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Advances in the diagnosis and treatment of liver fibrosis

Hepatoma Research 2017年第8期3卷 156-169页

作者： jenny yeuk-ki cheng Grace Lai-Hung Wong Institute of Digestive Disease The Chinese University of Hong KongShatinHong Kong 999077China Department of Medicine and Therapeutics 9/F Prince of Wales HospitalShatinHong Kong 999077China State Key Laboratory of Digestive Disease The Chinese University of Hong KongShatinHong Kong 999077China.

Liver fibrosis is the center of diagnosis and management of essentially all chronic liver diseases. While liver biopsy examination still has a role in diagnosis and drug development, it is replaced by non-invasive assessments of liver biopsy in majority of the clinical scenarios. Radiological approaches, namely transient elastography, acoustic radiation force impulse imaging, shear wave elastography, magnetic resonance elastography provide accurate diagnosis of advanced fibrosis and cirrhosis. Serum test formulae based on common laboratory parameters or more specialized parameters including those commercially available panels FibroTest?, FibroMeter? and Enhanced Liver Fibrosis are also available. Combining different modalities may further improve the accuracy. The role of all these non-invasive assessments has been further expanded from diagnostic to prognostic, e.g. risk prediction of hepatocellular carcinoma (HCC) by LSM-HCC score. Treatment of liver fibrosis can be achieved by controlling the underlying diseases, with chronic viral hepatitis as the most established disease model. Currently there are multiple clinical trials evaluating different treatment options to improve fibrosis in patients with non-alcoholic fatty liver disease. Specific anti-fibrotic treatment targets e.g. direct downregulation of hepatic stellate cell, collagen synthesis inhibitors and transforming growth factor-βantagonists have been tested in laboratory and pending further studies in clinical settings.

关键词： Chronic hepatitis B chronic hepatitis C fatty liver transient elastography

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BMP decision support system for evaluating stormwater management alternatives

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Frontiers of Environmental Science & Engineering 2009年第4期3卷 453-463页

作者： Mow-Soung cheng jenny X.ZHEN Leslie SHOEMAKER Department of Environmental Resources Prince George’s County Government9400 Peppercorn PlaceLargo MD 20774USA Tetra Tech Inc.10306 Eaton PlaceFairfax VA 22030USA

Prince George’s County,Maryland,in the Washington *** area has developed a best management practice decision support system(BMPDSS)to support analysis and decision making for stormwater management planning and design at both the site scale and the watershed *** paper presents a detailed description of the BMPDSS.A case study that demonstrates the application of the system is also *** case study involves a Green Highway project located in a highly urbanized area within the Anacostia River watershed of the *** best management practices(BMP)such as bioretention,filter vegetative swale,porous paving,and landscape infiltration are proposed for reducing highway runoff and improving water *** BMPDSS is used to identify and evaluate various alternatives to determine the most costeffective types and combinations of BMPs that minimize the highway runoff pollution.

关键词： best management practices decision support system low impact development geographic information system optimization

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Intravenous fluid selection rationales in acute clinical management

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World Journal of Emergency Medicine 2018年第1期9卷 13-19页

作者： Wing Yan Shirley Cheung Wai Kwan Cheung Chun Ho Lam yeuk Wai Chan Hau Ching Chow Ka Lok cheng Yau Hang Wong Chak Wah Kam Accident and Emergency Department Tuen Mun Hospital

BACKGROUND: Intravenous fluid(IVF) is commonly used in acute clinical management. This study aimed to review the choice and primary considerations in IVF prescriptions and to evaluate the adequacy of guidelines and trainings on it in the New Territories West Cluster(NTWC) of Hong ***: This is a descriptive study based on data collected from an online survey. Data were processed by SPSS for statistical analysis. This study focused on a general description and doctor-nurse between group comparison. Participants were asked the choice of IVF for nine acute clinical scenarios and provide reason. A 1–10 scale was used to assess the sufficiency of guideline, training and information, and time for revision on IVF ***: 0.9% sodium chloride was the most familiar IVF(36%), followed by 5% Dextrose solution(26%). In the nine scenarios, the most chosen IVF was 0.9% sodium chloride(37%–61%). There was significant difference in the choice of IVF between doctors and nurses in 7 cases. The second most chosen IVF for doctors was Plasma-Lyte A while that for nurses was Gelofusine. Departmental practice was the most chosen reason to account for the prescription. The adequacy of guideline, information and training, and time for revision was rated 5. Doctors had significantly more time at work than nurses to update knowledge in IVF prescription(5.41 versus 4.57).CONCLUSION: 0.9% sodium chloride was mostly chosen. The choice of IVF was mainly based on departmental practice. Adequacy of guideline, information and training, and time for revision on IVF prescription were average, indicating significant training deficit.

关键词： Intravenous fluid Acute care Resuscitation

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Energy-saving strategy for a transport bed flash calcination process applied to magnesite

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Carbon Resources Conversion 2021年第1期4卷 122-131页

作者： Ping An Zhennan Han Kangjun Wang Jiguang cheng Zhongkai Zhao Yohanes Andre Situmorang jenny Rizkiana Abuliti Abudula Guoqing Guan Education Ministry Key Laboratory of Resources Chemicals and Materials Shenyang University of Chemical TechnologyShenyangChina Graduate School of Science and Technology Hirosaki UniversityHirosaki1-BunkyochoJapan Laboratory of Energy Conversion Engineering Institute of Regional Innovation(IRI)Hirosaki University2-1-3 MatsubaraAomoriJapan Department of Chemical Engineering Institut Teknologi BandungGanesha 10Bandung 40132Indonesia

A transport bed flash calcination(TBFC)process applied to magnesite is systematically investigated through process simulation to optimize the energy-saving *** high-temperature calciner flue gas is used to preheat the fed magnesite,while the sensible heat with the caustic calcined magnesia(CCM)product is cooled by air sent to the ***-decomposition of magnesite during preheating is considered on basis of the kinetics measured using a micro fluidized bed reaction analyzer that allows the minimized effect of external diffusion on *** staged fuel gas supply the TBFC process allows the equivalence ratios around 1.2 for *** preferred arrangement of stages for magnesite preheating and CCM cooling are respectively 4 and 2,leading to the energy consumption of 4100 kJ/kg-CCM and the energy efficiency of 66.8%,which is almost doubly higher than the 33.9%of the conventional reverberatory furnaces(RF).The pre-decomposition occurs mainly in the 1st-stage preheater,and the maximal conversion is about 13%.Varying the stages of preheating appears more influential on the energy saving than varying the cooling stages,while residence time above 1 s in the preheaters has limited effect.

关键词： Energy efficiency Transport bed Calcination Heat recovery Process simulation

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选择性溶剂中胶束结构的耗散粒子动力学研究

选择性溶剂中胶束结构的耗散粒子动力学研究

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作者： jenny cheng Oi Lee（曾爱丽）北京化工大学

学位级别：硕士

本文采用耗散粒子动力学的方法模拟了两性梳形共聚物在溶液中的自组装过程。文章选择两种比较常见的梳形共聚物结构,分别是疏水主链—亲水侧链和亲水主链—疏水侧链。通过改变主链长度、侧链长度和侧链数对两种共聚物自组装结构特性进... 详细信息

本文采用耗散粒子动力学的方法模拟了两性梳形共聚物在溶液中的自组装过程。文章选择两种比较常见的梳形共聚物结构,分别是疏水主链—亲水侧链和亲水主链—疏水侧链。通过改变主链长度、侧链长度和侧链数对两种共聚物自组装结构特性进行分析。通过不断的改变模拟参数,我们得到很多稳定的共聚物自组装结构。包括球形、柱形胶束结构,环形、扁平状、长条形胶囊结构,以及类海马状、梯形、骨形、蝴蝶状、K形、Y形等特殊胶束结构。其中大部分结构已被实验观测证实存在,同时我们模拟厨实验中还没有发现的一些特殊结构。本文为充分了解梳形共聚物在溶液中的自组装过程提供了有用的信息,有助于更加全面地理解梳形共聚物的形貌和性质,进一步促进了它在各领域的应用。

关键词：嵌段共聚物自组装梳形共聚物耗散粒子动力学亲水性疏水性

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旅游道德感知结构与行业实践的影响

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旅游学刊 2017年第4期32卷 54-65页

作者：程强白凯田洁蔺国伟陕西师范大学旅游与环境学院陕西西安710119 陕西省旅游信息化工程实验室陕西西安710119 香港中文大学酒店及旅游管理学院河西学院历史文化与旅游学院甘肃张掖734000

旅游伦理研究是国内外旅游学界较少关注的研究领域,而日益凸显的旅游伦理问题又决定了行业和学界都迫切需要这方面的理论指导。为此,文章通过理论建构与实证检验,从个体微观角度,初步分析了旅游道德感知的组成结构及个体旅游实践经历对... 详细信息

旅游伦理研究是国内外旅游学界较少关注的研究领域,而日益凸显的旅游伦理问题又决定了行业和学界都迫切需要这方面的理论指导。为此,文章通过理论建构与实证检验,从个体微观角度,初步分析了旅游道德感知的组成结构及个体旅游实践经历对旅游道德感知的影响作用。研究结果表明:通过道德注意力、相对主义伦理立场、理想主义伦理立场所建构的旅游道德感知结构具有很好的可靠性及外部有效性;旅游行业实践经历与个体旅游道德感知的关系显著,能够显著影响个体的旅游道德感知。在理论方面,该研究适度拓展了旅游道德感知的研究内容,说明了旅游道德感知的架构具有较好的外部有效性。研究结果对指导旅游伦理教育、企业内部伦理建设及学生个体的道德感知提升均具有指导意义。

关键词：旅游道德感知旅游行业实践伦理立场道德注意力

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Characterization of CIAE developed double-sided silicon strip detector for charged particles

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Nuclear Science and Techniques 2018年第5期29卷 98-103页

作者： Xin-Xing Xu Fanurs C.E.Teh cheng-Jian Lin jenny Lee Feng Yang Zhao-Qiao Guo Tian-Shu Guo Li-Jie Sun Xin-Zhi Teng Jia-Jian Liu Peng-Jie Li Peng-Fei Liang Lei Yang Nan-Ru Ma Hui-Ming Jia Dong-Xi Wang Sylvain Leblond Taras Lokotko Qing-Qing Zhao Huan-Qiao Zhang China Institute of Atomic Energy Beijing 102413China Department of Physics The University of Hong KongPokfulam RoadHong KongChina College of Physics and Technology Guangxi Normal UniversityGuilin 541004China Beijing Kelixing Photoelectric Technology Co. Ltd.Beijing 102413China

A double-sided silicon strip detector(DSSD)with active area of 48 mm x 48 mm and thickness of300μm has been developed. Each side of DSSD consists of48 strips, each with width of 0.9 mm and inter-strip separation of 0.1 mm. Electrical properties and detection performances including full depletion bias voltage, reverse leakage current, rise time, energy resolution and cross talk have been studied. At a bias of 80 V, leakage current in each strip is less than 15 nA, and rise time for alpha particle at 5157 keV is approximately 15 ns on both *** energy resolutions have been achieved with0.65-0.80% for the junction strips and 0.85-1.00% for the ohmic strips. The cross talk is found to be negligible on both sides. The overall good performance of DSSD indicates its readiness for various nuclear physics experiments.

关键词： Double-sided silicon strip detector P-stop Detection performance Cross talk

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走进香薰

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中国化妆品 1999年第5期 49-49页

作者： jenny cheng

"香薰治疗"于80年代末期在法国及英国开始兴起,主要是以植物性的香精油来促进人体及肌肤健康。时至今日,各大小美容中心或百货商店都出售着各种各样的香薰用品,香薰的效用已受到肯定并逐渐被人们所接受。香精油是从植物中经过物理处理... 详细信息

"香薰治疗"于80年代末期在法国及英国开始兴起,主要是以植物性的香精油来促进人体及肌肤健康。时至今日,各大小美容中心或百货商店都出售着各种各样的香薰用品,香薰的效用已受到肯定并逐渐被人们所接受。香精油是从植物中经过物理处理而得到具挥发性及带有香味的产品,香精油是植物的精髓所在。

关键词：香薰植物香精油芳香油植物香料素一

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A novel kinetic cell-based methodology for biological screening of traditional Chinese natural herbs

A novel kinetic cell-based methodology for biological screen...

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2014年全国中药学术研讨会暨中国中西医结合学会第六届中药专业委员会换届改选会

作者： Huiying Fu Wenqing Fu Mingjiao Sun Qiyang Shou Yunyan Zhai Hongqiang cheng Li Teng Xiaozhou Mou Yanwei Li Shuying Wan Shanshan Zhang Qinqin Xu Xue Zhang Jiucun Wang jenny Zhu Xiaobo Wang Xiao Xu Guiyuan Lv Li Jin Wensheng Guo Yuehai Ke Program in Molecular Cell Biology Department of Basic Medical Sciences Zhejiang University School of Medicine Zhejiang University of Traditional Chinese Medicine Institute of Genetics Fudan University Center for Clinical Epidemiology and Biostatistics School of Medicine University of Pennsylvania

Natural products have always been a major source of therapeutic agents;however,the development of traditional herbal products has been currently hampered by the lack of analytic methods suitable for both high-throughput screening and evaluating the mechanism of *** processes such as proliferation,apoptosis,and toxicity are well orchestrated in real *** these events and their perturbation by natural products can provide high-rich information about cell physiological relevancies being ***,we report a novel cell-based phenotypic profiling strategy that uses electronic impedance readouts for real-time monitoring of cellular responses to traditional Chinese medicines(TCMs).The utility of this approach was used to screen natural herbs that have been historically documented to cure human diseases and that have been classified into seven clusters based on their mechanisms of *** results suggest that herbal medicines with similar cellular mechanisms produce similar time/dose-dependent cell response profiles(TCRPs).By comparing the TCRPs produced by the Chinese medicinal Cordyceps Sinensis with similar TCRPs of chemical compounds,we explored the potential use of herbal TCRPs for predicting cellular mechanisms of action,herbal authentications and bioactive ***,we further compared this novel TCRP technology with HPLC-based methods for herbal origin-tracing authentication and identification of bioactive ***,our findings suggest that using TCRP as an alternative to existing spectroscopic techniques can allow us to analyze natural products in a more convenient and physiologically relevant manner.

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蔗田土壤有机质平衡预测

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南方农业学报 2013年第1期44卷 87-91页

作者：刘忠唐其展陈桂芬蒙炎成何红顾明华广西农业科学院南宁530007 广西大学农学院南宁530005

【目的】进行蔗田土壤有机质平衡预测,为甘蔗生产中合理使用甘蔗残体、糖厂滤泥和酒精废液,提高土壤肥力及甘蔗产量提供依据。【方法】采用尼龙网袋将有机物料与土混合埋于新植蔗行间,埋置后1年后取样测定有机物料碳的残留量,确定土壤... 详细信息

【目的】进行蔗田土壤有机质平衡预测,为甘蔗生产中合理使用甘蔗残体、糖厂滤泥和酒精废液,提高土壤肥力及甘蔗产量提供依据。【方法】采用尼龙网袋将有机物料与土混合埋于新植蔗行间,埋置后1年后取样测定有机物料碳的残留量,确定土壤有机物料腐殖化系数,并根据jenny数学模型公式Ct=A/K-(A/K-C0)e-kt,对蔗田土壤有机质平衡进行预测。【结果】蔗叶、蔗根、蔗头、滤泥、酒精废液腐殖化系数分别为0.39、0.46、0.20、0.15与0.07;要保持蔗田土壤有机质平衡在21.19g/kg,每年需向土壤施入稳定有机质2004.0kg/ha,即需要蔗根4356.5kg/ha(干重),5138.5kg/ha蔗叶(干重)、10020.0kg/ha蔗头(干重)、13360.0kg/ha滤泥(干重)、28628.6kg/ha酒精发酵液(固形物);要稳步提高土壤有机质含量,培肥土壤时间越长,每年投入的有机质量越少,反之则越多。【结论】循环利用甘蔗糖业中的蔗叶、糖厂滤泥、糖厂酒精废液等有机物料,可以促进土壤肥力的提高。

关键词：蔗田有机物料土壤有机质平衡预测

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