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全景敞视主义是米歇尔·福柯发明的词汇。虽然杰里米·边沁并没有直接使用该词,但是实际上正是他在介绍塞缪尔·边沁设计的监视所方案时,第一次提出了这一理念。全景敞视主义适用于建筑物占用的空间不太大,又需要对一定数量的人进行监督的任何机构。它可以用来实现安全监护、禁闭、隔离、强制劳动、教育等目标。全景敞视建筑是圆形的,由隔间、中间区域、监视走廊、中心瞭望塔、中心区域等部分组成;并且在有顶的走廊的连接下,数栋建筑可以结合为一个整体。监督者的中心地位,以及"看,同时不被看"的处境,使得被监视者随时可能被监视,并相信自己此时可能正被监视。除此之外,杰里米·边沁还设计了一套全面的权力监督机制和公开机制,以防止监督者及其下属滥用权力。

关键词：杰里米·边沁全景敞视监狱监视所

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A Th2 phenotype of regulatory T cells that supports tissue protection

A Th2 phenotype of regulatory T cells that supports tissue p...

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第十二届全国免疫学学术大会

作者： Liu Quan Lott jeremy Zhao Yifei Li Huihua Mathews Lisa Zhu Qiang Delvin Jason Watkins Simon Greg Delgoffe Fan Ming-Hui Billiar Timothy Turnquist Heth University of Pittsburgh School of Medicine The 2nd Affiliated Hospital of Harbin Medical University Tsinghua University School of Medicine

Background:The capacities of cD4 Foxp3 regulatory T cells(T) in modulating organismal metabolism and maintaining tissue homeostasis have been recently *** of these T cells express ST2,receptor for the alarmin interleukin-33(IL-33).However,the immunobiological profile of ST2T cells is yet to be fully *** we report a Th2 phenotype of these cells that supports tissue ***:cells were analyzed by flow *** extracellular flux analysis was performed on FAcS-sorted T ***-13 in cell culture and whole lung lysates were tested by cytometric bead ***-sorted T cells were adoptively transfer into Rag2gamma(c) ***-sorted common lymphoid progenitors(cLP) were transplanted into irradiated Rag2gamma(c) *** damage was induced by bleomycin intratracheal ***:We found ST2cLP gave rise to both ST2 or ST2T *** adoptively transferring mouse ST2 or ST2Tcells,we demonstrated that mouse T cells dynamically gained and lost ST2 *** those from peripheral and lymphoid tissues were highly comparable in their expression of functional molecules,ST2 T cells were unique relative to their ST2counterparts in terms of metabolism and ***2 but not ST2" mouse T cells exhibited aerobic glycolysis and secreted IL-13 in response to TcR ***-33 also promoted human T proliferation and IL-13 *** mouse lung damage,IL-13 in I133 lungs was enormously lower than that in WT ***,I133 and I11 r11 mice were more susceptible to lung damage-associated lethality comparing with WT mice,which could be rescued by exogenous recombinant IL-33 or IL-13 in the presence of T cells,suggesting a critical tissue protection role of IL-33-ST2 ***:Taken together,our findings demonstrate a Th2 phenotype of ST2 T cells that is crucial to tissue protection and suggest potential therapeutic strategy for acute lung injury.

关键词： Treg IL-33 ST2 IL-13 tissue protection

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工作的未来

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作者： (美)赖安·库纳缇(Ryan coonerty) (美)杰里米·纽纳(jeremy Neuner)

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髂嵴综合症

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颈腰痛杂志 1984年第4期 40-40页

作者： jeremy c.T. ,吴力群青岛医学院

本文描述了7例称为髂峭综合症的局限性腰痛的病例。其中男性5人、女性2有,年龄最小20岁、最大54岁。发病时间一周到12月不等。6例为在某种动作时突发,1例为渐发。4例压痛点在左髂后上棘处,3例在右侧。经用麻醉剂(Bipuvicaine 0.5～10ml... 详细信息

本文描述了7例称为髂峭综合症的局限性腰痛的病例。其中男性5人、女性2有,年龄最小20岁、最大54岁。发病时间一周到12月不等。6例为在某种动作时突发,1例为渐发。4例压痛点在左髂后上棘处,3例在右侧。经用麻醉剂(Bipuvicaine 0.5～10ml)在压痛著处作局部浸润,除1例在一周后重复一次外,其余6例均注射一次而愈。随访1.5年至3年未再复发。4例在注射麻药时拍照X线照片,经与骨盆标本置针对照,发现痛点在髂嵴与臀后线相交处,相当

关键词：髂嵴骶棘肌压痛点

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RegcM3对东亚环流和中国气候模拟能力的检验

RegCM3对东亚环流和中国气候模拟能力的检验

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中国气象学会2005年年会

作者：张冬峰高学杰赵宗慈 jeremy S.Pal Filippo Giorgi 国家气候中心中国气象局气候研究开放实验室国家气候中心中国气象局气候研究开放实验室国家气候中心中国气象局气候研究开放实验室 The Abdus Salam International centre for Theoretical Physics Trieste Italy The Abdus Salam International centre for Theoretical Physics Trieste Italy

使用RegcM3区域气候模式,嵌套ERA40再分析资料,对东亚地区进行了15年（1987-2001）时间长度的数值积分试验,分析了模式对东亚平均环流及中国地区气温和降水的模拟。结果表明,模式较好地模拟了东亚环流和中国地区地面气温和降水的年、季... 详细信息

使用RegcM3区域气候模式,嵌套ERA40再分析资料,对东亚地区进行了15年（1987-2001）时间长度的数值积分试验,分析了模式对东亚平均环流及中国地区气温和降水的模拟。结果表明,模式较好地模拟了东亚环流和中国地区地面气温和降水的年、季地理分布和季节变化特征。同时模式模拟在测站稀少地区,提供了局地降水和气温分布更可靠的信息。整体而言,模式对地面气温的模拟效果好于降水。模式模拟在中国地区存在着系统性的冷偏差,同时模拟的降水在北方偏大,南方偏小,这是模式有待于重点改进完善之处。

关键词：区域气候模式气候模拟东亚中国地区

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Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab

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World Journal of Gastroenterology 2015年第17期21卷 5352-5358页

作者： Aflah Roohullah Hui-Li Wong Katrin M Sjoquist Peter Gibbs Kathryn Field Ben Tran jeremy Shapiro Joe Mckendrick Desmond Yip Louise Nott Val Gebski Weng Ng Wei chua Timothy Price Niall Tebbutt Lorraine chantrill Macarthur cancer Therapy centre CampbelltownNSW 2560Australia NHMRc clinical Trials centre CamperdownNSW 2050Australia Department of Medical Oncology Royal Melbourne HospitalParkvilleVIC 3052Australia Melbourne Medical School University of MelbourneMelbourneVIC 3000Australia Department of Medical Oncology Box Hill HospitalBox HillVIC 3128Australia St George cancer care centre KogarahNSW 2217Australia Department of Medical Oncology Western HospitalFootscrayVIC 3011Australia Department of Medical Oncology Cabrini HealthMelbourneVIC 3000Australia Department of Medical Oncology the Canberra HospitalGarranACT 2605Australia ANU Medical School Australia National UniversityCanberraACT 2600Australia Department of Medical Oncology Royal Hobart HospitalHobartTAS 7000Australia Liverpool cancer Therapy centre LiverpoolNSW 2170Australia Department of Medical Oncology the Queen Elizabeth HospitalWoodvilleSA 5011Australia Department of Medical Oncology Austin HealthHeidelbergVIC 3084Australia the Kinghorn cancer centre Garvan Institute of Medical ResearchDarlinghurstNSW 2010Australia

AIM:To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal ***:We compared rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving first-line chemotherapy with and without bevacizumab in three distinct cohorts:(1) the AGITG MAX trial(Phase Ⅲ randomised clinical trial comparing capecitabine vs capecitabine and bevacizumab vs capecitabine,bevacizumab and mitomycin c);(2) the prospective Treatment of Recurrent and Advanced colorectal cancer(TRAcc) registry(any first-line regimen ± bevacizumab);and(3) two cancer centres in New South Wales,Australia [Macarthur cancer Therapy centre and Liverpool cancer Therapy centre(NSWcc) from January 2005 to Decenber 2012,(any first-line regimen ± bevacizumab).For the AGITG MAX trial capecitabine was compared to the other two arms(capecitabine/bevacizumab and capecitabine/bevacizumab/mitomycin c).In the AGITG MAX trial and the TRAcc registry rates of gastrointestinal perforation were also collected in patients who did not have peritoneal *** endpoints included progression-free survival,chemotherapy duration,and overall ***-toevent outcomes were estimated using the Kaplan-Meier method and compared using the log-rank ***:Eighty-four MAX,179 TRAcc and 69 NSWcc patients had peritoneal *** were no gastrointestinal perforations recorded in either the MAX subgroup or the NSWcc *** the patients without peritoneal disease in the MAX trial,4/300(1.3%) in the bevacizumab arms had gastrointestinal perforations compared to 1/123(0.8%) in the capecitabine alone *** the TRAcc registry 3/126(2.4%) patients who had received bevacizumab had a gastrointestinal perforation compared to 1/53(1.9%) in the chemotherapy alone *** a further analysis of patients without peritoneal metastases in the TRAcc registry,the rate of gastrointestinal p

关键词： Peritoneal neoplasms colorectal neoplasms Bevacizumab Intestinal perforation capecitabine

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Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients

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World Journal of Gastrointestinal Oncology 2012年第5期4卷 103-108页

作者： Taher Abu Hejleh Barry R DeYoung Eric Engelman jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald clamon Division of Hematology Oncology and Marrow TransplantationDepartment of Internal MedicineUniversity of Iowa Hospitals and Clinics200 Hawkins DriveC32 GHIowa CityIA 52242-1081United States Department of Pathology University of Iowa Hospitals and Clinics200 Hawkins Drive5238C RCPIowa CityIA 52242-1081United States Department of Biostatistics College of Public HealthUniversity of Iowa200 Hawkins DriveN377 CPHBIowa CityIA 52242-1081United States Department of cardiothoracic Surgery University of Iowa Hospitals and Clinics200 Hawkins DriveSE514 GHIowa CityIA 52242-1081United States Department of Radiation Oncology University of Iowa Hospitals and Clinics200 Hawkins Drive1624 PFPIowa CityIA 52242-1081United States

AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following ***:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and clinics between 2000 and *** analyzed consisted of demographic and clinical *** brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were *** age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant *** complete and partial responses were achieved in 17(19%) and 71(81%) *** relapsed in 43/142(30%) *** brain was the first site of relapse in 9/43 patients(21%,95% cI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).cONcLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following *** studies will be required to validate this observation.

关键词： Esophageal neoplasm Esophageal cancer HER-2 Genes,erbB-2 Brain Neoplasms Brain metastasis

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加快大型数据中心服务的可重构结构

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中国集成电路 2015年第1期24卷 55-68,89页

作者： Andrew Putnam Adrian M.caulfield Eric S.chung Derek chiou Kypros constantinide John Demme Hadi Esmaeilzadeh jeremy Fowers Gopi Prashanth Gopal Jan Gray Michael Haselman Scott Hauck Stephen Heil Amir Hormati Joo-Young Kim Sitaram Lanka James Larus Eric Peterson Simon Pope Aaron smith Jason Thong Phillip Yi Xiao Doug Burger 微软公司

数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个... 详细信息

数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个实例都由嵌入48台机器的半机架6×8二维环面高端Stratix V FPGA组成。每台服务器中都放置了一个FPGA,可以通过PcIe来访问,并用成对的10 Gb SAS电缆直接连接到其他FPGA。在本文中,我们描述了这种结构在1,632台服务器组(bed)的中等规模的部署,并测量了其在加快Bing搜索引擎方面的功效。我们描述了系统的要求和架构,详细介绍了关键技术挑战,以及使系统在出现故障情况下保持鲁棒性所需的解决方案,还有根据排名候选文档测量的系统性能、功率和弹性。在高负载时,一定范围内的可重构结构提高了每台服务器固定延迟分布的吞吐量排名95%——或在保持等效吞吐量时,减少29%的尾延迟。

关键词：可重构结构服务器组数据中心 Stratix FPGA 计算能力工作负载软件服务

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