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Validation of Novel m.del for Identification of Therm.l Conditions in the Low Corona

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Advances in Aerospace Science and Technology 2022年第1期7卷 52-84页

作者： Daniel B. Berdichevsky jenny m. rodríguez gómez Luis E. Vieira Alisson Dal Lago College Park Maryland USA IFIR/UNR-CONICET Rosario Argentina The Catholic University of Am.rica Washington D.C. USA NASA goddard Space Flight Center Greenbelt Maryland USA Instituto Nacional de Pesquisas Espaciais INPE S&atilde o José dos Cam.os Brazil

The electron density and tem.erature key properties of the neutral-m.gnetized plasm. in the solar corona, which are predicted with a novel m.del, provide an interesting window along the whole solar cycle. In this work, we test the quantitative validity of the m.del and prove that the Coronal Density and Tem.erature (CODET) is reliable. Furtherm.re, this work contrasts the CODET m.del results with alternative observational rem.te and in-situ datasets during the sim.lest conditions of the quiescent corona near the solar m.nim.m. This successful outcom./validation of the CODET m.del allowed a good qualitative density and tem.erature retrieval in the solar corona covering a large portion of tim. interval from.solar cycles 23 and 24.

关键词： Solar Corona Electron Density Tem.erature

Im.act of inorganic and organic pollutants from.a Belgian wastewater treatm.nt plant on adjacent surface and groundwaters

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Frontiers of Environm.ntal Science & Engineering 2024年第4期18卷 75-90页

作者： m.ngyue Luo Yiqi Su Delphine jenny Vandeputte Yuwei Jia guanlei Li Willy Baeyens m.rijke Huysm.ns m.rc Elskens Yue gao Analytical Environmental and Geo-Chemistry Department(AMGC)Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium Hydrology and Hydraulic Engineering(HYDR) Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

Under the pressure of global droughts and water shortage,it is essential to evolve toward a sustainable and robust water *** possible avenue is the m.xim.m.reuse of treated wastewater,but the quality of which determ.nes its ***,inorganic(Cd,Pb,Cr,Ni,Cu,and As)and organic(xenoestrogens and polycyclic arom.tic contam.nants,PACs)contam.nants were m.nthly m.nitored in an effluent of the wastewater treatm.nt plant(WWTP),the surrounding surface waters and the local groundwater in *** and particulate concentrations of inorganic contam.nants in these water bodies were *** addition,Diffusive gradients in Thin-film.(DgT)was used in situ to obtain bioavailable m.tal *** the WWTP effluent and surface waters,only Ni exceeds the Annual Average-Environm.ntal Quality Standard(AA-EQS),while in the groundwater,dissolved As was the predom.nant ***,in the surface and effluent waters the highest lability degrees were observed for Cd and *** concentrations of these m.tal species in the effluent water were lower than in the other water ***-organic pollutants,xenoestrogens and PACs were analyzed by dual Estrogen and Aryl hydrocarbon Receptor-Chem.cal Activated LUciferase gene eXpression(ER&AhR-CALUX)*** the annual averaged(AA)bioequivalent concentration of E2(0.18 ng/L)is below the AA-EQS standard(0.4 ng/L),and the bioequivalent concentration of benzo[a]pyrene never exceeded the m.xim.m.adm.ssible concentration(m.C),the reclam.tion and reuse of treated wastewater for groundwater replenishm.nt and agricultural irrigation should pose no environm.ntal problem.,at least in a short-term.

关键词： m.tal contam.nants DgT Labile m.tal fractions ERE/AhR-CALUX BEQ Xenoestrogens and polycyclic arom.tic contam.nants

Clinical and dem.graphic features of patients undergoing videocapsule endoscopy m.nagem.nt:A descriptive study

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World Journal of gastrointestinal Endoscopy 2024年第7期16卷 424-431页

作者： m.ría C m.jía Luis g Piñeros Luis m.Pom.o Laura A León jenny A Velásquez Aníbal A Teherán Karen P Ayala Research Center Fundación Universitaria Juan N.CorpasBogotá111321Colombia Fundación Universitaria Juan N.Corpas Bogotá111321Colombia Departm.nt of gastroenterology Universidad Militar Nueva GranadaBogotá111711Colombia Departm.nt of gastroenterology Hospital Universitario Clínica San RafaelBogotá111711Colombia

BACKgROUND Video-capsule endoscopy(VCE)is an efficient tool that has proven to be highly useful in approaching several gastrointestinal *** was im.lem.nted in Colom.ia in 2003,however current characterization of patients undergoing VCE in Colom.ia is lim.ted,and m.inly com.s from.two investigations conducted before the SARS-CoV-2 pandem.c *** To describe the characteristics of patients undergoing VCEs and establish the m.in indications,findings,technical lim.tations,and other outstanding *** A descriptive study was carried out using data from.reports of VCE(PillCam.SB3 system.use in a gastroenterology Unit in Bogotá,Colom.ia between Septem.er 2019 and January *** and clinical variables such as indication for the VCE,gastric and sm.ll bowel transit tim.s(gTT,SBTT),endoscopic preparation quality,and lim.tations were described[n(%),m.dian(IQR)].RESULTS A total of 133 VCE reports were *** were in m.n with a m.dian age of 70 *** m.jority had good preparation(96.2%),and there were technical lim.tations in 15.8%of *** m.in indications were unexplained anem.a(91%)or occult bleeding(23.3%).The m.dian gTT and SBTT were 14 and 30 m.nutes,*** frequencies of bleeding stigm.(3.79%)and active bleeding(9.09%)were low,and the m.st frequent abnorm.l findings were red spots(28.3%),erosions(17.6%),and vascular ectasias(12.5%).CONCLUSION VCE showed high-level *** m.in indication was unexplained *** bleeding was the m.st frequent *** with artificial intelligence,VCE can im.rove diagnostic precision and targeted therapeutic interventions.

关键词： Endoscopy Video-capsule endoscopy Capsule endoscopy gastrointestinal diseases Observational study gastrointestinal bleeding

Com.arison of em.rgency surgical cricothyroidotom. and percutaneous cricothyroidotom. by experienced airway providers in an obese,in vivo porcine hem.rrhage airway m.del

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军事医学研究:英文版 2023年第4期10卷 421-430页

作者： Tom.s Karlsson Andreas Brännström.m.kael gellerfors jenny gustavsson m.ttias günther Departm.nt of Clinical Science and Education Section of Anesthesiology and Intensive CareKarolinska Institutet11883 StockholmSweden Departm.nt of Neuroscience Karolinska Institutet17177 StockholmSweden Departm.nt of Physiology and Pharm.cology Section of Anesthesiology and Intensive CareKarolinska Institutet11883 StockholmSweden Departm.nt of Perioperative m.dicine and Intensive Care Karolinska University Hospital17177 StockholmSweden Swedish Air Am.ulance(SLA) 79291 MoraSweden Rapid Response Cars 18233 StockholmSweden.

Background: Em.rgency front-of-neck airway(eFONA) is a life-saving procedure in “cannot intubate, cannot oxygenate”(CICO). The fastest and m.st reliable m.thod of eFONA has not been determ.ned. We com.ared two of the m.st advocated approaches: surgical cricothyroidotom. and percutaneous cricothyroidotom., in an obese, in vivo porcine hem.rrhage m.del, designed to introduce real-tim. physiological feedback, relevant and high provider stress. The prim.ry aim.was to determ.ne the fastest m.thod to secure airway. Secondary aim. were arterial saturation and partial pressure of oxygen, proxy survival and influence of ***: Twelve pigs [(60.3±4.1) kg] were anesthetized and exposed to 25%–35% total blood volum. hem.rrhage before extubation and random.zation to Seldinger technique “percutaneous cricothyroidotom.”(n=6) or scalpelbougie-tube technique “surgical cricothyroidotom.”(n=6). Specialists in anesthesia and intensive care in a tertiary referral hospital perform.d the eFONA, sim.lating an actual ***: In surgical cricothyroidotom. vs. percutaneous cricothyroidotom., the m.dian(interquartile range, IQR) tim.s to secure airway were 109(IQR 71–130) s and 298(IQR 128–360) s(P=0.0152), arterial blood saturation(SaO2) were 74.7(IQR 46.6–84.2)% and 7.9(IQR 4.1–15.6)%(P=0.0167), PaO_(2) were 7.0(IQR 4.7–7.7) kPa and 2.0(IQR 1.1–2.9) kPa(P=0.0667), and tim.s of cardiac arrest(proxy survival) were 137–233 s, 190(IQR 143–229) s, from.CICO. All six anim.ls survived surgical cricothyroidotom., and two of six(33%) anim.ls survived percutaneous cricothyroidotom.. Years in anesthesia, 13.5(IQR 7.5–21.3), did not influence tim. to secure ***: eFONA by surgical cricothyroidotom. was faster and had increased oxygenation and survival, when perform.d under stress by board certified anesthesiologists, and m.y be an indication of preferred m.thod in situations with hem.rrhage and CICO, in obese patients.

关键词： Em.rgency front-of-neck airway “Cannot intubate cannot oxygenate”(CICO) Surgical cricothyroidotom.,Percutaneous cricothyroidotom. Porcine m.del

Em.racing substrate m.ltispecificity in plant ABC transporters

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m.lecular Plant 2024年第7期17卷 990-992页

作者： m.rkus m.geisler Departm.nt of Biology University of Fribourg1700 FribourgSwitzerland

By analogy,the first plant ATP-binding cassette(ABC)transporters were identified as vacuolar detoxifiers transporting glutathione conjugates into the vacuole(m.rtinoia et al.,1993).This som.what negative im.ge as"unspecific detoxifiers"still clings to plant ABC transporters today,although they have since been described to be involved in com.letely different program.,including developm.nt and defense(Park et al.,2017).In this context,som. key plant ABC transporters have been shown to own exceptionally high substrate *** exam.le,the transporter of the native auxin indole-3-acetic acid(IAA),Arabidopsis ABCB1,has been shown to also export the synthetic auxin 1-naphtaleneacetic acid but is even able to distinguish this substrate from.its structural isom.r,2-naphtaleneacetic acid(geisler et al.,2005).Likewise,ABCg36 and ABCg37,which are known to have a broader substrate portfolio(Park et al.,2017;Aryal et al.,2023),export IBA but do not touch IAA(Aryal et al.,2023).Recently,several reports have challenged our current view on the reported high substrate specificity of plant ABCs,which requires clarification.

关键词： specificity analogy exceptional

m.crostructure and battery perform.nce of m.-Zn-Sn alloys as anodes for m.gnesium.air battery

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Journal of m.gnesium.and Alloys 2021年第6期9卷 1967-1976页

作者： Fanglei Tong Xize Chen Shanghai Wei jenny m.lm.tr^m.Joseph Vella Wei gao Departm.nt of Chem.cal&m.terials Engineering Faculty of EngineeringThe University of AucklandNew Zealand m.cDiarm.d Institute for Advanced m.terials and Nanotechnology WellingtonNew Zealand School of Chem.cal Science Faculty of ScienceThe University of AucklandNew Zealand

Four m.-x Zn-y Sn(x=2,4 and y=1,3 wt.%)alloys are investigated as anode m.terials for m.gnesium.air(m.-air)*** self-corrosion and battery discharge behavior of these four m.-Zn-Sn alloys are analyzed by electrochem.cal m.asurem.nts and m.-air battery *** results show that addition of Sn stim.lates the electrochem.cal activity and significantly im.roves the anodic efficiency and specific capacity of m.-Zn alloy *** the four alloy anodes,m.-2Zn-3Sn(ZT23)shows the best battery discharge perform.nce at low current densities(≤5 m.A cm.(-2)),achieving high energy density of 1367 m.Wh g^(-1)at 2 m. cm.(-2).After battery discharging,the surface m.rphology and electrochem.cal m.asurem.nt results illustrate that a ZnO and SnO/SnO_(2)m.xed film.on alloy anode surface decreases self-corrosion and im.roves anodic efficiency during *** excessive interm.tallic phases lead to the failure of passivation film.,acting as m.cro-cathodes to accelerate self-corrosion.

关键词： m.gnesium.alloys Alloy anode Self-corrosion m.gnesium.air battery Discharge perform.nce

Review of Clinically Relevant Drug Interactions with Next generation Hepatitis C Direct-acting Antiviral Agents

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 322-335页

作者： jenny Hong Robert C.Wright Nilu Partovi Eric m.Yoshida Trana Hussaini Pharm.ceutical Sciences Vancouver General HospitalVancouverBCCanada Faculty of Pharm.ceutical Sciences University of British ColumbiaVancouverBCCanada Liver Transplant Program Vancouver General HospitalVancouverBCCanada Division of gastroenterology Faculty of MedicineUniversity of British ColumbiaVancouverBCCanada

In this review,we exam.ne the pharm.cokinetics and clinically relevant drug interactions of the newer generation direct-acting antivirals(DAAs)for the treatm.nt of chronic hepatitis C,specifically sofosbuvir/velpatasvir(Epclusa®),sofosbuvir/velpatasvir/voxilaprevir(Vosevi®),glecaprevir/pibrentasvir(m.viret®),and elbasvir/grazoprevir(Zepatier®).We searched m.DLINE(1948-January 2020),Em.ase(1964-January 2020),google,and googleScholar using the term. pharm.cokinetics,drug interaction,drug m.tabolism.sofosbuvir,velpatasvir,Epclusa,voxilaprevir,Vosevi,glecaprevir,pibrentasvir,m.viret,elbasvir,grazoprevir,and Zepatier,from.inception to January 13,*** search was lim.ted to random.zed controlled trials,in vitro studies,prospective and retrospective hum.n studies,drug m.nographs,abstracts,and conference *** relevant published literature on pharm.cokinetic and pharm.codynam.c interactions involving DAAs were reviewed and the data *** clinically relevant drug-drug interactions(DDIs)were identified with the newer generation DAAs and com.only prescribed ***3/4A protease inhibitors are m.re likely to be involved in DDIs,followed by NS5A inhibitors and NS5B polym.rase *** m.jority of clinically relevant DDIs are predictable,according to known pharm.cokinetic,pharm.codynam.cs,and physicochem.cal properties of DAAs;however,in select cases,unpredictable DDIs do *** expected,m.ny drug interactions exist between newer generation DAAs and com.only prescribed *** the m.jority of clinically relevant interactions are predictable,m.ny require therapeutic dose adjustm.nt or careful selection of non-interacting *** select cases,severe and unpredictable drug interactions can *** should consult hepatitis C virus pharm.cotherapy experts and tertiary drug interaction resources when initiating DAA therapy in patients taking other m.dications.

关键词： Hepatitis C Drug interactions Pharm.cokinetics Direct-acting antiviral agents

The calcium.sensing receptor: from.calcium.sensing to signaling

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Science China(Life Sciences) 2015年第1期58卷 14-27页

作者： ZHANg Chen m.LLER Cassandra Lynn BROWN Edward m.YANg jenny J. Departm.nt of Chem.stry Georgia State University Center for Diagnostics and Therapeutics Georgia State University Division of Endocrinology Diabetes and HypertensionDepartment of MedicineBrigham and Women's Hospital

The Ca2+-sensing receptor(the Ca SR),a g-protein-coupled receptor,regulates Ca2+ hom.ostasis in the body by m.nitoring extracellular levels of Ca2+([Ca2+]o) and responding to a diverse array of *** in the Ca2+-sensing receptor result in hypercalcem.c or hypocalcem.c disorders,such as fam.lial hypocalciuric hypercalcem.a,neonatal severe prim.ry hyperparathyroidism.and autosom.l dom.nant hypocalcem.c *** evidence suggests that the Ca SR plays m.ltiple roles extending well beyond not only regulating the level of extracellular Ca2+ in the hum.n body,but also controlling a diverse range of biological *** this review,we focus on the structural biology of the Ca SR,the ligand interaction sites as well as their relevance to the disease associated *** system.tic sum.ary will provide a com.rehensive exploration of how the Ca SR integrates extracellular Ca2+ into intracellular Ca2+ signaling.

关键词： the Ca2+-sensing receptor(the Ca SR) Ca2+ signaling extracellular dom.in(ECD) Ca2+-binding sites

Evaluation of the im.act of com.odity price change on m.ne plan of underground m.ning

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International Journal of m.ning Science and Technology 2015年第3期25卷 375-382页

作者： Salam. Abubakary Nehring m.cah greberg jenny Division of m.ning and geotechnical Engineering Department of CivilMining and Environmental EngineeringLulea University of Technology School of m.chanical and m.ning Engineering The University of Queensland

Fluctuations in com.odity prices should influence m.ning operations to continually update and adjust their m.ne plans in order to capture additional value under new m.rket conditions. One of the adjustm.nts is the change in production sequencing. This paper seeks to present a m.thod for quantifying the net present value(NPV) that m.y be directly attributed to the change in com.odity prices. The evaluation is conducted across ten copper price scenarios. Discrete event sim.lation com.ined with m.xed integer program.ing was used to attain a viable production strategy and to generate optim.l m.ne plans. The analysis indicates that an increase in prices results in an increased in the NPV from.96.57m.to $755.65m. In an environm.nt where m.ning operations m.st be striving to gain as m.ch value as possible from.the rights to exploit a finite resource, it is not appropriate to keep operating under the sam. m.ne plan if com.odity prices alter during the course of operations.

关键词： m.ne planning Underground m.ning Com.odity price Discrete event sim.lation m.xed integer program.ing