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How Do Phytochromes Transmit the Light Quality Information to the Circadian Clock in Arabidopsis？

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Molecular Plant 2014年第11期7卷 1701-1704页

作者： Miii Yeom Hyunmin kim Junhyun Lim Ah- Young Shin Sunghyun Hong jeong-ii kim Hong Gil Nam Division of Molecular and Life Sciences PohangUniversity of Science and Technology Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Integrative Biosciences & Biotechnology in POSTECH Hyojadong Pohang Gyeongbuk 790-784 Republic of Korea Department of Molecular Biotechnology and Kumho Life Science Laboratory Chonnam National University Gwangju 500-757 Republic of Korea Center for Plant Aging Research Institute for Basic Science Daegu 711-873 Republic of Korea Department of New Biology DGIST Hyeongpoong-Myun Dalsung-gun Daegu 711-873 Republic of Korea

Dear Editor, Plants use light as an environmental signal to coor- dinate diverse physiological and developmental processes, thereby increasing their fitness. Light quality, quantity, and photoperiod change periodically under natural condi- tions of daily and seasonal cycles. Plants have developed a circadian clock to respond to these predictable, periodic environmental changes, providing plants with the ability to anticipate daily and seasonal environmental changes.

关键词：光照期拟南芥属植物

Gut–brain axis and environmental factors in Parkinson's disease:bidirectional link between disease onset and progression

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Neural Regeneration Research 2025年第12期20卷 3416-3429页

作者： Soo Jung Park Kyung Won kim Eun jeong Lee Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Life Science and Multidisciplinary Genome Institute Hallym UniversityChuncheonSouth Korea

Parkinson's disease has long been considered a disorder that primarily affects the brain,as it is defined by the dopaminergic neurodegeneration in the substantia nigra and the brain accumulation of Lewy bodies containingα-synuclein *** recent decades,however,accumulating research has revealed that Parkinson's disease also involves the gut and uncovered an intimate and important bidirectional link between the brain and the gut,called the“gut–brain axis.”Numerous clinical studies demonstrate that gut dysfunction frequently precedes motor symptoms in Parkinson's disease patients,with findings including impaired intestinal permeability,heightened inflammation,and distinct gut microbiome profiles and ***,α-synuclein deposition has been consistently observed in the gut of Parkinson's disease patients,suggesting a potential role in disease ***,individuals with vagotomy have a reduced Parkinson's disease *** these observations,researchers have hypothesized thatα-synuclein accumulation may initiate in the gut and subsequently propagate to the central dopaminergic neurons through the gut–brain axis,leading to Parkinson's *** review comprehensively examines the gut's involvement in Parkinson's disease,focusing on the concept of a gut-origin for the *** also examine the interplay between altered gut-related factors and the accumulation of pathologicalα-synuclein in the gut of Parkinson's disease *** the accessibility of the gut to both dietary and pharmacological interventions,targeting gut-localizedα-synuclein represents a promising avenue for developing effective Parkinson's disease therapies.

关键词： gut inflammation gut microbiome gut-brain axis micro/nano-plastics Parkinson’s disease α-synuclein

RGB Color-Discriminable Photonic Synapse for Neuromorphic Vision System

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Nano-Micro Letters 2025年第4期17卷 39-62页

作者： Bum Ho jeong Jaewon Lee Miju Ku Jongmin Lee Dohyung kim Seokhyun Ham Kyu-Tae Lee Young-Beom kim Hui Joon Park Department of Organic and Nano Engineering&Human-Tech Convergence Program Hanyang UniversitySeoul 04763Korea Department of Semiconductor Engineering Hanyang UniversitySeoul 04763Korea Department of Mechanical Engineering Hanyang UniversitySeoul 04763Korea Department of Physics Inha UniversityIncheon 22212Korea

To emulate the functionality of the human retina and achieve a neuromorphic visual system,the development of a photonic synapse capable of multispectral color discrimination is of paramount ***,attaining robust color discrimination across a wide intensity range,even irrespective of medium limitations in the channel layer,poses a significant ***,we propose an approach that can bestow the color-discriminating synaptic functionality upon a three-terminal transistor flash memory even with enhanced discriminating *** incorporating the strong induced dipole moment effect at the excitation,modulated by the wavelength of the incident light,into the floating gate,we achieve outstanding RGB color-discriminating synaptic functionality within a remarkable intensity range spanning from 0.05 to 40 mW cm^(-2).This approach is not restricted to a specific medium in the channel layer,thereby enhancing its *** effectiveness of this color-discriminating synaptic functionality is demonstrated through visual pre-processing of a photonic synapse array,involving the differentiation of RGB channels and the enhancement of image contrast with noise ***,a convolutional neural network can achieve an impressive inference accuracy of over 94%for Canadian-Institute-For-Advanced-Research-10 colorful image recognition task after the *** proposed approach offers a promising solution for achieving robust and versatile RGB color discrimination in photonic synapses,enabling significant advancements in artificial visual systems.

关键词： Organic field-effect transistor Photonic synapse Excited-state dipole moment RGB color discrimination Neuromorphic visual system

Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution

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Zoological Research 2025年第01期 165-176页

作者： Eun Jung Kwon Hyeon Mi Sung Hansong Lee Soyul Ahn Yejin kim Chae Rin Lee Kihun kim Kyungjae Myung Won Kyu kim Dokyoung kim Sanghwa jeong Chang-Kyu Oh Yun Hak kim Medical Research Institute Pusan National University Institute for Future Earth Pusan National University Department of Convergence Medical Sciences School of Medicine Pusan National University Department of Biomedical Informatics School of Medicine Pusan National University Department of Anatomy School of Medicine Pusan National University Center for Genomic Integrity Institute for Basic Science Department of Biomedical Engineering College of Information-Bio Convergence Engineering Ulsan National Institute of Science and Technology Natural Product Research Center Korea Institute of Science and Technology (KIST) Department of Convergence Medicine Yonsei University Wonju College of Medicine Natural Product Applied Science KIST School University of Science and Technology (UST) Department of Biomedical Science Graduate School Kyung Hee University Department of Anatomy and Neurobiology College of Medicine Kyung Hee University Department of Precision Medicine Graduate School Kyung Hee University Center for Converging Humanities Kyung Hee University KHU-KIST Department of Converging Science and Technology Kyung Hee University UC San Diego Materials Research Science and Engineering Center Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute Core Research Institute (CRI)Kyung Hee University Center for Brain Technology Brain Science Institute Korea Institute of Science and Technology (KIST) School of Biomedical Convergence Engineering Pusan National University Department of Biochemistry School of Medicine Pusan National University

Polystyrene nanoparticles pose significant toxicological risks to aquatic ecosystems, yet their impact on zebrafish(Danio rerio) embryonic development, particularly erythropoiesis, remains underexplored. This study used single-cell RNA sequencing to comprehensively evaluate the effects of polystyrene nanoparticle exposure on erythropoiesis in zebrafish embryos. In vivo validation experiments corroborated the transcriptomic findings,revealing that polystyrene nanoparticle exposure disrupted erythrocyte differentiation, as evidenced by the decrease in mature erythrocytes and concomitant increase in immature erythrocytes. Additionally, impaired heme synthesis further contributed to the diminished erythrocyte *** findings underscore the toxic effects of polystyrene nanoparticles on hematopoietic processes, highlighting their potential to compromise organismal health in aquatic environments.

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Molecules“buckle up”to drive layered hybrid perovskites into single-crystal nanowires in water

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Science China Chemistry 2025年第1期68卷 3-4页

作者： Seokhyoung kim Department of Chemistry Michigan State UniversityEast LansingMI 48824USA

Layered 2D metal halide perovskites(MHPs)are one of the most exciting candidates for next-generation light sources owing to their outstanding optoelectronic *** properties are readily tunable by controlling the halide composition,number of inorganic layers,and the chemistry of organic *** key element that can substantially impact the materials’functionalities is crystal morphology^([1]).

关键词： nanowires perovskite halide

TMEM39A and TMEM131 facilitate bulk transport of ECM proteins through large COPii vesicle formation

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Journal of Genetics and Genomics 2025年第2期52卷 189-203页

作者： Jee Young Sung Ga-Eun Lim Jarim Goo Kyung Jin Jung jeong Min Chung Hyun Suk Jung Yong-Nyun kim Jaegal Shim Cancer Metastasis Branch Research InstituteNational Cancer Center323 Ilsan-roGoyang-siGyeonggi-do10408Republic of Korea Experimental Clinical Research Center Biomedical Research InstituteSeoul National University Bundang HospitalSeongnamGyeonggi-do13620Republic of Korea Department of Biochemistry College of Natural SciencesKangwon National UniversityChuncheonKangwon-do24341Republic of Korea

The growth of Caenorhabditis elegans involves multiple molting processes,during which old cuticles are shed and new cuticles are rapidly *** process requires the regulated bulk secretion of cuticle *** transmembrane protein-39(TMEM-39)mutant exhibits distinct dumpy and ruptured phenotypes characterized by notably thin ***-39 primarily co-localizes with the coat protein ii complex(COPii)in large vesicles rather than small COPii *** TMEM-39-associated large vesicles(TMEM-39-LVs)form robustly during the molting period and co-localize with various extracellular matrix components,including BLI-1 collagen,BLI-3 dual oxidase,and *** immunoprecipitation using TMEM39A-FLAG and proteomics analysis in human sarcoma cells,we identify TMEM39A-associated proteins,including *** of TMEM131 results in reduced TMEM39A-LV formation and collagen secretion in both *** and human sarcoma cells,indicating a cooperative role between TMEM39A and TMEM131 in the secretion of extracellular components through the formation of large COPii *** the conservation of TMEM39A and its associated proteins between *** and humans,TMEM39A-LVs may represent a fundamental machinery for rapid and extensive secretion across metazoans.

关键词： Bulk secretion Collagen COPii ECM TMEM39A TMEM131

Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

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Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo Sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein