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The SARS-CoV-2 spike protein induces lung cancer migration and invasion in a TLR2-dependent manner

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Cancer Communications 2024年第2期44卷 273-277页

作者： mi-jeong kim Ji Young kim Ji Hye Shin Juhee Son Yeeun Kang Soo-Kyung jeong Duk-Hwan kim Kyun-Hwan kim Eunyoung Chun Ki-Young Lee Department of Immunology Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSuwonRepublic of Korea Research and Development Center CHA Vaccine InstituteSeongnam-siRepublic of Korea Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonRepublic of Korea Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences&TechnologySamsung Medical CenterSungkyunkwan UniversitySeoulRepublic of Korea

Dear editor,Severe acute respiratory syndrome coronavirus2(SARS-CoV-2)infection can lead to severe outcomes in patients with cancer[1].It has been reported that patients with lung cancers disproportionately manifest severe COVID-19 with a high rate of hospitalization and death[2].Notably,the SARS-CoV-2 Spike(S)protein can induce hyper-inflammation in both epithelial cells and macrophages through toll-like receptor(TLR)1/TLR2 or TLR2/6-dependent nuclear factor-kappaB(NF-κB)path-way[3].However,molecular and cellular evidence on whether the SARS-CoV-2 virus affects the severity of lung cancer patients through TLR1/2 or TLR2/6 signaling remains unclear.

关键词： lung TLR2 invasion

Electrostabilized homogeneous dispersion of boron nitride nanotubes in wide-range of solvents achieved by surface polarity modulation through pyridine attachment

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Nano Research 2020年第2期13卷 344-352页

作者： mi Se Chang min-Sun Jang Sangsun Yang Jihun Yu Taehoon kim Sedong kim Hyomin jeong Chong Rae Park Jae Won jeong Powder/Ceramic Research Division Korea Institute of Materials Science797 Changwondae-roSeongsan.guChangwon 51508Republic of Korea Research Institute of Advanced Materials and Department of Materials Science and Engineering Seoul National University Seoul 08826Republic of Korea Composites Research Division Korea Institute of Materials Science797 Changwondae-roSeongsan-guChangwon 51508Republic of Korea Dept.of Energy and Mech.Eng Gyeongsang National UniversityCheondaegukchi-Gil 38Tongyeong 53064Republic of Korea

Boron nitride nanotubes(BNNTs)show exceptional physical properties including high mechanical strength and thermal conductivity;however,their applications have been restricted due to limited dispersibility in processing ***,a novel BNNT dispersion method with exceptional dispersibility in a wide range of solvents has been demonstrated by surtace polarity modulation through short-molecule pyridine *** atoms in pyridine are selectively bonded to electron-deficient boron atoms of the BNNT surface through Lewis acid-base reaction,which changes the surface polarity of BNNTs from neutral to ***-dispersing pyridine-attached BNNTs(Py-BNNTs)create a thick and stable electronic double layer(EDL),resulting in uniform dispersion of BNNTs in solvents with an exceptional solubility parameter range of 18.5-48 MPa^1/*** uniform dispersion of BNNTs is maintained even after the mixing with diverse ***,composites incorporating uniformly-distributed BNNTs have been realized,and extraordinary property enhancements have been *** thermal conductivity of 20 wt.%Py-BNNT/epoxy composite has been significantly improved by 69.6%and the tensile strength of 2 wt.%Py-BNNT/PVA has been dramatically improved by 75.3%.Our work demonstrates a simple and facile route to dispersing BNNTs in diverse solvents,consequently leading to selective utlization of BNNT dispersed solvents in various application fields.

关键词： boron nitride nanotube one-dimensional nanomaterials surface polarity modulation electrostabilization boron nitride nanotube composite

Predictive factors for early clinical response in community-onset Escherichia coli urinary tract infection and effects of initial antibiotic treatment on early clinical response

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World Journal of Clinical Cases 2020年第19期8卷 4342-4348页

作者： Young Jun kim jeong-mi Lee Jae-Hoon Lee Department of Internal Medicine Wonkwang University College of MedicineIksan 54538South Korea Department of Public Health Wonkwang University College of MedicineIksan 54538South Korea Department of Internal Medicine and Institute of Wonkwang Medical Science Wonkwang University College of MedicineIksan 54538South Korea

BACKGROUND Urinary tract infection(UTI)is a common *** often requires hospitalization,and severe presentations,including sepsis and other complications,have a mortality rate of 6.7%-8.7%.AIM To evaluate the predictive factors for early clinical response and effects of initial antibiotic therapy on early clinical response in community-onset Escherichia coli(***)urinary tract infections(UTIs).METHODS This retrospective study was conducted at Wonkwang University Hospital in South Korea between January 2011 and December *** patients(aged>18 years)who were diagnosed with community-onset *** UTI were enrolled in this *** A total of 511 hospitalized patients were included.66.1%of the patients had an early clinical *** mean length of hospital stay in patients with an early clinical response were each 4.3 d shorter than in patients without an early clinical *** the multiple regression analysis,initial appropriate antibiotic therapy(OR=2.449,P=0.006),extended-spectrum(3-lactamase(ESBL)-producing ***(OR=2.112,P=0.044),improper use of broad-spectrum antimicrobials(OR=0.411,P=0.006),and a stay in a healthcare facility before admission(OR=0.562,P=0.033)were the factors associated with an early clinical *** broadspectrum antibiotic therapy was not associated with an early clinical *** ESBL producing ***,and the type of residence before hospital admission were the factors associated with an early clinical *** of initial antibiotic therapy was a predictive factor for an early clinical response,but broadspectrum of initial antibiotic therapy did not impact early clinical response.

关键词： Escherichia coli Urinary tract infections Adult Community acquired infections

Supercooling phenomena in protein based food matrix composed of various fat,salt,and water contents

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Food Bioscience 2023年第1期51卷 447-454页

作者： Dong Hyeon Park Eun jeong kim mi-Jung Choi Department of Food Science and Biotechnology of Animal Resources Konkuk UniversitySeoul05029Republic of Korea Refrigerator Research of Engineering Division Home Appliance and Air Solution CompanyLG ElectronicsChangwon51533Republic of Korea

Supercooling is recognized as a novel preservation method because it maintains the freshness of food without tissue damage caused by ice *** is a complicated matrix composed of several components with varying freezing points depending on the food *** this study,effects of food compositions on stability of supercooling preservation were investigated using a model food to define the interaction between supercooling maintenance and the factor of food ***,chicken meat(leg and wing)was used to confirm food freshness during extended *** higher the fat and salt content of the model food,better was the maintenance of the supercooled state;however,higher the moisture content,worse was the maintenance of supercooled *** presence of the fat layer affected the supercooling maintenance *** experiments with real food,the chicken leg and wing samples were 80%and 90%supercooled,*** samples conserved at superooling presented significantly lower drip loss,total volatile basic nitrogen,and total aerobic count than those of the *** addition,water holding capacity of supercooled samples were not significant differences compared to frozen samples.

关键词： Food composition Supercooling Freshness Chicken meats

PIF1 Regulates Plastid Development by Repressing Photosynthetic Genes in the Endodermis

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Molecular Plant 2016年第10期9卷 1415-1427页

作者： Keunhwa kim Jinkil jeong jeongheon kim Nayoung Lee mi Eon kim Sangil Lee Sun Chang kim Giltsu Choi Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea Center for Gas Analysis Division of Metrology for Quality of Life Korea Research Institute of Standards and Science (KRISS) Daejeon 305-340 Republic of Korea

Mutations in Phytochrome Interacting Factors （PIFs） induce a conversion of the endodermal amyloplasts necessary for gravity sensing to plastids with developed thylakoids accompanied by abnormal activation of photosynthetic genes in the dark. In this study, we investigated how PIFs regulate endodermal plastid development by performing comparative transcriptome analysis. We show that both endodermal expression of PIF1 and global expression of the PIF quartet induce transcriptional changes in genes enriched for nuclear-encoded photosynthetic genes such as LHCA and LHCB. Among the 94 shared differentially expressed genes identified from the comparative transcriptome analysis, only 14 genes are demonstrated to be direct targets of PIF1, and most photosynthetic genes are not. Using a co-expression analysis, we identified a direct target of PIF, whose expression pattern shows a strong negative correlation with many photo- synthetic genes. We have named this gene REPRESSOR OF PHOTOSYNTHETIC GENES1 （RPGE1）. Endodermal expression of RPGE1 rescued the elevated expression of photosynthetic genes found in the pff quadruple （pifQ） mutant and partly restored amyloplast development and hypocotyl negative gravitropism. Taken together, our results indicate that RPGE1 acts downstream of PIF1 in the endodermis to repress photosynthetic genes and regulate plastid development.

关键词： phytochrome PIF1 hypocotyl negative gravitropism photosynthetic gene

Identification of differentially expressed miRNAs associated with chronic kidney disease-mineral bone disorder

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Frontiers of Medicine 2017年第3期11卷 378-385页

作者： Kyung Im kim Sohyun jeong Nayoung Han Jung mi Oh Kook-Hwan Oh In-Wha kim College of Pharmacy Korea University Sejong 30019 Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences -Seoul National University Seoui 08826 Republic of Korea Divisionof-Nephrology Department of Internai Medicine Seoul National University Hospital Seoul 03080 Republic of Korea

The purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney disease （CKD） to predict putative microRNA （miRNA） in CKD-mineral bone disorder （CKD- MBD） and confirm the changes in these genes and miRNA expression under uremic conditions by using a cell culture system. PubMed searches using MeSH terms and keywords related to CKD, uremia, and mRNA arrays were conducted. Through a computational analysis, a meta-signature that characterizes the significant intersection of differentially expressed mRNA and expected miRNAs associated with CKD-MBD was determined. Additionally, changes in gene and miRNA expressions under uremic conditions were confirmed with human Saos-2 osteoblast-like cells. A statistically significant mRNA meta-signature of upregulated and downregulated mRNA levels was identified. Furthermore, miRNA expression profiles were inferred, and computational anaIyses were performed with the imputed mieroRNA regulation based on weighted ranked expression and putative microRNA targets （IMRE） method to identify miRNAs associated with CKD occurrence. TLR4 and miR-146b levels were significantly associated with CKD-MBD. TLR4 levels were significantly downregulated, whereas pri- miR-146b and miR-146b were upregulated in the presence of uremic toxins in human Saos-2 osteoblast-like cells. Differentially expressed miRNAs associated with CKD-MBD were identified through a computational analysis, and changes in gene and miRNA expressions were confirmed with an in vitro cell culture system.

关键词： chronic kidney disease microRNA mineral bone disorder uremia

Feasibility of full-spectrum endoscopy:Korea's first full-spectrum endoscopy colonoscopic trial

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World Journal of Gastroenterology 2016年第8期22卷 2621-2629页

作者： jeong-Yeop Song Youn Hee Cho mi A kim jeong-Ae kim Chun Tek Lee Moon Sung Lee Division of Gastroenterology Department of Internal Medicine LCT Hospital Division of Gastroenterology Department of Internal Medicine Soon Chun Hyang University Bucheon Hospital

AIM: To evaluate the full-spectrum endoscopy(FUSE) colonoscopy system as the first report on the utility thereof in a Korean ***: We explored the efficacy of the FUSE colonoscopy in a retrospective, single-center feasibility study performed between February 1 and July 20, 2015. A total of 262 subjects(age range: 22-80) underwent the FUSE colonoscopy for colorectal cancer screening, polyp surveillance, or diagnostic evaluation. The cecal intubation success rate, the polyp detection rate(PDR), the adenoma detection rate(ADR), and the diverticulum detection rate(DDR), were calculated. Also, the success rates of therapeutic interventions were evaluated with biopsy ***: All patients completed the study and the success rates of cecal and terminal ileal intubation were 100% with the FUSE colonoscope; we found 313 polyps in 142 patients and 173 adenomas in 95. The overall PDR, ADR and DDR were 54.2%, 36.3%, and 25.2%, respectively, and were higher in males, and increased with age. The endoscopists and nurses involved considered that the full-spectrum colonoscope improved navigation and orientation within the *** colonoscopy was aborted because of colonoscope ***: The FUSE colonoscopy yielded a higher PDR, ADR, DDR than did traditional colonoscopy, without therapeutic failure or complications, showing feasible, effective, and safe in this first Korean trial.

关键词： Colonoscopy Colonoscopes Feasibility studies Colonic polyps

Effect of supercooling storage applied with stepwise algorithm for fishes(salmon and olive flounder)and its freshness during extended storage

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Food Bioscience 2022年第5期49卷 774-782页

作者： Dong Hyeon Park SangYoon Lee Yeong mi Byeon Eun jeong kim mi-Jung Choi Department of Food Science and Biotechnology of Animal Resources Konkuk UniversitySeoul05029South Korea Refrigerator Research of Engineering Division Home Appliance and Air Solution CompanyLG ElectronicsChangwon51533South Korea

Supercooling storage reduces the temperature of a product by lowering its freezing point without phase transition and may extend its shelf ***,it is difficult to maintain the supercooled state of food as it is thermodynamically metastable.A slow cooling rate and minimal fluctuation are essential for achieving stable supercooling ***,a stepwise algorithm was adopted for supercooling storage in this *** and olive flounder were stored at 3℃(refrigeration),􀀀18℃(freezing),and􀀀2℃(supercooling)for 12 *** were maintained in a supercooled state and unfrozen during the storage *** stored after the supercooling treatment were superior with respect to drip loss and water holding capacity(WHC)compared to frozen samples,regardless of the type of *** and total volatile basic nitrogen values of olive flounder was higher than those in salmon owing to the higher water and protein content in olive flounder than in ***,the supercooled samples inhibited the increase in trimethylamine and volatile basic nitrogen *** growth was ***,a stepwise algorithm for stable supercooled storage was achieved,which effectively preserved fish quality better than freezing and refrigeration storage.

关键词： Salmon Olive flounder Supercooling Stepwise algorithm Freshness

Emerging role of ^(18)F-fluorodeoxyglucose positron emission tomography for guiding management of hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第11期25卷 1289-1306页

作者： Sang mi Lee Hong Soo kim Sangheun Lee jeong Won Lee Department of Nuclear Medicine Soonchunhyang University Cheonan Hospital Department of Internal Medicine Soonchunhyang University Cheonan Hospital Division of Hepatology Department of Internal medicineCatholic Kwandong University College of MedicineInternational St.Mary’s Hospital Institute for Health and Life Science Catholic Kwandong University College of MedicineInternational St.Mary’s Hospital Department of Nuclear Medicine Catholic Kwandong University College of MedicineInternational St.Mary’s Hospital

Hepatocellular carcinoma(HCC) is one of major causes of cancer mortality worldwide. For decades, ^(18)F-fluorodeoxyglucose(FDG) positron emission tomography(PET) has been widely used for staging, predicting prognosis, and detecting cancer recurrence in various types of malignant diseases. Due to low sensitivity of FDG PET for detecting intrahepatic HCC lesions, the clinical value of FDG PET in HCC patients has been limited. However, recent studies with diverse analytic methods have shown that FDG PET has promising role in aiding management of HCC patients. In this review, we will discuss the clinical role of FDG PET for staging, predicting prognosis, and evaluating treatment response in HCC. Further, we will focus on recent clinical studies regarding implication of volumetric FDG PET parameters, the significance of FDG uptake in HCC for selecting treatment and predicting treatment response, and the use of radiomics of FDG PET in HCC.

关键词： Hepatocellular carcinoma Fluorodeoxyglucose F18 Positron emission tomography Staging Prognosis