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乳源酵母Pichia fermentans的抗氧化特性

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哈尔滨工业大学学报 2010年第2期42卷 292-296页

作者：陈历水马莺 jean-louis MAUBOIS 刘巧红哈尔滨工业大学食品科学与工程学院哈尔滨150090 法国农业科学研究院雷恩乳品中心雷恩法国35042

为得到新的天然抗氧化剂,采用DPPH法和抑制脂质过氧化法对11株来源于牛乳的酵母菌抗氧化活性进行测定,包括他们的完整细胞和无细胞提取物,发现Pichia fermentans BY5有较好的抗氧化活性.分析不同条件下*** BY5细胞提取物的抗氧化活性,... 详细信息

为得到新的天然抗氧化剂,采用DPPH法和抑制脂质过氧化法对11株来源于牛乳的酵母菌抗氧化活性进行测定,包括他们的完整细胞和无细胞提取物,发现Pichia fermentans BY5有较好的抗氧化活性.分析不同条件下*** BY5细胞提取物的抗氧化活性,发现培养基的起始pH值、培养时间、培养基种类对酵母菌的抗氧化活性和蛋白质含量影响显著(P<0.05);而抗氧化活性与蛋白质含量显著相关(P<0.01).将酵母BY5在pH6的麦芽培养基中培养2d后清除DPPH活性可达60%;在pH6的YPD培养基中培养4d后抑制脂质过氧化能力达到74%.

关键词： Pichia fermentans 抗氧化活性蛋白质原料乳

Totally laparoscopic trans-hiatal gastroesophagectomy for benign diseases of the esophago-gastric junction

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World Journal of Gastroenterology 2007年第2期13卷 285-288页

作者： jean-louis Dulucq Pascal Wintringer Ahmad Mahajna Department of Abdominal Surgery Institute of Laparoscopic Surgery Maison de Santé Protestante Bagatelle Hospital Route de Toulouse 203 Talence-Bordeaux 33401 France

AIM： To prospectively present our initial experience with totally laparoscopic transhiatal esophagogastrectomies for benign diseases of the cardia and distal esophagus. METHODS： Laparoscopic gastric mobilization and tubularization combined with transhiatal esophageal dissection and intrathoradc esophagogastric anastomosis accomplished by a circular stapler was done in 3 patients. There were 2 females and 1 male patient with a mean age of 73 ± 5 years. RESULTS： Two patients were operated on due to benign stromal tumor of the cardia and one patient had severe oesophageal peptic stenosis. Mean blood loss was 47 ± 15 mL and mean operating time was 130 ± 10 rain. There were no cases that required conversion to laparotomy. All patients were extubated immediately after surgery. Soft diet intake and ambulation times were 5.1 ± 0.4 d and 2.6 ±0.6 d, respectively. There were no intraoperative and postoperative complications and there were no perioperative deaths. The average length of hospital stay was 9.3 ± 3 d. All procedures were curative and all resected margins were tumor free. The mean number of retrieved lymph nodes was 18 ±8. CONCLUSION： Laparoscopic transhiatal esophagogastrectomy for benign lesions has good effects and proves feasible and safe.

关键词： Esophagogastrectomy Transhiatal resection Cardial tumor Laparoscopy Stromal tumor

Joint Management of Shared Resources, Issues and Conflicts of the Nso and Oku Tribes in the Ngongbaa Montane Forest Area, NWR of Cameroon

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Natural Resources 2024年第6期15卷 149-172页

作者： jean-louis Tatah Elvis Kah Department of Geography Faculty of Arts Letters and Social Sciences University of Yaounde I Yaounde Cameroon School of Geology and Mining Engineering University of Ngaoundere Ngaoundere Cameroon

Wherever people live together in or near homelands that harbour joint natural resources such as forest, water, minerals, oil etc., they must collaborate, co-exist and share these resources irrespective of their genetic, social, cultural, and political peculiarities. This is not always the case when self-interest, ethnic divisions, elitist politics, economic interest and power tussle set in. The Nso and Oku people who reside in the Ngongbaa Forest area constitute an example of joint management of resources where at one period, their relationship over the management of the Oku Mountain Forest was cordial and at another, the relationship became conflictive. This study was designed to study the influence of the KIFP forest management policies on the Nso indigenous forest Management system in Ngongbaa Forest, and its implications. The data collected for the study was secured through the administration of a questionnaire to residents of 10 villages adjacent to the Ngongbaa Forest, and forest users who carried out livelihood activities there between 1963 and 2015. These forest user groups include beekeepers, rat trappers, grazers, mushroom gatherers, ground honey/tree honey harvesters, carvers, etc. The investigation also extended to the traditional leaders of Nso and Oku who are in charge of the land tenure systems. The findings show that the Oku Mountain Forest is jointly owned by the Nso and Oku people. The Nso own the eastern half of the forest known as Ngongbaa Forest while the Oku own the western half, known as the Kilum Forest. The cordial relationship that existed between these people ensured the conservation of the forest. But the conflicts that later set in, especially due to the creation of the Kilum Mountain Forest Project in 1987 later changed to the Kilum Ijim Forest Project (KIFP) in 1992 sidelined the local communities which was contrary to the dispositions of the new Cameroon forest law enacted in 1994. Thus, the indigenous conservation practices became ig

关键词： Conflict Joint Management Shared Resources Ngongbaa Kilum Conservation

Experimental evidence of obesity as a risk factor for severe acute pancreatitis

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World Journal of Gastroenterology 2009年第42期15卷 5260-5265页

作者： jean-louis Frossard Pierre Lescuyer Catherine M Pastor Service of Gastroenterology Geneva University HospitalsGeneva 1205Switzerland Laboratory of pathophysiology and molecular imaging Geneva University HospitalsGeneva 1205Switzerland Service of Genetics and Central Laboratory Geneva University HospitalsGeneva 1205Switzerland

The incidence of acute pancreatitis, an inflammation of the pancreas, is increasing worldwide. Pancreatic injury is mild in 80%-90% of patients who recover without complications. The remaining patients may develop a severe disease with local complications such as acinar cell necrosis, abscess and remote organ injury including lung injury. The early prediction of the severity of the disease is an important goal for physicians in management of patients with acute pancreatitis in order to optimize the therapy and to prevent organ dysfunction and local complications. For that purpose, multiple clinical scale scores have been applied to patients with acute pancreatitis. Recently, a new problem has emerged： the increased severity of the disease in obese patients. However, the mechanisms by which obesity increases the severity of acute pancreatitis are unclear. Several hypotheses have been suggested：（1） obese patients have an increased inflammation within the pancreas; （2） obese patients have an increased accumulation of fat within and around the pancreas where necrosis is often located; （3） increase in both peri- and intra-pancreatic fat and inflammatory cells explain the high incidence of pancreatic inflammation and necrosis in obese patients; （4） hepatic dysfunction associated with obesity might enhance the systemic inflammatory response by altering the detoxiflcation of inflammatory mediators; and （5） ventilation/perfusion mismatch leading to hypoxia associated with a low pancreatic flow might reduce the pancreatic oxygenation and further enhance pancreatic injury. Recent experimental investigations also show an increased mortality and morbidity in obese rodents with acute pancreatitis and the implication of the adipokines leptin and adiponectin. Such models are important to investigate whether the inflammatory response of the disease is enhanced by obesity. It is exciting to speculate that manipulation of the adipokine milieu has the potential to influence the severi

关键词： Acute pancreatitis Obesity Adiponectin Leptin

Sliding walls: a new paradigm for fluidic actuation and protocol implementation in microfluidics

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Microsystems & Nanoengineering 2020年第1期6卷 1093-1102页

作者： Bastien Venzac Yang Liu Ivan Ferrante Pablo Vargas Ayako Yamada Remi Courson Marine Verhulsel Laurent Malaquin jean-louis Viovy Stephanie Descroix Laboratoire Physico Chimie Curie Institut CuriePSL Research UniversityCNRS UMR16875005 ParisFrance Sorbonne Universites UPMC Univ Paris 0675005 ParisFrance Institut Pierre-Gilles de Gennes PSL Research University75005 ParisFrance Institut Curie PSL Research UniversityCNRS UMR 14475005 ParisFrance LAAS-CNRS Universitéde ToulouseCNRS31400 ToulouseFrance

Currently,fluidic control in microdevices is mainly achieved either by external pumps and valves,which are expensive and bulky,or by valves integrated in the *** types of internal valves or actuation methods have been proposed,but they generally impose difficult compromises between performance and fabrication *** propose here a new paradigm for actuation in microfluidic devices based on rigid or semi-rigid walls with transversal dimensions of hundreds of micrometres that are able to slide within a microfluidic chip and to intersect microchannels with hand-driven or translation stage-based *** this new concept for reconfigurable microfluidics,the implementation of a wide range of functionalities was facilitated and allowed for no or limited dead volume,low cost and low *** demonstrate here several fluidic operations,including on/off or switch valving,where channels are blocked or reconfigured depending on the sliding wall *** valves sustain pressures up to *** and reversible compartmentalisation of large microfluidic chambers were also *** last possibility was applied to a“4D”migration assay of dendritic cells in a collagen ***,sliding walls containing a hydrogel-based membrane were developed and used to concentrate,purify and transport biomolecules from one channel to another,such functionality involving complex fluidic transport patterns not possible in earlier microfluidic ***,this toolbox is compatible with“soft lithography”technology,allowing easy implementation within usual fabrication workflows for polydimethylsiloxane *** new technology opens the route to a variety of microfluidic applications,with a focus on simple,hand-driven devices for point-of-care or biological laboratories with low or limited equipment and resources.

关键词： walls hundreds operations

Clopidogrel and proton pump inhibitors-where do we stand in 2012?

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World Journal of Gastroenterology 2012年第18期18卷 2161-2171页

作者： Michael D Drepper Laurent Spahr jean louis Frossard Division of Gastroenterology Department of Internal MedicineGeneva University Hospital14 Geneva CH-1211Switzerland

Clopidogrel in association with aspirine is considered state of the art of medical treatment for acute coronary syndrome by reducing the risk of new ischemic *** treatment with proton pump inhibitors in order to prevent gastrointestinal side effects is recommended by clinical *** needs metabolic activation predominantly by the hepatic cytochrome P450 isoenzyme Cytochrome 2C19(CYP2C19) and proton pump inhibitors(PPIs) are extensively metabolized by the CYP2C19 isoenzyme as *** pharmacodynamic studies investigating a potential clopidogrel-PPI interaction found a significant decrease of the clopidogrel platelet antiaggregation effect for omeprazole,but not for *** clinical cohort studies in 2009 reported an increased risk for adverse cardiovascular events,when under clopidogrel and PPI treatment at the same *** observations led the United States Food and Drug Administration and the European Medecines Agency to discourage the combination of clopidogrel and PPI(especially omeprazole) in the same *** contrast,more recent retrospective cohort studies including propensity score matching and the only existing randomized trial have not shown any difference concerning adverse cardiovascular events when concomitantly on clopidogrel and PPI or only on *** meta-analyses report an inverse correlation between clopidogrel-PPI interaction and study quality,with high and moderate quality studies not reporting any association,rising concern about unmeasured confounders biasing the low quality ***,no definite evidence exists for an effect on *** PPI induced risk reduction clearly overweighs the possible adverse cardiovascular risk in patients with high risk of gastrointestinal bleeding,combination of clopidogrel with the less CYP2C19 inhibiting pantoprazole should be recommended.

关键词： Clopidogrel Thienopyridine Proton pump inhibitors Drug interaction Platelet reactivity Antiplatelet therapy Cytochromes Acute coronary syndrome Gastrointestinal bleeding

Interactive Pedagogy and Massification ＂Empirical Study＂

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Chinese Business Review 2015年第11期14卷 528-538页

作者： jean louis Monino Soraya Sedkaoui Montpellier University Montpellier France Khemis Miliana University Khemis Miliana Algeria

The training is now expanding in quantity and variety. Massification--which sank--forces universities to meet the challenge of public diversity and to justify pedagogical research. This article takes into consideration particular way of these new requirements heuristic and praxeological referred to teaching that must take into account the expectation of the learner. This work is in a descriptive and explanatory approach and aims to promote higher teaching practices through the new interactive technology tools to stimulate educational innovation within the university system. The aim of this work is the inclusion of massification to contribute to the development of a model for interactivity and effectiveness of learning. This model was developed from a theoretical approach since the state of the art and an empirical approach for several experiments. The study focused on a database C2i exams ＂IT and lnternet certification of all learners of the Academy of Montpeilier （n = 4,254） on the online formapro platform＂. The results have shown that the success rate is highly correlated with the duration of prior self. The integration of these technologies in universities offers interactivity and learning environment for adjusting teaching practices and acquiring new skills.

关键词： interactive teaching distance learning internet and computer certificate dematerialization of certificates massification

Is There an Earthquake Weather?

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Open Journal of Earthquake Research 2020年第2期9卷 69-82页

作者： Michel Parrot jean-louis Pincon LPC2E CNRSOrleansFrance University of Orleans OrleansFrance

The aim of this study is to check if there is a relationship between the seismic activity and the whistlers observed by the micro-satellite DEMETER. Whistlers are the waves emitted by lightning strokes during thunderstorm activity. They use to propagate in the Earth-ionosphere waveguide but also in the ionosphere and the magnetosphere mainly along the magnetic field lines. Due to this reason we have checked the whistler occurrence not close to earthquake epicenters but close to the magnetically conjugate point of these epicenters at the satellite altitude. The number of whistlers is given by a neural network in operation onboard the satellite. It appears that the whistler amplitude is attenuated at the satellite altitude around the magnetic equator. It is why we have removed the earthquakes occurring at low geomagnetic latitudes in the statistic. The whistler rate is normalized with a background value to take into account the seasons and the epicenter locations. A superposed epoch method is used to display the results between -15 and +5 days around the earthquake day and up to 1000 km from the conjugate point of the epicenters. It is shown that the whistler rate is higher the day before the earthquake at a distance less than 200 km. It would be unrealistic to believe in the possibility to use this study for earthquake prediction because everyday thunderstorm activity reliably masks seismic effects. But it is further evidence that there is a lithosphere-atmosphere-ionosphere coupling at the time of the seismic activity.

关键词： Data Processing Earthquake Whistler Ionosphere

The Development of Agroecology at Barani （Burkina Faso）

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Journal of Agricultural Science and Technology(B) 2013年第8期3卷 545-550页

作者： jean louis Yengue Maude Cochonneau UMR CITERES 7324 Department of Geography University of Tours Tours 37000 France

Many researches deal with practices which could adduce reliable answers to insure an ecological development which meets the nowadays global issue ＂feed the world＂ in a sustainable way. But scientific research is much less prolific about social adhesion to those practices. How could we be certain that peasants will integrate them and transform their agriculture？ It is at that particular point that we settled our contribution. Our goal is to determine what are the levers which could be activated to promote agroecological practices, and, on the contrary, what are the obstacles which could prevent social adhesion to agroecology. The meticulous fieldwork carried in Barani, a landlocked small village in the North-West of the Burkina Faso, shows that all the ingredients for the development and the dissemination of agroecology already exist. Indeed, traditional agriculture is not so far from agroecology. But we noticed among peasants ofBarani a rejection of the local farming system synonymous, according to them, with backwardness, and an attraction for industrial agriculture, sign of modernity. Dissemination of agroecology will have to go through a major confidence-building work of the peasants with their own practices, as opposed to multiple trainings where they are always being taught what they already know.

关键词： Agroecology agrosystem social adhesion Burkina Faso.