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HCV Extrahepatic Manifestations

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Journal of Clinical and Translational Hepatology 2019年第2期7卷 172-182页

作者： Lucija Kuna jelena Jakab Robert Smolic George y Wu Martina Smolic Department of Pharmacology and Biochemistry Faculty of Dental Medicine and HealthJ.J.Strossmayer University of OsijekOsijekCroatia Department of Pathophysiology and Physiology with Immunology Faculty of Dental Medicine and HealthJ.J.Strossmayer University of OsijekOsijekCroatia Department of Internal medicine Faculty of MedicineJ.J.Strossmayer University of OsijekOsijekCroatia Department of Pharmacology Faculty of MedicineJ.J.Strossmayer University of OsijekOsijekCroatia Department of medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Hepatitis C virus(HCV)has been shown to affect many tissues other than ***,of the many extrahepatic manifestations(EMs)that have been associated with HCV,including cryoglobulinemia,lymphoma,insulin resistance,type 2 diabetes and neurological disorders,only a few have been shown to be directly related to HCV infection of extrahepatic ***-triggered immune-mediated mechanisms account for most of the *** is estimated that up to 74%of patients with chronic hepatitis C can develop at least one *** HCV patients with EMs should be considered for antiviral therapy,although not all will resolve with sustained virological response.

关键词： Hepatitis C virus Hepatic stellate cells B cell lymphomas pancreatic B cell TGF-β-dependent signaling pathway Extrahepatic manifestations Direct-acting antivirals

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Interaction between adjacent left-lateral strike-slip faults and thrust faults: the 1976 Songpan earthquake sequence

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Chinese Science Bulletin 2008年第16期53卷 2520-2526页

作者： y. john CHEN Department of Geophysics School of Earth and Space Sciences Peking University

Based on the published focal mechanisms we have built the fault model of the main shocks of the 1976 Songpan earthquake sequence and calculated the coseismic Coulomb stress changes in the region. The results show that most of the aftershocks had occurred in the region where the Coulomb stresses had been increased, indicating a triggering relationship between the main shocks and the aftershocks. We also show that the first main shock (Ms = 7.2), which is a left-lateral slip event, had increased the Coulomb stresses by 5×105 Pa at the second main shock (a thrust event with Ms = 6.7). Therefore, we conclude that the first main shock had triggered the second main shock. The third main shock is also a left-lateral event, however, the triggering relationship between the third main shock and the previous two events is less obvious. General model calculations show that there is a good triggering relation- ship between adjacent left-lateral slip fault and thrust fault, but triggering between parallel slip faults is rather weak.

关键词：松潘大地震序列断层地震波

Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen CS De Oliveira Luiz C Di Stasi Ligia y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

Solar wind entry via flux tube into magnetosphere observed by Cluster measurements at dayside magnetopause during southward IMF

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Science China(Technological Sciences) 2009年第7期52卷 2104-2111页

作者： M. Dunlop A. Balogh H. Rème y. V. Bogdanova A. Fazakerley Rutherford Appleton Laboratory Didcot United Kingdom Imperial College of Science Technology and Medicine London United Kingdom CESR BP4346 31028 Toulouse Cedex 4 France Mullard Space Science Laboratory Dorkink United Kingdom Department of Physics La Trobe University Victoria 3086 Australia

By analyzing hot ion and electron parameters together with magnetic field measurements from Cluster, an event of magnetopause crossing of the spacecraft has been investigated. At the latitude of about 40° and magnetic local time (MLT) of 13:20 during the southward interplanetary magnetic field (IMF), a transition layer was observed, with the magnetospheric field configuration and cold dense plasma features of the magnetosheath. The particle energy-time spectrograms inside the layer were similar to but still a little different from those in the magnetosheath, obviously indicating the solar wind entry into the magnetosphere. The direction and magnitude of the accelerated ion flow implied that reconnection might possibly cause such a solar wind entry phenomenon. The bipolar signature of the normal magnetic component BN in magnetopause coordinates further supported happening of reconnection there. The solar wind plasma flowed toward the magnetopause and entered the magnetosphere along the reconnected flux tube. The magnetospheric branch of the reconnected flux tube was still inside the magnetosphere after reconnection and supplied the path for the solar wind entry into the dayside magnetosphere. The case analysis gives observational evidence and more details of how the reconnection process at the dayside low latitude magnetopause caused the solar wind entry into the magnetosphere.

关键词： transport process magnetic reconnection solar wind-magnetosphere interactions

Photometric and Spectroscopic Study of Two Low Mass Ratio Contact Binary Systems:CRTS J225828.7-121122 and CRTSJ030053.5+230139

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Research in Astronomy and Astrophysics 2023年第11期23卷 1-6页

作者： Surjit S.Wadhwa jelena Petrović Nick F.H.Tothill Ain y.De Horta Miroslav D.Filipović Gojko Djurašević School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Astronomical Observatory Volgina 711060 BelgradeSerbia

The study reports photometric and spectroscopic observations of two recently recognized contact binary *** systems show total eclipses and analysis of the light curves indicates both have very low mass ratios of less than *** derive absolute parameters from color and distance based calibrations and show that,although both have low mass ratios,they are likely to be in a stable orbit and unlikely to *** other respects,both systems have characteristics similar to other contact binaries with the secondary larger and brighter than their main sequence counterparts and we also find that the secondary is considerably denser than the primary in both systems.

关键词： (stars:)binaries:eclipsing stars:mass-loss techniques:photometric

Plastic deformation behavior of Mg97Zn1y2 extruded alloys

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Transactions of Nonferrous metals Society of China 2010年第7期20卷 1259-1268页

作者： K.HAGIHARA A.KINOSHITA y.SUGINO M.yAMASAKI y.KAWAMURA H.y.yASUDA y.UMAKOSHI Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1Yamada-okaSuitaOsaka 565-0871Japan Department of Materials Science Kumamoto University2-39-1KurokamiKumamoto 860-8555Japan National Institute for Materials Science 1-2-1SengenTsukubaIbaraki 305-0047Japan

The mechanical properties of the Mg97Znly2 extruded alloy containing the long-period stacking ordered phase, the so-called LPSO-phase, with a volume fraction of 24%-25%, were examined by compression tests and cyclic tension-compression deformation tests. The plastic behavior of the extruded alloys with compositions of Mg99.2Zn0.2y0.6 and Mg89Zn4y7 （molar fraction, %）, which were almost the same compositions of Mg matrix phase and LPSO phase in Mg97Zn1y2 Mg/LPSO two-phase alloy, respectively, were also prepared. By comparing their mechanical properties, the strengthening mechanisms operating in the Mg97Zn1 y2 extruded alloy were discussed. Existence of the LPSO-phase strongly enhanced the refinement of Mg matrix grain size during extrusion, which led to a large increment of the strength of alloy. In addition, the LPSO-phases, which were aligned along the extrusion direction in Mg97Zn1y2 extruded alloy, acted as hardening phases, just like reinforced fibers.

关键词： plastic deformation yield stress LPSO-phase dislocation twinning

Circadian rhythms in liver metabolism and disease

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Acta Pharmaceutica Sinica B 2015年第2期5卷 113-122页

作者： Jessica M.Ferrell john y.L.Chiang Department of Integrative medical Sciences Northeast Ohio Medical University

Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and ***, these associations are reviewed with respect to liver metabolism and disease.

关键词： Circadian rhythm Liver metabolic syndrome Type 2 diabetes