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Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： Hyun-Kyung so Hyebeen Kim Jinwoo Lee Chang-Lim You Chae-eun Yun Hyeon-Ju jeong eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Dise.s.s AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle.s.em cell function and muscle *** the current study,we.s.t out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative.s.re.s.and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stre.s.response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

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sleep-based neuronal oscillations as a physiological biomarker for Alzheimer's dise.s.:is night time the right time?

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Neural Regeneration Research 2024年第7期19卷 1417-1418页

作者： Jonathan Witton erica s.Brady Michael T.Craig Department of Clinical and Biomedical sciences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Gladstone Institute for Neurological Dise.s. San FranciscoCAUSA school of Psychology and Neuroscience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dementia is a devastating syndrome characterized by memory proble.s.confusion,and behavior changes that prevent people from performing everyday *** is the leading cause of dependency and disability amongst older people,resulting in a global economic cost of ~$1.3 *** 58 million people are currently afflicted by dementia worldwide,with Alzheimer s dise.s.(AD) causing most(60-70%) of these cases.

关键词： Alzheimer everyday performing

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enhancing high-temperature oxidation resistance(at 1000 °C) of nickel superalloy obtained by laser powder bed fusion via reactive electric spark treatment

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Transactions of Nonferrous Metals society of China 2024年

作者： s.K.MUKANOV M.I.PeTRZHIK A.e.KUDRYAsHOV e.A.NAUMOVA F.A.BAsKOV P.A.LOGINOV e.A.LeVAsHOV National Unive.s.ty of science and Technology MIsIs

The high-temperature oxidation resistance of the nickel superalloy grown by the Laser Powder Bed Fusion (LPBF) has been significantly incre.s.d as a result of in-situ formation of a thermal barrier layer (α-Al2O3+ CaMoO4) during oxidative annealing of surface laye.s.modified by electric spark treatment (esT). The reactive esT of the LPBF-built ite.s.based on nickel eP741NP alloy was carried out with low-melting Al-12%si， Al-6%Ca-0.6%si and Al-7%Ca-1%Mn electrodes. It was found that at esT done by Al-7%Ca-1%Mn electrode an intermetallic (β-NiAl + γ’-Ni3Al) 15 microns thick layer reinforced by spherical oxide (CaMe)O nanoparticles was formed. Formation of that structure incre.s.s the wear resistance of LPBF nickel superalloy by 4.5 times. Further oxidative annealing at 1000 °C lead to a formation of continuous two-layered coating with an inner layer of α-Al2O3and an outer layer of CaMoO4， which together act as an effective barrier preventing the diffusion of oxygen into the volume of the.s.peralloy.

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Mast cell activation syndrome:An up-to-date review of literature

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World Journal of Clinical Pediatrics 2024年第2期13卷 104-113页

作者： ÖnerÖzdemir Gökçe Kasımoğlu Ayşegül Bak Hüseyin sütlüoğlu süreyya savaşan Department of Pediatric Allergy and Immunology Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Kocaeli City HospitalKocaeli 50123Türkiye Department of Pediatrics Children’s Hospital of MichiganHematology/OncologyCentral Michigan University College of MedicineMount PleasantMI 48859United States Barbara Ann Karmanos Cancer Institute Wayne State UniversityDetroitMI 12345United States

Mast cells are a subtype of white blood cells and are involved in the immune *** cells contain many chemical substances called mediators,which are involved in the allergic *** fact that mast cells play a role in many events that require urgent intervention,especially anaphylaxis,has led to a more detailed study of these *** dise.s.s also caused by dysfunctions of mast cells have been examined in many *** instance,mast cell activation syndrome is known as an augmented number of cells due to decre.s.d cell death,resulting in clinical symptoms affecting many *** main common symptoms include flushing,hypote.s.on,urticaria,angioedema,headache,vomiting and *** the underlying mechanism is not yet clearly known,we aim to review the literature in a broad pe.s.ective and bring together the existing knowledge in the light of the literature due to the dive.s.ty of its involvement in the body and the fact that it is a little known syndrome.

关键词： Mast cell Mast cell activation syndrome Tryptase Histamine

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effect of eu3+,Bi3+,and Li+ doping on luminescent property of GdNbO4

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Journal of Rare earths 2024年第1期42卷 66-75页

作者： s.W.Wi Y.s.Lee Department of Physics and Integrative Institute of Basic sciences Soongsil University

We investigated the emission properties of eu3+-doped GdNbO4-based oxide phosphors,aiming at improving the eu3+emission by codoping of Bi3+and Li+.eu3+singly doped,eu3+and Bi3+doubly doped,and eu3+,Bi3+,and Li+triply doped GdNbO4were prepared using a high-temperature.s.lid-state reaction *** red-orange emissions from eu3+in the.s.ngly doped samples are.s.gnificantly improved by the codoping of Bi3+,mainly due to the energy transfer from Bi3+to eu3+.The additional codoping of Li+is found to incre.s. the eu3+emission *** improvement might be attributed to the incre.s. in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence.s.ectra show that the local lattice environment around eu3+in GdNbO4does not change.s.gnificantly with the codoping of Bi3+and Li+.Our results indicate that Li+doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO4phosphors.

关键词： eu 3+ GdNbO 4 Codoping of Li + Photoluminescence se.s.tizer Rare earths

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Antibacterial HA-coatings on bioresorbable Mg alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1965-1985页

作者： K.V.Nadaraia D.V.Mashtalyar M.A.Piatkova A.I.Pleshkova I.M.Imshine.s.iy M.s.Gerasimenko e.A.Belov V.V.Kumeiko D.N.Kozyrev K.A.Fomenko V.V.Mostovaya B.R.Torpanov A.R.Biktimirov I.s.Osmushko s.L.sinebryukhov s.V.Gnedenkov Institute of Chemistry FeB RAs 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far e.s.ern Federal Unive.s.ty 10 Ajax BayRussky IslandVladivostok 690922Russia A.V.Zhirmunsky National scientific Center of Marine Biology FeB RAs 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical Dermatovenerological Dispe.s.ry 18 V St.GamarnikaVladivostok 690033Russia NMIC“Treatment and Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this study,a calcium-phosphate coating was formed on a Mg-Mn-Ce alloy by the plasma electrolytic oxidation(PeO).The antibiotic vancomycin,widely used in the treatment of infections caused by staphylococcus aure.s.***),was impregnated into the *** with vancomycin showed high bactericidal activity against *** mechanical and electrochemical properties of the formed coatings were.s.udied,as well as in vitro cytotoxicity tests and in vivo tests on mature male rats were *** to seM,e.s.XRD and XPs data,coatings had a developed morphology and contained hydroxyapatite,which indicates high *** analysis of roughne.s.of coatings without and with vancomycin did not reveal any differences,confirming the high roughne.s.of the *** electrochemical tests,an incre.s. in corrosion resistance by more than two times after the application of PeO coatings was *** to the results of an in vivo study,after 28 days of the implantation of samples with calcium phosphate PeO coating and vancomycin,no signs of inflammation were observed,while an inflammatory reaction developed in the area of implantation of bare alloy,followed by *** rele.s. tests from the coatings show a sharp decre.s. in the concentration of the rele.s.d antibiotic on day 7 and then a gradual decre.s. until day *** the experiment,no significant deviations in the condition and behavior of the animals were observed;clinical tests did not reveal a systemic toxic reaction.

关键词： Bioactive coatings Biocompatibility Mg alloy Plasma electrolytic oxidation Hydroxyapatite Vancomycin

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Prevalence of nonalcoholic fatty liver dise.s. in pediatrics and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第6期20卷 569-580页

作者： eun Joo Lee Miyoung Choi sang Bong Ahn jeong-Ju Yoo seong Hee Kang Yuri Cho Do seon song Hong Koh Dae Won Jeon Hye Won Lee Department of Pediatrics Yonsei University College of MedicineSeoulKorea Clinical evidence Research National Evidence-Based Healthcare Collaborating Agency(NECA)SeoulKorea Department of Internal Medicine Nowon Eulji Medical CenterEulji University College of MedicineSeoulKorea Department of Internal Medicine Soonchunhyang University Bucheon HospitalBucheonKorea Department of Internal Medicine Sangkye Paek HospitalInje University College of MedicineSeoulKorea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangKorea Department of Internal Medicine College of MedicineSt.Vincent's HospitalThe Catholic University of KoreaSuwonKorea Department of Internal Medicine Hanyang University College of MedicineSeoulKorea Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background As childhood obesity escalates worldwide,the prevalence of nonalcoholic fatty liver dise.s.(NAFLD)in pediatric and adolescent populations is also ***,systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain *** The MeDLINe,Korean Medical Database(KMBAse),embase,Global Health,and Cochrane Library databases were.s.arched from January 1997 to April *** terms included NAFLD or steatosis;nonalcoholic or steatohepatitis;child(ren),adolescent,or teenager;and prevalence,incidence,or epidemiology.A random-effects meta-analysis model was used to estimate the prevalence of pediatric *** A total of 2116 publications were found,of which 62 were included in the *** them,27 reported the prevalence in the general population and 39 in the obese *** worldwide pooled prevalence of pediatric NAFLD was 13%[95%confidence interval(CI)9-18%]in the general population and 47%(95%CI 41%–53%)in the obese *** 16 studies in the general population and 18 in the obese population,NAFLD prevalence varied by *** the general population,the prevalence of NAFLD was 15%(95%CI 8%–23%)in males and 10%(95%CI 6%–15%)in *** the obese population,it was 54%(95%CI 46%–61%)in males and 39%(95%CI 30%–49%)in *** The global prevalence of pediatric NAFLD is rising in both the general and obese *** the incre.s.ng rates of childhood obesity,epidemiological studies on the prevalence and incidence of NAFLD are needed.

关键词： Meta-analysis Nonalcoholic fatty liver dise.s. Pediatric Prevalence

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First evidence for chiral wobbling of triaxial nuclei

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Nuclear science and Techniques 2024年第7期35卷 4-7页

作者： s.Frauendorf Department of Physics and Astronomy University of Notre DameNotre DameIN 46556USA

Chirality(Greek“handine.s.)is a property of many com-plex *** molecules exist in two forms,one being the mirror image of the *** for our hands,it is impossible to make the images identical by a suitable *** two forms are called left-handed and *** have the.s.me binding energy,because the electro-magnetic interaction,which holds the molecule together,does not change under a *** properties that are inse.s.tive to the geometry are also the *** different geometry is the re.s.n why the left-handed form turns the polarization plane of transmitted light in one direction by some angle while the right-handed form turns it in the oppo-site direction by the.s.me ***,the geometrical differences between the two species may have other *** two species of the carvon molecule.s.own in Fig.1 taste quite differently.

关键词： turns Chiral mirror

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Tribological behavior of lubricant-impregnated porous polyimide

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Friction 2024年第4期12卷 711-725页

作者： Jinbang LI Ningning ZHOU Janet s.s.WONG school of Mechanical engineering and Mechanics Ningbo UniversityNingbo 315211China Beijing Key Laboratory of Long-life Technology of Precise Rotation and Transmission Mechanisms Beijing Institute of Control EngineeringBeijing 100029China Department of Mechanical engineering Imperial College LondonLondon SW72AZUK

Porous materials impregnated with lubricants can be used in conditions where limited lubricant is *** this work,three porous polyimides(PPI)with different de.s.ties were ***(PAO)impregnated PPI(iPPI)discs were rubbed against steel and sapphire *** operando observations of the iPPI-sapphire contacts show that oil is rele.s.d under an applied load,forming a meniscus around *** at the outlet is created at high sliding *** amount of rele.s.d oil incre.s.s with incre.s.ng PPI *** moduli,e*,estimated based on the actual contact size.s.ow that trapped oil in iPPIs contributes to load *** higher spee.s.tribological rehydration of the contact occurs in low de.s.ty iPPI,with that e*rises with *** high de.s.ty PPIs,high spee.s.give a constantly high e*which is limited by the viscoelastic properties of the PPI network and possibly the rate of oil *** of iPPI-steel contacts is governed by the mechanical properties of the PPI,the flow of the lubricant,and the roughne.s.of the PPI *** low-and medium-de.s.ty(highly porous,high roughne.s.PPIs,large amount of oil is rele.s.d,and lubrication is mainly via lubricant restricted in the contact in the pores and possibly tribological *** high de.s.ty(low porosity)PPI,with lower roughne.s.hydrodynamic lubrication is achieved which gives the lowest *** results show that polymeric porous materials for effective lubrication require the optimization of its surface roughne.s.stiffne.s.oil flow,and oil retentions.

关键词： polyimide porous material friction mechanism polymer limited lubrication

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Machine Learning and Deep Learning for smart Urban Transportation syste.s.with GPs， GIs， and Advanced Analytics: A Comprehe.s.ve Analysis

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Journal of Harbin Institute of Technology(New series) 2024年

作者： e. Kalaivanan s.Brindha Department of Computer science and Applications st.Pete.s.Institute of Higher education And Research

As urbanization continues to accelerate， the challenges associated with managing transportation in metropolitan are.s.become incre.s.ngly complex. The.s.rge in population de.s.ty contributes to traffic congestion， impacting travel experiences and posing safety risks. smart urban transportation management emerges as a strategic solution， conceptualized here as a multidime.s.onal big data problem. The.s.cce.s.of this strategy hinges on the effective collection of information from dive.s.， exte.s.ve， and heterogeneous data sources， nece.s.tating the implementation of full-stack Information and Communication Technology (ICT) solutions. The main idea of the work is to investigate the current technologies of ITs and enhance the.s.fety of urban transportation syste.s. Machine learning mode.s. trained on historical data， can predict traffic congestion， allowing for the implementation of preventive me.s.res. Deep learning architectures， with their ability to handle complex data representations， further refine traffic predictions， contributing to more accurate and dynamic transportation management. The background of this research unde.s.ores the challenges posed by traffic congestion in metropolitan are.s.and emphasizes the need for advanced technological solutions. By integrating GPs and GIs technologies with machine learning algorithms， this work aims to pay attention to the development of intelligent transportation syste.s.that not only addre.s.current challenges but also pave the way for future advancements in urban transportation management.

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