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Pearls and pitfalls in magnetic resonance imaging of hepatocellular carcinoma

World Journal of Gastroenterology 2020年第17期26卷 2012-2029页

作者： jelena djokic kovac Tamara Milovanovic Vladimir Dugalic Igor Dumic Departament of Radiology Clinical Center SerbiaBelgrade 11000Serbia School of Medicine Belgrade UniversityBelgrade 11000Serbia Departament of Hepatology Clinical Center SerbiaBelgrade 11000Serbia Departament of Surgery Clinical Center SerbiaBelgrade 11000Serbia Divison of Hospital Medicine Mayo Clinic College of Medicine and SciencesMayo Clinic Health SystemNew YorkNY 10029United States

Hepatocellular carcinoma(HCC)is the most common primary hepatic malignancy,which usually arises in cirrhotic *** the typical enhancement pattern,consisting of late arterial hyperenhancement followed by washout,is present in nodules larger than 1 cm,HCC can be confidently diagnosed without the need for tissue ***,HCC can display an atypical enhancement pattern,either as iso or hypovascular lesion,or hypervascular lesion without *** only the enhancement pattern of HCC could be atypical,but also a variety of histological types of HCC,such as steatotic,scirrhous,fibrolamellar,or combined hepatocellular-cholangiocellular carcinoma could raise diagnostic *** addition,distinct morphological types of HCC or different growth pattern can *** of these atypical and rare HCC presentations on magnetic resonance imaging is important for accurate differentiation from other focal liver lesions and timely diagnosis,which allows optimal treatment of patients.

关键词： Hepatocellular carcinoma Cirrhosis Magnetic resonance imaging Hepatocarcinogenesis

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Low-grade fibromyxoid sarcoma of the liver: A case report

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World Journal of Clinical Cases 2021年第1期9卷 175-182页

作者： Vladimir Dugalic Igor I Ignjatovic jelena djokic kovac Nikola Ilic jelena Sopta Slavenko R Ostojic Dragan Vasin Marko D Bogdanovic Igor Dumic Tamara Milovanovic Department of Hepatobiliary&Pancreatic Surgery Clinic for Digestive SurgeryClinical Center of SerbiaBelgrade 11000Serbia Department of Radiology Clinical Center of SerbiaBelgrade 11000Serbia Clinic for Vascular and Endovascular Surgery Clinical Center of SerbiaBelgrade 11000Serbia Institute of Pathology University of BelgradeBelgrade 11000Serbia Mayo Clinic Health System Mayo Clinic College of Medicine and ScienceRochesterNY 10029United States Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaSchool of MedicineUniversity of BelgradeBelgrade 11000Serbia

BACKGROUND Low grade fibromyxoid sarcoma(LGFMS)is a rare and benign mesenchymal tumor with indolent course,most commonly found in young or middle-aged *** majority of the LGFMSs are located in the trunk and deep soft tissue of the lower *** appear as well circumscribed,although not encapsulated,which often leads to incomplete surgical *** their seemingly benign appearance,these tumors have aggressive behavior with high metastatic and recurrence *** histopathologic examination of the specimen and its immunohistochemical analysis are mandatory for a precise *** SUMMARY We report a case of a 38 year-old-man who presented with jaundice and upper abdominal ***-detector computed tomography and magnetic resonance imaging showed a large left liver tumor mass,extending to the hepatoduodenal *** hepatectomy was performed with resection and reconstruction of hepatic artery and preservation of middle hepatic *** examination confirmed the tumor being a low-grade fibromyxoid *** and a half years after surgery,the patient died after being diagnosed with spine *** Due to poor response to all modalities of adjuvant treatment,we consider that the focus of treatment should be on surgery as the only option for curing the disease.

关键词： Fibromyxoid sarcoma Liver Resection Histopathology Case report

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Pulmonary Immune Responses to Aspergillus Fumigatus in Rats

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Biomedical and Environmental Sciences 2014年第9期27卷 684-694页

作者： MIRKOV Ivana EL-MUZGHI Amal Atia Mhfuod djokic jelena NINKOV Marina POPOV ALEKSANDROV Aleksandra GLAMOCLIJA Jasmina KATARANOVSKI Milena Department of Ecology Institute for Biological Research ‘Sinisa Stankovic'University of Belgrade Department of Plant Physiology (Mycology Lab) Institute for Biological Research ‘Sinisa Stankovic'University of Belgrade Institute of Physiology and Biochemistry Faculty of BiologyUniversity of Belgrade

Objective To evaluate immunologic mechanisms underlying Aspergillus fumigatus pulmonary infections in immunocompetent Dark Agouti （DA） and Albino Oxford （AO） rats recognized as being susceptible to some inflammatory diseases in different manners. Methods Lung fungal burden （quantitative colony forming units, CFU, assay）, leukocyte infiltration （histology, cell composition） and their function （phagocytosis, oxidative activity, CDllb adhesion molecule expression） and cytokine interferon-y （IFN-y） and interleukin-17 and -4 （IL-17 and IL-4） lung content were evaluated following infection （intratracheally, lxl07 conidia）. Results Slower reduction of fungal burden was observed in AO rats in comparison with that in DA rats, which was coincided with less intense histologically evident lung cell infiltration and leukocyte recovery as well as lower level of most of the their activities including intracellular myeloperoxidase activity, the capacity of nitroblue tetrazolium salt reduction and CDllb adhesion molecule expression （except for phagocytosis of conidia） in these rats. Differential patterns of changes in proinflammatory cytokine levels （unchanged levels of IFN-v and transient increase of IL-17 in AO rats vs continuous increase of both cytokines in DA rats） and unchanged levels of IL-4 were observed. Conclusion Genetically-based differences in the pattern of antifungal lung leukocyte activities and cytokine milieu, associated with differential efficiency of fungal elimination might be useful in the future use of rat models in studies of pulmonary aspergillosis.

关键词： A. fumigatus Rats Lung immune responses

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Giant pseudoaneurysm of the splenic artery within walled of pancreatic necrosis on the grounds of chronic pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 87-89页

作者： Milica Mitrovic Jovanovic Dusan Saponjski Aleksandra Djuric Stefanovic Aleksandra Jankovic Stefan Milosevic Katarina Stosic Djordje Knezevic jelena kovac Department of Abdominal Radiology Center for Radiology and MRIClinical Center of SerbiaBelgradeSerbia Faculty of Medicine University of BelgradeBelgradeSerbia Clinic for Digestive Surgery–First Surgical Clinic Clinical Center of SerbiaBelgradeSerbia

Chronic pancreatitis is a long-standing inflammation of the pancreas,characterized by progressive inflammatory and fibrotic changes,resulting in permanent structural damage of pancreatic parenchyma[1].Pancreatitis(chronic or acute)is the primary risk factor for pseudo-splenic artery aneurysms,along with pancreatic pseudocysts and *** the disease progresses,patients with chronic pancreatitis may develop complications due to exocrine and endocrine pancreatic functional loss,such as fat malabsorption with steatorrhea,glucose intolerance,and ultimately diabetes mellitus[1,2].Furthermore,severe pancreatic inflammation can cause weakening of vessel walls,with subsequent formation of arterial *** artery is the most commonly affected visceral artery[2,3].Liver cirrhosis,portal hypertension,liver transplantation,atherosclerosis,hypertension,pregnancy and multiparity are main risk factors for true splenic artery aneurysms[2].Rupture and intraperitoneal bleeding is the cause of death in 30%−50%of ***,prompt diagnosis and appropriate treatment are of great clinical importance[4,5].Herein,we present a case of a giant splenic artery pseudoaneurysm within a walled of necrosis involving pancreatic parenchyma,as a complication of long standing chronic pancreatitis.

关键词： pancreatitis aneurysm inflammation

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