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Diffusion tensor imaging in the courtroom:Distinction between scientific specificity and legally admissible evidence

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World Journal of Clinical Cases 2023年第19期11卷 4477-4497页

作者： jennifer christine van velkinburgh Mark D Herbst Stewart M Casper Science Communication Filipodia Publishing LLCSanta FeNM 87505United States Diagnostic Radiology Independent Diagnostic Radiology IncSt PetersburgFL 33711United States Personal Injury Law Casper&DeToledo LLCStamfordCT 06905United States

Interest and uptake of science and medicine peer-reviewed literature by readers outside of a paper’s topical subject,field or even discipline is *** the application of knowledge from one field or discipline to others can stimulate innovative solutions to problems facing modern society,it is also fraught with danger for *** the practice of law in the United States,academic papers are submitted to the courts as evidence in personal injury litigation from both the plaintiff(complainant)and *** transcendence of an academic publication over disciplinary boundaries is immediately met with the challenge of application by a group that inherently lacks in-depth knowledge on the scientific method,the practice of evidence-based medicine,or the publication process as a structured and internationally synthesized process involving peer review and guided by ethical standards and norms.A modern-day example of this is the ongoing conflict between the sensitivity of diffusion tensor imaging(DTI)and the legal standards for admissibility of evidence in litigation cases of mild traumatic brain injury(mTBI).In this review,we amalgamate the peer-reviewed research on DTI in mTBI with the court’s rationale underlying decisions to admit or exclude evidence of DTI abnormalities to support claims of brain *** found that the papers which are critical of the use of DTI in the courtroom reflect a primary misunderstanding about how diagnostic biomarkers differ legally from relevant and admissible *** clinical use of DTI to identify white matter abnormalities in the brain at the chronic stage is a valid methodology both clinically as well as forensically,contributes data that may or may not corroborate the existence of white matter damage,and should be admitted into evidence in personal injury trials if supported by a *** also delve into an aspect of science publication and peer review that can be manipulated by scientists and clinicians to

关键词： Diffuse axonal injury Mild brain injury Magnetic resonance imaging Neuroimaging Medicolegal Litigation Medical jurisprudence Ethics Peer review Publishing

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Nonsteroidal anti-inflammatory drugs before endoscopic ultrasound guided tissue acquisition to reduce the incidence of post procedural pancreatitis

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World Journal of Gastroenterology 2024年第8期30卷 811-816页

作者： Mike de Jong Foke van Delft christine Roozen Erwin-Jan van Geenen Tanya Bisseling Peter Siersema Marco Bruno Department of Gastroenterology and Hepatology Radboud University Medical CenterNijmegen 6525 GANetherlands Department of Gastroenterology and Hepatology Erasmus University Medical CenterRotterdam 3015 GDNetherlands

Endoscopic ultrasound(EUS)with fine needle aspiration or fine needle biopsy is the gold standard for sampling tissue to diagnose pancreatic cancer and auto-immune pancreatitis or to analyze cyst *** most common reported adverse event of fine needle aspiration and/or fine needle biopsy is acute pancreatitis,which is likely induced by the same pathophysiological mechanisms as after en-doscopic retrograde cholangiopancreatography(ERCP).According to the current European Society of Gastrointestinal Endoscopy guideline,nonsteroidal anti-inflammatory drugs are administered prior to ERCP as a scientifically proven treatment to reduce post-ERCP pancreatitis incidence rate.A single suppository of diclofenac or indomethacin prior to EUS guided tissue acquisition(TA)is harm-less in healthy *** it is associated with low costs and,most important,may prevent a dreadsome complication,we strongly recommend the adminis-tration of 100 mg diclofenac rectally prior to *** will explain this recom-mendation in more detail in this review as well as the risk and pathophysiology of post-EUS TA pancreatitis.

关键词： Pancreatitis Endoscopic ultrasound Tissue acquisition Nonsteroidal antiinflammatory drugs Pancreatic cancer

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Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy Chemistry 2024年第10期97卷 438-443页

作者： Lucas Hanssens Maarten Houlleberghs C.Vinod Chandran Geert Watson Sambhu Radhakrishnan Pascal van Der Voort Joeri F.M.Denayer christine E.A.Kirschhock Johan A.Martens Eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team (COK-KAT) NMR/X-Ray Platform for Convergence Research (NMRCoRe) Centre for Ordered Materials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Department of Chemical Engineering Vrije Universiteit Brussel

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH4 /CO2 exchange Direct gas exchange ENERGY-STORAGE CONFINED NANOSPACE TO-METHANE GAS MECHANISMS ADSORPTION HYDROGEN

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How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van Ierssel Olivia Galea Kirsten Holte Caroline Luszawski Elizabeth Jenkins jennifer O’Neil Carolyn A Emery Rebekah Mannix Kathryn Schneider Keith Owen Yeates Roger Zemek Children’s Hospital of Eastern Ontario Research Institute OttawaON K1H 8L1Canada The Centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand Sport Injury Prevention Research Centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta Children’s Hospital Research Institute University of Calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain Institute University of CalgaryCalgaryAB T2N 4N1Canada Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada School of Rehabilitation Sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research Institute OttawaON K1N 5C8Canada Departments of Pediatrics and Emergency Medicine Harvard Medical SchoolBostonMA 02115USA Departments of Pediatrics and Emergency Medicine University of OttawaOttawaON K1H 8M5Canada

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following ***:We searched MEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to May *** reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the Cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TIDieR and CERT publication,but p

关键词： Concussion Intervention Randomized controlled trial Systematic review

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Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 17-28页

作者： Nguyen Hoa Binh Quang Vo Luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria christine Huynh Huy Ba Dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob Dang Thi Minh Ha Nguyen Lan Huu Shedrawy Jad L?nnroth Knut Nguyen Tuan Dinh van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;P<0.001). This resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

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Simultaneous genetic transformation and genome editing of mixed lines in soybean(Glycine max)and maize(Zea mays)

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aBIOTECH 2024年第2期5卷 169-183页

作者： Michelle Valentine David Butruille Frederic Achard Steven Beach Brent Brower-Toland Edward Cargill Megan Hassebrock jennifer Rinehart Thomas Ream Yurong Chen Bayer Crop Science 700 Chesterfield Parkway WChesterfieldMO 63017USA

Robust genome editing technologies are becoming part of the crop breeding ***,genome editing is usually conducted either at a single locus,or multiple loci,in a variety at one *** parallel genomics platforms,multifaceted genome editing capabilities,and flexible transformation systems enable targeted variation at nearly any locus,across the spectrum of genotypes within a *** demonstrate here the simultaneous transformation and editing of many genotypes,by targeting mixed seed embryo explants with genome editing machinery,followed by re-identification through genotyping after plant *** and Editing of Mixed Lines(TREDMIL)produced transformed individuals representing 101 of 104(97%)mixed elite genotypes in soybean;and 22 of 40(55%)and 9 of 36(25%)mixed maize female and male elite inbred genotypes,*** of edited genotypes for the regenerated individuals identified over 800 distinct edits at the Determinate1(Dt1)locus in samples from 101 soybean genotypes and 95 distinct Brown midrib3(Bm3)edits in samples from 17 maize *** results illustrate how TREDMIL can help accelerate the development and deployment of customized crop varieties for future precision breeding.

关键词： Maize Soybean Seed embryo explants TREDMIL Genetic transformation Genome editing

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Logical hypothesis:Low FODMAP diet to prevent diverticulitis

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 503-512页

作者： Yoshiharu Uno jennifer C van velkinburgh Office Uno Column(Medical Science Publisher) Initiative for Collaboratory Biomedical Research

Despite little evidence for the therapeutic benefits of a high-fiber diet for diverticulitis, it is commonly recommended as part of the clinical management. The ongoing uncertainty of the cause(s) of diverticulitis confounds attempts to determine the validity of this therapy. However, the features of a high-fiber diet represent a logical contradiction for colon diverticulitis. Considering that Bernoulli’s principle, by which enlarged diameter of the lumen leads to increased pressure and decreased fluid velocity, might contribute to development of the diverticulum. Thus, theoretically, prevention of high pressure in the colon would be important and adoption of a low FODMAP diet (consisting of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) may help prevent recurrence of diverticulitis.

关键词： Diverticular disease High-fiber diet Low FODMAP diet Bernoulli&rsquo s principle Irritable bowel syndrome

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Remote sensing image fusion: an update in the context of Digital Earth

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International Journal of Digital Earth 2014年第2期7卷 158-172页

作者： christine Pohl John van Genderen Institute of Geospatial Science&Technology(INSTeG) Universiti Teknologi MalaysiaJohor BahruMalaysia Faculty of Geoinformation Science and Earth Observation University of TwenteEnschedeThe Netherlands

Remote sensing image fusion has come a long way from research experiments to an operational image processing *** established a framework for image fusion at the end of the 90s,we now provide an overview on the advances in image fusion during the past 15 *** information about new remote sensing image fusion techniques,recent technical developments and their influence on image fusion,international societies and working groups,and new journals and publications,we provide insight into new *** becomes clear that image fusion facilitates remote sensing image *** aims at achieving better and more reliable information to better understand complex Earth *** numerous publications during the last decade show that remote sensing image fusion is a well-established research *** experiences gained foster other technological developments in terms of sensor configuration and data ***-modal data usage enables the implementation of the concept of Digital *** order to advance in this respect,we recommend that updated guidelines and a set of commonly accepted quality assessment criteria are needed in image fusion.

关键词： remote sensing image fusion algorithms quality assessment needs

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Current understanding of the functional roles of aberrantly expressed micro RNAs in esophageal cancer

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World Journal of Gastroenterology 2016年第1期22卷 1-7页

作者： christine Kestens Peter D Siersema Jantine WPM van Baal Department of Gastroenterology and Hepatology University Medical Center Utrecht

The incidence of esophageal cancer is rising,mostly because the increasing incidence of esophageal adenocarcino main Western *** eimprovements in diagnosis and treatment,the overall5-year survival rates remain *** RNAs(mi RNAs)are small non-coding RNA molecules that regulate the expression of target ***,disease specific mi RNAs have been identified,which act as tumor suppressors or *** this review,we will summarize the current knowledge about the function of aberrantly expressed mi RNAs in esophageal *** selected 5 mi RNAs(mi RNA-21,-143,-145,-196a and let-7)based on the available literature,and described their potential role in regulating pathways that are deregulated in esophageal *** we will highlight the current achievements of using and targeting mi *** these mi RNAs likely have important regulatory roles in cancer development,they open a therapeutic window for new treatment modalities.

关键词： Esophageal cancer Esophageal squamouscell carcinoma Esophageal adenocarcinoma MicroRNAs Target genes

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Towards the Tipping Point for FAIR Implementation

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Data Intelligence 2020年第1期2卷 264-275页

作者： Mirjam van Reisen Mia Stokmans Mariam Basajja Antony Otieno Ong’ayo christine Kirkpatrick Barend Mons Liacs Institute of Advanced Computer Science Leiden UniversityLeidenThe Netherlands Tilburg School of Humanities and Digital Sciences Tilburg University901535000 LE TilburgThe Netherlands International Institute of Social Studies Erasmus University297762502 LT The HagueThe Netherlands San Diego Supercomputer Center University of California San DiegoSan Diego CA 92093USA Leiden University Medical Center Leiden2333 ZAThe Netherlands

This article explores the global implementation of the FAIR Guiding Principles for scientific management and data stewardship,which provide that data should be findable,accessible,interoperable and *** implementation of these principles is designed to lead to the stewardship of data as FAIR digital objects and the establishment of the Internet of FAIR Data and Services(IFDS).If implementation reaches a tipping point,IFDS has the potential to revolutionize how data is managed by making machine and human readable data discoverable for ***,this article examines the expansion of the implementation of FAIR Guiding Principles,especially how and in which geographies(locations)and areas(topic domains)implementation is taking place.A literature review of academic articles published between 2016 and 2019 on the use of FAIR Guiding Principles is *** investigation also includes an analysis of the domains in the IFDS Implementation Networks(INs).Its uptake has been mainly in the Western *** investigation found that implementation of FAIR Guiding Principles has taken firm hold in the domain of bio and natural *** achieve a tipping point for FAIR implementation,it is now time to ensure the inclusion of non-European ascendants and of other scientific *** from equal opportunity and genuine global partnership issues,a permanent European bias poses challenges with regard to the representativeness and validity of data and could limit the potential of IFDS to reach across continental *** article concludes that,despite efforts to be inclusive,acceptance of the FAIR Guiding Principles and IFDS in different scientific communities is limited and there is a need to act now to prevent dampening of the momentum in the development and implementation of the *** is further concluded that policy entrepreneurs and the GO FAIR INs may contribute to making the FAIR Guiding Principles more flexible in including different rese

关键词： FAIR Data Health Digital Health mHealth data-driven science FAIR Implementation Networks GO-FAIR

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