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膜技术在乳品工业中的应用

食品科学 2010年第17期31卷 402-409页

作者：马莺董晶莹 jean-louis Maubois 哈尔滨工业大学食品科学与工程学院黑龙江哈尔滨150090 北京三元食品股份有限公司技术中心北京100085 法国农科院法国布列塔尼大区雷恩35042

综述膜的设计及结构,以及膜技术在乳品工业中应用的研究进展。随着膜技术的发展以及人们对乳成分知识的深入了解,膜技术在液态乳的除菌、乳蛋白的分离、干酪的加工、乳清的处理、初乳的处理,乃至干酪盐水及废水处理与纯化等方面的应用... 详细信息

综述膜的设计及结构,以及膜技术在乳品工业中应用的研究进展。随着膜技术的发展以及人们对乳成分知识的深入了解,膜技术在液态乳的除菌、乳蛋白的分离、干酪的加工、乳清的处理、初乳的处理,乃至干酪盐水及废水处理与纯化等方面的应用日益广泛。膜技术将为提高乳制品质量、新产品开发、提高生产效率及增加产品利润提供新的途径,成为在不破坏乳成分的前提下保证乳制品安全的强有力的加工手段。

关键词：膜技术液态乳乳蛋白干酪乳清初乳盐水

Seasonal Variations of Solar Wind Parameters during Solar Cycles 23 and 24

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Open Journal of Applied Sciences 2022年第9期12卷 1527-1546页

作者： Somaïla Koala Yacouba Sawadogo jean louis Zerbo Laboratoire de Matériaux d’Héliophysique et Environnement (La.M.H.E) ED/ST Université Nazi BONI Bobo-Dioulasso Burkina Faso Unité de Formation et de Recherche en Sciences Exactes et Appliquées (UFR/SEA) Université Nazi BONI Bobo-Dioulasso Burkina Faso

In this paper, we analyzed diurnal and annual seasonal variations of solar wind parameters such as interplanetary magnetic field (IMF), proton density (N), solar wind speed (V) and solar wind dynamic pressure (Pdym), during the solar cycles 23 and 24. Our study shows that strong geomagnetic disturbances are observed at the equinoxes during both solar cycles. The highest proton densities are observed at solstices during both solar cycles. The greatest solar wind speeds are observed at the equinoxes of solar cycle 23 and at the solstices of solar cycle 24. The highest solar wind dynamic pressures are observed at the solstices of both solar cycles. We also observed an asymmetrical evolution of the seasonal diurnal values of the solar wind parameters during the two cycles, except for the proton density. Our investigations also highlight the fact that the seasonal diurnal values of the solar wind parameters are significant at solar cycle 23 compared to solar cycle 24 characterized by a global weak in solar plasma conditions since the deep minimum that followed the solar cycle 23 leading to an absence of a persistent polar coronal hole. The drop observed in polar field and solar winds parameters during solar cycle 24 is reproduced on seasons (solstices and equinoxes). The solar cycle 23 and 24 appear to be two magnetically opposite solar cycles regardless the time scales.

关键词： Diurnal Seasonal Solar Winds Parameters Variation Solar Cycle

Catalytic Peptide Dendrimers as Artificial Proteins: Functional Selection and Optimization from Combinatorial Libraries

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复旦学报（自然科学版） 2005年第5期44卷 837-837页

作者： jean-louis Reymond University of Berne Freiestrasse 3 CH-3012 Berne Switzerland

In de novo protein design one attempts to create artificial proteins with defined structure and function from first principles, usually with the help of trial-and-error procedures that scan a large number of possible amino acid sequences. Our approach to de novo protein design is based on peptide dendrimers. Dendrimers are tree-like structures that adopt a globular or disk-shaped structure as a consequence of topology rather than folding. Our peptide dendrimers are obtained by alternating alpha-aminoacids with branching diaminoacids[1].Dendrimers containing combinations of histidine, serine and aspartate display enzyme-like catalytic properties for the hydrolysis of esters, including enantiomeric discrimination[1d]. The catalytic effect involves cooperative substrate binding and catalysis by a positive dendritic effect[1d].

关键词：缩氨酸催化作用人造蛋白质选择性基因序列

Quantum Mechanics Corrected [ed.]

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2005年

作者： jean-louis Basdevant jean Dalibard

来源：畅想之星图书光盘版（南... 评论

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乳源乳酸菌在发酵乳制品中的应用

中国乳品工业 2008年第11期36卷 41-46页

作者：陈历水马莺 jean-louis Maubois 哈尔滨工业大学哈尔滨150090 法国农业科学院法国雷恩35042

为了满足市场需求,全球乳品加工企业都在努力提高产品的多样化程度,并且希望从原料乳或以生鲜乳发酵的乳制品中找到一些潜在的发酵剂来开发新产品。针对这一情况,对乳酸菌在不同发酵乳制品中的主要作用进行了分类综述,并介绍了乳源乳酸... 详细信息

为了满足市场需求,全球乳品加工企业都在努力提高产品的多样化程度,并且希望从原料乳或以生鲜乳发酵的乳制品中找到一些潜在的发酵剂来开发新产品。针对这一情况,对乳酸菌在不同发酵乳制品中的主要作用进行了分类综述,并介绍了乳源乳酸菌在发酵乳制品的应用研究现状。

关键词：乳酸菌干酪酸乳含酒精乳饮料酸酪乳酸奶油

Reliability of neutrophil gelatinase-associated lipocalin in detecting acute tubular necrosis in decompensated cirrhosis:Systematic review and meta-analysis

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World Journal of Hepatology 2024年第11期16卷 1331-1338页

作者： Nirav Agrawal Scarlet louis-jean Zoya Ladiwala Harsha Adnani Ayesha Kamal Mitchell Karpman Albert Steven Fleisher Sanmeet Singh Department of Internal Medicine Anne Arundel Medical CenterAnnapolisMD 21401United States Department of Biostatistics Anne Arundel Medical CenterAnnapolisMD 21401United States Department of Gastroenterology Anne Arundel Medical CenterAnnapolisMD 21401United States

BACKGROUND Acute kidney injury(AKI)in cirrhosis is *** diagnosis of AKI in cirrhosis patients depends on clinical presentation and laboratory tests like serum ***,urine biomarkers could also be used to assess the type of AKI and the severity of the *** performed a systematic review with metaanalysis to evaluate the association with urine neutrophil gelatinase-associated lipocalin(NGAL)marker in identifying acute tubular necrosis(ATN)in patients with *** To assess the reliability of urine NGAL in the detection of ATN in patients with *** We systematically searched MEDLINE and PubMed using keywords including“urine biomarkers”,“NGAL”,“kidney dysfunction”,and“cirrhosis”to identify relevant *** was screened and *** studies assessed hospitalized cirrhosis patients with AKI using the urine NGAL *** synthesized the data using diagnostic odds ratio(DOR),comparative and descriptive analyses,and Cochran Mantel-Haenszel(CMH)statistics to evaluate *** Three thousand seven hundred and one patients with cirrhosis were analyzed from a total of 21 cohort *** DOR of 14 of those studies[pooled DOR:22.150,(95%CI:17.58-27.89),P<0.0001]demonstrated a significant association between urine NGAL levels and its identification of *** stratification by cirrhosis status,heterogeneity was analyzed and showed a significant non-zero correlation between NGAL and AKI(CMH statistic=702.19,P<0.0001).CONCLUSION In patients with cirrhosis,the use of urine NGAL is a reliable biomarker for detecting ATN and identifying the etiology of AKI.

关键词： Neutrophil gelatinase-associated lipocalin Acute tubular necrosis Acute kidney injury Cirrhosis Biomarker Severe liver dysfunction

Endothelial nitric oxide synthase regulation is altered in pancreas from cirrhotic rats

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World Journal of Gastroenterology 2006年第2期12卷 228-233页

作者： jean-louis Frossard Rafael Quadri Antoine Hadengue Philippe Morel Catherine M Pastor Division de Gastroenterologie Hpitaux Universitaires de Geneve Departement de Chirurgie Hopitaux Universitaires de Geneve Laboratoire de Physiopathologie Hepatique et Imagerie Moleculaire Hpitaux Universitaires de Geneve

AIM： To determine whether biliary cirrhosis could induce pancreatic dysfunction such as modifications in endothelial nitric oxide synthase（eNOS） expression and whether the regulation of eNOS could be altered by the regulatory proteins caveolin and heat shock protein 90 （Hsp90）, as well as by the modifications of calmodulin binding to eNOS. METHODS： Immunoprecipitations and Western blotting analysis were performed in pancreas isolated from sham and cirrhotic rats. RESULTS： Pancreatic injury was minor in cirrhotic rats but eNOS expression importantly decreased with the length （and the severity） of the disease. Because coimmunoprecipitation of eNOS with both Hsp90 and caveolin similarly decreased in cirrhotic rats, eNOS activity was not modified by this mechanism. In contrast, drrhosis decreased the calmodulin binding to eNOS with a concomitant decrease in eNOS activity. CONCLUSION： In biliary cirrhosis, pancreatic injury is minor but the pancreatic nitric oxide （NO） production is significantly decreased by two mechanisms： a decreased expression of the enzyme and a decreased binding of calmodulin to eNOS.

关键词： Pancreas Biliary cirrhosis Endothelial NO synthase Caveolin Heat shock protein 90

Telaprevir- and boceprevir-based tritherapies in real practice for F3-F4 pretreated hepatitis C virus patients

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World Journal of Hepatology 2014年第9期6卷 660-669页

作者： Delphine Bonnet Matthieu Guivarch Anais Palacin Laurent Alric Emilie Bérard jean-Marc Combis Andre jean Remy Andre Glibert jean-louis Payen Sophie Metivier Karl Barange Herve Desmorat Florence Nicot Florence Abravanel Internal Medicine-Digestive Department Purpan University Hospital31059 Toulouse cedex 9France UMR152 IRD Toulouse III University 31400 ToulouseFrance Department of Epidemiology Health Economics and Public HealthToulouse University Hospital31073 ToulouseFrance UMR-1027 INSERM-Toulouse III University 31062 ToulouseFrance Clinique Ambroise Pare 31300 ToulouseFrance Perpignan General Hospital 66000 PerpignanFrance Tarbes General Hospital 65000 TarbesFrance Montauban General Hospital 82000 MontaubanFrance Hepatogastroenterology-Digestive Department Purpan University Hospital31059 Toulouse cedex 9France Clinique du Parc 31078 Toulouse Cedex 4France Virology Unit INSERM U1043 31059 Toulouse cedex 9France

AIM:To assess,in a routine practice setting,the sus-tained virologic response(SVR) to telaprevir(TPV) or boceprevir(BOC) in hepatitis C virus(HCV) nullresponders or relapsers with severe liver ***:One hundred twenty-five patients were treated prospectively for 48 wk with TPV or BOC + pegylated-interferon(peg-INF) α2a + ribavirin(PR) according to standard treatment schedules without *** patients were treated in routine practice settings in 10 public or private health care centers,and the data were prospectively *** patients with severe liver fibrosis(Metavir scores of F3 or F4 upon liver biopsy or liver stiffness assessed by elastography),genotype 1 HCV and who were null-responders or relapsers to prior PR combination therapy were included in this ***:The Metavir fibrosis scores were F3 in 35(28%) and F4 in 90(72%) of the *** total,62.9% of the patients were null-responders and 37.1% relapsers to the previous PR *** overall SVR rate at 24 wk post-treatment withdrawal was 59.8%.The SVR was 65.9% in the TPV group and 44.1% in the BOC *** predictive factors of an SVR included a response to previous treatment,relapsers vs null-responders [OR = 3.9;(1.4,10.6),P = 0.0084],a rapid virological response(RVR) [OR 6.9(2.6,18.2),P = 0.001] and liver stiffness lower than 21.3 kPa [OR = 8.2(2.3,29.5),P = 0.001].During treatment,63 patients(50.8%) had at least one severe adverse event(SAE) of grade 3 or 4.A multivariate analysis identified two factors associated with SAEs:female gender [OR = 2.4(1.1,5.6),P = 0.037] and a platelet count below 150 × 103/ mm3 [OR = 5.3(2.3,12.4),P ≤ 0.001].CONCLUSION:More than half of these difficult-to-treat patients achieved an SVR and had SAEs in an actual practice *** SVR rate was influenced by the response to previous PR treatment,the RVR and liver stiffness.

关键词： Hepatitis C virus Hepatitis C Antiviral therapy Protease inhibitors Fibroscan Liver stiffness Cirrhosis Boceprevir Telaprevir Ribavirin

External and Environmental Radiation Dosimetry with Optically Stimulated Luminescent Detection Device Developed at the ***

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World Journal of Nuclear Science and Technology 2012年第1期2卷 6-15页

作者： Reinhard Boons Mark Van Iersel jean louis Genicot 不详

The laboratory of Radiation Dosimetry and Calibration of the Belgian Nuclear Research Centre (***) is using thermoluminescence dosimetry for more than thirty years for routine measurements and for R&D investigations. In 2002, it has developed an experimental device based on the optically stimulated luminescence (OSL) technique. This device is working with AL2O3:C crystals stimulated by the green line (488 nm) emitted by a 150 mW argon laser. This paper describes this device, its characteristics, some applications in space dosimetry and the R&D works initiated in this field during the next few years.

关键词： External Dosimetry OSL Optically Stimulated Dosimetry