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Unified deep learning model for El Niño/Southern Oscillation forecasts by incorporating seasonality in climate data

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Science Bulletin 2021年第13期66卷 1358-1366,M0004页

作者： Yoo-Geun Ham jeong-hwan kim Eun-Sol kim Kyung-Yun On Department of Oceanography Chonnam National UniversityGwangju 61186South Korea Kakao Brain Bundang-guSeongnam-siGyeonggi-do 13494South Korea

Although deep learning has achieved a milestone in forecasting the El Niño-Southern Oscillation(ENSO),the current models are insufficient to simulate diverse characteristics of the ENSO,which depends on the calendar ***,a model was generated for specific seasons which indicates these models did not consider physical constraints between different target seasons and forecast lead times,thereby leading to arbitrary fluctuations in the predicted time *** overcome this problem and account for ENSO seasonality,we developed an all-season convolutional neural network(A_CNN)*** correlation skill of the ENSO index was particularly improved for forecasts of the boreal spring,which is the most challenging season to ***,activation map values indicated a clear time evolution with increasing forecast lead *** study findings reveal the comprehensive role of various climate precursors of ENSO events that act differently over time,thus indicating the potential of the A_CNN model as a diagnostic tool.

关键词： Deep learning ENSO forecasts Seasonality of the ENSO

Comparative study for predictability of type 1 gastric variceal rebleeding after endoscopic variceal ligation:High-frequency intraluminal ultrasound study

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World Journal of Clinical Cases 2021年第34期9卷 10566-10575页

作者： jeong hwan kim Won Hyeok Choe Sun-Young Lee So Young Kwon In-Kyung Sung Hyung Seok Park Department of Internal Medicine Konkuk University School of MedicineKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Konkuk University Medical CenterSeoul 143729South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Korea Department of Internal Medicine Digestive Disease CenterKonkuk University School of MedicineSeoul 05030South Korea

BACKGROUND The efficacy of endoscopic ultrasonography for the follow-up of gastric varices treated with endoscopic variceal ligation(EVL)has not been *** To evaluate the diagnostic correlation of esophagogastroduodenoscopy(EGD)and high-frequency intraluminal ultrasound(HFIUS)for type 1 gastric varices(GOV1)after EVL and to identify the predictability for rebleeding of EGD and *** In liver cirrhosis patients with GOV1,we performed endoscopic follow-up using EGD and HFIUS synchronously after EVL for hemorrhage from *** grading and red color signs were analyzed using EGD,and the largest variceal cross-sectional areas were measured using *** addition,1-year follow-up was *** rebleeding was defined as the presence of hematemesis,hematochezia,or melena without other evidence of bleeding on endoscopic *** In 26 patients with GOV1,variceal cross-sectional areas on HFIUS of GOV1 was poorly correlated with EGD grading of GOV1(r=0.36).In 17 patients who completed the 1-year follow-up,variceal cross-sectional areas on HFIUS was a good predictor of subsequent rebleeding,whereas EGD grading was not a predictor of subsequent *** HFIUS measurement is more predictive of GOV1 rebleeding than EGD grading,so HFIUS measurement may be necessary for endoscopic follow-up after EVL in patients with GOV1.

关键词： Endoscopic variceal ligation Esophagogastroduodenoscopy High-frequency intraluminal ultrasound Rebleeding Type 1 gastric varices

Polyelectrolyte complex micelles by self-assembly of polypeptide-based triblock copolymer for doxorubicin delivery

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Asian Journal of Pharmaceutical Sciences 2014年第4期9卷 191-198页

作者： jeong hwan kim Thiruganesh Ramasamy Tuan Hiep Tran Ju Yeon Choi Hyuk Jun Cho Chul Soon Yong Jong Oh kim College of Pharmacy Yeungnam University214-1Dae-DongGyongsan 712-749South Korea

Polyelectrolyte complex micelles were prepared by self-assembly of polypeptide-based triblock copolymer as a new drug carrier for cancer *** triblock copolymer,poly(L-aspartic acid)-b-poly(ethylene glycol)-b-poly(L-aspartic acid)(PLD-b-PEG-b-PLD),spontaneously self-assembled with doxorubicin(DOX)via electrostatic interactions to form spherical micelles with a particle size of 60e80 nm(triblock ionomer complexes micelles,TBIC micelles).These micelles exhibited a high loading capacity of 70%(w/w)at a drug/polymer ratio of 0.5 at pH *** showed pH-responsive release patterns,with higher release at acidic pH than at physiological ***,DOX-loaded TBIC micelles exerted less cytotoxicity than free DOX in the A-549 human lung cancer cell *** microscopy in A-549 cells indicated that DOX-loaded TBIC micelles were transported into lysosomes via *** micelles possessed favorable pharmacokinetic characteristics and showed sustained DOX release in ***,these findings indicate that PLDb-PEG-b-PLD polypeptide micelles are a promising approach for anti-cancer drug delivery.

关键词： Polyelectrolyte Micelles Drug delivery Poly(L-aspartic acid) Poly(ethylene glycol)

Efficacy and safety of rebamipide/nizatidine in patients with erosive gastritis: A randomized, multicenter, phase 4 study

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World Journal of Gastroenterology 2024年第48期30卷 5152-5161页

作者： Donghoon Kang Myung-Gyu Choi Ki-Nam Shim Hye-Kyung Jung Seung-Joo Nam Jung Ho Park Sang Gyun kim Nam-Hoon kim Su Jin Hong Tae Joo Jeon Jae Il Chung Hang Lak Lee Ju Yup Lee Tae Oh kim Chang Min Lee Sun Moon kim jeong-hwan kim Jang Eon kim jeong Seop Moon Ho Dong kim Wan-Sik Lee Hong Jun Park Department of Internal Medicine Seoul St.Mary’s HospitalThe Catholic University of KoreaSeoul 06591South Korea Department of Internal Medicine Ewha Womans University Seoul HospitalGastroenterology and Hepatology CenterSeoul 07985South Korea Department of Internal Medicine Ewha Womans University Mokdong HospitalSeoul 07985South Korea Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289South Korea Department of Medicine Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181South Korea Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul 03080South Korea Department of Internal Medicine Ilsan Paik HospitalInje University College of MedicineGoyang 10380South Korea Department of Internal Medicine Digestive Disease CenterSoonchunhyang University Bucheon HospitalBucheon 31538South Korea Department of Internal Medicine Inje University College of MedicineSanggye Paik HospitalSeoul 01757South Korea Department of Gastroenterology Sahmyook Medical CenterSeoul 02500South Korea Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Internal Medicine Inje University Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea Department of Internal Medicine Gyeongsang National University School of MedicineGyeongsang National University HospitalJinju 52727South Korea Department of Internal Medicine Konyang University HospitalDaejeon 35365South Korea Gastroenterology Center Konkuk University Medical CenterSeoul 05030South Korea Department of Gastroenterology Seoul Medical CenterSeoul 02053South Korea Department of Gastroenterology Inje University Busan Paik HospitalBusan 47392South Korea Department of Gastroenterology St.Carollo HospitalSooncheon 57931South Korea Division of Gastroenterology Department of Internal

BACKGROUND For the treatment of gastritis,rebamipide,a mucoprotective agent,and nizatidine,a gastric acid suppressant,are commonly employed *** To compare the efficacy of Mucotra®SR(rebamipide 150 mg)and Axid®(nizatidine 150 mg)combination therapy with the sole administration of Axid®in managing erosive *** A total of 260 patients diagnosed with endoscopically confirmed erosive gastritis were enrolled in this open-label,multicenter,randomized,phase 4 clinical trial,allocating them into two groups:Rebamipide/nizatidine combination twice daily vs nizatidine twice daily for 2 *** full-analysis set analysis encompassed 239 patients(rebamipide/nizatidine,n=121;nizatidine,n=118),while the per-protocol analysis included 218 patients(n=110 vs 108).Post-treatment assessments comprised primary(erosion improvement rate)and secondary(erosion and edema cure rates,erythema improvement rates,hemorrhage,and gastrointestinal symptoms)***,drug-related adverse effects were *** Primary efficacy assessment showed a statistically significant improvement rate in mucosal erosions in the combination group compared to the control group in the full-analysis set(rebamipide/nizatidine 62.0%,nizatidine 49.2%,P=0.046),with a similar trend noted in the per-protocol analysis(62.7%vs 50.0%,P=0.058).Both groups were effective in curing erosion and edema and improvement of bleeding,erythema,and gastrointestinal symptoms,whereas no inter-group differences were *** confined to the participants with gastritis symptoms,improvement of erosion was more optimal in the combination group(63.0%vs 49.5%,P=0.046).No adverse events related to the drugs were *** Rebamipide/nizatidine combination is effective in treatment of erosive gastritis.

关键词： Gastritis Erosive gastritis Combination therapy Rebamipide Nizatidine

Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy

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World Journal of Gastroenterology 2008年第12期14卷 1903-1907页

作者： jeong hwan kim Sun-Young Lee Byung Kook kim Won Hyeok Choe So Young Kwon In-Kyung Sung Hyung-Seok Park Choon-Jo Jin Department of Internal Medicine Konkuk University School of Medicine Seoul 143-729 Korea

AIM: To examine the characteristics of colonic polyps, where it is difficult to distinguish adenomatous polyps from hyperplastic polyps, with the aid of acetic acid chromoendoscopy. METHODS: Acetic acid spray was applied to colonic polyps smaller than 10 mm before complete excision. Endoscopic images were taken before and 15-30 s after the acetic acid spray. Both pre-and post-sprayed images were shown to 16 examiners, who were asked to interpret the lesions as either hyperplastic or adenomatous polyps. Regression analysis was performed to determine which factors were most likely related to diagnostic accuracy. RESULTS: In 50 cases tested by the 16 examiners, the overall accuracy was 62.4% (499/800). Regression analysis demonstrated that surrounding colonic mucosa was the only factor that was significantly related to accuracy in discriminating adenomatous from hyperplastic polyps (P < 0.001). Accuracy was higher for polyps with linear surrounding colonic mucosa than for those with nodular surrounding colonic mucosa (P < 0.001), but was not related to the shape, location, or size of the polyp. CONCLUSION: The accuracy of predicting histology is significantly related to the pattern of colonic mucosa surrounding the polyp. Making a histological diagnosis of colon polyps merely by acetic acid spray is helpful for colon polyps with linear, regularly patterned surrounding colonic mucosa, and less so for those with nodular, irregularly patterned surrounding colonic mucosa.

关键词： Colon polyp Chromoendoscopy Acetic acid

Change in renal function after sodium phosphate preparation for screening colonoscopy

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World Journal of Gastroenterology 2010年第16期16卷 2010-2016页

作者： Dong Choon Seol Sung Noh Hong jeong hwan kim In Kyung Sung Hyung Seok Park Jung Hyun Lee Chan Sup Shim Department of Internal Medicine Konkuk University School of Medicine Department of Health Promotion Healthcare CenterKonkuk University Medical Center Healthcare Center Konkuk University Medical CenterDepartment of Internal MedicineKonkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology Department of Internal Medicine Konkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology

AIM:To investigate the changes in renal function at 12-24 mo in patients following sodium phosphate(NaP) preparation for screening ***:We carried out a retrospective study on the results from patients who received health check-up services as part of an employer-provided wellness program performed between August 2006 and May 2008 and who were followed up for 12-24 *** to screening colonoscopy,224 patients underwent bowel cleansing with NaP(NaP group) and 113 patients with polyethylene glycol(PEG group).The control group comprised 672 age-matched *** compared the changes in the creatinine levels and the glomerular filtration rates(GFRs) from baseline to 12-24 mo between the NaP,PEG,and control groups using two-way repeated measured analysis of *** addition,multivariate linear regression analysis was performed to assess the risk factors for a decreased ***:The baseline mean serum creatinine level in the NaP,PEG,and control groups was 1.12 ± 0.15,1.12 ± 0.16,and 1.12 ± 0.15 mg/dL,which increased to 1.15 ± 0.15,1.15 ± 0.18,and 1.15 ± 0.15 mg/dL,respectively,after 12-24 *** baseline mean GFR in the NaP,PEG,and control groups was 69.0 ± 7.7,68.9 ± 8.0,and 69.6 ± 6.7 mL/min per 1.73 m2,which decreased to 66.5 ± 7.8,66.5 ± 8.3,and 67.4 ± 6.4 mL/min per 1.73 m2,respectively,after 12-24 *** changes in serum creatinine levels and GFRs were not significantly between the NaP,PEG,and control groups(P = 0.992 and P = 0.233,respectively).Using multivariate linear regression analysis,only the baseline GFR was associated with the change in GFR(P < 0.001).Indeed,the bowel preparations were not associated with the change in GFR(P = 0.297).CONCLUSION:NaP bowel preparation in subjects with normal renal function was not associated with renal injury,and NaP can thus be used safely for screening colonoscopy.

关键词： Sodium phosphate Polyethylene glycol Purgatives Colonoscopy Creatinine Glomerular filtration rate

Diabetic factors associated with gastrointestinal symptoms in patients with type 2 diabetes

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World Journal of Gastroenterology 2010年第14期16卷 1782-1787页

作者： jeong hwan kim Hyung Seok Park Soon Young Ko Sung Noh Hong In-Kyung Sung Chan Sub Shim Kee-Ho Song Dong-Lim kim Sook Kyung kim Jeeyoung Oh Department of Internal Medicine Digestive Disease Center Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Medical Immunology Center Institute of Biomedical Science and Technology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Internal Medicine Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Neurology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea

AIM: To determine whether gastrointestinal (GI) symptoms are more frequent in type 2 diabetic patients and to examine which diabetic factors are associated with the symptoms. METHODS: Consecutive subjects with diabetes and age-/gender-matched normal controls were recruited for this study. GI symptoms were assessed using a structured questionnaire divided into two GI symptomcategories (upper and lower GI symptoms), and consisting of 11 individual symptoms. In the diabetic patient group, diabetic complications including peripheral neuropathy, nephropathy and retinopathy, glycosylated hemoglobin (HbA1c) level and diabetes duration were evaluated. RESULTS: Among the total 190 diabetic patients and 190 controls enrolled, 137 (72%) of the diabetic patients and 116 (62%) of the controls had GI symptoms. In the diabetic patient group, 83 (43%) had upper GI symptoms and 110 (58%) lower GI symptoms; in the control group, 59 (31%) had upper GI symptoms and 104 (55%) lower GI symptoms. This difference between the two groups was significant for only the upper GI symptoms (P = 0.02). Among the diabetic factors, the HbA1c level was the only independent risk factor for upper GI symptoms in the multiple logistic regression analysis (odds ratio = 2.01, 95% confidence interval: 1.02-3.95). CONCLUSION: Type 2 diabetes was associated with an increased prevalence of upper GI symptoms and these symptoms appeared to be independently linked to poor glycemic control, as measured by the HbA1c levels.

关键词： Diabetes HbA1c Upper gastrointestinal symptoms

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韩国和顺煤田淳昌剪切带的构造特征

世界地质 1993年第3期12卷 29-39页

作者： jeong hwan kim Weon Seo Kee 金伯录

沿着和顺煤田东部边界分布的淳昌剪切带持有N—S至NE—SW走向的不连续性韧性剪切带,局部地段尚可表现出一些连续性韧性剪切带的特征。在前寒武纪花岗质片麻岩区内发育着宽数米至700m不等的糜棱岩带,具有低侧伏角的拉伸线理和高角度糜棱... 详细信息

沿着和顺煤田东部边界分布的淳昌剪切带持有N—S至NE—SW走向的不连续性韧性剪切带,局部地段尚可表现出一些连续性韧性剪切带的特征。在前寒武纪花岗质片麻岩区内发育着宽数米至700m不等的糜棱岩带,具有低侧伏角的拉伸线理和高角度糜棱岩叶理构造。基底岩中糜棱岩带剪切位移量推算为3km以上。由于二轴性应变作用,使剪切带中发生强烈的非均质性多相变形,并伴随叶理构造,它具有渐发性弯曲及各种非对称微细构造。其错动方向属右型运动,从应变分析获知,剪切带有限应变为简单剪切加上较弱的纯剪切和伴随体积减少的渐进应变过程累积形成。推测韧性剪切作用是在绿片岩相变质条件下于三叠纪末至侏罗纪中期发生的。

关键词：煤田和顺煤田淳昌剪切带剪切带

Does the antibody production ability affect the serum anti-Helicobacter pylori Ig G titer?

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World Journal of Gastrointestinal Pathophysiology 2016年第3期7卷 288-295页

作者： Hyun Ah Chung Sun-Young Lee Hee Won Moon jeong hwan kim In-Kyung Sung Hyung Seok Park Chan Sup Shim Hye Seung Han Department of Internal Medicine Konkuk University School of Medicine Department of Laboratory Medicine Konkuk University School of Medicine Department of Pathology Konkuk University School of Medicine

AIM: To investigate the relationship between serum titers of anti-Helicobacter pylori(***) immunoglobulin G(IgG) and hepatitis B virus surface antibody(HBsA b).METHODS: Korean adults were included whose samples had positive Giemsa staining on endoscopic biopsy and were studied in the hepatitis B virus surface antigen(HBsA g)/HBsA b serologic assay,pepsinogen(PG) assay,and *** serologic test on the same *** were excluded if they were positive for HBs Ag,had a recent history of medication,or had other medical condition(s).We analyzed the effects of the following factors on serum titers of HBsA b and the *** IgG : Age,density of *** infiltration in biopsy samples,serum concentrations of PG Ⅰ and PG Ⅱ,PG Ⅰ/Ⅱ ratio,and white blood cell ***: Of 111 included subjects,74(66.7%) exhibited a positive HBsA b *** serum *** IgG titer did not correlate with the serum HBsA b titer(P = 0.185); however,it correlated with the degree of *** infiltration on gastric biopsy(P < 0.001) and serum PG Ⅱ concentration(P = 0.042).According to the density of *** infiltration on gastric biopsy,subjects could be subdivided into those with a marked(median: 3.95,range 0.82-4.00)(P = 0.458),moderate(median: 3.37,range 1.86-4.00),and mild *** infiltrations(median: 2.39,range 0.36-4.00)(P < 0.001).Subjects with a marked *** infiltration on gastric biopsy had the highest serological titer,whereas in subjects with moderate and mild *** infiltrations titers were correspondingly lower(P < 0.001).After the successful eradication,significant decreases of the degree of *** infiltration(P < 0.001),serum *** IgG titer(P < 0.001),and serum concentrations of PG I(P = 0.028) and PG Ⅱ(P = 0.028) were ***: The *** IgG assay can be used to estimate the burden of bacteria in immunocompetent hosts with *** infection,regardless of the HBsA b titer after HBV vaccination.

关键词： Antibody Helicobacter pylori Hepatitis B Immunoglobulin G Pepsinogen