检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

定量药理学与儿童药物研发和合理用药

中国临床药理学与治疗学 2010年第1期15卷 1-10页

作者：史军 jeffrey s.barrett Daiichi-sankyo Pharma Development Edison The Children's Hospital of Philadelphia Philadelphia

This article provides a comprehensive overview of key issues related to pediatric drug development and rational dosing guidance in pediatrics with an emphasis on how pharmacometrics can improve the efficiency and productivity of pediatric *** pharmacokinetics(PK)and pharmacodynamics(PD)of drugs are often different between adult and pediatric populations which necessitate specific studies in *** aims of this review are to discuss a number of recent methodological developments of modeling and simulation that facilitate the evaluation of drugs in *** focus has been placed on addressing the key issues of PK/PD scaling,sparse sampling,colinearity,covariate evaluation,dose optimization for trial design and label,modeling strategies and validation *** features and potential advantages of Bayesian hierarchical model,physiology-based PK models,and K-PD models are also presented.

关键词：儿童合理用药药物研发定量药理学药理学工作者药物试验弱势群体受试者

在线全文

学校读者我要写书评

暂无评论

儿童临床试验设计在药物研发和评估中的应用

中华儿科杂志 2011年第12期49卷 952-956页

作者： Di Wu 申昆玲王晓玲曹进 jeffrey s. barrett Laboratory for Applied PK/PD Division of Clinical Pharmacology ＆ Therapeutics Department of Pediatrics The Children＇s Hospital of Philadelphia Kinetic Modeling and simulation Core Institute of Translational Medicine and Therapeutics University of Pennsylvania Philadelphia PA 19104 USA 首都医科大学附属北京儿童医院中国食品药品检定研究院

儿童具有生长和发育两个特点，其个体发育包括药物代谢酶、转运蛋白、受体和器官的发育。儿童的生长和发育使得药物的吸收、分布、代谢和排泄及药物在儿童的不同发育阶段对发育中器官的药效都存在着与成人显著不同的差异。

关键词：药物研发儿童试验设计个体发育药物代谢酶应用评估临床

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

对儿童用药和临床试验的思考

临床儿科杂志 2012年第3期30卷 298-300页

作者：吴荻曹进王晓玲 jeffrey s.barrett Laboratory for Applied PK/PD Division of Clinical Pharmacology ＆ TherapeuticsThe Children's Hospital of Philadelphia Kinetic Modeling and Simulation CoreInstitute for Translational Medicine and TherapeuticsUniversity of Pennsylvania 中国食品药品检定研究院北京100050 首都医科大学附属北京儿童医院北京100045

近年来,有高达79%的儿科药物在没有明确标识或者没有额外获得儿童使用许可的情况下使用[1]。2006年,我国医院对于4亿儿科患者使用的1 103种药品中仅有64种（占5.8%）是按说明书指导使用的[2]。另有数据显示,中国患病儿童占总患病人口的... 详细信息

近年来,有高达79%的儿科药物在没有明确标识或者没有额外获得儿童使用许可的情况下使用[1]。2006年,我国医院对于4亿儿科患者使用的1 103种药品中仅有64种（占5.8%）是按说明书指导使用的[2]。另有数据显示,中国患病儿童占总患病人口的20%左右,但80%以上的已上市药品没有儿童使用标识,90%的药物没有儿童剂型[3]。

关键词：儿童用药临床试验儿科药物上市药品儿科患者数据显示患病儿童说明书

在线全文

学校读者我要写书评

暂无评论

转化型研究中的定量药理学(英文)

转化型研究中的定量药理学(英文)

Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

中国药理学会临床药理学专业委员会会议暨第十次全国临床药理学学术会议

作者： jeffrey s barrett Laboratory for Applied PK/PD Clinical Pharmacology & Therapeutics Division The Children’s Hospital of Philadelphia Pediatrics DepartmentSchool of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

转化型研究一般是指将基础科学发现应用到治疗或预防疾病或损伤,其价值通常是基于探索或发展可产生有效疗法的可能性。当今的制药工业已发展成为一个从事转化型研究的高度专业化行业, 在美国国立卫生研究院的倡议及激励下,医学科研队伍...

转化型研究一般是指将基础科学发现应用到治疗或预防疾病或损伤,其价值通常是基于探索或发展可产生有效疗法的可能性。当今的制药工业已发展成为一个从事转化型研究的高度专业化行业, 在美国国立卫生研究院的倡议及激励下,医学科研队伍同样接受了这一模式。临床和转化型研究奖的设立可以为能从事此类研究机构所需的多学科环境创造机会。临床和转化型研究奖的一个关键组成部分以及美国国立卫生研究院的工作路线图和美国食品药物管理局的关键路径计划中的一个元素就是通过定量药理学研究桥接基础与临床科学。关国宾夕法尼亚大学/费城儿童医院临床和转化型研究相对突出,两项研究和教育目标均依赖于定量药理学。美国国立卫生研究院所赞助的一项旨在探索神经激肽1受体拮抗用于治疗神经性爱滋病的研究案例, 正是用来说明运用定量药理进行转化型研究的范例。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry Timothy barrett sovan sarkar I-sTEM CECSCorbeil-EssonnesFrance UniversitéParis-saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute of Cancer and Genomic sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

定量药理学:一个促进药物开发及转换型研究严谨思考的多学科领域

在线全文

学校读者我要写书评

暂无评论

中国临床药理学与治疗学 2008年第5期13卷 481-493页

作者： jeffrey s barrett Michael J Fossler K.David Cadieu Marc R Gastonguay 沈杰谢海棠孙瑞元 Laboratory for Applied PKPD Clinical Pharmacology & Therapeutics Divisionthe Children's Hospital of PhiladelphiaPediatrics DepartmentSchool of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Clinical Pharmacokinetics Modeling and SimulationGlaxoSmithKlineKing of PrussiaPennsylvania 19406USA KDC Group Inc.New JerseyNJ 08648USA Metrum Institute ConnecticutUSA 皖南医学院弋矶山医院药物临床评价中心

尽管从事定量药理学研究的科学工作者一再强调将定量分析的原则应用于促进新药研发的决策,定量药理学的发展还是超过了上述领域。普通研究和决策领域总是期望着常规和传统的研究范例发生进步,当与定量药理学相关的领域自身在发展并与其... 详细信息

尽管从事定量药理学研究的科学工作者一再强调将定量分析的原则应用于促进新药研发的决策,定量药理学的发展还是超过了上述领域。普通研究和决策领域总是期望着常规和传统的研究范例发生进步,当与定量药理学相关的领域自身在发展并与其交互作用时,自然便产生对临床药理学的协同作用。创新性和可塑性训练计划和策略均是将来临床研究工作中必不可少的要素。掌握定量药理学领域的知识成为对药理科学家的要求,具有定量药理学背景的人员可望获得更高的薪水。目前定量药理学相关培训计划,教学资料,及学术权威均比较贫乏,学生们可以从企业化、调控性的背景的教师等多种机构的教职员那获得指导,此外也可以通过在线课程,可视化教学进修课程,与他们的导师保持联系。对课程和学位的管理可以采取灵活的态度,这样可在短期内培养更多的定量药理学工作者。

关键词：定量药理学关键路径国立卫生研究院(NIH)路线图教育临床药理学(Pharmacometrics)

Rock mechanics for design of Brisbane tunnels and implications of recent thinking in relation to rock mass strength

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 676-683页

作者： L.B.McQueen A.Purwodihardjo s.V.L.barrett Golder Associates Pty Ltd. 124 Pacific HighwaySt.LeonardsNSW2065Australia Golder Associates Pty Ltd. 147 Coronation DriveMiltonQueensland4064Australia Golder Associates Pty Ltd. Building 7Botanicca Corporate Park570 e 588 Swan StreetRichmondVictoria3121Australia

This paper explores the potential implications of recent thinking in relation to rock mass strength for future tunnelling projects in Brisbane,Australia,particularly as they are constructed within deep horizons where the in situ stress magnitudes is *** mass failure mechanisms for the current tunnels in Brisbane are generally discontinuity controlled and the potential for stress-induced failure is relatively *** the road tunnels which have been constructed in Brisbane over the last 12 years,the strength of the more massive rock masses for continuum analysis has been estimated by the application of the Hoek-Brown(H-B)failure criterion using the geological strength index(GsI)to determine the H-B parameters mb,s and *** the last few years,alternative approaches to estimating rock mass strength for‘massive to moderately jointed hard rock masses’have been proposed by others,which are built on the work completed by *** and *** in this area over their joint *** paper explores one of these alternative approaches to estimating rock mass strength for one of the geological units(the Brisbane Tuff),which is often encountered in tunnelling projects in *** potential implications of these strength forecasts for future tunnelling projects are discussed along with the additional work which will need to be undertaken to confirm the applicability of such alternative strength criteria for this rock mass.

关键词： Rock mass strength Hoek-Brown(H-B)failure criterion Triaxial testing Brittle failure Brisbane Tuff

Impacts of a Japan–south Korea power system interconnection on the competitiveness of electric power companies according to power exchange prices

在线全文

学校读者我要写书评

暂无评论

Global Energy Interconnection 2020年第3期3卷 292-302页

作者： Romain Zissler jeffrey s.Cross school of Environment and society Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8550Japan

In many regions,international power system interconnections provide economic,energy-security,environmental,and technical *** contrast,such interconnections remain scarce in Northeast *** 2016,after approving a joint memorandum of understanding between major electric power companies from China,Japan,south Korea,and Russia,related initiatives regained momentum in the ***,the corresponding developments in Japan remain limited,mainly owing to the lack of involvement of Japanese electric power *** study represents a pioneering attempt to provide an economic assessment based on power exchange prices of a power system interconnection between Japan and south Korea regarding the competitiveness of electric power companies in terms of competitive business segments and strategic *** found that although the position of Japanese generators may slightly deteriorate,that of the supply segment would substantially improve,thus suggesting that more opportunities than threats are derived from the *** promising outcome may foster the adoption of an interconnection with south Korea considering the positive economic and business perspectives in ***,realizing the interconnection may improve the energy security and air quality in the region.

关键词： Electricity grid interconnection Japan south Korea Electric power company Power exchange price

New insights into the pathogenesis of intestina dysfunction:secretory diarrhea and cystic fibrosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第4期6卷 470-474页

作者： Kim E. barrett Professor and Vice-Chair for Research Department of MedicineUniversity of CaliforniaSan DiegoSchool of MedicineSan DiegoCA 92103USA

INTRODUCTIONA major function of the intestinal epithelium is to controlthe amount of fluid entering into and being absorbed fromthe *** healthy conditions,net fluid movementfollows an absorptive vector,although signif... 详细信息

关键词： gatrointestinal motility diarrhea/etiology cystic fibrosis intestinal secretions chlorides Crohn’s disease intestinal absorption