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Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture

Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： jean-daniel malcor Emma J.Hunter Natalia Davidenko daniel V.Bax Ruth Cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUVECs),by inhibiting cell–collagen ***,we have improved crucial HUVEC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUVEC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

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Covalent functionalization/polycarboxylation of tungsten disulfide inorganic nanotubes （INTs-WS2）

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Nano Research 2015年第5期8卷 1454-1463页

作者： daniel Raichman David A. Strawser jean-Paul Lellouche Department of Chemistry Nanomaterials Research Center Institute of Nanotechnology & Advanced Materials Bar-Ilan University Ramat-Gan 5290002 Israel

Inorganic nanotubes of tungsten disulfide （INTs-WS2） are insoluble in common solvents and practically inert, hindering their usefulness in both research and commercial applications. The covalent attachment of functional species onto the surface of INT-WS2 is a critical first step in realizing the potential that INT-WS2 offer for high-performance materials and products. Although a few attempts have been reported regarding preparing modified nanotubes, only a limited range of surface functionalities is possible with these methods. We have developed a versatile method, based on a modified, highly electrophilic acidic Vilsmeier- Haack reagent, to produce covalently bonded, polycarboxylated functional WS2 nanotubes that are dispersible in polar liquids, including water. The surface polycarboxylated shell provides a means for additional derivatization, enabling matching compatibility of derivatized nanotubes to both hydrophobic and hydrophilic materials. Nanocomposites incorporating derivatized INT-WS2 are expected to show improved properties as a result of enhanced interfacial compatibility, made possible by the large number of classes of functionalization available through the initial polycarboxylation step.

关键词： tungsten disulfide nanotubes inorganic nanotube of tungsten disulfide(INT-WS2) Vilsmeier-Haack reagents polycarboxylation inorganic nanotube functionalization

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How to model the effect of mechanical erosion control practices at a catchment scale?

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International Soil and Water Conservation Research 2021年第3期9卷 370-380页

作者： Elizeu Jonas Didoné jean Paolo Gomes Minella daniel Gustavo Allasia Piccilli Federal University of Santa Maria Department of Soil Science1000 Avenue RoraimaCamobiCEP 97105-900Santa MariaRSBrazil Federal University of Santa Maria Department of Environmental and Sanitary Engineering1000 Avenue RoraimaCamobiCEP 97105-900Santa MariaRSBrazil

Conservation agriculture practices are a crucial factor in mitigating and controlling erosion by *** address water erosion estimates,most environmental models use the USLE,RUSLE,and MUSLE *** practices that affect soil erosion by modifying the flow pattern,such as contour farming,strip farming,or terracing,are represented within these models as a support practice(P)***,due to the difficulty in accurately mapping the P-factor,many studies choose to ignore it,using only the default value P-factor 1 which represents the absence of sowing at the level or cultivation in *** study proposes a methodology that evaluates the current P-factor based on the angle between the crop row orientation and the elevation contour *** method was tested in four areas under soybean crop fields in southern Brazil,totaling 25 km^(2).The reason for choosing four areas is to select different characteristics of rural properties and topographic *** ideal values of the P-factor are expected to be between 0.5 and 0.6;however,in our case,a P-factor greater than 0.8 was obtained in 60%of the area,indicating the low occurrence of contour farming reduces erosion *** results show that policymakers could potentially use this methodology(angle between the crop rows and contour lines)to run soil-erosion risk scenarios for a broader application of contour *** allows the P-factor to be quantified via a thematic map instead of assigning uniform P-factor *** a detailed study of the P-factor on the slopes,there is a better understanding of where to target support practices to reduce erosion.

关键词： Conservation practices Modeling P-Factor Planting efficiency

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Slowβrelaxation in La-based metallic glasses based on mechanical spectroscopy measurements

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Journal of Iron and Steel Research International 2017年第4期24卷 397-401页

作者： Ji-chao Qiao jean-marc Pelletier Ning Li daniel Crespo Yao Yao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina Universite de Lyon MATEISUMR-CNRS5510Bat.B.PascalINSA LyonF-69621 Villeurbanne cedexFrance Department of Materials Science and Engineering State Key Laboratory for Materials Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074HubeiChina Departament de Fisica EETACUniversitat Politecnica de CatalunyaCastelldfels 08860BarcelonaSpain

Dynamic mechanical relaxations of La-based metallic glasses were investigated by mechanical *** the framework of the mixing enthalpy of constituent atoms,it was found thatβrelaxation was less evident by the addition of Cu to replace Ni in the LaCuNiAl glassy *** introducing Cu into the LaNiAl metallic glass,the mixing enthalpy was less negative,which led to weakerβrelaxation of the metallic ***αrelaxation of the La-based metallic glasses could be described by a Kohlrausch-Williams-Watts（KWW）function with a Kohlrausch exponentβKWW around *** should be noted that physical aging above the glass transition temperature Tginduced a decrease ofβrelaxation intensity in the La-based metallic glass.

关键词： Metallic glass Mechanical relaxation βrelaxation Mixing enthalpy

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Dynamic mechanical relaxation and thermal creep of high-entropy La_(30)Ce_(30)Ni_(10)Al_(20)Co_(10)bulk metallic glass

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Science China(Physics,Mechanics & Astronomy) 2021年第9期64卷 93-103页

作者： LangTing Zhang YaJuan Duan daniel Crespo Eloi Pineda YunJiang Wang jean-Marc Pelletier JiChao Qiao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an 710072China Department of Physics Barcelona Research Center in Multiscale Science and TechnologyInstitute of Energy TechnologiesUniversitat Politècnica de CatalunyaBarcelona 08019Spain State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 101408China MATEIS UMR CNRS5510Universitéde LyonINSA-LyonVilleurbanne Cedex F-69621

Dynamic mechanical relaxation is a fundamental tool to understand the mechanical and physical properties of viscoelastic materials like *** spectroscopy shows that the high-entropy bulk metallic glass(La_(30)Ce_(30)Ni_(10)Al_(20)Co_(10))exhibits a distinctβ-relaxation *** the present research,dynamic mechanical analysis and thermal creep were performed using this bulk metallic glass material at a temperature domain around theβ*** components of total strain,including ideal elastic strain,anelastic strain,and viscous-plastic strain,were analyzed based on the model of shear transformation zones(STZs).The stochastic activation of STZ contributes to the anelastic *** the temperature or external stress is high enough or the timescale is long enough,the interaction between STZs induces viscous-plastic *** all the spectrum of STZs is activated,the quasi-steady-state creep is achieved.

关键词： high-entropy bulk metallic glass mechanical relaxation creep recovery process shear transformation zone structural heterogeneity

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Evaluating and quantifying the effect of various spruce budworm intervention strategies on forest carbon dynamics in Atlantic Canada

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Forest Ecosystems 2022年第4期9卷 547-557页

作者： Zelin Liu Changhui Peng David AMacLean Louis De Grandpre jean-Noel Candau daniel Kneeshaw School of Geographic Sciences Hunan Normal UniversityChangsha410081China Department of Biological Sciences University of Qu�ebec at MontrealMontrealQC H3C 3P8Canada Faculty of Forestry and Environmental Management University of New BrunswickFrederictonNB E3B 5A3Canada Laurentian Forestry Centre Canadian Forest ServiceNatural Resources CanadaQC G1V 4C7Canada Great Lake Forestry Centre Canadian Forest ServiceNatural Resources CanadaON P6A 2E5Canada

Spruce budworm (SBW) outbreaks are one of the most devastating natural disturbances in spruce-balsam fir forests of eastern North America. Both early intervention strategy (EIS) and foliage protection strategy (FP) are being tested to limit forest losses, but the quantitative impact on forest carbon (C) dynamics is still unclear. In this study, we designed 19 separate scenarios of no intervention or varying success of EIS, FP, and their combination on SBW caused defoliation and mortality. We then used the TRIPLEX-Insect model to quantify their effects on forest C dynamics in the forests of the four provinces of Atlantic Canada. A scenario applying FP to 10%of the area with the greatest potential C losses of living biomass, protecting foliage in 10%of the forests is more realistic than higher proportion of FP given the high cost and large areas involved, resulted in reducing average cumulative net ecosystem productivity (NEP) from 2020 to 2039 by 56%–127%compared to a no outbreak *** results showed that FP would have to be applied everywhere to reduce tree mortality and increase NEP more than 8 years of successful EIS applied. However, if EIS can be successfully implemented for 12 years, it will maintain more forest C than FP applied everywhere during a moderate outbreak. We also found that the combination of EIS followed by FP in 10%of the areas disturbed by the SBW could maintain average cumulative NEP at similar levels to no defoliation in every province of Atlantic Canada. Black/red spruce forests younger than 60years old underwent the smallest changes in C dynamics whether using EIS, FP, or both. This highlights the importance of forest species, forest age, and their interactions on the effectiveness of a treatment during SBW outbreak. Overall, 31%–76%of the study area in Atlantic Canada could convert from a C sink to a source by 2039,if no protective measures are used under the worst-case scenarios, thus contributing to future climate warming.

关键词： Annual defoliation Natural disturbance Forest protection Net ecosystem productivity TRIPLEX-Insect Conifers

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Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

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Journal of Molecular Cell Biology 2011年第5期3卷 301-308页

作者： Mohamed Abu-Farha Sylvain Lanouette Fred Elisma Veronique Tremblay Jeffery Butson daniel Figeys jean-Francois Couture Ottawa Institute of Systems Biology Department of BiochemistryMicrobiology and ImmunologyUniversity of Ottawa451 Smyth RoadRoger-Guindon HallOttawaONK1H8M5Canada Biochemistry and Molecular Biology Unit Dasman Diabetes InstituteDasman 15462Kuwait

The SMYD(SET and MYND domain)family of lysine methyltransferases(KMTs)plays pivotal roles in various cellular processes,including gene expression regulation and DNA damage *** identified as genuine histone methyltransferases,specific members of this family have recently been shown to methylate non-histone proteins such as p53,VEGFR,and the retinoblastoma tumor suppressor(pRb).To gain further functional insights into this family of KMTs,we generated the protein interaction network for three different human SMYD proteins(SMYD2,SMYD3,and SMYD5).Characterization of each SMYD protein network revealed that they associate with both shared and unique sets of *** those,we found that HSP90 and several of its co-chaperones interact specifically with the tetratrico peptide repeat(TPR)-containing SMYD2 and ***,using proteomic and biochemical techniques,we provide evidence that SMYD2 methylates K209 and K615 on HSP90 nucleotide-binding and dimerization domains,*** addition,we found that each methylation site displays unique reactivity in regard to the presence of HSP90 co-chaperones,pH,and demethylation by the lysine amine oxidase LSD1,suggesting that alternative mechanisms control HSP90 methylation by ***,this study highlights the ability of SMYD proteins to form unique protein complexes that may underlie their various biological functions and the SMYD2-mediated methylation of the key molecular chaperone HSP90.

关键词： SMYD proteins HSP90 lysine methylation SET domain histone methylation

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Elderly patients with inflammatory bowel disease: Updated review of the therapeutic landscape

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World Journal of Gastroenterology 2019年第30期25卷 4158-4171页

作者： jean-Frédéric LeBlanc daniel Wiseman Peter L Lakatos Talat Bessissow Department of Adult Gastroenterology McGill University Health CentreMontrealQC H3G 1A4Canada Department of Medicine McGill University Health CentreMontrealQC H3G 1A4Canada 1^st Department of Medicine Semmelweis UniversityBudapest 1083Hungary

High-quality data remains scarce in terms of optimal management strategies in the elderly inflammatory bowel disease(IBD)***,available trials have been mostly retrospective,of small sample size,likely owing to underrepresentation of such a population in the major randomized controlled ***,in the last five years,there has been a steady increase in the number of published trials,helping clarify the estimated benefits and toxicity of the existing IBD *** the Everhov trial,prescription strategies were recorded over an average follow-up of 4.2 years.A minority of elderly IBD patients(1%-3%)were treated with biologics within the five years following diagnosis,whilst almost a quarter of these patients were receiving corticosteroid therapy at year five of follow-up,despite its multiple *** low use of biologic agents in real-life settings likely stems from limited data suggesting lower efficacy and higher *** minireview will aim to highlight current outcome measurements as it portends the elderly IBD patient,as well as summarize the available therapeutic strategies in view of a growing body of evidence.

关键词： Inflammatory bowel disease Elderly Outcomes Glucocorticoids Biological therapy Surgery

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Characteristics of patients with Wilson disease in the United States: An insurance claims database study

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World Journal of Hepatology 2024年第5期16卷 791-799页

作者： Thomas daniel-Robin Pradeep Kumar Bernard Benichou jean-Philippe Combal Vivet Therapeutics Paris 75008France Clarivate Noida 201301Uttar PradeshIndia

BACKGROUND Wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous *** its low prevalence,collecting data on large cohorts of patients with WD is *** insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare *** To describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims *** This retrospective,longitudinal study was performed in the Clarivate Real-World Data Product *** patients with≥2 claims associated with an Interna-tional Classification of Diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study *** were divided into two groups by whether or not they were documented to have received a specific treatment for *** manifestations,hospital-isations,liver transplantation and death were *** Overall,5376 patients with an ICD-10 diagnostic code for WD were *** mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter *** inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented *** follow-up,273 patients(5.1%)*** with the American general population,the standardised mortality ratio was *** proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 *** Patients treated for WD in the United States had an excess early mortality compared with the American *** findings indicate that there is a significant unmet need for effective treatment for WD in the United States.

关键词： Wilson disease Mortality Treatment Copper chelators Zinc acetate United States

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Amplification of M2 response and switch in excita- tion-contraction coupling in bovine tracheal smooth muscle

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Acta Pharmacologica Sinica 1996年第1期 80-81页

作者： daniel Kwasi AMOAKO,关超然,jean-Pierre BOURREAU Department of Physiology Faculty of Medicine The University of Hong Kong Hong Kong Department of Physiology Faculty of Medicine The University of Hong Kong Hong Kong Department of Physiology Faculty of Medicine The University of Hong Kong Hong Kong

AIM: To assess whether internal Ca2+stores depletion could amplify M2response leading to a switch in coupling mode. METHOD: Isolated bovine tracheal smooth muscle strips were studied employing functional studies; using

关键词： tion-contraction coupling in bovine tracheal smooth muscle Amplification of M2 response and switch in excita

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