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Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system

World Journal of Gastroenterology 2020年第16期26卷 1879-1887页

作者： Katherine Roth jenna strickland Bryan L Copple Department of Pharmacology and Toxicology Institute for Integrative ToxicologyMichigan State UniversityEast LansingMI 48824United States

The liver functions,in part,to prevent exposure of the body to potentially harmful substances ingested in the *** it is highly efficient at accomplishing this,it is frequently prone to liver injury due to the biotransformation of xenobiotics into toxic *** counter this injury,the liver has evolved a unique capacity to rapidly and efficiently repair *** resolution of acute liver injury relies on hepatic macrophage populations that orchestrate the reparative *** injury,Kupffer cells,the resident macrophages of the liver,become activated and secrete proinflammatory *** cytokines recruit other immune cells,including monocyte-derived macrophages,to the liver where they contribute to the repair ***-derived macrophages traffic into the necrotic foci where they rapidly phagocytose dead cell *** with this process,these cells change phenotype from a proinflammatory macrophage to a prorestorative macrophage that produce pro-mitogenic growth factors and antiinflammatory *** this process triggers resolution of inflammation,and along with proliferation of other hepatic cells,restores the liver architecture and *** the mechanisms regulating specific macrophage functions during repair remain to be elucidated,recent studies indicate a key role for the fibrinolytic system in coordinating macrophage function during *** this review,we will highlight the function and role of hepatic macrophages in repair after acute liver injury,and will discuss the role of the fibrinolytic enzyme,plasmin,in regulation of these various processes.

关键词： Macrophage Plasmin Acetaminophen Liver injury Liver repair

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