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Studies on the cytocompatibility,mechanical and antimicrobial properties of 3D printed poly(methyl methacrylate)beads

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Bioactive Materials 2018年第2期3卷 157-166页

作者： David K.Mills Uday Jammalamadaka Karthik Tappa jeffery weisman Center for Biomedical Engineering and Rehabilitation Science USA The School of Biological Sciences Louisiana Tech UniversityRustonLA 71272USA

Osteomyelitis is typically a bacterial infection(usually from Staphylococcus)or,more rarely,a fungal infection of the *** can occur in any bone in the body,but it most often affects the long bones(leg and arm),vertebral(spine),and bones of the *** success in osteomyelitis is due to their ability to form biofilms which inhibit the wound healing process and increases resistance to anti-infective ***,biofilms do not allow easy penetration of antibiotics into their matrix making clinical treatment a *** development of local antibiotic delivery systems that deliver high concentrations of antibiotics to the affected site is an emerging area of research with great *** treatment includes antibiotic therapy,either locally or systemically and refractory cases of osteomyelitis may lead to surgical intervention and a prolonged course of antibiotic treatment involving placement of antibiotic-doped beads or spacers within the wound *** are disadvantages with this treatment modality including insufficient mixing of the antibiotic,lack of uniform bead size,resulting in lower antibiotic availability,and limitations on the antibiotics ***,a method is needed to address biofilm formations in the wound and on the surface of the surgical implants to prevent *** this study,we show that all antibiotics studied were successfully doped into PMMA and antibiotic-doped 3D printed beads,disks,and filaments were easily *** growth inhibition capacity of the antibiotic-loaded PMMA 3D printed constructs was also demonstrated.

关键词： 3D printing Antibacterials Drug delivery Halloysite nanotubes Medical devices Nanotechnology

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