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Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice

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Neural Regeneration Research 2017年第4期12卷 588-595页

作者： Teresa Neri-Gomez Judith Espinosa-Raya Sofia Diaz Cintra Julia Segura-Uribe Sandra Orozco-Suarez Juan Manuel Gallardo christian Guerra-Araiza Unidad de Investigación Médica en Farmacología Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México Laboratorio de Farmacología Conductual Escuela Superior de Medicina Instituto Politécnico Nacional Plan de San Luis y Díaz Mirón Col. Sto. Tomás Ciudad de México México Departamento de Neurobiología del Desarrollo y Neurofisiología Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Querétaro México enfermedades Neurológicas (Neurological Diseases) Hospital de Especialidades Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México enfermedades Nefrológicas (Kidney Diseases) Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de Mexico Mexico

Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles （NFTs）; these hormones can regulate Tau phosphorylation and the principal kinase GSK3β involved in this process. Hormone replacement therapy decreases NFTs, but it increases the risk of some types of cancer. However, other synthetic hormones such as tibolone （TIB） have been used for hormone replacement therapy. The aim of this work was to evaluate the long-term effects of TIB （0.01 mg/kg and 1mg/kg, intragastrically for 12 weeks） on the content of total and hyperphosphorylated Tau （PHF-1） proteins and the regulation of GSK3β/Akt/PI3K pathway and CDK5/p35/p25 complexes in the hippocampus of aged male mice. We observed that the content of PHF-1 decreased with TIB administration. In contrast, no changes were observed in the active form of GSK3β or PI3K. TIB decreased the expression of the total and phosphorylated form of Akt while increased that of p110 and p85. The content of CDK5 was differentially modified with TIB： it was increased at low doses and decreased at high doses. When we analyzed the content of CDK5 activators, an increase was found on p35; however, the content of p25 decreased with administration of low dose of TIB. Our results suggest a possible mechanism of action of TIB in the hippocampus of aged male mice. Through the regulation of Tau and GSK3β/Akt/PI3K pathway, and CDK5/p35/p25 complexes, TIB may modulate neuronal plasticity and regulate learning and memory processes.

关键词： nerve regeneration Tibolone hippocampus aged mice sex steroids Akt GSK3β PI3K neuralplasticity Tau neurofibrillary tangles neural regeneration

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Eclats de vert

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中国与非洲（法文版） 2024年第6期16卷 32-33页

作者： DR christian SEKOMO BIRAME directeur général de l'Agence nationale de recherche et de développement industriels au Rwanda

Au fil des années,le continent africain a importédes véhicules d'occasionàessence et au diesel,souventâgés de plus de 10 *** véhiculesémettent du dioxyde de carbone,un gazàeffet de serre(GES)majeur responsable du changement *** Rwanda,le transport routier represente 13% desémissions de GES du pays,selon I'Autoritéde gestion environnementale du *** tant que continent en développement,I'Afrique continue de polluer l'air,en partie à cause de l'importation de voitures d'occasion en provenance des pays développés.

关键词： des continent les

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The nucleolus as a genomic safe harbor for strong gene expression in Nannochloropsis oceanica

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Molecular Plant 2022年第2期15卷 340-353页

作者： christian Südfeld Ana Pozo-Rodríguez Sara A.Manjavacas Díez RenéH.Wijffels Maria J.Barbosa Sarah D'Adamo Wageningen University Bioprocess EngineeringPO Box 166700 AA WageningenNetherlands Faculty of Biosciences and Aquaculture Nord University8049 BodøNorway

Microalgae are used in food and feed,and they are considered a potential feedstock for sustainably pro-duced chemicals and ***,production of microalgal-derived chemicals is not yet economically *** engineering could bridge the gap to industrial application and facilitate the production of novel products from ***,we report the discovery of a novel gene expression system in the oleaginous microalga Nannochloropsis that exploits the highly efficient transcriptional activity of RNA po-lymerase I and an internal ribosome entry site for *** identified the nucleolus as a genomic safe harbor for Pol I transcription and used it to construct transformant strains with consistently strong trans-gene *** new expression system provides an outstanding tool for genetic and metabolic en-gineering of microalgae and thus will probably make substantial contributions to microalgal research.

关键词： Nannochloropsis gene expression nucleolus RNA polymerase I IRES aIRES

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营养支持对有营养风险胃肠病患者临床结局的影响以及成本-效果比初步探讨：275例前瞻性队列研究

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中华临床营养杂志 2013年第6期21卷 333-338页

作者：王艳蒋朱明 jens Kondrup 王杨 Marie Nolan 钱家鸣于康中国医学科学院北京协和医学院北京协和医院基本外科 100730 哥本哈根大学Rigshospitalet医院临床营养室丹麦DK-1455 中国医学科学院北京协和医学院阜外心血管病医院医学统计室北京100037 Johns Hopkins大学护理学院美国21218 中国医学科学院北京协和医学院北京协和医院消化内科 100730 中国医学科学院北京协和医学院北京协和医院营养科 100730

目的研究营养支持对有营养风险的胃肠病患者的临床结局影响，并初步收集成本一效果有关信息，对成本一效果比进行初步探讨。方法本研究为前瞻性队列研究设计，采用定点连续抽样，随访记录研究对象整个住院期间的营养支持应用情况、感染... 详细信息

目的研究营养支持对有营养风险的胃肠病患者的临床结局影响，并初步收集成本一效果有关信息，对成本一效果比进行初步探讨。方法本研究为前瞻性队列研究设计，采用定点连续抽样，随访记录研究对象整个住院期间的营养支持应用情况、感染性并发症发病和治疗情况、住院天数等方面信息，并收集研究对象住院期间营养支持的直接费用、并发症的诊断和治疗费用。用多因素统计分析方法评估营养支持对感染性并发症的影响。将“无感染性并发症患者比例”作为效果指标，对肠内营养、肠外营养、肠内和肠外联合营养及无营养支持的4个队列进行成本-效果比的初步探讨。结果对有营养风险的患者，接受营养支持群体与未接受营养支持群体相比感染性并发症发病率显著降低（6．8％比19．6％，X^2=9．0，P=0．003），但住院总费用增高（P=0．0001）。肠外营养、肠内营养、肠外营养一肠内营养联合应用以及未使用营养支持队列，经多因素调整后的成本分别是5635、1212、5220和1339元，而“无感染性并发症患者比例”分别是92．3％、96．4％、91．9％和80．4％。肠外营养、肠内营养和肠外营养．肠内营养支持与无营养支持队列相比，增量成本效果比分别为36101、-794及33748元。结论对有营养风险的胃肠病患者接受营养支持有助于改善患者结局。由于本研究收集成本一效果比有关数据的范围不够，无法通过“广义估计方程”对可能影响结果的因素进行调整，其结果不符合卫生经济学的全面要求，不能直接引用。本初步结果尚需收集更多成本一效果比方面数据的临床研究来校正和补充。

关键词：营养风险营养不良(营养不足) 营养支持成本-效果比胃肠病患者增量成本-效果比

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Low-Temperature Performance of Chinese Automotive engine Oils-Status and Perspectives

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润滑油 2007年第6期22卷 53-60,64页

作者： Theodore Selby christian Neveu Alex Tsay Savant Group MidlandMichiganU.S.A. Degussa RohMax France S.A.SParisFrance Degussa China ShanghaiChina

Performance of automotive engine oils at low temperature has been extensively investigated in the last 50 *** resulting understanding of engine oil rheology has been used to devise bench tests that predict their per- formance under cold starting *** starting the engine has been essentially overcome for passenger car en- gines with fuel injection but pumpability of the engine oil has grown more *** tests(MRV TP1 and the Scanning Brookfield Technique with Gelation Index measurement)have become the measures of quality in pumpabili- ty response at low *** such they have become ASTM Methods and are included in a number of interna- tional specifications such as SAE J300 and ILSAC/API GF-1,2,3,and 4 accompanied by appropriate limits. For a number of years,the Institute of Materials(IOM) has generated a database for Asia-Pacific engine oils for IOM *** database can be used to assess and compare the performance of Chinese engine oils at low temperature to one another and to the larger world of engine oils also covered by the IOM *** IOM survey of Asia-Pacific provides a complete 36-test analysis of 300 passenger car engine oils from the region including a wide range of chemical analysis,rheological measurements and performance *** this paper we concen- trate on the low temperature analysis of the rheology of samples collected in China since 2000. The important factors affecting formulation of engine oils in China today are: *** recent inclusion of the MRV TP-1 and Scanning Brookfield Gelation Index requirements in China's National Standards for engine oil quality; *** availability of higher quality oils; *** higher treat rate of additives will require increased attention from the formulators in the selection of VI Improvers and Pour Point Depressants(PPDs). In the latter case,new PPDs are likely to be required to provide formulators with robust and economical solu- tions to face these new challen

关键词：低温条件中国汽车用油倾点

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High quality genome sequences of thirteen Hypoxylaceae(Ascomycota)strengthen the phylogenetic family backbone and enable the discovery of new taxa

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Fungal Diversity 2021年第1期106卷 7-28页

作者： Daniel Wibberg Marc Stadler Christopher Lambert Boyke Bunk Cathrin Spröer christian Rückert Jörn Kalinowski Russell JCox Eric Kuhnert Center for Biotechnology(CeBiTec) Bielefeld UniversityUniversitätsstraße 2733615 BielefeldGermany Department Microbial Drugs Helmholtz Centre for Infection Research(HZI)and German Centre for Infection Research(DZIF)Partner Site Hannover-BraunschweigInhoffenstrasse 738124 BraunschweigGermany Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures Inhoffenstraße 7B38124 BraunschweigGermany Centre of Biomolecular Drug Research(BMWZ) Institute for Organic ChemistryLeibniz University HannoverSchneiderberg 3830167 HannoverGermany

The Hypoxylaceae(Xylariales,Ascomycota)is a diverse family of mainly saprotrophic fungi,which commonly occur in angiosperm-dominated forests around the *** their importance in forest and plant ecology as well as a prolific source of secondary metabolites and enzymes,genome sequences of related taxa are scarce and usually derived from envi-ronmental *** address this lack of knowledge thirteen taxonomically well-defined representatives of the family and one member of the closely related Xylariaceae were genome sequenced using combinations of Illumina and Oxford nanopore technologies or PacBio *** workflow leads to high quality draft genome sequences with an average N50 of 3.0 Mbp.A backbone phylogenomic tree was calculated based on the amino acid sequences of 4912 core genes reflecting the current accepted taxonomic concept of the Hypoxylaceae.A Percentage of Conserved Proteins(POCP)analysis revealed that 70%of the proteins are conserved within the family,a value with potential application for the definition of family boundaries within the order ***,Hypomontagnella spongiphila is proposed as a new marine derived lineage of *** based on in-depth genomic comparison and morphological differences of the *** results showed that both species share 95%of their genes corresponding to more than 700 strain-specific *** difference is not reflected by standard taxonomic assessments(morphology of sexual and asexual morph,chemotaxonomy,phylogeny),preventing species delimitation based on traditional *** changes are likely to be the result of environmental adaptations and selective pressure,the driving force of *** data provide an important starting point for the establishment of a stable phylogeny of the Xylariales;they enable studies on evolution,ecological behavior and biosynthesis of natural products;and they significantly advance the taxonomy of fungi.

关键词： AAI ANI Cazyme Oxford nanopore Phylogenomics POCP Xylariales

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Proteomic and metabolomic profiling underlines the stage- and time-dependent effects of high temperature on grape berry metabolism

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Journal of Integrative Plant Biology 2020年第8期62卷 1132-1158页

作者： David Lecourieux christian Kappel Stéphane Claverol Philippe Pieri Regina Feil John E.Lunn Marc Bonneu Lijun Wang Eric Gomès Serge Delrot Fatma Lecourieux UMR1287 EGFV INRAEBordeaux Sciences AgroBordeaux UniversityISVV33140 Villenave d'OrnonFrance Institut of Biochemistry and Biology Potsdam UniversityD-14476 PotsdamGermany Proteome Platform Bordeaux Functional Genomic CenterBordeaux University33076 BordeauxFrance Max Planck Institute of Molecular Plant Physiology 14476 PotsdamGolmGermany Institute of Botany the Chinese Academy of SciencesBeijing 100093China UMR1287 EGFV CNRSINRAEBordeaux Sciences AgroBordeaux UniversityISVV33140 Villenave d'OrnonFrance

Climate change scenarios predict an increase in mean air temperatures and in the frequency,intensity,and length of extreme temperature events in many wine-growing regions *** elevated temperature has detrimental effects on berry growth and composition,it threatens the economic and environmental sustainability of wine *** Cabernet Sauvignon fruit-bearing cuttings,we investigated the effects of high temperature(HT)on grapevine berries through a label-free shotgun proteomic analysis coupled to a complementary metabolomic *** the 2,279 proteins identified,592 differentially abundant proteins were found in berries exposed to *** gene ontology categories“stress,”“protein,”“secondary metabolism,”and“cell wall”were predominantly altered under *** temperatures strongly impaired carbohydrate and energy metabolism,and the effects depended on the stage of development and duration of *** amounts correlated poorly with protein expression levels in HT berries,highlighting the value of proteomic studies in the context of heat ***,this work reveals that HT alters key proteins driving berry development and ***,we provide a list of differentially abundant proteins that can be considered as potential markers for developing or selecting grape varieties that are better adapted to warmer climates or extreme heat waves.

关键词： metabolism extreme high

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Physical insights into trapping effects on vertical GaN-on-Si trench MOSFETs from TCAD

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Journal of Semiconductors 2024年第3期45卷 45-52页

作者： NicolòZagni Manuel Fregolent Andrea Del Fiol Davide Favero Francesco Bergamin Giovanni Verzellesi Carlo De Santi Gaudenzio Meneghesso enrico Zanoni christian Huber Matteo Meneghini Paolo Pavan Department of engineering“enzo Ferrari” University of Modena and Reggio EmiliaModena 41125Italy Department of Information engineering University of PadovaPadova 35131Italy Department of Sciences and Methods for engineering(DISMI) University of Modena and Reggio EmiliaReggio Emilia 42122Italy en&TECH Center University of Modena and Reggio EmiliaReggio Emilia 42122Italy Advanced Technologies and Micro Systems Department Robert Bosch GmbHRenningen 71272Germany

Vertical GaN power MOSFET is a novel technology that offers great potential for power switching *** still in an early development phase,vertical GaN devices are yet to be fully optimized and require careful studies to foster their *** this work,we report on the physical insights into device performance improvements obtained during the development of vertical GaN-on-Si trench MOSFETs(TMOS’s)provided by TCAD simulations,enhancing the dependability of the adopted process optimization ***,two different TMOS devices are compared in terms of transfer-curve hysteresis(H)and subthreshold slope(SS),showing a≈75%H reduction along with a≈30%SS *** allow attributing the achieved improvements to a decrease in the border and interface traps,respectively.A sensitivity analysis is also carried out,allowing to quantify the additional trap density reduction required to minimize both figures of merit.

关键词： vertical GaN trench MOSFET SiO_(2) interface traps border traps hysteresis BTI

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The functional complex network approach to foster forest resilience to global changes

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Forest Ecosystems 2019年第3期6卷 194-209页

作者： christian Messier Jürgen Bauhus Frederik Doyon Fanny Maure Rita Sousa-Silva Philippe Nolet Marco Mina Núria Aquilué Marie-Josée Fortin Klaus Puettmann Département des sciences naturelles and Institut des sciences de la forêt tempérée (ISFORT) Université du Québec en Outaouais(UQO)58 rue PrincipaleRiponQC J0V 1V0 Canada Centre d’étude de la forêt Université du Québec à Montréal (UQAM)Case postale 8888succursale Centre-VilleMontréalQC H3C 3P8Canada Chair of Silviculture Institute of Forest SciencesUniversity of FreiburgTennenbacherstr.479106 FreiburgGermany Swiss Federal Institute for Forest Snow and Landscape Research WSLBirmensdorfSwitzerland Department of Ecology and Evolution University of TorontoTorontoON M5S 3B2Canada Department of Ecosystems and Society Oregon State UniversityCorvallisOR 97331USA

Human impacts on Earth's ecosystems have greatly intensified in the last decades. This is reflected in unexpected disturbance events, as well as new and increasing socio-economic demands, all of which are affecting the resilience of forest ecosystems worldwide and the provision of important ecosystem services. This Anthropocene era is forcing us to reconsider past and current forest management and silvicultural practices, and search for new ones that are more flexible and better at dealing with the increasing uncertainty brought about by these accelerating and cumulative global changes. Here, we briefly review the focus and limitations of past and current forest management and silvicultural practices mainly as developed in Europe and North America. We then discuss some recent promising concepts, such as managing forests as complex adaptive systems, and approaches based on resilience, functional diversity, assisted migration and multi-species plantations, to propose a novel approach to integrate the functionality of species-traits into a functional complex network approach as a flexible and multi-scale way to manage forests for the Anthropocene. This approach takes into consideration the high level of uncertainty associated with future environmental and societal changes. It relies on the quantification and dynamic monitoring of functional diversity and complex network indices to manage forests as a functional complex network. Using this novel approach, the most efficient forest management and silvicultural practices can be determined, as well as where, at what scale, and at what intensity landscape-scale resistance, resilience and adaptive capacity of forests to global changes can be improved.

关键词： forest management North America Ecosystem services

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试论美国“社会福音”运动的兴起

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历史教学问题 2011年第1期 12-19页

作者：王恩铭上海外国语大学美国研究中心

19世纪末20世纪初,美国在工业化、城市化两股力量的冲击下产生了大量的社会问题;这一时期蜂拥而入的东、南欧移民使众多社会矛盾日益加剧。面对这一局面,美国新教进步派在欧洲基督教社会主义和＂高级批评＂思想的影响下,在汲取美国新教... 详细信息

19世纪末20世纪初,美国在工业化、城市化两股力量的冲击下产生了大量的社会问题;这一时期蜂拥而入的东、南欧移民使众多社会矛盾日益加剧。面对这一局面,美国新教进步派在欧洲基督教社会主义和＂高级批评＂思想的影响下,在汲取美国新教传统精神的基础上,提出了以基督教博爱精神和社会公正为根本的思想观点,并主张运用这一思想去应对和解决当时的各种社会弊病。以此为基点,新教进步派在与其他社会进步力量的互相声援中掀起了一场旨在匡正社会弊端、提升社会公正、扶助社会弱势群体的＂社会福音＂运动。

关键词：工业化城市化“ 新”移民新教进步派“ 社会福音”

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