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In vivo measurement of NADH fluorescence lifetime in skeletal muscle via -ber-coupled time-correlated single photon counting

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 121-134页

作者： Kathryn M.Priest Jacob V.Schluns Nathania Nischal colton L.Gattis jeffrey c.Wolchok Timothy J.Muldoon Department of Biomedical Engineering University of Arkansas FayettevilleARUSA

Nicotinamide adenine dinucleotide(NADH)is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation(OXPHOS).NADH is autofluorescent,and itsfluorescence lifetime can be used to infer metabolic dynamics in living ***-coupled time-correlated single photon counting(TcSPc)equipped with an implantable needle probe can be used to measure NADH lifetime in vivo,enabling investigation of changing metabolic demand during muscle contraction or tissue *** study illustrates a proof of concept for point-based,minimally-invasive NADHfluorescence lifetime measurement in *** muscle loss(VML)injuries were created in the left tibialis anterior(TA)muscle of male Sprague Dawley *** lifetime measurements were collected before,during,and after a 30 s tetanic contraction in the injured and uninjured TA muscles,which was subsequently-t to a biexponential decay model to yield a metric of NADH utilization(cytoplasmic vs protein-bound NADH,the A11/A22 ratio).On average,this ratio was higher during and after contraction in uninjured muscle compared to muscle at rest,suggesting higher levels of free NADH in contracting and recovering muscle,indicating increased rates of *** injured muscle,this ratio was higher than uninjured muscle overall but decreased over time,which is consistent with current knowledge of inflammatory response to injury,suggesting tissue regeneration has *** data suggest that-ber-coupled TcSPc has the potential to measure changes in NADH binding in vivo in a minimally invasive manner that requires further investigation.

关键词： Glycolysis oxidative phosphorylation energy metabolism volumetric muscle loss

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13q31.1位点与欧洲人群非综合征型唇腭裂相关性研究

13q31.1位点与欧洲人群非综合征型唇腭裂相关性研究

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2015中国遗传学会大会

作者：贾仲林 Elizabeth J.Leslie Margaret E.cooper Azeez Butali Jennifer Standley Jennifer Rigdon Satoshi Suzukil Ayana Gongorjav T.Enkhtur Shonkhuuz Nagato Natsume 石冰 Mary L.Marazita jeffrey c.murray 四川大学华西口腔医学院口腔疾病国家重点实验室 Department of Pediatrics University of Iowa 四川大学华西口腔医院唇腭裂外科 center for craniofacial and Dental Genetics Department of Oral BiologySchool of Dental MedicineUniversity of Pittsburgh Department of Oral Pathology Radiologyand MedicineCollege of DentistryUniversity of Iowa Divisionof Research and Treatment for Oral and Maxillofacial congenital Anomalies School of DentistryAichi-Gakuin University

全基因组关联研究已成功地发现了十几个位点与唇腭裂的发生相关。然而,这些信号可能只与特定人群相关联,需要在其他人群进行反复验证以发现真正致病SNP位点。我们在来自欧洲(美国和丹麦)、亚洲(日本和蒙古)人群的946个家系(3436个人)验... 详细信息

全基因组关联研究已成功地发现了十几个位点与唇腭裂的发生相关。然而,这些信号可能只与特定人群相关联,需要在其他人群进行反复验证以发现真正致病SNP位点。我们在来自欧洲(美国和丹麦)、亚洲(日本和蒙古)人群的946个家系(3436个人)验证唇腭裂全基因组关联研究Meta分析发现的6个显著相关的位点:rs742071(1p36),rs7590268(2p21),rs7632427(3p11.1),rs12543318(8q21.3),rs8001641(13q31.1)和rs7179658(15q22.2);同时对来自美国,蒙古,和菲律宾三个人群的713个病例,438个正常对照及485个核心家系在SPRY2基因下游200Kb的三个非编码保守区进行直接测序。我们发现rs8001641位点显著与欧洲人群非综合征型唇裂伴腭裂的发生相关((p=4 x 10-5,ORtransmission=1.86和95%cI:1.38-2.52)。我们还在亚洲和欧洲的病例中发现了一些位于保守区域的遗传变异,它们可帮助定位与唇腭裂发生风险相关的常见遗传变异。这项研究进一步证实了先前报道的rs8001641和欧洲人群唇腭裂之间的关联。

关键词：全基因组关联研究非综合征型口面裂

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Photoionisation detection of a single Er3+ ion with sub-100-ns time resolution

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National Science Review 2024年第4期11卷 38-45页

作者： Yangbo Zhang Wenda Fan Jiliang Yang Hao Guan Qi Zhang Xi Qin changkui Duan Gabriele G.de Boo Brett c.Johnson jeffrey c.Mc callum Matthew J.Sellars Sven Rogge chunming Yin Jiangfeng Du cAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of China cAS center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China centre of Excellence for Quantum computation and communication Technology School of Physics University of New South Wales centre of Excellence for Quantum computation and communication Technology School of Engineering RMIT University centre of Excellence for Quantum computation and communication Technology School of Physics University of Melbourne centre of Excellence for Quantum computation and communication Technology Research School of Physics and Engineering Australian National University

Efficient detection of single optical centres in solids is essential for quantum information processing, sensing and single-photon generation *** this work,we use radio-frequency（RF） reflectometry to electrically detect the photoionisation induced by a single Er3+ion in *** high bandwidth and sensitivity of the RF reflectometry provide sub-100-ns time resolution for the photoionisation *** this technique,the optically excited state lifetime of a single Er3+ion in a Si nano-transistor is measured for the first time to be 0.49±0.04μ*** results demonstrate an efficient approach for detecting a charge state change induced by Er excitation and *** approach could be used for fast readout of other single optical centres in solids and is attractive for large-scale integrated optical quantum systems thanks to the multi-channel RF reflectometry demonstrated with frequency multiplexing techniques.

关键词： single optical centres erbium ions RF reflectometry photoionisation detection

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A medium chain fatty acid, 6-hydroxyhexanoic acid (6-HHA), protects against obesity and insulin resistance

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1892-1894页

作者： Sara c.Sebag Meihua Hao Qingwen Qian chawin Upara Qiong Ding Min Zhu jeffrey A.Banas Huojun cao Liu Hong Ling Yang Department of Anatomy and cell Biology University of Iowa Carver College of MedicineIowa CityIA 52242USA Fraternal Order of Eagles Diabetes Research center University of Iowa Carver College of MedicineIowa CityIA 52242USA Pappajohn Biomedical Institute University of Iowa Carver College of MedicineIowa CityIA 52242USA Iowa Institute for Oral Health Research University of Iowa College of DentistryIowa CityIA 52242USA

To the Editor,Obesity,one of the most serious health concerns worldwide,exacerbates periodontitis pathogenesis and reduces the effectiveness of ***,periodontitis-associated inflammation disrupts systemic lipid and glucose homeostasis,the major risk factors for developing obesity-associated *** studies have demonstrated that certain supplemental dietary lipids such as dietary polyunsaturated fatty acids,have beneficial outcomes for diabetic and obese *** addition to dietary lipid supply,the oral and gut microbiota produce fatty acids(FAs)which provide the host with essential nutrients and aid in defense against *** medium chain FAs(McFAs;6–12 carbons)are bacterial-derived lipids shown to have anti-inflammatory and insulin sensitization effects in diverse cell types such as ***,whether and to what extent oral microbiota-produced McFAs may ameliorate obesity-associated metabolic dysfunction are largely unknown.

关键词： obesity dietary lipids

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Perception of artificial conspecifics by bearded dragons(Pogona vitticeps)

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Integrative Zoology 2019年第2期14卷 214-222页

作者： Anna FROHNWIESER Thomas W.PIKE John c.murray Anna WILKINSON School of Life Sciences University of LincolnLincolnUK School of computer Science University of LincolnLincolnUK Wildlife Research center Kyoto UniversityKyotoJapan

Artificial animals are increasingly used as conspecific stimuli in animal behavior ***,researchers often have an incomplete understanding of how the species under study perceives conspecifics,and,hence,which features are needed for a stimulus to be perceived *** investigate the features that bearded dragons(Pogona vitticeps)attend to,we measured their lateralized eye use when assessing a successive range of *** ranged through several stages of realism in artificial conspecifics,to see how features such as color,the presence of eyes,body shape and motion influence *** found differences in lateralized eye use depending on the sex of the observing bearded dragon and the artificial conspecific,as well as the artificial conspecific’s ***,this approach can inform the design of robotic animals that elicit biologically-meaningful responses in live animals.

关键词： bearded dragons conspecifics lateralized eye use perception

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Promoting the production of challenging proteins via induced expression in cHO cells and modified cell-free lysates harboring T7 RNA polymerase and mutant eIF2α

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Synthetic and Systems Biotechnology 2024年第3期9卷 416-424页

作者： jeffrey L.Schloßhauer Lena Tholen Alexander Korner Stefan Kubick Sofia chatzopoulou Anja Honow Anne Zemella Fraunhofer Project Group PZ-Syn of the Fraunhofer Institute for cell Therapy and Immunology-IZI Branch Bioanalytics and Bioprocesses-IZI-BBAm MühlenbergPotsdamGermany Fraunhofer Institute for cell Therapy and Immunology-IZI Branch Bioanalytics and Bioprocesses-IZI-BBAm MühlenbergPotsdamGermany Faculty of Health Sciences Joint Faculty of the Brandenburg University of Technology Cottbus-SenftenbergThe Brandenburg Medical School Theodor FontaneUniversity of PotsdamPotsdamGermany Institute for chemistry and Biochemistry Laboratory of Protein BiochemistryFreie Universitat BerlinThielallee 6314195BerlinGermany Institute of Biotechnology Technische Universit¨at BerlinStraße des 17.Juni 13510623BerlinGermany New/era/mabs GmbH August-Bebel-Str.8914482PotsdamGermany

chinese hamster ovary(cHO)cells are crucial in biopharmaceutical production due to their scalability and capacity for human-like post-translational ***,toxic proteins and membrane proteins are often difficult-to-express in living ***,cell-free protein synthesis can be *** study explores innovative strategies for enhancing the production of challenging proteins through the modification of cHO cells by investigating both,cell-based and cell-free approaches.A major result in our study involves the integration of a mutant eIF2 translation initiation factor and T7 RNA polymerase into cHO cell lysates for cell-free protein *** resulted in elevated yields,while eliminating the necessity for exogenous additions during cell-free production,thereby substantially enhancing ***,we explore the potential of the Rosa26 genomic site for the integration of T7 RNA polymerase and cell-based tetracycline-controlled protein *** findings provide promising advancements in bioproduction technologies,offering flexibility to switch between cell-free and cell-based protein production as needed.

关键词： Inducible expression cHO cells cell-free protein synthesis cRISPR T7 RNA polymerase eIF2 Rosa26

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Predictors of survival in autoimmune liver disease overlap syndromes

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World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph Wendy cheng Simon Hazeldine Briohny W Smith Gerry c MacQuillan Michael c Wallace George Garas Leon A Adams Gary P jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BAcKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBc)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSc)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBc,27%AIH-PSc).There was no significant difference in survival between AIH-PBc and *** was a significant predictor of liver-related mortality(Pc(n=14)but not AIH-PSc(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBc patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's c-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBc *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

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The proximity between hydroxyl and single atom determines the catalytic reactivity of Rh1/ceO_(2) single-atom catalysts

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Nano Research 2024年第1期17卷 397-406页

作者： Danfeng Wu Shuyun Zhou congcong Du Juan Li Jianyu Huang Hong-xia Shen Abhaya K.Datye Shan Jiang jeffrey T.Miller Sen Lin Haifeng Xiong State Key Laboratory of Physical chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350002China clean Nano Energy center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China college of Biology and chemical Engineering Jiaxing UniversityJiaxing 314000China Department of chemical&Biological Engineering University of New MexicoAlbuquerqueNM 8731-0001USA Davidson School of chemical Engineering Purdue UniversityWest LafayetteIN 47907-2100USA Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China Fujian Key Laboratory of Rare-earth Functional Materials Fujian Shanhai Collaborative Innovation Center of Rare-earth Functional MaterialsLongyan 366300China

The local structure of the metal single-atom site is closely related to the catalytic activity of metal single-atom catalysts(SAcs).However,constructing SAcs with homogeneous metal active sites is a challenge due to the surface heterogeneity of the conventional ***,we prepared two Rh1/ceO_(2)SAcs(0.5Rh1/r-ceO_(2)and 0.5Rh1/c-ceO_(2),respectively)using two shaped ceO_(2)(rod and cube)exposing different facets,i.e.,ceO_(2)(111)and ceO_(2)(100).In cO oxidation reaction,the T100 of 0.5Rh1/r-ceO_(2)SAcs is 120°c,while the T100 of 0.5Rh1/c-ceO_(2)SAcs is as high as 200°*** in-situ cO diffuse reflectance infrared Fourier transform spectroscopy(cO-DRIFTS),we found that the proximity between OH group and Rh single atom on the plane surface plays an important role in the catalytic activity of Rh1/ceO_(2)SAc system in cO *** Rh single atom trapped at the ceO_(2)(111)crystal surface forms the Rh1(OH)adjacent species,which is not found on the ceO_(2)(100)crystal surface at room ***,during cO oxidation,the OH group far from Rh single atom on the 0.5Rh1/c-ceO_(2)disappears and forms Rh1(OH)adjacent species when the temperature is above 150°*** formation of Rh1(OH)adjacentcO intermediate in the reaction is pivotal for the excellent catalytic activity,which explains the difference in the catalytic activity of Rh single atoms on two different ceO_(2)*** formed Rh1(OH)adjacent-O-ce structure exhibits good stability in the reducing atmosphere,maintaining the Rh atomic dispersion after cO oxidation even when pre-reduced at high temperature of 500°*** functional theory(DFT)calculations validate the unique activity and reaction path of the intermediate Rh1(OH)adjacentcO species *** work demonstrates that the proximity between metal single atom and hydroxyl can determine the formation of active intermediates to affect the catalytic performances in catalysis.

关键词： crystal plane Rh1/ceO_(2)single-atom catalyst proximity of Rh and hydroxyl coordination structure cO oxidation

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Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of castration-Resistant Prostate cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulmottaleb E.Zetrini HoYin Lip Azhar Z.Abbasi Ibrahim Alradwan Taksim Ahmed chunsheng He jeffrey T.Henderson Andrew M.Rauth Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of Medical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatment of castration-resistant prostate cancer (cRPc), including radiation therapy and immunotherapy alone or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive nature of the tumor microenvironment. Herein, we exploited the bioreactivity of novel polymer–lipid manganese dioxide nanoparticles (PLMDs) to remodel the tumor immune microenvironment (TIME) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced immunogenic cell death. This study demonstrated that PLMD treatment sensitized hypoxic human and murine cRPc cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultimately cell death, which enhanced the secretion of damage-associated molecular patterns, attributable to the induction of autophagy and endoplasmic reticulum stress. Reoxygenation via PLMDs also polarized hypoxic murine RAW264.7 macrophages toward the M1 phenotype, enhancing tumor necrosis factor alpha release, and thus reducing the viability of murine cRPc TRAMP-c2 cells. In a syngeneic TRAMP-c2 tumor model, intravenous injection of PLMDs suppressed, while radiation alone enhanced recruitment of regulatory T cells and myeloid-derived suppressor cells. Pretreatment with PLMDs followed by radiation down-regulated programmed death-ligand 1 and promoted the infiltration of antitumor cD8+ T cells and M1 macrophages to tumor sites. Taken together, TIME modulation by PLMDs plus radiation profoundly delayed tumor growth and prolonged median survival compared with radiation alone. These results suggest that PLMDs plus radiation is a promising treatment modality for improving therapeutic efficacy in radioresistant and immunosuppressive solid tumors.

关键词： RAW264.7 alone treatment

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canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng connie chen Yonghui Wang Annie Wang Zander Schwartz jeffrey Hong Lily Song William Wagstaff Rex c.Haydon Hue H.Luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-chuan He Lewis L.Shi chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Department of clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PcP,and the noncanonical Wnt/ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

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