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Endothelial nitric oxide synthase regulation is altered in pancreas from cirrhotic rats

2005年

作者： jean-louis Basdevant jean Dalibard

来源：畅想之星图书光盘版（南... 评论

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World Journal of Gastroenterology 2006年第2期12卷 228-233页

作者： jean-louis Frossard Rafael Quadri Antoine Hadengue Philippe Morel Catherine M Pastor Division de Gastroenterologie Hpitaux Universitaires de Geneve Departement de Chirurgie Hopitaux Universitaires de Geneve Laboratoire de Physiopathologie Hepatique et Imagerie Moleculaire Hpitaux Universitaires de Geneve

AIM： To determine whether biliary cirrhosis could induce pancreatic dysfunction such as modifications in endothelial nitric oxide synthase（eNOS） expression and whether the regulation of eNOS could be altered by the regulatory proteins caveolin and heat shock protein 90 （Hsp90）, as well as by the modifications of calmodulin binding to eNOS. METHODS： Immunoprecipitations and Western blotting analysis were performed in pancreas isolated from sham and cirrhotic rats. RESULTS： Pancreatic injury was minor in cirrhotic rats but eNOS expression importantly decreased with the length （and the severity） of the disease. Because coimmunoprecipitation of eNOS with both Hsp90 and caveolin similarly decreased in cirrhotic rats, eNOS activity was not modified by this mechanism. In contrast, drrhosis decreased the calmodulin binding to eNOS with a concomitant decrease in eNOS activity. CONCLUSION： In biliary cirrhosis, pancreatic injury is minor but the pancreatic nitric oxide （NO） production is significantly decreased by two mechanisms： a decreased expression of the enzyme and a decreased binding of calmodulin to eNOS.

关键词： Pancreas Biliary cirrhosis Endothelial NO synthase Caveolin Heat shock protein 90

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乳源乳酸菌在发酵乳制品中的应用

中国乳品工业 2008年第11期36卷 41-46页

作者：陈历水马莺 jean-louis Maubois 哈尔滨工业大学哈尔滨150090 法国农业科学院法国雷恩35042

为了满足市场需求,全球乳品加工企业都在努力提高产品的多样化程度,并且希望从原料乳或以生鲜乳发酵的乳制品中找到一些潜在的发酵剂来开发新产品。针对这一情况,对乳酸菌在不同发酵乳制品中的主要作用进行了分类综述,并介绍了乳源乳酸... 详细信息

为了满足市场需求,全球乳品加工企业都在努力提高产品的多样化程度,并且希望从原料乳或以生鲜乳发酵的乳制品中找到一些潜在的发酵剂来开发新产品。针对这一情况,对乳酸菌在不同发酵乳制品中的主要作用进行了分类综述,并介绍了乳源乳酸菌在发酵乳制品的应用研究现状。

关键词：乳酸菌干酪酸乳含酒精乳饮料酸酪乳酸奶油

External and Environmental Radiation Dosimetry with Optically Stimulated Luminescent Detection Device Developed at the ***

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World Journal of Nuclear Science and Technology 2012年第1期2卷 6-15页

作者： Reinhard Boons Mark Van Iersel jean louis Genicot 不详

The laboratory of Radiation Dosimetry and Calibration of the Belgian Nuclear Research Centre (***) is using thermoluminescence dosimetry for more than thirty years for routine measurements and for R&D investigations. In 2002, it has developed an experimental device based on the optically stimulated luminescence (OSL) technique. This device is working with AL2O3:C crystals stimulated by the green line (488 nm) emitted by a 150 mW argon laser. This paper describes this device, its characteristics, some applications in space dosimetry and the R&D works initiated in this field during the next few years.

关键词： External Dosimetry OSL Optically Stimulated Dosimetry

Modeling the Dispersion and Atmospheric Mitigation of Pollutants in the Dibamba-Douala Thermal Power Plant

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Journal of Geoscience and Environment Protection 2020年第3期8卷 102-115页

作者： Marius Tony Kibong jean Gaston Tamba louis Monkam Technologies and Applied Sciences Laboratory University Institute of Technology University of Douala Douala Cameroon

This work simulates the dispersion and atmospheric attenuation of pollutants from the Dibamba-Douala thermal power plant. The objective of this research is to study the dispersion of air pollutants and mitigate the impact of pollutants on the populations living around the power plant. The methodology used is as follows: the Gaussian model is used for the representation of the dispersion in the form of a plume, the finite difference method for digital resolution. Finally, dispersion charts are constructed which allow the heights of the chimneys to be fixed for which the concentrations of pollutants discharged comply with ambient air quality standards. The results obtained using the simulation made in the MATLAB software version 2016 show that, for a wind regime of 1.5 m/s;we have a predicted distance of 150 m at which the concentration is canceled out. Then, for the wind speed of 2 m/s;we had a predicted distance of 125 m and finally for a wind speed of 2.5 m/s;we observed the 120 m distance at which the concentration is canceled. In addition, for the same wind regimes, the attenuation of pollutants at ground level is obtained for a height of 60 m.

关键词： Modeling Atmospheric Pollution Thermal Power Plant Gaussian Model Dispersion

On the Diversity of Long-Term Temperature Responses to Varying Levels of Solar Activity at Ten European Observatories

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Atmospheric and Climate Sciences 2019年第3期9卷 498-526页

作者： Vladimir Kossobokov jean-louis Le Mouel Vincent Courtillot Institute of Earthquake Prediction Theory and Mathematical Geophysics Russian Academy of Sciences Moscow Russia Geomagnetism and Paleomagnetism Institut de Physique du Globe de Paris Sorbonne Paris Cité Paris France

We analyze ten of the longest (127 to 230 year-long) time series of European daily temperatures available from five different Köppen-Geiger climate classes. We split these according to the level of solar cycle activity (H for “higher than median” and L for “lower than median”). This reveals coherent patterns in the temperature differences: when TH-TL?are stacked according to their calendar date, the daily averages from January 1 to December 31st disclose characteristic features in addition to the dominant annual seasonal wave, namely variations up to 2°C lasting for about 1.5 to 3 months. The five observatories at intermediate latitudes in a band from Oxford in the West to Prague in the East (same climate class) have very similar signatures. These similarities are most unlikely to be due to pure chance (confirmed by confidence levels in excess of 99% with the Kolmogorov-Smirnov and Kuiper nonparametric tests). The TH-TL patterns carry a regional signature, modulated by a more local response function. On the other hand, northern European observatories (St Petersburg and Arkhangelsk), those south of the Alps (Milan and Bologna), and the easternmost one in Astrakhan, corresponding to different climate classes, have different signatures. Similarly, preliminary study of long air pressure recordings confirms what emerges from the analysis of temperatures. These new observations lead us to conclude that the climate in different regions presents different responses to variations in solar activity. Moreover, the distributions of the lower, middle, and higher quartiles of the temperature and pressure indices in solar cycles with high versus low activity are significantly different, providing further robust statistical confirmation to this conclusion (confidence level higher to much higher than 99% using the Kuiper test).

关键词： Solar Variability Multi-Decadal Temperature Changes Long Temperature Series Nonparametric Hypotheses Testing Kolmogorov-Smirnov Test Kuiper Test

Modulation of monocyte subsets in infectious diseases

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World Journal of Immunology 2014年第3期4卷 185-193页

作者： Mignane B Ka Daniel Olive jean-louis Mege Inserm Unité Mixte de Recherche(UMR) 1068 Centre de Recherche en Cancérologie de Marseille13009 MarseilleFrance Department of Immunology and Infectious Diseases Aix Marseille UniversityURMITEUM63CNRS 7278IRD 198INSERM 109513005 MarseilleFrance

Monocytes are effector immune cells but a precise anal-ysis of their role in immune response has been preclud-ed by their heterogeneity. Indeed, human monocytesare composed of at least three different subsets withdifferent phenotypic characteristics and functional prop-erties, the so-called classical, intermediate and non-classical monocytes. A review of the literature showsthat these monocyte subsets are differently affectedduring viral, bacterial, parasitic and fungal *** expansion of the CD16＋ compartment （intermedi-ate and non-classical monocytes） is typically observedin the majority of infectious diseases and the increasedproportion of CD16＋ monocytes is likely related totheir activation through their direct interaction with thepathogen or the infammatory context. In contrast, thenumber of non-classical and intermediate monocytesis decreased in Q fever endocarditis, suggesting thatcomplex mechanisms govern the equilibrium among monocyte subsets. The measurement of monocyte sub-sets would be useful in better understanding of the role of monocyte activation in the pathophysiology of infec-tious diseases.

关键词： Monocytes subsets Infection Virus Bacte-ria

采用中子衍射研究内锡法Nb_3Sn的相形成

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稀有金属材料与工程 2006年第9期35卷 1367-1370页

作者：张超武周廉唐先德 jean-louis Soubeyroux Andre Sulpice 张平祥卢亚峰陕西科技大学西北有色金属研究院陕西西安710016 西北有色金属研究院法国国家科研中心

选取2种ITER用内锡法Nb3Sn复合超导线,采用原位中子衍射测量技术检测超导相的形成过程,通过添加第3种元素研究合金化Sn芯和合金化Nb芯对超导相形成过程及超导线超导性能的影响。结果表明:合金化Sn芯比合金化Nb芯丝有利于提高超导性能;... 详细信息

选取2种ITER用内锡法Nb3Sn复合超导线,采用原位中子衍射测量技术检测超导相的形成过程,通过添加第3种元素研究合金化Sn芯和合金化Nb芯对超导相形成过程及超导线超导性能的影响。结果表明:合金化Sn芯比合金化Nb芯丝有利于提高超导性能;少量添加第3种元素Ti与Sn形成合金能显著促进Sn的扩散和A15相的形成,并且能有效抑制Nb3Sn晶粒的生长,因此增加了晶界面积和钉扎力,增强了超导特性,提高了非铜区临界电流密度Jcn。

关键词： Nb3Sn超导线内锡法中子衍射

A Comparison of 3D Methods for Identifying the Stance Phase in Treadmill Running for Both Rearfoot and Forefoot Runners

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Journal of Sports Science 2016年第3期4卷 124-131页

作者： Dorian Deflandre Cedric Schwartz jean-Pierre Weerts jean-louis Croisier Thierry Bury Department of Motricity Sciences University of Liege Liege Liege 4000 Belgium

We compared six 3D methods, OptoGait, and Myotest Run for the determination of contact time for runners with different foot strike patterns. Twenty male participants were divided into two groups： the heel group, who attack the ground with the heel （n = 12）, and the toe group, who attack the ground with the middle/front of the foot （n = 8）. They performed trials at speeds of 8 km/h then 16 km/h. To detect foot strike, the use of peak velocity of 3D markers located on the heel, the fifth metatarsal, and the great toe provided the best results for both groups. To detect the toe off, the minimum vertical position of a 3D marker placed in line with the great toe gave the most satisfactory results for both groups. In this way, the values of contact time measured with the 3D methods are consistent. Values measured with OptoGait appear consistent too, while those of the Myotest Run underestimate the contact time for both speeds. 3D analysis provides interesting opportunities for calculation of contact time for both rearfoot and forefoot runners, using specific peak velocities to determine foot strike and marker displacement to determine toe off.

关键词： Contact time running 3D OptoGait Myotest Run.

Role of the epididymis in sperm competition

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Asian Journal of Andrology 2007年第4期9卷 493-499页

作者： Russell C. Jones jean-louis Dacheux Brett Nixon Heath W. Ecroyd Discipline of Biological Sciences University of Newcastle Callaghan 2308 Australia UMR INRA-CNRS 6073 Physiologie de la Reproduction et des Comportements Nouzilly 37380 France Department of Chemistry University of Adelaide Adelaide 5005 Australia

Although it is generally understood that the testes recruited kidney ducts for reproductive function during the evolution of vertebrates, little is understood of the biological significance of the adaptation. In the context of the evolution of the mammalian epididymis, this report provides evidence that a major role of the epididymis is to enhance a male＇s chance of achieving paternity in a competitive mating system. A unique example of sperm cooperation in monotremes is used as evidence that the epididymis produces sperm competition proteins to form groups of 100 sperm into bundles that have a forward motility nearly thrice that of individual spermatozoa. As it required 3-h incubation in vitro under capacitation conditions to release motile sperm from the bundles, it is suggested that the monotremes provide an example of capacitation that is quite different from capacitation in higher mammals. It is suggested that variation between species in the intensity of sperm competition could explain the variation that occurs between species in the amount of post-testicular sperm maturation and storage in the epididymis, an explanation of why the human epididymis does not play as important a role in reproduction as the epididymis of most mammals. （Asian J Androl 2007 July; 9： 493-499）

关键词： epididymis sperm maturation sperm storage capacitation sperm competition sperm cooperation