solving PDEs with a Hybrid Radial Basis Function:Power-Generalized Multiquadric Kernel

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Advances in Applied Mathematics and Mechanics 2022年第5期14卷 1161-1180页

作者： Cem Berk Senel jeroen van Beeck Atakan Altinkaynak von Karman Institute for Fluid Dynamics Belgium Istanbul Technical University Mechanical Engineering DepartmentIstanbulTurkey

Radial Basis Function(RBF)kernels are key functional forms for advanced solutions of higher-order partial differential equations(PDEs).In the present study,a hybrid kernel was developed for meshless solutions of PDEs widely seen in several engineering *** kernel,Power-Generalized Multiquadric-Power-GMQ,was built up by vanishing the dependence of e,which is significant since its selection induces severe problems regarding numerical instabilities and convergence *** drawback of e-dependency is that the optimal e value does not exist in *** present the Power-GMQ kernel which combines the advantages of Radial Power and Generalized Multiquadric RBFs in a generic ***-GMQ RBF was tested in higher-order PDEs with particular boundary conditions and different ***-Finite Difference(RBF-FD)discretization was also implemented to investigate the characteristics of the proposed *** results revealed that our proposed kernel makes similar or better estimations as against to the Gaussian and Multiquadric kernels with a mild increase in computational ***-QR method may achieve better accuracy in some cases with considerably higher computational *** using Power-GMQ RBF,the dependency of solution on e was also substantially relaxed and consistent error behavior were obtained regardless of the selected e accompanied.

关键词： Meshfree collocation methods Radial Basis Function(RBF) partial differential equations(PDEs)

An OT Analysis of Nasal-obstruent Clusters in English

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外国语 2013年第6期36卷 2-17页

作者： ZHENG Jizheng jeroen van de Weijer Shanghai Customs College Shanghai 201204 Shanghai International Studies University Shanghai 200083 China

This paper argues in favor of an Optimality Theory(OT)constraint hierarchy governing the phonotactics of nasal+obstruent clusters in *** paper shows that in careful speech English has a strong tendency favoring voiceless obstruents after nasals both in medial and coda positions,and retains a contrast between voiced and voiceless obstruents,as supported by statistical *** the paper proposes that,in English,the Optimality constraint IDENT-IO(ObsVce)dominates**** also show that in English voiced coronal stops are retained post-nasally,whereas voiced peripheral(labial and velar)stops are deleted(or,rather,not permitted).To explain this phenomenon,the paper proposes that the markedness constraint VOICED-CODA ranks between MAX-COR and MAX-PER,and the constraints IDENT-IO(ObsVce)and*VOICED-CODA work in tandem to result in the deletion of peripheral voiced *** shows that the same constraint hierarchy also applies to nasal+non-stop obstruent clusters,*** with fricatives and affricates,both medially and in final ***,It is pointed out that as language is changing,this is reflected in a changing constraint hierarchy as ****VOICEDCODA and*NO become higher ranked,this would cause either devoicing or deletion of voiced obstruents in the coda,or it would cause obstruents after nasals to become *** processes are found in faster,informal speech styles and may reflect change in progress.

关键词：英语学习阅读知识学习方法阅读材料

A great thermal divergence in the mantle beginning 2.5 Ga:Geochemical constraints from greenstone basalts and komatiites

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Geoscience Frontiers 2016年第4期7卷 543-553页

作者： Kent C.Condie Richard C.Aster jeroen van Hunen Department of Earth and Environmental Science New Mexico Tech Geosciences Department Colorado State University Department of Earth Sciences University of Durham

Greenstone basalts and komatiites provide a means to track both mantle composition and magma generation temperature with time. Four types of mantle are characterized from incompatible element distributions in basalts and komatiites： depleted, hydrated, enriched and mantle from which komatiites are derived. Our most important observation is the recognition for the first time of what we refer to as a Great Thermal Divergence within the mantle beginning near the end of the Archean, which we ascribe to thermal and convective evolution. Prior to 2.5 Ga, depleted and enriched mantle have indistinguishable thermal histories, whereas at 2.5-2.0 Ga a divergence in mantle magma generation temperature begins between these two types of mantle. Major and incompatible element distributions and calculated magma generation temperatures suggest that Archean enriched mantle did not come from mantle plumes, but was part of an undifferentiated or well-mixed mantle similar in composition to calculated primitive mantle. During this time, however, high-temperature mantle plumes from dominantly depleted sources gave rise to komatiites and associated basalts. Recycling of oceanic crust into the deep mantle after the Archean may have contributed to enrichment ofTi, A1, Ca and Na in basalts derived from enriched mantle sources. After 2.5 Ga, increases in Mg# in basalts from depleted mantle and decreases in Fe and Mn reflect some combination of growing depletion and cooling of depleted mantle with time. A delay in cooling of depleted mantle until after the Archean probably reflects a combination of greater radiogenic heat sources in the Archean mantle and the propagation of plate tectonics after 3 Ga.

关键词： Archean greenstones Mantle thermal evolution Basalts Mantle geochemistry Komatiites

Scalable fabrication,compartmentalization and applications of living microtissues

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Bioactive Materials 2023年第1期19卷 392-405页

作者： Maik Schot Nuno Araújo-Gomes Bas van Loo Tom Kamperman jeroen Leijten Department of Developmental Bioengineering Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522NBEnschedethe Netherlands

Living microtissues are used in a multitude of applications as they more closely resemble native tissue physiology,as compared to 2D *** are typically composed of a combination of cells and materials in varying combinations,which are dictated by the applications’design *** applications range wide,from fundamental biological research such as differentiation studies to industrial applications such as cruelty-free meat ***,their translation to industrial and clinical settings has been hindered due to the lack of scalability of microtissue production *** microfluidic processes provide an opportunity to overcome this limitation as they offer higher throughput production rates as compared to traditional batch techniques,while maintaining reproducible control over microtissue composition and *** this review,we provide a comprehensive overview of the current approaches to engineer microtissues with a focus on the advantages of,and need for,the use of continuous processes to produce microtissues in large ***,an outlook is provided that outlines the required developments to enable large-scale microtissue fabrication using continuous processes.

关键词： Tissue engineering Micromaterials Microfluidics Upscaling Clinical translation Industrial translation

Changes of the glutathione redox system during the weaning transition in piglets, in relation to small intestinal morphology and barrier function

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Journal of Animal Science and Biotechnology 2020年第4期11卷 993-1008页

作者： jeroen Degroote Hans Vergauwen Wei Wang Chris van Ginneken Stefaan De Smet Joris Michiels Laboratory for Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal Sciences and Aquatic EcologyFaculty of Bioscience EngineeringGhent UniversityBlock FCampus CoupureCoupure Links 6539000 GhentBelgium Laboratory of Applied Veterinary Morphology Department of Veterinary SciencesFaculty of BiomedicalPharmaceutical and Veterinary SciencesUniversity of AntwerpUniversiteitsplein 1WilrijkBelgium.

Background: Weaning is known to result in barrier dysfunction and villus atrophy in the immediate post-weaning phase, and the magnitude of these responses is hypothesized to correlate with changes in the glutathione(GSH)redox system. Therefore, these parameters were simultaneously measured throughout the weaning phase, in piglets differing in birth weight category and weaning age, as these pre-weaning factors are important determinants for the weaning transition. Low birth weight(LBW) and normal birth weight(NBW) littermates were assigned to one of three weaning treatments;i.e. weaning at 3 weeks of age(3 w), weaning at 4 weeks of age(4 w) and removal from the sow at 3 d of age and fed a milk replacer until weaning at 3 weeks of age(3 d3 w). For each of these treatments, six LBW and six NBW piglets were euthanized at 0, 2, 5, 12 or 28 d post-weaning piglets, adding up 180 ***: Weaning increased the glutathione peroxidase activity on d 5 post-weaning in plasma, and duodenal and jejunal mucosa. Small intestinal glutathione-S-transferase activity gradually increased until d 12 post-weaning, and this was combined with a progressive rise of mucosal GSH up till d 12 post-weaning. Oxidation of the GSH redox status(GSH/GSSG Eh) was only observed in the small intestinal mucosa of 3 d3 w weaned piglets at d 5 postweaning. These piglets also demonstrated increased fluorescein isothiocyanate dextran(FD4) and horseradish peroxidase fluxes in the duodenum and distal jejunum during the experiment, and specifically demonstrated increased FD4 fluxes at d 2 to d 5 post-weaning. On the other hand, profound villus atrophy was observed during the weaning transition for all weaning treatments. Finally, LBW and NBW piglets did not demonstrate notable differences in GSH redox status, small intestinal barrier function and histo-morphology throughout the ***: Although moderate changes in the GSH redox system were observed upon weaning, the GSH redox status remai

关键词： Barrier function Glutathione Oxidative stress Redox status Small intestine Weaned piglet

A physically active lifestyle is related to a lower level of skin autofluorescence in a large population with chronic-disease(LifeLines cohort)

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Journal of Sport and Health Science 2022年第2期11卷 260-265页

作者： Saskia Corine van de Zande jeroen Klaas de Vries Inge van den Akker-Scheek Johannes Zwerver Andries Jan Smit Department of Internal Medicine Division of Vascular MedicineUniversity of GroningenUniversity Medical Center GroningenGroningen9700 RBthe Netherlands Department of Internal Medicine Antonius Hospital SneekSneek8601 ZKthe Netherlands Department of Orthopaedics University of GroningenUniversity Medical Center GroningenGroningen9700 RBthe Netherlands Center for Human Movement Sciences University of GroningenUniversity Medical Center GroningenGroningen9700 RBthe Netherlands Sports Valley Gelderse Vallei HospitalEde6716 RPthe Netherlands

Background:Physical activity(PA)has substantial health benefits and is important in combatting chronic diseases,which have been associated with elevated levels of advanced glycation endproducts(AGEs).AGEs play a role in the aging process,and an association between PA and AGEs has been *** aimed to investigate the relationship between PA and AGE accumulation in a general population and in a population with chronic ***:This large cross-sectional population study used data from adult participants in the LifeLines project,with participant information drawn from the LifeLines database as well data from patients with diabetes mellitus or renal and/or cardiovascular *** AGE accumulation was assessed non-invasively by skin-autofluorescence(SAF)using an AGE reader(DiagnOptics Technologies BV,Groningen,the Netherlands).PA was assessed using the short questionnaire to assess health-enhancing physical activity(SQUASH).Multivariate linear regression analyses were adjusted for age,body mass index,sex,and smoking ***:Data from 63,452 participants(general population n=59,177,chronic disease n=4275)were *** general population was significantly younger(43.58±11.77 years,mean±SD)and had significantly lower SAF(1.90±0.42 arbitrary units(AU))compared to the population with chronic disease(age:55.51±12.07 years;SAF:2.27±0.51 AU).In the group with chronic disease,more hours of moderate to vigorous physical activities per week were associated with lower SAF(β=-0.002,95%confidence interval(95%CI):-0.002 to-0.001).For the general population,there was no association between hours of moderate to vigorous activity and SAF(β=3.2×10^(-5),95%CI:0.000-0.001,p=0.742).However,there was an association in the general population between total hours of PA per week and SAF(β=4.2×10^(-4),95%CI:0.000-0.001,p<0.001),but this association was not found in the chronic disease population(β=-3.2×10^(-4),95%CI:-0.001 to 0.000,p=0.347).Conclusion:Our study demons

关键词： Advanced glycation endproducts Chronic disease population General population Physical activity Skin autofluorescence

Comprehensive scan for nonmagnetic Weyl semimetals with nonlinear optical response

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npj Computational Materials 2020年第1期6卷 1398-1404页

作者： Qiunan Xu Yang Zhang Klaus Koepernik Wujun Shi jeroen van den Brink Claudia Felser Yan Sun Max Planck Institute for Chemical Physics of Solids 01187 DresdenGermany Leibniz Institute for Solid State and Materials Research 01069 DresdenGermany School of Physical Science and Technology ShanghaiTech UniversityShanghai 200031China Center for Nanoscale Systems Faculty of Arts and SciencesHarvard University11 Oxford StreetLISE 308CambridgeMA 02138USA

First-principles calculations have recently been used to develop comprehensive databases of nonmagnetic topological materials that are protected by time-reversal or crystalline ***,owing to the low symmetry requirement of Weyl points,a symmetry-based approach to identifying topological states cannot be applied to Weyl semimetals(WSMs).To date,WSMs with Weyl points in arbitrary positions are absent from the well-known databases.

关键词： symmetry topological metals

Data-driven placemaking: Public space canopy design through multi-objective optimisation considering shading, structural and social performance

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Frontiers of Architectural Research 2022年第2期11卷 308-323页

作者： jeroen van Ameijde Chun Yu Ma Garvin Goepel Clive Kirsten Jeff Wong School of Architecture The Chinese University of Hong KongHong KongChina Lightweight Works Hong KongChina APS Research Ltd. Hong KongChina

In the context of ongoing densification of cities and aging urban populations,public spaces are a crucial infrastructure to support the physical and mental wellbeing of urban *** design of public space furniture elements is often standardised,and not considered in relation to environmental conditions and mechanisms of social *** article presents a digital workflow to generate site-specific designs for shaded public seating,considering the relationships of local public places to their surroundings.A strategy for customised and site-specific design is developed through the use of multiple software tools,employing evolutionary algorithms and multi-objective *** method is applied to a small public space canopy prototype installed within a public housing estate in Hong Kong,incorporating additional criteria to achieve a low-cost and light-weight *** multiple stages of refinement and optimisation,a material,structural and social performance-driven outcome was achieved that creates a shaded space for public seating,people watching and social *** part of a larger research agenda exploring architectural form-finding and environmental psychology,the project represents potential new applications in the emerging field of socially driven computational design.

关键词： Public space Tensile membrane structures Structural design Environmental performance Multi-objective optimisation Evolutionary algorithms