Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system

作     者：Katherine Roth Jenna Strickland Bryan L Copple 

作者机构：Department of Pharmacology and ToxicologyInstitute for Integrative ToxicologyMichigan State UniversityEast LansingMI 48824United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第16期

页      面：1879-1887页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Institutes of Health Grant,No.DK073566(to Copple BL) National Institutes of Health Training Grant,No.ES007255(to Roth K and Strickland J) 

主　　题：Macrophage Plasmin Acetaminophen Liver injury Liver repair 

摘      要：The liver functions,in part,to prevent exposure of the body to potentially harmful substances ingested in the *** it is highly efficient at accomplishing this,it is frequently prone to liver injury due to the biotransformation of xenobiotics into toxic *** counter this injury,the liver has evolved a unique capacity to rapidly and efficiently repair *** resolution of acute liver injury relies on hepatic macrophage populations that orchestrate the reparative *** injury,Kupffer cells,the resident macrophages of the liver,become activated and secrete proinflammatory *** cytokines recruit other immune cells,including monocyte-derived macrophages,to the liver where they contribute to the repair ***-derived macrophages traffic into the necrotic foci where they rapidly phagocytose dead cell *** with this process,these cells change phenotype from a proinflammatory macrophage to a prorestorative macrophage that produce pro-mitogenic growth factors and antiinflammatory *** this process triggers resolution of inflammation,and along with proliferation of other hepatic cells,restores the liver architecture and *** the mechanisms regulating specific macrophage functions during repair remain to be elucidated,recent studies indicate a key role for the fibrinolytic system in coordinating macrophage function during *** this review,we will highlight the function and role of hepatic macrophages in repair after acute liver injury,and will discuss the role of the fibrinolytic enzyme,plasmin,in regulation of these various processes.