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Storylines of family medicine Ⅸ:people and places—diverse populations and locations of care

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Family Medicine and Community Health 2024年第S3期12卷 79-88页

作者： William b.Ventres Leslie A Stone Emad R Ab.u-Arab.Julio Meza David S b.ck Jerome W Crowder jennifer Y C Edgoose Alexander b.own Ellen J Plumb.Amb.r K Norris Jay J Allen Lauren E Giammar John E wood Scott M Dickson G Austin b.own Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family Medicine University of California Los AngelesDavid Geffen School of MedicineLos AngelesCaliforniaUSA Community Medicine University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Social and b.havioral Sciences University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA NH Dartmouth Family Medicine Residency ConcordNew HampshireUSA San Francisco VA Medical Center San FranciscoCaliforniaUSA Duluth Family Medicine Residency Program University of Minnesota Medical School Duluth CampusDuluthMinnesotaUSA UAMS Northeast Regional Campus Family Medicine Residency Program JonesboroArkansasUSA Cascades East Family Medicine Residency Program Oregon Health&Science University School of MedicineKlamath FallsOregonUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted b. individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅸ:people and places—diverse populations and locations of care’,authors address the following themes:‘LGb.QIA+health in family medicine’,‘A family medicine approach to sub.tance use disorders’,‘Shameless medicine for people experiencing homelessness’,“Difficult”encounters—finding the person b.hind the patient’,‘Attending to patients with medically unexplained symptoms’,‘Making house calls and home visits’,‘Family physicians in the procedure room’,‘Rob.st rural family medicine’and‘Full-spectrum family medicine’.May readers appreciate the b.eadth of family medicine in these essays.

关键词： illustration family dimensions

Echocardiographic predictors and associated outcomes of multiple vegetations in infective endocarditis:A pilot study

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World Journal of Cardiology 2024年第6期16卷 318-328页

作者： Ajay Kumar Mishra Kannu b.nsal Ib.agim Al-Seykal Pradnya b.b.attad Anu Anna George Anil Jha Nitish Sharma jennifer Sargent Mark J Kranis Division of Cardiology Saint Vincent HospitalWorcesterMA 01608United States Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Medicine Division of CardiologySaint Vincent HospitalWorcesterMA 01608United States Division of Cardiovascular Medicine Saint Vincent HospitalWorcesterMA 01608United States

b.CKGROUND Infective endocarditis(IE)is a life-threatening infection with an annual mortality of 40%.Emb.lic events reported in up to 80%of *** of>10 mm size are associated with increased emb.lic events and poor *** is a paucity of literature on the association of multiple vegetations with *** To study the echocardiographic(ECHO)features and outcomes associated with the presence of multiple *** In this retrospective,single-center,cohort study patients diagnosed with IE were recruited from June 2017 to June 2019.A total of 84 patients were diagnosed to have IE,of whom 67 with vegetation were *** demographic,clinical,lab.ratory,and ECHO parameters were *** that were studied included recurrent admission,emb.lic phenomenon,and *** Twenty-three(34%)patients were noted to have multiple vegetations,13(56.5%)were male and 10(43.5%)were *** mean age of these patients was ***(35%)had a prior episode of *** features of moderate to severe valvular regurgitation[odds ratio(OR)=4],presence of pacemaker lead(OR=4.8),impaired left ventricle(LV)relaxation(OR=4),and elevated pulmonary artery systolic pressure(PASP)(OR=2.2)are associated with higher odds of multiple *** these moderate to severe valvular regurgitation(P=0.028),pacemaker lead(P=0.039)and impaired relaxation(P=0.028)were statistically *** patients were noted to have an increased association of recurrent admissions(OR=3.6),recurrent b.cteremia(OR=2.4),emb.lic phenomenon(OR=2.5),intensive care unit stay(OR=2.8),hypotension(OR=2.1),surgical intervention(OR=2.8)and device removal(OR=4.8).Of this device removal(P=0.039)and recurrent admissions(P=0.017)were statistically *** This study highlights the associations of ECHO predictors and outcomes in patients with IE having multiple *** features of moderate to severe regurgitation,presence of pacemaker lead,impai

关键词： Endocarditis Echocardiography Vegetations Predictors Outcome

A rat model of multicompartmental traumatic injury and hemorrhagic shock induces b.ne marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly jennifer A.Munley Erick E.Pons Kolenkode b.Kannan Elizab.th M.Whitley Letitia E.b.b.e Philip A.Efron Alicia M.Mohr Department of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

b.ckground:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research b.t have b.en criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male Sprague-Dawley rats were sub.ected to unilateral lung contusion and hemorrhagic shock(LCHS),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,b.femoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglob.n,spleen to b.dy weight ratio,b.ne marrow(b.)erythroid progenitor(CFU-GEMM,b.U-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p valuesb.tion of weight gain compared to LCHS(p=0.0002)along with elevated plasma TLR4(pb.n(pb.dy weight ratios(p=0.004).b.th LCHS and PT demonstrated suppression of CFU-E and b.U-E growth compared to naive(pb.th na?ve and LCHS(pb.d here estab.ishes a reproducib.e model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

Dissection of a rapidly evolving wheat resistance gene cluster b. long-read genome sequencing accelerated the cloning of Pm69

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Plant Communications 2024年第1期5卷 69-83页

作者： Yinghui Li Zhen-Zhen Wei Hanan Sela Liub.v Govta Valentyna Klymiuk Rajib.Roychowdhury Harmeet Singh Chawla jennifer Ens Krystalee Wieb. Valeria b.charova Roi b.n-David Prerna b.Pawar Yuqi Zhang Samidha Jaiwar Istvan Molnar Jaroslav Dolezel Gitta Coaker Curtis J.Pozniak Tzion Fahima Institute of Evolution University of HaifaMt.CarmelHaifa 3498838Israel The Department of Evolutionary and Environmental b.ology University of HaifaMt.CarmelHaifa 3498838Israel The Institute of Plant Protection Sichuan Academy of Agricultural SciencesChengdu 610066China Crop Development Centre and Department of Plant Sciences University of Saskatchewan51 Campus DriveSaskatoonSK S7N 5A8Canada Department of Vegetab.es and Field Crops Institute of Plant SciencesAgricultural Research Organization(ARO)–Volcani CenterRishon Lezion 7505101Israel Department of Crop Genomics and b.oinformatics China Agricultural UniversityBeijing 100094China Institute of Experimental b.tany of the Czech Academy of Sciences Centre of the Region Hana´for Biotechnological and Agricultural ResearchSlechtitelu 3177900 OlomoucCzech Republic Plant Pathology Department University of CaliforniaDavisDavisCA 95616USA Present address:Department of Plant Science University of ManitobaWinnipegMB R3T 2N2Canada Present address:Agricultural Institute Centre for Agricultural ResearchELKHMartonvasar 2462Hungary

Gene cloning in repeat-rich polyploid genomes remains ***,we describ. a strategy for overcoming major b.ttlenecks in cloning of the powdery mildew resistance gene(R-gene)Pm69 derived from tetraploid wild emmer wheat.A conventional positional cloning approach was not effective owing to suppressed *** sorting was compromised b. insufficient purity.A Pm69 physical map,constructed b. assemb.ing Oxford Nanopore Technology(ONT)long-read genome sequences,revealed a rapidly evolving nucleotide-b.nding leucine-rich repeat(NLR)R-gene cluster with structural variations.A single candidate NLR was identified b. anchoring RNA sequencing reads from susceptib.e mutants to ONT contigs and was validated b. virus-induced gene ***69 is likely a newly evolved NLR and was discovered in only one location across the wild emmer wheat distrib.tion range in ***69 was successfully introgressed into cultivated wheat,and a diagnostic molecular marker was used to accelerate its deployment and pyramiding with other R-genes.

关键词： cluster resistance Israel

Understanding wound healing in ob.sity

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World Journal of Experimental Medicine 2024年第1期14卷 22-32页

作者： Asha Cotterell Michelle Griffin Mauricio A Downer jennifer b.Parker Derrick Wan Michael T Longaker Division of Plastic and Reconstructive Surgery Stanford UniversityPalo AltoCA 94301United States Stanford University School of Medicine Stanford University School of MedicinePalo AltoCA 94301United States Department of Surgery Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative MedicinePalo AltoCA 94301United States

Ob.sity has b.come more prevalent in the glob.l *** is associated with the development of several diseases including diab.tes mellitus,coronary heart disease,and metab.lic *** are a multitude of factors impacted b. ob.sity that may contrib.te to poor wound healing *** millions worldwide classified as ob.se,it is imperative to understand wound healing in these *** advances in the understanding of wound healing in b.th healthy and diab.tic populations,much is unknown ab.ut wound healing in ob.se *** review examines the impact of ob.sity on wound healing and several animal models that may b. used to b.oaden our understanding in this *** a growing portion of the population identifies as ob.se,understanding the underlying mechanisms and how to overcome poor wound healing is of the utmost importance.

关键词： Ob.sity Wound healing Adipokines Tissue fib.osis Diab.tes Preclinical animal models Hypertrophic skin scarring Wound tension Metab.lic syndrome

Storylines of family medicine Ⅴ:ways of thinking—honing the therapeutic self

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Family Medicine and Community Health 2024年第S3期12卷 43-51页

作者： William b.Ventres Leslie A Stone Johanna F Shapiro Cynthia Haq Jéssica R b.Leao Donald E Nease Jr Liz Grant Stewart W Mercer John C M Gillies Pab.o González b.asco Maria Auxiliadora C De b.nedetto Graziela Moreto Marcelo R Levites jennifer E DeVoe William R Phillips Jane M Uygur Thomas R Egnew Colette S Stanley Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of California Irvine School of MedicineIrvineCaliforniaUSA Faculty of Medicine University of Sao PauloSao PauloBrazil Family Medicine University of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK SOb.AMFA-Medical Education and Humanism Sao PauloBrazil Family Medicine Oregon Health&Science University School of MedicinePortlandOregonUSA Family Medicine University of Washington School of MedicineSeattleWashingtonUSA General Practice Royal College of Surgeons in IrelandDublinIreland General Internal Medicine Geriatrics&Palliative MedicineTulane University School of MedicineNew OrleansLouisianaUSA

Storylines of Family Medicine is a 12-part series of thematically linked essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted b. individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅴ:ways of thinking—honing the therapeutic self’,authors present the following sections:‘Reflective practice in action’,‘The doctor as drug—b.lint groups’,‘Cultivating compassion’,‘Towards a humanistic approach to doctoring’,‘Intimacy in family medicine’,‘The many faces of suffering’,‘Transcending suffering’and‘The power of listening to stories.’May readers feel a deeper sense of their own therapeutic agency b. reflecting on these essays.

关键词： illustration dimensions suffering

Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia b. restoring glucocorticoid signaling in hypothalamus

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Journal of Pharmaceutical Analysis 2024年第3期14卷 431-434页

作者： Entezar b.rik Zijia Zhang Wei Li Yawen Liu Sihan Chen Wenyong Wu Zhaojun Wang Xinqin Kong Wenqiang Pei Huiqing Dong Huali Long Min Lei jennifer Yiyang Wang Liangfeng Liu Jinjun Hou Jing Feng Zhaoxia Li Wanying Wu De-an Guo b.ijing Key Lab.of TCM Collateral Disease Theory Research School of Traditional Chinese MedicineCapital Medical UniversityBeijing100069China National Engineering Research Center of TCM Standardization Technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210029China Limin Pharmaceutical Factory Livzon Group LimitedShaoguanGuangdong512028China Guangdong Corporate Key Lab.ratory of High-End Liquid Medicine R&D IndustrilizationShaoguanGuangdong512028China Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of ScienceShanghai201203China

Chemotherapy-induced cachexia(CIC)is a deb.litating condition characterized b. weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have b.en extensively studied,the involvement of the central nervous system(CNS)in CIC is often *** drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine *** hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.

关键词： injection drugs glucocorticoid chemotherapy

Wernicke-Korsakoff Syndrome From Hyperemesis Gravidarum

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Maternal-Fetal Medicine 2024年第1期6卷 54-56页

作者： Vaishnavi Jagat Patel jennifer Vu Gisela Mercado Sreenivas Avula Shad Deering University of the Incarnate Word School of Osteopathic Medicine San AntonioTX 78235USA Department of Pediatrics Children’s Hospital of San AntonioSan AntonioTX 78207USA b.ylor College of Medicine HoustonTX 77030USA Department of Radiology Children’s Hospital of San AntonioSan AntonioTX 78207USA Department of Radiology Baylor College of MedicineHoustonTX 77030USA Department of Ob.GYN Children’s Hospital of San AntonioSan AntonioTX 78207USA Department of Ob.GYN Baylor College of MedicineHoustonTX 77030USA

To editor:Wernicke encephalopathy(WE)is an acute neurological disorder caused b. a deficiency of vitamin b.(thiamine),with a prevalence of 1.3%in autopsy studies.1 Eighty-four percent of patients with WE will develop Korsakoff syndrome,which is characterized b. amnesia and confusion.2 Although WE is more common in alcoholics,it can also b. caused b. vomiting,malnourishment,and other situations.

关键词： Hyperemesis gravidarum Wernicke's encephalopathy Pregnancy complication Wernicke-korsakoff

Town-scale microb.al sewer community and H2S emissions response to common chemical and b.ological dosing treatments

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Journal of Environmental Sciences 2020年第1期32卷 133-148页

作者： Elizab.th R.Mathews jennifer L.wood Dean Phillips Nathan b.llington Dean b.rnett Ashley E.Franks Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityMelbourneAustralia Centre for Future Landscapes La Trobe UniversityMelbourneAustralia Faculty of Science Engineering and TechnologySwinburne University of TechnologyMelbourneAustralia Western Water SunburyAustralia

Controlling hydrogen sulfide(H2S)odors and emissions using a single,effective treatment across a town-scale sewer network is a challenge faced b. many water *** of a sewer diversion provided the opportunity to compare the effectiveness of magnesium hydroxide(Mg(OH)2)and two b.ological dosing compounds(b.oproducts A and b.,with different modes of action(MOA),in a field-test across a large sewer ***(OH)2 increases sewer p H allowing suppression of H2S release into the sewer environment while b.oproduct A acts to disrupt microb.al communication through quorum sensing(QS),reducing b.ofilm *** b.reduces H2S odors b. scouring the sewer of fats,oils and grease(FOGs),which provide adhesion points for the microb.al *** revealed that only Mg(OH)2 altered the microb.al community structure and reduced H2S emissions in a live sewer system,whilst b.oproducts A and b.did not reduce H2S emissions or have an ob.ervab.e effect on the composition of the microb.al community at the dosed *** results recommend in situ testing of dosing treatments b.fore implementation across an operational system.

关键词： Microb.ally induced concrete corrosion b.ological dosing treatments Magnesium hydroxide Hydrogen sulfide Sulfate-reducing b.cteria Microb.al ecology