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Associated factors for a hyperechogenic pancreas on endoscopic ultrasound

World Journal of Gastroenterology 2010年第34期16卷 4329-4334页

作者： Cheol Woong Choi Gwang Ha Kim Dae Hwan Kang Hyung Wook Kim Dong Uk Kim jeong Heo Geun Am Song Do Youn Park suk Kim Department of Internal Medicine Pusan National University School of Medicine and the Medical Research Institute Pusan National University Hospital Department of Internal Medicine Pusan National University School of Medicine and the Medical Research Institute Department of Pathology Pusan National University School of Medicine and the Medical Research Institute Department of Radiology Pusan National University School of Medicine and the Medical Research Institute

AIM: To identify the associated risk factors for hyperechogenic pancreas (HP) which may be observed on endoscopic ultrasound (EUS) and to assess the relationship between HP and obesity. METHODS: From January 2007 to December 2007, we prospectively enrolled 524 consecutive adults who were scheduled to undergo EUS. Patients with a history of pancreatic disease or with hepatobiliary or advanced gastrointestinal cancer were excluded. Finally,284 patients were included in the analyses. We further analyzed the risk of HP according to the categories of visceral adipose tissue (VAT) and subcutaneous adipose tissue in 132 patients who underwent abdominal computed tomography scans. RESULTS: On univariate analysis, age older than 60 years, obesity (body mass index > 25 kg/m 2 ), fatty liver, diabetes mellitus, hypertension and hypercholesterolemia were identified as risk factors associated with HP (P < 0.05). On multivariate analysis, fatty liver [P = 0.008, odds ratio (OR) = 2.219], male gender (P = 0.013, OR = 2.636), age older than 60 years (P = 0.001, OR = 2.874) and hypertension (P = 0.044, OR = 2.037) were significantly associated with HP. In the subgroup analysis, VAT was a statistically significant risk factor for HP (P = 0.010, OR = 5.665, lowest quartile vs highest quartile). CONCLUSION: HP observed on EUS was associated with fatty liver, male gender, age older than 60 years, hypertension and VAT.

关键词： Endoscopic Ultrasound Hyperechogenic pancreas Obesity

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Clinical correlations of infliximab trough levels and antibodies to infliximab in South Korean patients with Crohn's disease

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World Journal of Gastroenterology 2017年第8期23卷 1489-1496页

作者： Eun Hye oh Dae-Hyun Ko Hyungil Seo Kiju Chang Gwang-Un Kim Eun Mi Song Myeongsook Seo Ho-Su Lee Sung Wook Hwang Dong-Hoon Yang Byong Duk Ye jeong-Sik Byeon Seung-Jae Myung suk-Kyun Yang Sang Hyoung Park Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center Department of Laboratory Medicine Hallym University College of MedicineDongtan Sacred Heart Hospital Department of Gastroenterology University of Ulsan College of MedicineAsan Medical Center Health Screening and Promotion Center University of Ulsan College of MedicineAsan Medical Center

To investigate the clinical implications of infliximab trough levels (IFX-TLs) and antibodies to infliximab (ATI) levels in Crohn’s disease (CD) patients in Asian ***-TL and ATI level were measured using prospectively collected samples obtained with informed consent from CD patients being treated at Asan Medical Center, South Korea. We analyzed the correlations between IFX-TLs/ATI levels and the clinical activity of CD (quiescent vs active disease) based on the CD activity index, C-reactive protein level, and physician’s judgment of patients’ clinical status at enrollment. The impact of concomitant immunomodulators was also *** study enrolled 138 patients with CD (84 with quiescent and 54 with active disease). In patients with quiescent and active diseases, the median IFX-TLs were 1.423 μg/mL and 0.163 μg/mL, respectively (P < 0.001) and the median ATI levels were 8.064 AU/mL and 11.209 AU/mL, respectively (P < 0.001). In the ATI-negative and -positive groups, the median IFX-TLs were 1.415 μg/mL and 0.141 μg/mL, respectively (P < 0.001). In patients with and without concomitant immunomodulator use, there were no differences in IFX-TLs (0.632 μg/mL and 1.150 μg/mL, respectively; P = 0.274) or ATI levels (8.655 AU/mL and 9.017 AU/mL, respectively; P = 0.083).CONCLUSIONIFX-TL/ATI levels were well correlated with the clinical activity in South Korean CD patients. Our findings support the usefulness of IFX-TLs/ATI levels in treating CD patients receiving IFX in clinical practice.

关键词： Infliximab Drug effect Antibody Crohn’s disease Drug monitoring

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Analysis on sports and recreation activity-related eye injuries presenting to the Emergency Department

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1499-1505页

作者： Sungbae Moon Hyun Wook Ryoo Jae Yun Ahn Jung Bae Park Kang suk Seo Sang Do Shin Kyoung Jun Song Kang Hyun Lee In Sool Yoo Jin Seong Cho Hyun Ho Ryu Tae oh jeong Seok Ran Yeom Young Taek Kim Sung Ok Hong Department of Emergency Medicine School of MedicineKyungpook National University Daegu 700-721 Korea Department of Emergency Medicine College of MedicineSeoul National University Seoul 110-799 Korea Department of Emergency Medicine Wonju College of Medicine Yonsei University Wonju Gangwon-do 220-701Korea Department of Emergency Medicine School of MedicineChungnam National University Daejeon 301-747 Korea Department of Emergency Medicine Gachon University Gil Medical Center Incheon 406-799 Korea Department of Emergency Medicine School of MedicineChonnam National University Gwangju 501-746 Korea Department of Emergency Medicine School of MedicineChonbuk National University Jeonju Jeollabuk-do 561-180Korea Department of Emergency Medicine School of MedicinePusan National University Busan 602-739 Korea Korean Centers for Disease Control & Prevention Cheongiu Chungcheongbuk-do 361-951 Korea

AIM：To investigate the incidence and general characteristics of sports-related eye injuries in patients visiting the Emergency Department. METHODS： A cross-sectional,multi-center,observational *** with an injured eye who visited the Emergency Department at one of nine hospitals in Korea were *** data were prospectively collected between March and September 2010 using a *** injuries that occurred during risky sports were examined by gender and ***,the rate of open globe injuries that occurred with and without protective eyewear was examined for each *** variables were compared using Student＇s t-test and categorical variables were compared using Chi-square ***： A total of 446 patients had sports-related eye ***（10-19 years old） and young adults（20-29 years old） had the most eye *** injuries accounted for 0.2% of Emergency Department *** was the most common cause of sports-related eye injuries,followed by soccer and *** gear was worn by 9.4% of all *** that were 30-39 years of age had the highest rate of protective gear use,followed by patients that were 40-49 years of *** proportion of sports-related eye injuries that were open-globe injuries was highest for soccer and ***： Although injuries were most common in patients below the age of 10 years,these patients had the lowest rate of protective eyewear *** in adults over 40 years of age most commonly occurred during hiking,but the rate of protective eyewear use was *** athletes should be educated on and provided with protective eyewear and policies protective gear use should be *** older adults,eye protection should be encouraged,especially during hiking.

关键词： athletic injuries eye injuries protective devices sports.

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Improving hydroxyapatite coating ability on biodegradable metal through laser-induced hydrothermal coating in liquid precursor:Application in orthopedic implants

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Bioactive Materials 2023年第7期25卷 796-806页

作者： Jaeho Park Seung-Hoon Um Youngmin Seo Jaehong Lee Yu-Chan Kim Myoung-Ryul Ok suk-Won Hwang jeong-Yun Sun Hyung-Seop Han Hojeong Jeon Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792South Korea Department of Materials Science and Engineering Seoul National University(SNU)Seoul08826South Korea Division of Biomedical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul02792South Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841South Korea

During the past decade,there has been extensive research toward the possibility of exploring magnesium and its alloys as biocompatible and biodegradable materials for implantable *** practical medical application,however,has been limited to specific areas owing to rapid corrosion in the initial stage and the consequent *** coatings can significantly reduce the initial corrosion of Mg alloys,and several studies have been carried out to improve the adhesion strength of the coating to the surfaces of the *** composition of hydroxyapatite(HAp)is very similar to that of bone tissue;it is one of the most commonly used coating materials for bone-related implants owing to favorable osseointegration *** this study,HAp was coated on Mg using nanosecond laser coating,combining the advantages of chemical and physical *** heat generated in the liquid precursor by the laser improved the adhesion of the coating through the precipitation and growth of HAp at the localized nanosecond laser focal area and increased the corrosion resistance and cell adhesion of *** physical,crystallographic,and chemical bondings were analyzed to explore the mechanism through which the surface adhesion between Mg and the HAp coating layer *** applicability of the coating to Mg screws used for clinical devices and improvement in its corrosion property were *** liquid environment-based laser surface coating technique offers a simple and quick process that does not require any chemical ligands,and therefore,overcomes a potential obstacle in its clinical use.

关键词： Biodegradable metal HAp coating Nanosecond laser Photothermal synthesis Soret effect(thermophoresis)

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Evaluation of recurrence in gastric carcinoma: Comparison of contrast-enhanced computed tomography and positron emission tomography/computed tomography

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World Journal of Gastroenterology 2017年第35期23卷 6448-6456页

作者： Jong Hyeon Kim suk Hee Heo Jin Woong Kim Sang Soo Shin Jung Jun Min Seong Young Kwon Yong Yeon jeong Heoung Keun Kang Department of Radiology Chonnam National University Medical SchoolChonnam National University Hwasun Hospital Department of Radiology Chonnam National University Medical SchoolChonnam National University Hospital Department of Nuclear Medicine Chonnam National University Medical SchoolChonnam National University Hwasun Hostpital

AIM To compare the value of contrast-enhanced abdominal computed tomography(CT) and fluorodeoxyglucose(FDG) positron emission tomography/computed tomography(PET/CT) for detecting gastric carcinoma *** We retrospectively examined data from 2475 patients who underwent both contrast-enhanced abdominal CT and FDG PET/CT for the surveillance of gastric carcinoma curative resection. Patients had an interval of less than 1 mo between their CT and PET/CT scans. Sixty patients who had recurrence were enrolled. Among 1896 patients who did not have recurrence, 60 were selected by simple random sampling. All CT and PET/CT images were reviewed retrospectively by two reviewers blinded to all clinical and pathologic information except curative resection due to gastric carcinoma. RESULTS The pathological stage of the recurrence group was statistically significantly higher than that of the control group(P < 0.001). In the 60 patients who had recurrence, there were 79 recurrent lesions. Fortyfour patients had only one location of recurrence, 13 patients had two locations, and 3 patients had three. In the detection of patient-based overall recurrence, no statistically significant differences existed between the two modalities(P = 0.096). However, for peritoneal carcinomatosis, CT had a statistically significantly higher sensitivity compared to PET/CT(96% vs 50%, P = 0.001). Adenocarcinoma was the most common type of gastric carcinoma. On the pathology-based analysis, CT also had a statistically significantly higher sensitivity compared to PET/CT(98% vs 80%, P = 0.035).CONCLUSION Contrast-enhanced CT was superior to PET/CT in the detection of peritoneal carcinomatosis and pathologic type of adenocarcinoma.

关键词： Gastric carcinoma Surgery Contrastenhanced abdominal computed tomography Fluorodeoxyglucose positron emission tomograph/computed tomography Surveillance Recurrence

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Bon Appetit! An Investigation About the Best and Worst Color Combinations of Lighting and Food

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Journal of Literature and Art Studies 2012年第5期2卷 559-566页

作者： Hyeon-jeong suk Geun-Ly Park Yoonsook Kim KAIST (Korea Advanced Institute of Science and Technology) Daejeon Republic of Korea Korea Food Research Institute Seongnam Republic of Korea

We investigated an interaction effect between lighting color and food color that stimulates or discourages one＇s appetite. Facilitated by the LED （light-emitting diode） as an additional chromatic lighting source, observers selected the best and worst lighting colors by themselves using a ＂Mini Living Colors （PhilipsTM）＂ in the preliminary test （N = 30） and then color picker software in the main experiment （N = 30）. Food stimuli were composed of two aspects, type--natural or processed--and complexity--low or high, and consequently they were grouped into four categories. We measured the selected lighting color in terms of chromaticity and illumination level, and analyzed the best and worst combinations based on these measurements. Throughout the two empirical studies, we found three tendencies： First, except for the white, yellow lighting stimulates while red and blue discourages one＇s appetite. Second, when color categories of lighting and food are similar to each other, it stimulates the appetite whereas complementary, it discourages it. Third, the type of food does not act as an influencing factor.

关键词： food color lighting color appetite color

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Pancreatic adenocarcinosarcoma of monoclonal origin:A case report

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World Journal of Gastroenterology 2014年第35期20卷 12682-12686页

作者： Hyun Seon Kim Jin Il Kim Minyoung jeong Jae Hyun Seo Il Kyu Kim Dae Young Cheung Tae-Jung Kim Chang suk Kang Department of Internal Medicine The Catholic University of KoreaCollege of MedicineYeouido St.Mary’s Hospital Hospital Pathology Department The Catholic University of KoreaCollege of MedicineYeouido St.Mary’s Hospital

Adenocarcinosarcoma, a neoplasm containing both carcinomatous and sarcomatous components, is a rare form of a cancer and the pathophysiology is currently poorly understood. Moreover, definitive treatment guidelines for this disease have not yet been established. Pancreatic adenocarcinosarcoma is even more rare and the prognosis is fatal. Here, we report a case of a 77-year-old male with pancreatic adenocarcinosarcoma and metastasis to the liver. The patient presented at our hospital with uncontrolled glucose levels and diabetes mellitus. The patient’s laboratory findings were unremarkable with the exception of elevated carbohydrate antigen 19-9 levels. Biopsies of the tumors in the pancreas and the liver revealed two types of tumors: pancreatic adenocarcinoma and a poorly differentiated sarcoma. To determine if KRAS mutations were present, we performed a peptide nucleic acid (PNA) clamp PCR-based assay. DNA sequencing by PNA clamp PCR identified a point mutation in codon 12 of exon 2 within KRAS from both tumor types. Because the KRAS mutation is observed in both tumor components, our findings support a monoclonal tumor origin followed by subsequent divergent differentiation into the sarcomatous and carcinomatous tumor populations. After we considered the patient’s status and the late stage of tumor detection, gemcitabine chemotherapy was administered.

关键词： Pancreas Adenocarcinosarcoma Metastasis KRAS DNA sequencing

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Cerebral and pulmonary embolisms after transcatheter arterial chemoembolization for hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第30期14卷 4834-4837页

作者： Chang Soo Choi Ki Hoon Kim Geom Seog Seo Eun Young Cho Hyo jeong oh Suck Chei Choi Tae Hyeon Kim Haak Cheoul Kim Byung suk Roh Department of Internal Medicine and Digestive Disease Research Institute Wonkwang University School of Medicine Department of Radiology Wonkwang University School of Medicine

A cerebral lipiodol embolism is an extremely rare complication of transcatheter arterial chemoembolization for hepatocellular carcinoma. We present a case of cerebral lipiodol embolism that occurred after the third ar... 详细信息

关键词： Transcatheter arterial chemoembolization Cerebral embolism Complication Hepatocellular carcinoma Lipiodol

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Induction of Apoptosis and Acetylation of Histone H3 and H4 by Arctigenin in the Human Melanoma Cell Line SK-MEL-28

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Food and Nutrition Sciences 2011年第2期2卷 128-132页

作者： Jin Boo jeong Se Chul Hong Jin suk Koo Hyung Jin jeong 不详

Cutaneous melanoma is one of the most aggressive forms of skin cancer. Arctigenin, one of the major bioactive compo-nents of Arctii Fructus, has been reported to exhibit antioxidant, antitumor and anti-inflammatory activities. In the pre-sent study, we investigated the effect of arctigenin on induction of apoptosis in highly metastatic SK-MEL-28 human melanoma cells. Arctigenin inhibited growth of SK-MEL-28 cells in a dose-dependent manner. Treatment of SK-MEL-28cells with arctigenin caused cleavage of caspases 3, 7 and 9, and poly (ADP-ribose) polymerase in a dose-dependent manner. Furthermore, acetylation of histone H3 and H4 in the SK-MEL-28 cells was dramatically increased by arctigenin treatment. Collectively, these findings indicate that arctigenin-induces apoptosis of SK-MEL-28 melanoma cells via activation of caspases and histone acetylation.

关键词： Arctigenin Apoptosis Histone Acetylation Caspases Melanoma

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Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

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World Journal of Gastroenterology 2016年第42期22卷 9427-9436页

作者： Junhyeon Cho Sang Soo Lee Yun suk Choi Yejoo Jeon Jung Wha Chung Joo Yeong Baeg Won Keun Si Eun Sun Jang Jin-Wook Kim Sook-Hyang jeong Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Internal Medicine Gyeongsang National University Changwon Hospital Gyeongsang National University College of Medicine

AIM To clarify the prevalence of occult hepatitis B virus(HBV) infection(OBI) and the association between OBI and liver disease progression, defined as development of liver cirrhosis or hepatocellular carcinoma(HCC), worsening of Child-Pugh class, or mortality in cases of chronic hepatitis C virus(HCV) infection. METHODS This prospective cohort study enrolled 174 patients with chronic HCV infection(chronic hepatitis, n = 83; cirrhosis, n = 47; HCC, n = 44), and evaluated disease progression during a mean follow-up of 38.7 mo. OBI was defined as HBV DNA positivity in 2 or moredifferent viral genomic regions by nested polymerase chain reaction using 4 sets of primers in the S, C, P and X open reading frame of the HBV genome. RESULTS The overall OBI prevalence in chronic HCV patients at enrollment was 18.4%, with 16.9%, 25.5% and 13.6% in the chronic hepatitis C, liver cirrhosis and HCC groups, respectively(P = 0.845). During follow-up, 52 patients showed disease progression, which was independently associated with aspartate aminotransferase > 40 IU/L, Child-Pugh score and sustained virologic response(SVR), but not with OBI positivity. In 136 patients who were not in the SVR state during the study period, OBI positivity was associated with neither disease progression, nor HCC development. CONCLUSION The prevalence of OBI in chronic HCV patients was 18.4%, and OBI was not associated with disease progression in South Koreans.

关键词： Hepatitis B virus Hepatitis C virus Disease control Oncogenesis

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