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Transjugular intrahepatic portosystemic shunt vs conservative treatment for recurrent ascites:A propensity score matched comparison

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World Journal of Gastroenterology 2022年第41期28卷 5944-5956页

作者： Martin Philipp Theresia Blattmann Jörn Bienert kristian Fischer Luisa Hausberg jens-christian kröger Thomas Heller Marc-AndréWeber Georg Lamprecht Department of Medicine Division of Gastroenterology and EndocrinologyRostock University Medical CenterRostock 18057Germany Institute of Diagnostic and Interventional Radiology Pediatric Radiology and NeuroradiologyRostock University Medical CentreRostock 18057Germany

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS) placement is an effective intervention for recurrent tense ascites. Some studies show an increased risk of acute on chronic liver failure(ACLF) associated with TIPS placement. It is not clear whether ACLF in this context is a consequence of TIPS or of the pre-existing liver *** To better understand the risks of TIPS in this challenging setting and to compare them with those of conservative *** Two hundred and fourteen patients undergoing their first TIPS placement for recurrent tense ascites at our tertiary-care center between 2007 and 2017 were identified(TIPS group). Three hundred and ninety-eight patients of the same time interval with liver cirrhosis and recurrent tense ascites not undergoing TIPS placement(No TIPS group) were analyzed as a control group. TIPS indication,diagnosis of recurrent ascites, further diagnoses and clinical findings were obtained from a database search and patient records. The in-hospital mortality and ACLF incidence of both groups were compared using 1:1 propensity score matching and multivariate logistic *** After propensity score matching, the TIPS and No TIPS groups were comparable in terms of laboratory values and ACLF incidence at hospital admission. There was no detectable difference in mortality(TIPS: 11/214, No TIPS 13/214). During the hospital stay, ACLF occurred more frequently in the TIPS group than in the No TIPS group(TIPS: 70/214, No TIPS: 57/214, P = 0.04). This effect was confined to patients with severely impaired liver function at hospital admission as indicated by a significant interaction term of Child score and TIPS placement in multivariate logistic regression. The TIPS group had a lower ACLF incidence at Child scores < 8 points and a higher ACLF incidence at ≥ 11 points. No significant difference was found between groups in patients with Child scores of 8 to 10 *** TIPS placement for recurrent tense as

关键词： Liver cirrhosis Ascites Transjugular intrahepatic portosystemic shunt Acute on chronic liver failure Mortality Propensity score

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Automatic route planning for GPS art generation

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Computational Visual Media 2019年第3期5卷 303-310页

作者： Andre Waschk jens krüger University of Duisburg-Essen

In this paper, we present a novel approach to automated route generation of global positioning system(GPS) artwork. The term GPS artwork describes the generation of drawings by leaving virtual traces on digital maps. Until now, the creation of these images has required a manual planning phase in which an artist designs the route by hand. Once the route for this artwork has been planned, GPS devices have been used to track the movement. Using our solution, the lengthy planning phase can be significantly shortened,thereby opening art creation to a broader public.

关键词： GPS art walking routing shape detection navigation

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Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

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Experimental investigations of a full model with adaptive elasto-flexible membrane wings

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Chinese Journal of Aeronautics 2021年第7期34卷 211-218页

作者： Jonathan PFLU ger christian BREITSAMTER Chair of Aerodynamics and Fluid Mechanics Technical University of MunichGarching 85748Germany

The morphing wing concept aims to constantly adapt the aerodynamics to different flight *** wing is able to adapt to different flight conditions by an adjustable Aspect Ratio(AR)and sweep.A high AR configuration provides high aerodynamic efficiency,while a low AR configuration,with highly swept wings offers a good ***,the flexible membrane allows the wing surface to stretch and contract in-plane as well as the airfoil to adapt to different aerodynamic *** the context of this work,the aerodynamic characteristics of a full model with form-adaptive elasto-flexible membrane wings are investigated *** focus is on the high-lift regime and on the analysis of the aerodynamic coefficients as well as their ***,the lateral aerodynamic derivatives at asymmetric wing positions are of interest.

关键词： Experimental aerodynamics Flexible wing surface Force and moment measurements Morphing wing Particle image velocimetry

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Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber krebs Steffen Kautzmann christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

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IRFs as competing pioneers in T-cell differentiation

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Cellular & Molecular Immunology 2017年第8期14卷 649-651页

作者： Andrea kröger Institute for Medical Microbiology Molecular MicrobiologyOtto-von-Guericke University of MagdeburgMagdeburg D-39120Germany

CD4-expressing T lymphocytes are among of the best-characterized immune system cells.1 They develop in the thymus and acquire the potential to differentiate into distinct *** leaving the thymus,T helper cells further ... 详细信息

关键词： lymphocytes expressing pioneer

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Gust response of an elasto-flexible morphing wing using fluid–structure interaction simulations

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Chinese Journal of Aeronautics 2024年第2期37卷 45-57页

作者： Jonathan PFLÜger christian BREITSAMTER Department of Mechanical Engineering Technical University of MunichGarching 85748Germany

Small and micro unmanned aircraft are the focus of scientific interest due to their wide range of *** often operate in a highly unstable flight environment where the application of new morphing wing technologies offers the opportunity to improve flight *** investigated concept comprises port and starboard adjustable wings,and an adaptive elastoflexible membrane serves as the lifting *** focus is on the benefits of the deforming membrane during the impact of a one-minus-cosine type *** a low Reynolds number of Re=264000,the morphing wing model is investigated numerically by unsteady fluid-structure interaction ***,the numerical results are validated by experimental data from force and moment,flow field,and deformation ***,with the rigid wing as the baseline,the flexible case is investigated,focusing on the advantages of the elastic *** all configurations studied,the maximum amplitude of the lift coefficient under gust load shows good agreement between the experimental and numerical *** the decay of the gust,they differ more the higher the aspect ratio of the *** considering the flow field,the main differences are due to the separation behavior on the upper side of the *** flow reattaches earlier in the experiments than in the simulations,which explains the higher lift values observed in the *** at one intermediate configuration does the lift amplitude of the rigid configuration exceeds that of the flexible by about 12%,with the elastic membrane resulting in a smaller and more uniform peak load,which is also evident in the wing loading and hence in the root bending moment.

关键词： Membrane wing Morphing wing Flexible wing surface Computational fluid dynam-ics Fluid-structure interaction Unsteady inflow condition Gust response

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Add on the next level—the time point of the type I IFN response orchestrates the immune response

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Cellular & Molecular Immunology 2020年第8期17卷 791-793页

作者： Angela Wedekind David Fritzsch Andrea kröger Research Group Molecular Microbiology Institute of Microbiology and Hospital HygieneOtto von Guericke University39120MagdeburgGermany Research Group Innate Immunity and Infection Helmholtz Centre for Infection Research38124BraunschweigGermany

The directed control of an effective cellular or adaptive immune response is the aim of vaccine strategies and tumor *** antibodies prevent the spread of pathogens,while efficient cellular immunotherapy is used to overcome T-cell exhaustion and unresponsiveness toward *** such settings,the type I interferon(IFN)system mediates pleiotropic effects of the immune system that can be either immunostimulating or *** a recent work,De Giovanni et *** a novel regulatory checkpoint by which type I IFN regulates CD4^(+)T-cell *** study dissects the time point of type I IFN induction as a central regulator of the adaptive immune response that determines the balance between humoral and cellular *** findings identify an intriguing and previously undescribed checkpoint that can potentially be manipulated for ***,the authors demonstrate that CD4^(+)T-cell polarization could be influenced by manipulating the IFN response during infection.

关键词： al. vaccine interferon

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一种自动驾驶电动汽车线束布局优化方法

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同济大学学报（自然科学版） 2022年第S1期50卷 186-191页

作者： Jonas MAIER Benjamin krüger Hans-christian REUSS 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

近年来,随着汽车自动驾驶、数字化、电动化技术的不断发展,汽车的功能不断增加,车辆内部线束也随之增加。由于过多的线束导致车辆自重增加的问题日益突出。为了实现能源的高效利用和出行方式的可持续性,开发人员需要通过优化线束布置来... 详细信息

近年来,随着汽车自动驾驶、数字化、电动化技术的不断发展,汽车的功能不断增加,车辆内部线束也随之增加。由于过多的线束导致车辆自重增加的问题日益突出。为了实现能源的高效利用和出行方式的可持续性,开发人员需要通过优化线束布置来尽可能多的减轻车辆自重,同时降低成本。由于与线束相连的车辆零件位置固定,因此需要一个算法在车辆零件位置为限制条件下,优化车辆线束布局。之前的研究方法通常只考虑线束设计的部分限制因素,且没有考虑线束三维结构。在本文研究中,开发了一种新型的优化线束布局的方法,该方法考虑了与包装,温度负载以及装配难易相关的各种限制因素。该方法可以根据设计需求来控制线束布置方法,如在沿着车辆纵轴方向布置更多线束,以避免在车辆外围布置线束。通过该方法,可以高效地计算出线束长度、直径,以及精确的布线路径。

关键词：电动汽车汽车线束布线优化 Dijkstra算法

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Contribution of Fluid Dynamics to Woodwind Instruments Investigations of Timbre and Pitch of Bassoon Bocals

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Journal of Thermal Science 2005年第3期14卷 264-266页

作者： Roger GRUNDMANN Johannes BAUMGART Andreas RICHTER Hans krüger Technische Universitt Dresden Institute for Aerospace Engineering D-01062 Dresden Germany ProfessorTechnische Universitt Dresden Institute for Aerospace Engineering D-01062 Dresden GermanyTechnische Universitt Dresden Institute for Aerospace Engineering D-01062 Dresden GermanyTechnische Universit?t Dresden Institute for Aerospace Engineering D-01062 Dresden Germany

The discussed topic of isolating certain parameters which describe the timbre in connection with bocals of bassoons is of major interest for manufacturers and artist likewise since a reduction in the overall shear stress of these kinds of technical diffusors is very helpful but not sufficient. The timbre seen from the side of the musician has to be the same. Up to now two criteria have been isolated which have a deep influence on the easier blowing of the bassoon and on the comparable timbre due to geometrical reasons. If the geometrical outer contour is designed carefully, it is possible to modify the shape and preserve the timbre.

关键词： musical instrument bocal bassoon timbre principal component analysis

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