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Diagnostic accuracy of the tongue blade test combined with clinical signs to detect maxillary and mandibular fractures in the emergency department

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World Journal of Emergency Medicine 2023年第2期14卷 122-127页

作者： Jee Yen Kuck Abdul Muhaimin Noor Azhar Neena wee Rishya Manikam Emergency Department University of MalayaKuala Lumpur 50603Malaysia

BACKGROUND: To evaluate the diagnostic accuracy of clinical signs combined with the tongue blade test(TBT) to detect maxillary and mandibular ***: A cross-sectional study enrolled patients with maxillary and mandibular injuries in the emergency department. Physical examination and the TBT were performed, followed by radiological imaging(facial X-ray or computed tomography [CT]). The diagnostic accuracy was calculated for individuals and a combination of clinical findings at predicting maxillary and mandibular ***: A total of 98 patients were identified, of whom 31.6% had maxillary fractures and9.2% had mandibular fractures. The combination of malocclusion, tenderness on palpation and swelling with positive TBT had 100% specificity to detect maxillary and mandibular fractures. In the absence of malocclusion, the combination of tenderness on palpation and swelling with positive TBT produced a specificity of 97.8% for maxillary fracture and a specificity of 96.2% for mandibular fracture. A clinical decision tool consisting of malocclusion, tenderness on palpation, swelling and TBT revealed a specificity of 100% and a positive predictive value of 100%.CONCLUSION: The clinical decision tool is potentially useful to rule out mandibular fractures,thus preventing unnecessary radiation exposure.

关键词： Maxillary fractures Mandibular fractures Tongue blade test Diagnostic accuracy Clinical decision tool Emergency department

Nasopharyngeal carcinoma treatment paradigm after HK0501–a potential way forward

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Cancer Communications 2022年第9期42卷 801-803页

作者： Sharon S Poh Joseph TS wee Department of Radiation Oncology National Cancer Centre SingaporeSingapore 169610Singapore Oncology Academic Clinical Program Duke-NUS Medical SchoolSingapore 169857Singapore

The Hong Kong Nasopharyngeal Carcinoma(NPC)Study Group 0501 trial(HK0501)is the first trial that directly compares induction(IC)versus adjuvant chemotherapy(AC)both given together with concurrent chemoradiation(CCRT)treatment,which long has been a contentious issue[1].Its most salient finding is that when adjusted for platinum doses and other significant factors,the timing of the chemotherapy sequence is not *** the era where chemotherapy is administered at maximum tolerated doses(MTD),the induction strategy has the advantage because of better *** the other hand,with the realization that there may be more ways to skin a cat,adjuvant metronomic chemotherapy has gained traction at the 2021 American Society of Clinical Oncology(ASCO)meeting[2]and provides an alternative to the decades’old dogma of *** chemotherapy works by exerting an anti-angiogenic effect[3-6]and also has immune effects like removing regulatory T cells(Tregs)[7]and myeloid-derived suppressor cells(MDSCs)from the tumour microenvironment[8]and causing dendritic cell maturation,which upregulates and primes the anti-tumor T cell immune response[9,10].Pediatricians are probably the first to successfully incorporate 2 years of maintenance metronomic chemotherapy in their childhood acute lymphoblastic leukaemia protocols[11]which now boast cure rates of over 90%[12].

关键词： doses Nasopharyngeal Carcinoma

Solar-powered chemistry: Engineering low-dimensional carbon nitride-based nanostructures for selective CO_(2) conversion to C_(1)- C_(2) products

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InfoMat 2022年第1期4卷 40-104页

作者： Sue-Faye Ng Joel Jie Foo wee-Jun Ong School of Energy and Chemical Engineering Xiamen University MalaysiaSepangSelangorMalaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSepangSelangorMalaysia College of Chemistry and Chemical Engineering Xiamen UniversityXiamenChina

CO_(2)capture and conversion has been prospected as an auspicious technology to simultaneously tackle the rise in global CO_(2)emission and produce valueadded fuels with the goal of accomplishing carbon neutrality.A sustainable route to achieve this is via the utilization of solar energy,thereby harnessing the abundant and nonexhaustive resource to shift our reliance away from rapidly depleting fossil *** carbon nitride(g-C_(3)N_(4))and its allotrope have earned its rank as a fascinating metal-free photocatalyst due to its superior stability,high surface-area-to-volume ratio,and tunable surface *** leveraging these properties,robust carbon nitride-based nanostructures are engineered for photocatalytic CO_(2)conversion to energy-rich C_(1)-C_(2) product,which is indispensable in the chemical ***,this review presents the latest panorama of experimental and computational research on tuning the local electronic,surface chemical coordination environment,charge dynamics and optical properties of low-dimensional carbon nitride and its allotropes toward highly selective and efficient CO_(2)*** name a few,structural engineering,point-defect engineering,heterojunction construction,and cocatalyst *** advance this frontier,critical insights are elucidated to establish the structure-performance relationship and unravel primary factors dictating the selectivity of C_(1)-C_(2) molecules from CO_(2)***-field assisted photocatalysis such as with electric(photoelectro-)and heat(photothermal)is discussed to uncover the synergistic contributions that drive the development in ***,future challenges and prospects are outlined for the potential application of solar-driven CO_(2)conversion,along with the scale-up strategy from the economic viewpoint toward the rational development of high-efficiency carbon nitride catalysts.

关键词： carbon nitride CO_(2)reduction external fields interfacial design nanostructure photocatalysis

Novel Apodized Fiber Bragg GratingApplied for Medical Sensors:Performance Investigation

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Computer Modeling in Engineering & Sciences 2023年第4期135卷 301-323页

作者： Ramya Arumugam Ramamoorthy Kumar Samiappan Dhanalakshmi Khin wee Lai Lei Jiao Xiang Wu Department of Electronics and Communication Engineering College of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathurChengalpattu603203India Department of Biomedical Engineering Faculty of EngineeringUniversiti MalayaKuala Lumpur50603Malaysia General Hospital of Xuzhou Mining Group Xuzhou221000China School of Medical Information&Engineering Xuzhou Medical UniversityXuzhou221000China

Sensors play an important role in shaping and monitoring human *** of methods to use Fiber Bragg Grating(FBG)with enhanced sensitivity has attracted great interest in the field of medical *** this paper,a novel apodization function is proposed and performance evaluation and optimization of the same have been made.A comparison was conducted between various existing apodization functions and the proposed one based on optical characteristics and sensor *** results evince the implementation of the proposed apodization function for vital sign *** optical characteristics considered for evaluation are Peak Resonance Reflectivity level,Side Lobes Reflectivity level and FullWidth HalfMaximum(FWHM).The proposed novel apodization novel function has better FWHM,which is narrower than the FWHM of uniform *** characteristics like a quality parameter,detection accuracy and sensitivity also show *** proposed novel apodization function is demonstrated to have a better shift in wavelength in terms of temperature and pulse measurement than the existing *** sensitivity of the proposed apodized function is enhanced with a Poly-dimethylsiloxane coating of varying thickness,which is 6 times and 5.14 times greater than uniform Fiber Bragg grating and FBG with the proposed novel apodization function,respectively,enhancing its utilization in the field of medicine.

关键词： Fiber bragg grating apodization optical sensing temperature strain sensitivity

Point-to-face contact heterojunctions:Interfacial design of 0D nanomaterials on 2D g-C_(3)N_(4)towards photocatalytic energy applications

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Carbon Energy 2022年第5期4卷 665-730页

作者： Xin-Quan Tan Sue-Faye Ng Abdul Rahman Mohamed wee-Jun Ong School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul EhsanMalaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSelangor Darul EhsanMalaysia Low Carbon Economy(LCE)Research Group School of Chemical EngineeringUniversiti Sains MalaysiaNibong TebalPulau PinangMalaysia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujianChina Shenzhen Research Institute of Xiamen University ShenzhenGuangdongChina

Green energy generation is an indispensable task to concurrently resolve fossil fuel depletion and environmental issues to align with the global goals of achieving carbon ***,a process that transforms solar energy into clean fuels through a photocatalyst,represents a felicitous direction toward ***-rich metal-free graphitic carbon nitride(g-C_(3)N_(4))is profiled as an attractive photocatalyst due to its fascinating properties,including excellent chemical and thermal stability,moderate band gap,visible light-active nature,and ease of ***,the shortcomings of g-C_(3)N_(4)include fast charge recombination and limited surface-active sites,which adversely affect photocatalytic *** the modification strategies,point-to-face contact engineering of 2D g-C_(3)N_(4)with 0D nanomaterials represents an innovative and promising synergy owing to several intriguing attributes such as the high specific surface area,short effective charge-transfer pathways,and quantum confinement *** review introduces recent advances achieved in experimental and computational studies on the interfacial design of 0D nanostructures on 2D g-C_(3)N_(4)in the construction of point-to-face heterojunction ***,0D materials such as metals,metal oxides,metal sulfides,metal selenides,metal phosphides,and nonmetals on g-C_(3)N_(4)with different charge-transfer mechanisms are systematically discussed along with controllable synthesis *** applications of 0D/2D g-C_(3)N_(4)-based photocatalysts are focused on solar-to-energy conversion via the hydrogen evolution reaction,the CO_(2)reduction reaction,and the N2 reduction reaction to evaluate the photocatalyst activity and elucidate reaction ***,future perspectives for developing high-efficiency 0D/2D photocatalysts are proposed to explore potential emerging carbon nitride allotropes,large-scale production,machine learning integration,and multidiscipli

关键词： 0D/2D heterojunction charge-transfer mechanisms g-C_(3)N_(4)nanosheets heterojunction interface photocatalysis solar-to-energy conversion

Evaluating the accuracy and reproducibility of ChatGPT-4 in answering patient questions related to small intestinal bacterial overgrowth

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Artificial Intelligence in Gastroenterology 2024年第1期5卷 14-21页

作者： Lauren Schlussel Jamil S Samaan Yin Chan Bianca Chang Yee Hui Yeo wee Han Ng Ali Rezaie Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCA 90048United States Bristol Medical School University of BristolBS81THBristolUnited Kingdom Medically Associated Science and Technology Program Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Small intestinal bacterial overgrowth(SIBO)poses diagnostic and treatment challenges due to its complex management and evolving *** often seek online information related to their health,prompting interest in large language models,like GPT-4,as potential sources of patient *** To investigate ChatGPT-4's accuracy and reproducibility in responding to patient questions related to *** A total of 27 patient questions related to SIBO were curated from professional societies,Facebook groups,and Reddit *** question was entered into GPT-4 twice on separate days to examine reproducibility of accuracy on separate ***-4 generated responses were independently evaluated for accuracy and reproducibility by two motility fellowship-trained gastroenterologists.A third senior fellowship-trained gastroenterologist resolved *** of responses were graded using the scale:(1)Comprehensive;(2)Correct but inadequate;(3)Some correct and some incorrect;or(4)Completely *** responses were generated for every question to evaluate reproducibility in *** In evaluating GPT-4's effectiveness at answering SIBO-related questions,it provided responses with correct information to 18/27(66.7%)of questions,with 16/27(59.3%)of responses graded as comprehensive and 2/27(7.4%)responses graded as correct but *** model provided responses with incorrect information to 9/27(33.3%)of questions,with 4/27(14.8%)of responses graded as completely incorrect and 5/27(18.5%)of responses graded as mixed correct and incorrect *** varied by question category,with questions related to“basic knowledge”achieving the highest proportion of comprehensive responses(90%)and no incorrect *** the other hand,the“treatment”related questions yielded the lowest proportion of comprehensive responses(33.3%)and highest percent of completely incorrect responses(33.3%).A total of 77.8%of questions yielded repr

关键词： Small intestinal bacterial overgrowth Motility Artificial intelligence Chat-GPT Large language models Patient education

Temperature-induced Evolution of Micro-structure and Chain Dynamics in Thermoplastic Polyurethane with Low Hard Segment Content as Studied by In Situ Synchrotron SAXS and Time-Domain NMR Experiments

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Chinese Journal of Polymer Science 2023年第12期41卷 1902-1911,I0008页

作者： Hong-Ru Wang Victor Litvinov Wei Yu Kar wee Eddie Peh Qian-Li Yu Yong-Feng Men State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China BASF Polyurethane Specialties(China)Co.Ltd. Shanghai 200137China V.Lit.Consult Gozewijnstraat 46191 WV Beekthe Netherlands

The microstructural evolution of a thermoplastic polyurethane(TPU)with low hard segment content has been monitored utilizing in situ real-time synchrotron small angle X-ray scattering(SAXS)and time-domain nuclear magnetic resonance(NMR)*** TPU is composed of 23 wt% of[4,4-methylenediphenyl diisocyanate(MDI)]-[1,4-butanediol(BD)]chain segments,which form hard domains,as[polytetrahydrofuran(PTHF)]forming soft *** number and distribution of monomer units in hard blocks is determined by the successive self-nucleation and annealing thermal fractionation *** situ SAXS method reveals heating-induced increase in the spacing of hard and soft domains,while time-domain ^(1)H-NMR characterizes the changes in the phase composition and chain dynamics in these domains.A glassy fraction of short MDI-BD chain segments in hard domains passes through T_(g) above ambient *** higher temperatures,MDI-BD nanocrystals start to *** length distribution of MDI-BD chain segments causes a distribution in crystal sizes and wide melting temperature *** melting is accompanied by the mixing of MDI-BD with PTHF segments in soft domains,and by increase in segmental mobility in these *** 180℃,the TPU melt is homogeneous on the scale above nanometers according to SAXS data.

关键词： Phase separation Thermoplastic polyurethane Melting behavior Time-domain NMR SAXS

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Soy, soil and beyond

Soil Ecology Letters 2023年第4期5卷 1-3页

作者： wee Kee Tan Jingling Zhu Jun Li Choon Nam Ong NUS Environmental Research Institute National University of Singapore5A Engineering Drive 1T-Lab#02-01Singapore 117411Singapore Department of Biomedical Engineering National University of Singapore7 Engineering Drive 1Singapore 117574Singapore Saw Swee Hock School of Public Health National University of Singapore12 Science Drive 2Singapore 117549Singapore

Summary Soy and its quest for future food ***,or soybean(Glycine max),is a leguminous plant that has played a significant role in various civilizations throughout human *** are native to East Asia and have been cultivated in China for thousands of *** a food source,soy has a wide range of uses,they include tofu,tempeh,soy milk,soy sauce,miso,soy-based meat alternatives,desserts and *** products serve as alternatives to animal-based proteins and dairy products for vegetarians,vegans,and individuals with dietary *** addition,soybean oil is one of the most widely consumed cooking oils *** is used for frying,baking,sautéing,and salad dressings due to its mild flavour and high smoke *** oil is also used as an ingredient in margarine,mayonnaise,and other food products.

关键词： soybean smoke soil

Health analytics in business research:a literature review

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Journal of Management Analytics 2023年第3期10卷 447-476页

作者： Quanchen Liu Mengli Yu Bingqing Xiong Zhao Cai Pengzhu Zhang Chee-wee Tan Antai College of Economics&Management Shanghai Jiao Tong UniversityShanghaiPeople’s Republic of China Department of Digitalization Copenhagen Business SchoolFrederiksbergDenmark School of Journalism and Communication Nankai UniversityTianjinPeople’s Republic of China Convergence Media Research Center Nankai UniversityTianjinPeople’s Republic of China Deakin Business School Deakin UniversityBurwoodVICAustralia fNottingham University Business School China University of Nottingham Ningbo ChinaNingboChina

Technological advances have enabled the collection of large quantities of valuable data for health-related ***,a growing number of scholars are paying attention to the application of health analytics to business topics.A comprehensive analysis of health analytics application in business research is necessary to realize the commercial value of health *** this article,we summarize peer-reviewed articles that have been published in business journals,with an eye toward formulating a roadmap for applying health analytics across multiple business ***,we demonstrate how health-related data can be harnessed to inform business ***,we endeavor to consolidate the available datasets and analytical techniques commonly employed to explore health analytics in business ***,we discuss the practical challenges confronting scholars in health analytics,as well as future research *** from our study yields insights that can be leveraged by business scholars interested in health analytics research.

关键词： health analytics business topics literature review managerial challenges big data