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Apoptosis in rat transient focal cerebral ischemic stroke: clinical implications

中国临床神经科学 2000年第Z1期8卷 18-19页

作者： Shoushu Jiao Jue Wang Gal Hever Rongzheng Kuang jean-Claude louis Ella Magal Department of Neuroscience Amgen Inc. One Amgen Center Dr. Thousand Oaks California 91320 USA Department of Neuroscience Amgen Inc. One Amgen Center Dr. Thousand Oaks California 91320 USA Department of Neuroscience Amgen Inc. One Amgen Center Dr. Thousand Oaks California 91320 USA Department of Neuroscience Amgen Inc. One Amgen Center Dr. Thousand Oaks California 91320 USA Department of Neuroscience Amgen Inc. One Amgen Center Dr. Thousand Oaks California 91320 USA

　　In the early phase of cerebral ischemia, factors threatening neuronal survival in the penumbra include mainly glutamate excitotoxicity, free radical damage and energy failure resulting from recurrent depolarization waves. However, at later times, other mechanisms come into play. The initial ischemic event activates a variety of genetic programs that unfold over the course of hours and days. Both positron emission tomography and magnetic resonance based techniques demonstrate that the development of irretrievable tissue damage is relatively slow, progressing over the course of several days in some cases, and a viable tissue, defined by hemodynamic and metabolic criteria,is still present many hours after stroke in human or in monkey. These findings suggest that the brain can potentially be “rescued” from infarction many hours after onset of ischemia and challenge the widespread notion of an early and short “therapeutic window” (～3-6h). This realization is of critical importance for stroke therapy because most patients reach medical attention at a time when current therapeutic strategies may no longer be effective. Therefore, it would be highly desirable to develop therapeutic interventions that can be instituted many hours after the onset of ischemia. We believe that addressing the mechanisms of delayed cell death is key to a successful therapy. The studies presented here were designed to document the potential contribution of apoptosis to ischemia induced neuronal death. We will discuss the morphological, biochemical and pharmacological evidence for apoptosis in the ischemic stroke. 　　……

关键词： positron emission tomography magnetic resonance cerebral ischemia ischemic stroke neuronal death cell death

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The economic impact of schistosomiasis

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Infectious Diseases of Poverty 2021年第6期10卷 106-106页

作者： Daniele Rinaldo Javier Perez‑Saez Penelope Vounatsou Jürg Utzinger jean-louis Arcand Department of Economics and Land EnvironmentEconomics and Policy Institute(LEEP)University of ExeterExeterEngland 不详

Background:The economic impact of schistosomiasis and the underlying tradeofs between water resources devel‑opment and public health concerns have yet to be *** exerts large health,social and fnan‑cial burdens on infected individuals and *** irrigation schemes are one of the most important policy responses designed to reduce poverty,particularly in sub-Saharan Africa,they facilitate the propagation of schistoso‑miasis and other ***:We estimate the economic impact of schistosomiasis in Burkina Faso via its efect on agricultural produc‑*** create an original dataset that combines detailed household and agricultural surveys with high-resolution geo-statistical disease *** develop new methods that use the densities of the intermediate host snails of schis‑tosomiasis as instrumental variables together with panel,spatial and machine learning ***:We estimate that the elimination of schistosomiasis in Burkina Faso would increase average crop yields by around 7%,rising to 32%for high infection *** schistosomiasis unchecked,in turn,would correspond to a loss of gross domestic product of approximately 0.8%.We identify the disease burden as a shock to the agricultural productivity of *** poorest households engaged in subsistence agriculture bear a far heavier disease burden than their wealthier counterparts,experiencing an average yield loss due to schistosomiasis of between 32 and 45%.We show that the returns to water resources development are substantially reduced once its health efects are taken into account:villages in proximity of large-scale dams sufer an average yield loss of around 20%,and this burden decreases as distance between dams and villages ***:This study provides a rigorous estimation of how schistosomiasis afects agricultural production and how it is both a driver and a consequence of *** further quantifes the tradeof between the economics of wa

关键词： Schistosomiasis Neglected Tropical Diseases Sub-Saharan Africa Agriculture Water Resources Development Poverty

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Impact of high-fat diet on antioxidant status, vascular wall thickening and cardiac function in adult female LDLR<sup>–/–</sup>mice

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World Journal of Cardiovascular Diseases 2012年第3期2卷 184-192页

作者： Stéphanie Delemasure Carole Richard Ségolène Gambert jean-Claude Guilland Catherine Vergely Patrick Dutartre Luc Rochette jean-louis Connat Biochemistry Department University Hospital Dijon France COHIRO Biotechnology Faculty of Medicine Dijon France Laboratory of Cardio-Metabolic Pathophysiology and Pharmacology Faculty of Medicine University of Burgundy Inserm UMR866 Dijon France

Background: Western diet, rich in saturated fatty acids and cholesterol, is associated with increased cardiovascular risk. We thus investigated in female mice the influence of this diet on plasma antioxidant status, vascular wall thickening and cardiac function. Methods and Results: Adult female C57BL/6J wild type (WT) and LDLR–/– mice were fed a normal diet (ND) or a high-fat diet (HFD) for 17 weeks. HFD induced an increase in plasma lipids and vitamin C (Vit C) levels in both groups but at a much higher level in LDLR–/– and a decrease in plasma ascorbyl free radical levels to Vit C ratio (an endogenous oxidative stress index) in LDLR–/–. We only found a slight decrease in circulating antioxidant status evaluated by the Oxygen Radical Absorbance Capacity (ORAC) assay in WT, but not in LDLR–/–. Echocardiography evidenced an increase in arterial wall thickness in aortic arch at atherosclerosis predilection sites in HFD LDLR–/– as compared to ND LDLR–/– and HFD WT. This result was confirmed by histology. Further-more, histological examination of aortic valves showed an increase in atherosclerotic lesions. Our study, using echocardiography, show that chronic HFD does not induce any major modifications of systolic function in the both mice groups. Conclusions: High-fat intake in mice causes serious disturbances in lipid plasma levels associated to variations of circulating antioxidant status due, at least in part, to an increase in Vit C. At this stage, atherosclerotic lesions, observed in aortic arch and valve, do not impair cardiac function in HFD-fed mice.

关键词： Ascorbyl Free Radical Echocardiography Vitamin C High-Fat Diet Oxygen Radical Absorbance Capacity Oxidant/Antioxidant Status Systolic Function Aortic Arch

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桑沟湾和胶州湾沉积物耗氧率研究

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海洋科学进展 2006年第1期24卷 91-96页

作者：张学雷朱明远陈尚 GRANT Jon MARTIN jean-louis 国家海洋局第一海洋研究所达尔豪斯大学法国海洋开发研究院生态养殖中心

为评价浅海海域底层在碳元素生物地化循环中的作用,采用现场取样培养法测定了黄海桑沟湾和胶州湾的沉积物耗氧率。桑沟湾5月和8月的沉积物耗氧率分别为15和24 mmol.m-2.d-1;胶州湾8月的沉积物耗氧率为18 mmol.m-2.d-1。回归分析表明,2... 详细信息

为评价浅海海域底层在碳元素生物地化循环中的作用,采用现场取样培养法测定了黄海桑沟湾和胶州湾的沉积物耗氧率。桑沟湾5月和8月的沉积物耗氧率分别为15和24 mmol.m-2.d-1;胶州湾8月的沉积物耗氧率为18 mmol.m-2.d-1。回归分析表明,2个湾的沉积物耗氧率分别与沉积物表层的有机碳和总氮含量正相关。取呼吸商为0.8,得到桑沟湾底层对有机碳的矿化率占水层初级生产力的102%(5月)和67%(8月),胶州湾底层对有机碳的矿化率占水层初级生产力的28%(8月)。取桑沟湾颗粒有机碳的生物沉积速率为236 mg.m-2.d-1,得到底层对有机碳的埋置效率为40%(5月)和3%(8月),埋置的有机碳占水层初级生产力的69%(5月)和2%(8月);胶州湾颗粒有机碳的自然沉积速率为251 mg.m-2.d-1,底层对有机碳的埋置效率为32%(8月),埋置的有机碳占水层初级生产力的13%(8月)。

关键词：耗氧率底层通量有机碳矿化有机碳埋置

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刊首寄语：山特维克可乐满创新驱动发展

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工具技术 2018年第1期52卷 I0002-I0003页

作者： jean-louis MACEY 山特维克可乐满大中华区

2017年是市场不断向好的一年，山特维克可乐满的业务从年初到年尾始终保持着强劲的增长。整个机械加工市场在2017年实现了多年不见的两位数增长，而来自于汽车行业的需求贡献最大。我们也高兴地看到，这股增长势头直到目前没有放缓的趋... 详细信息

2017年是市场不断向好的一年，山特维克可乐满的业务从年初到年尾始终保持着强劲的增长。整个机械加工市场在2017年实现了多年不见的两位数增长，而来自于汽车行业的需求贡献最大。我们也高兴地看到，这股增长势头直到目前没有放缓的趋势，因此我们预测2018年也将是一个不错的年份。受C919试飞成功等积极因素的推动，我们在新的一年中非常看好航空航天产业的发展。

关键词：可乐山特驱动创新航空航天产业机械加工汽车行业两位数

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Complexation Properties and Synthesis of 1,2-Bis(2 ,2' -bipyridinyl)ethylene and 1,2-Bis(2,2' -bipyridinyl)ethane Ligands with Cu(I)

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Chemical Research in Chinese Universities 1990年第3期6卷 183-187页

作者： He Yongbing and Lehn jean-Marie (Institut Le Bel,Universite louis Pasleur, A, rue Blaise Pascal, 67000 Strasbourg, France) Department of Chemistry, Wuhan University, Wuhan.

l,2-Bis(2,2'-bipyridinyl)ethylene(1) ligand was synthesized by Wittig-Horner reaction and 1, 2-Bis(2, 2'-bipyridinyl)ethane(2) ligand(which can be obtained via another route ) was prepared by hydrogenation of (1). The formation of complexes of (1) and (2) with copper (I) has been studied. The influence of the different bridge chains (CH =CH, CH2CH2) on complexation is discussed on the basis of 1H NMR spectra. Keywords Dipyridine aldehyde, Dipyridine derivative, Copper complex

关键词： BP Complexation Properties and Synthesis of 1,2-Bis bipyridinyl)ethylene and 1,2-Bis bipyridinyl)ethane Ligands with Cu

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拿破仑的流放之地

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科学大观园 2015年第12期 9-11页

作者： jean-louis Trembais

隶属于英国的圣赫勒拿岛有着复杂的身份:距离巴西2900千米、非洲大陆1900千米,同时又被美国人当作航空母舰基地和监听站,但岛上却有三处地方被法国赎回后变成了法国国土。200年前的1815年,为了杜绝在滑铁卢战役失败的拿破仑有任何反击... 详细信息

隶属于英国的圣赫勒拿岛有着复杂的身份:距离巴西2900千米、非洲大陆1900千米,同时又被美国人当作航空母舰基地和监听站,但岛上却有三处地方被法国赎回后变成了法国国土。200年前的1815年,为了杜绝在滑铁卢战役失败的拿破仑有任何反击的可能,反法同盟为他安排了终老之地——位于南大西洋的这座神秘小岛,两个世纪以来,到达岛上的唯一交通方式是船舶。到2016年,圣赫勒拿岛才会有座机场将启用,但现在还是

关键词：拿破仑圣赫勒拿岛詹姆斯敦

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