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Tips and Techniques in Laparoscopic Surgery 2005

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New insights in diabetic foot infection

2005年

作者： jean-louis Dulucq

ISBN: (数字)9783540270201

ISBN: (纸本)9783540209027

Performing a surgical operation could be compared to na- gating inside the human body. Two essential requirements are necessary for a successful apprenticeship: ? A perfect understanding of the roadmap, the anatomy ? Regular training with expert surgeon teachers showing str- egies, tactics, manoeuvres, and gestures to make the journey safe, efficient and fast For decades this was the way taken by apprentice-surgeons and also by surgeons already in practice concerned about upd- ing their knowledge. For years their only travelling companions were books, drawings, and pictures. However, printed medium cannot satisfactorily and properly reproduce the movements of a manoeuvring surgeon. In open surgery, only the two first - sistants can precisely capture by direct vision what is happ- ing in the depth of the operating field. Therefore, the duration of apprenticeship is long and restricted to a small number of people per teacher. The introduction of movie cameras into the operating rooms improved the quality of surgical education. But filming in open surgery is not so easy. The cameraperson has to be well trained to catch good takes in the depth of a pit between the heads, shoulders, and fingers of the surgeon and assistants. Most of the time, those constraints disturb the op- ator’s manoeuvres, altering their pedagogical value. With the introduction of laparoscopic surgery (LS), using a video camera providing images in real time on a television screen, everything changed.

关键词： Laparoscopy

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World Journal of Diabetes 2011年第2期2卷 24-32页

作者： jean-louis Richard Albert Sotto jean-Philippe Lavigne Department of Nutritional Diseases and Diabetology Medical CentreUniversity Hospital of NmesLe Grau du Roi 30240France Department of Infectious Diseases Carémeau HospitalUniversity Hospital of Nmes30029 Nmes and INS- ERMERI 26UFR de Médecine30908 Nmes Cedex 02 France Laboratory of Bacteriology Carémeau HospitalUniversity Hospital of Nmes30029 NmesFrance and INSERMERI 26UFR de Médecine30908 Nmes Cedex 02France

Foot ulcers are common in diabetic patients,have a cumulative lifetime incidence rate as high as 25%and frequently become *** spread of infection to soft tissue and bone is a major causal factor for lowerlimb *** this reason,early diagnosis and appropriate treatment are essential,including treatment which is both local(of the foot)and systemic(metabolic),and this requires coordination by a multidisciplinary *** treatment also often involves extensive surgical debridement and management of the wound base,effective antibiotic therapy,consideration for revascularization and correction of metabolic abnormalities such as *** article focuses on diagnosis and management of diabetic foot infections in the light of recently published data in order to help clinicians in identification,assessment and antibiotic therapy of diabetic foot infections.

关键词： Diabetic foot ulcer Infection Management

Rural Wireless Mesh Network: A Design Methodology

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International Journal of Communications, Network and System Sciences 2015年第1期8卷 1-9页

作者： jean louis Ebongue Kedieng Fendji jean Michel Nlong University Institute of Technology (UIT) The University of Ngaoundéré Ngaoundéré Cameroon Faculty of Science The University of Ngaoundéré Ngaoundéré Cameroon

Wireless Mesh Network is presented as an appealing solution for bridging the digital divide between developed and under-developed regions. But the planning and deployment of these networks are not just a technical matter, since the success depends on many other factors tied to the related region. Although we observe some deployments, to ensure usefulness and sustainability, there is still a need of concrete design process model and proper network planning approach for rural regions, especially in Sub-Saharan Africa. This paper presents a design methodology to provide network connectivity from a landline node in a rural region at very low cost. We propose a methodology composed of ten steps, starting by a deep analysis of the region in order to identify relevant constraints and useful applications to sustain local activities and communication. Approach for planning the physical architecture of the network is based on an indoor-outdoor deployment for reducing the overall cost of the network.

关键词： Design Methodology Planning Rural Regions Wireless Mesh Network

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两株抗氧化活性酵母的鉴定及对乳成分的影响

哈尔滨工业大学学报 2010年第12期42卷 1932-1937页

作者：陈历水马莺丁庆波刘巧红 jean louis MAUBOIS 哈尔滨工业大学食品科学与工程学院哈尔滨150090 中粮集团有限公司创新管理部食品研发中心北京100020 法国农业科学研究院雷恩乳品中心雷恩35042

为获得有抗氧化活性的工业用酵母菌株,对2株来源于原料乳中有较强抗氧化活性的酵母菌进行鉴定.根据菌株的表型、生理生化特征和基因型的特性,初步将这2株菌鉴定为毕赤氏发酵酵母(Pichia fermentans).将这2株酵母菌在高温灭菌(UHT)牛乳... 详细信息

为获得有抗氧化活性的工业用酵母菌株,对2株来源于原料乳中有较强抗氧化活性的酵母菌进行鉴定.根据菌株的表型、生理生化特征和基因型的特性,初步将这2株菌鉴定为毕赤氏发酵酵母(Pichia fermentans).将这2株酵母菌在高温灭菌(UHT)牛乳中培养以研究其对牛乳主要成分的影响,结果表明:这2株酵母能在UHT牛乳中产乙醇,具有促进蛋白水解活性与脂肪水解活性的能力,能有效提高乳中的游离氨基酸和脂肪酸的含量.

关键词： Pichia fermentans 鉴定乳糖发酵蛋白水解活性脂肪水解活性

Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches

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CCS Chemistry 2022年第9期4卷 3036-3050页

作者： Jielin Chen Mingpan Cheng Petr Stadlbauer JiříŠponer jean-louis Mergny Huangxian Ju Jun Zhou State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 Institute of Biophysics of the Czech Academy of Sciences Královopolská135Brno 61265 Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute(CATRIN)Palacky University OlomoucŠlechtitelů241/27Olomouc–Holice 78371 Laboratoire d’Optique et Biosciences Ecole PolytechniqueCNRSINSERMInstitut Polytechnique de ParisPalaiseau 91128

As nonclassical nucleic acid structures,G-quadruplexes(G4s)not only play important roles in gene regulation and stability maintenance,but are also widely used in *** diversity is one of the main factors explaining the popularity of G4s,but a comprehensive and integrated study of different factors determining G4 structural versatility is currently lacking.

关键词： G-quadruplex G-quadruplex topology Gswitch sequence composition structural versatility

Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study

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World Journal of Hepatology 2017年第27期9卷 1125-1132页

作者： Charlotte Nicolas Amelie Le Gouge louis d’Alteroche jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau jean-Marc Perarnau STIC-TIPS group Service d’Hepato-Gastroenterologie Hopital TrousseauCHRU Tours CIC CHRU de Tours INSERM United’echographie-doppler Hopital TrousseauCHRU Tours Service de Radiologie Hopital de la Timone Centre Hepato-Biliaire Hopital Paul Brousse Service de Radiologie CHRU Dijon Service d’Imagerie Medicale Diagnostique et interventionnelle Hopital de l’ArchetⅡNice Service de Radiologie et Echographie CHRU Poitiers Service d’Imagerie Medicale Hopital Saint Andre CHRU Bordeaux Service d’Imagerie viscerale et vasculaire CHRU Clermont Ferrand Service de Radiologie CHRU Caen Service de Radiologie CHRU Nantes 不详

AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic *** This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of *** Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction.

关键词： Transjugular intrahepatic portosystemic shunt Dysfunction Doppler-ultrasonography

一株抗氧化活性酵母菌产多糖的纯化与结构分析

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分析化学 2010年第3期38卷 409-412页

作者：陈历水马莺刘天一 jean-louis Maubois 哈尔滨工业大学食品科学与工程学院 Laboratoire de Recherches de Technologie Laitière INRA65 rue de Saint Brieuc

研究了Pichia fermentans酵母菌产多糖YP5的单糖组成和结构。将酵母菌进行超声破碎后,采用乙醇沉淀法得到粗多糖,然后进行DEAE-纤维素色谱柱分离,得到均一的水溶性多糖YP5。经气相色谱分析表明,糖基由鼠李糖、阿拉伯糖、木糖、甘露糖、... 详细信息

研究了Pichia fermentans酵母菌产多糖YP5的单糖组成和结构。将酵母菌进行超声破碎后,采用乙醇沉淀法得到粗多糖,然后进行DEAE-纤维素色谱柱分离,得到均一的水溶性多糖YP5。经气相色谱分析表明,糖基由鼠李糖、阿拉伯糖、木糖、甘露糖、葡萄糖与半乳糖组成,其摩尔比为9.51∶1.33∶2.31∶0.94∶84.93∶0.96。乌氏粘度计法测得多糖的分子量为8.3×104。结合红外光谱和核磁共振1HNMR分析表明,该多糖YP5具有多糖特征性的红外吸收峰,存在酰胺结构,主要由β-D-葡聚糖组成。

关键词：酵母多糖纯化单糖组成结构

Macrophage populations and self-renewal:Changing the paradigm

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World Journal of Immunology 2015年第3期5卷 131-141页

作者： Rym Belhareth jean-louis Mège URMITE Faculté de Médecine Laboratoire de Neurophysiologie Fonctionnelle et Pathologies UR/11ES09 FST Campus Universitaire

The origin of macrophages has been considered since several decades to be a continuum from bone marrow （BM） to tissue via monocytes as precursors. The development of new tools such as genetic lineage tracing,parabiosis and BM chimeras changed the paradigm of macrophage origin. In steady state, most resident macro-phages are of embryonic origin, whereas a monocyte origin remains prominent in pathological conditions. The findings of a proliferation of mature macrophages will oblige us to reappraise the relationship between proliferation and differentiation in macrophages. This review is based on the recent explosion of high impact articles on macrophage biology. It summarizes new data on the origin of macrophages and their self-renewal potential in steady states. While monocytes are required for intestinal macrophage development, the microglia is independent of monocyte influx and skin macrophages provide an excellent model of the balance between monocyte input and self-renewal. In addition, macrophage proliferation requires intrinsic and extrinsic factors including growth factors and cytokines. It also analyzes the impact of this new paradigm in human diseases such as athrosclerosis, cancer, infe-ctious diseases and neurodegenerative diseases. In atherosclerosis, the fnding of macrophage proliferation within the lesions will change our understanding of disease pathophysiology, this new paradigm may have therapeutical impact in the future.

关键词： Macrophages Self-renewal Proliferation Homeostasis Diseases

Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples

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World Journal of Gastroenterology 2006年第21期12卷 3344-3351页

作者： Henrik Laurell Michèle Bouisson Philippe Berthelémy Philippe Rochaix Sébastien Déjean Philippe Besse Christiana Susini Lucien Pradayrol Nicole Vaysse louis Buscail INSERM U531 IFR31 Institut Louis BugnardBP 8422531432 Toulouse Cedex 4France Service de Gastroentérologie Centre Hospitaller de Pau PauFrance Laboratoire d'Anatomo-Pathologie Institut Claudius Regaud ToulouseFrance Laboratoire de Statistique et Probabilités Université Paul Sabatier ToulouseFrance INSERM U531 IFR31 Institut Louis BugnardBP 8422531432 Toulouse Cedex 4France Service de Gastroenterologie et de la NutritionCHU RangueilToulouseFrance

AIM： To compare gene expression profiles of pancreatic adenocarcinoma tissue specimens, human pancreatic and colon adenocarcinoma and leukemia cell lines and normal pancreas samples in order to distinguish differentially expressed genes and to validate the differential expression of a subset of genes by quantitative real-time RT-PCR （RT-QPCR） in endoscopic ultrasound-guided fine needle aspiration （EUS-guided FNA） ***： Commercially dedicated cancer cDNA macroarrays （Atlas Human Cancer 1.2） containing 1176 genes were used. Different statistical approaches （hierarchical clustering, principal component analysis （PCA） and SAM） were used to analyze the expression data. RT-QPCR and immunohistochemical studies were used for validation of ***： RT-QPCR validated the increased expression of LCN2 （lipocalin 2） and for the first time PLAT （tissue-type plasminogen activator or tPA） in malignant pancreas as compared with normal pancreas. Immunohistochemical analysis confirmed the increased expression of LCN2 protein localized in epithelial cells of ducts invaded by carcinoma. The analysis of PLAT and LCN2 transcripts in 12 samples obtained through EUS-guided FNA from patients with pancreatic adenocarcinoma showed significantly increased expression levels in comparison with those found in normal tissues, indicating that a sufficient amount of high quality RNA can be obtained with this ***： Expression profiling is a useful method to identify biomarkers and potential target genes. Molecular analysis of EUS-guided FNA samples in pancreatic cancer appears as a valuable strategy for the diagnosis of pancreatic adenocarcinomas.

关键词： Pancreas Colon Adenocarcinoma Gene expression profiling Endoscopic ultrasonography Ultrasound Fine needle aspiration