Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients

作     者：Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon 

作者机构：Division of HematologyOncology and Marrow TransplantationDepartment of Internal MedicineUniversity of Iowa Hospitals and Clinics200 Hawkins DriveC32 GHIowa CityIA 52242-1081United States Department of PathologyUniversity of Iowa Hospitals and Clinics200 Hawkins Drive5238C RCPIowa CityIA 52242-1081United States Department of BiostatisticsCollege of Public HealthUniversity of Iowa200 Hawkins DriveN377 CPHBIowa CityIA 52242-1081United States Department of Cardiothoracic SurgeryUniversity of Iowa Hospitals and Clinics200 Hawkins DriveSE514 GHIowa CityIA 52242-1081United States Department of Radiation OncologyUniversity of Iowa Hospitals and Clinics200 Hawkins Drive1624 PFPIowa CityIA 52242-1081United States 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2012年第4卷第5期

页      面：103-108页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by The Iowa Leukemia and Cancer Research Fund at University of Iowa Hospitals and clinics 

主　　题：Esophageal neoplasm Esophageal cancer HER-2 Genes,erbB-2 Brain Neoplasms Brain metastasis 

摘      要：AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following ***:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and *** analyzed consisted of demographic and clinical *** brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were *** age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant *** complete and partial responses were achieved in 17(19%) and 71(81%) *** relapsed in 43/142(30%) *** brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following *** studies will be required to validate this observation.