检索结果-南通市图书馆

Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India

Precision Clinical Medicine 2018年第2期1卷 75-87页

作者： Archana Sharma-Oates Abeer M.Shaaban Ian Tomlinson Luke Wynne jean-baptiste cazier Sudha Sundar Centre for Computational Biology Haworth BuildingUniversity of BirminghamEdgbastonBirminghamB152TTUK Institute of Cancer and Genomic Sciences College of Medical and Dental SciencesHaworth BuildingUniversity of BirminghamEdgbastonBirminghamB152TTUK Department of Cellular Pathology University Hospitals Birmingham NHS Foundation TrustQueen Elizabeth Hospital BirminghamMindelsohn WayBirminghamB152THUK Pan-Birmingham Gynaecological Cancer Centre City HospitalDudley RoadBirminghamWest MidlandsB187QHUK

Breast and ovarian cancers now account for one in three cancers in Indian women and their incidence is *** differences in the clinical presentation of breast and ovarian cancers exist between India and the United *** example,Indian patients with breast cancer typically present a decade earlier than in the *** for this could be multifactorial,including differences in underlying biology,environmental risks,and other systematic factors including access to *** possible explanation lies in variable incidence or penetrance of germline mutations in genes such as BRCA1 and *** performed a methodical database and literature review to investigate the prevalence and spectrum of high-risk cancer susceptibility genes in Indian patients with breast and ovarian *** identified 148 articles,but most studies were small,with inconsistent inclusion criteria and based on heterogeneous technologies,so that mutation frequency could not be reliably *** were also often lacking on penetrance,histopathology,and survival *** filtering out unsuitable studies,only 13 remained,comprising 1028 ***-scale research studies are urgently needed to determine mutation prevalence,spectra,and clinico-pathological features,and hence derive guidelines for screening,treatment,and prevention specific to the Indian population.

关键词： BRCA1 BRCA2 hereditary cancer sporadic cancer India breast cancer ovarian cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genetic factors for differentiated thyroid cancer in French Polynesia:new candidate loci

引用

Precision Clinical Medicine 2023年第2期6卷 57-66页

作者： Monia Zidane Marc Haber Thérèse Truong Frédérique Rachédi Catherine Ory Sylvie Chevillard Hélène Blanché Robert Olaso Anne Boland Éric Conte Mojgan Karimi Yan Ren Constance Xhaard Vincent Souchard Jacques Gardon Marc Taquet André Bouville jean-François Deleuze Vladimir Drozdovitch Florent de Vathaire jean-baptiste cazier University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Radiations Epidemiology"Villejuif 94805France Centre for Computational Biology University of BirminghamBirmingham B152TTUK Institute of Cancer and Genomic Sciences University of BirminghamBirmingham B152TTUK University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Exposome and Heredity"Villejuif 94805France Endocrinology Unit Territorial Hospital TaaoneF-98713PapeeteTahiti 98713French Polynesia CEA Laboratoire de Cancérologie FondamentaleInstitut de Biologie François JacobiRCMSREITLaboratoire de Cancérologie Expérimentale(LCE)UniversitéParis-SaclayFontenay aux Roses 92265France Fondation jean Dausset-Centre d’Etude du Polymorphisme Humain Paris 75010France UniversitéParis-Saclay CEACentre National de Recherche en Génomique HumaineEvry 91057France U.S.R.2003(CNRS/UPF) Faa’aTahiti 98702France University of Lorraine INSERM CIC 1433Nancy CHRUINSERM U1116Nancy 54500France Hydrosciences Montpellier Research Institute for DevelopmentCNRSUniversity of MontpellierMontpellier 62307France Research Institute for Development Center IRD on TahitiArueTahiti 98713French Polynesia National Cancer Institute(retired) BethesdaMD 20892USA Division of Cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Background:Populations of French Polynesia(FP),where France performed atmospheric tests between 1966 and 1974,experience a high incidence of differentiated thyroid cancer(DTC).However,up to now,no sufficiently large study of DTC genetic factors in this population has been performed to reach definitive *** research aimed to analyze the genetic factors of DTC risk among the native FP ***:We analyzed more than 300000 single nucleotide polymorphisms(SNPs)genotyped in 283 DTC cases and 418 matched controls born in FP,most being younger than 15 years old at the time of the first nuclear *** analyzed the genetic profile of our cohort to identify population *** then completed a genome-wide analysis study on the whole ***:We identified a specific genetic structure in the FP population reflecting admixture from Asian and European *** identified three regions associated with increased DTC risk at 6q24.3,10p12.2,and *** lead SNPs at these loci showed respective p-values of 1.66×10^(−7),2.39×10^(−7),and 7.19×10^(−7) and corresponding odds ratios of 2.02,1.89,and ***:Our study results suggest a role of the loci 6q24.3,10p12.2 and 17q21.32 in DTC ***,a whole genome sequencing approach would be better suited to characterize these factors than genotyping with microarray chip designed for the Caucasian ***,the functional impact of these three new loci needs to be further explored and validated.

关键词： differentiated thyroid cancer population genetics genetic susceptibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Corrigendum to:Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India

引用

Precision Clinical Medicine 2018年第3期1卷 134-134页

作者： Archana Sharma-Oates Abeer M.Shaaban Ian Tomlinson Luke Wynne jean-baptiste cazier Sudha Sundar 不详

This is a correction notice for article pby010(Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India;DOI:https://***/10.1093/pcmedi/pby010),published on 22 September *** authors were mistakenly listed as being affiliated with the following:‘Centre for Computational Biology,Institute of Cancer and Genomic Sciences,College of Medical and Dental Sciences,Haworth Building,University of Birmingham,Edgbaston,Birmingham,B152TT,UK.’Their affiliations should instead have been given as follows.

关键词： breast cancer susceptibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of Genomics and in Silico Related Technologies in the Drug Discovery Process

引用

Chinese Journal of Chemistry 2003年第10期21卷 1241-1246页

作者： LEATUTE jean-baptiste DepartmentofValorizationandIndustrialRelationships Paris7University2PlaceJussieu75005ParisFrance

In order to evaluate to what extent will genomics and in silico related technologies improve overall drug discovery process, we analyzed three studies comparing cost, time and attrition rate at each step of the dr... 详细信息

关键词： in silico drug discovery bioinformatics chemoinformatics drug design functional and structural genomics virtual screening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dry reforming of methane on doped Ni nanoparticles:Featureassisted optimizations and ranking of doping metals for direct activations of CH_(4) and CO_(2)

引用

Nano Research 2022年第10期15卷 9670-9682页

作者： Shiru Lin jean-baptiste Tristan Yang Wang Junwei Lucas Bao Department of Chemistry Boston CollegeChestnut HillMassachusetts 02467USA Department of Computer Science Boston CollegeChestnut HillMassachusetts 02467USA

As a vital energy resource and raw material for many industrial products,syngas(CO and H_(2))is of great *** reforming of methane(DRM)is an important approach to producing syngas(with a hydrogen-to-carbon-monoxide ratio of 1:1 in principle)from methane and carbon dioxide,with a lower operational cost as compared to other reforming ***,many pure metallic catalysts used in DRM face deactivation issues due to coke formation or sintering of the metal particles.A systematic search for highly efficient metallic catalysts,which reduce the reaction barriers for the rate-determining steps and resist carbon deposition,is urgently *** is a typical low-cost transition metal for activating the C–H bond in *** this work,we applied a two-step workflow to search for nickel-based bimetallic catalysts with doping metals M(M-Ni)by combining density functional theory(DFT)calculations and machine learning(ML).We focus on the two critical steps in DRM—CH_(4) and CO_(2) direct *** used DFT and slab models for the Ni(111)facet to explore the relevant reaction pathways and constructed a data set containing structural and energetic information for representative M-Ni *** used this dataset to train ML models with chemical-knowledge-based features and predicted CH_(4) and CO_(2) dissociation energies and barriers,which revealed the composition–activity relationships of the bimetallic *** also used these models to rank the predicted catalytic performance of candidate systems to demonstrate the applicability of ML for catalyst *** emphasized that ML ranking models would be more valuable than regression models in high-throughput ***,we used our trained model to screen 12 unexplored M-Ni systems and showed that the DFT-computed energies and barriers are very close to the ML-predicted values for top candidates,validating the robustness of the trained model.

关键词： Ni-based bimetallic catalysts dry reforming of methane syngas production CH_(4)and CO_(2)direct activations ranking model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances in cytokines:Therapeutic implications for inflammatory bowel diseases

引用

World Journal of Gastroenterology 2011年第5期17卷 547-556页

作者： Guillaume Bouguen jean-baptiste Chevaux Laurent Peyrin-Biroulet Inserm UMR991 Department of HepatoGastroenterologyUniversity Hospital of RennesPontchaillou35000 RennesFrance Inserm U954 Department of Hepato-GastroenterologyUniversity Hospital of Nancy54511 Vandoeuvre-les-NancyFrance

Inflammatory bowel diseases （IBDs） are complex and chronic disabling conditions resulting from a dysregulated dialogue between intestinal microbiota and components of both the innate and adaptive immune systems. Cytokines are essential mediators between activated immune and non-immune cells, including epithelial and mes- enchymal cells. They are immunomodulatory peptides released by numerous cells and these have significant effects on immune function leading to the differentiation and survival of T cells. The physiology of IBD is becom- ing a very attractive field of research for development of new therapeutic agents. These include cytokines involved in intestinal immune inflammation. This review will focus on mechanisms of action of oytokines involved in IBD and new therapeutic opportunities for these diseases.

关键词： Inflammatory bowel disease Ulcerative coli-tis Crohn's disease Cytokine Pathophysiology Biologi-cal therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Formation mechanisms of sub-micron pharmaceutical composite particles derived from far-and near-field Raman microscopy

引用

Journal of Pharmaceutical Analysis 2021年第4期11卷 480-489页

作者： Jakob Hübner jean-baptiste Coty Yan Busby Denis Spitzer Nanomateriaux pour Les Systemes Sous Sollicitations Extr^emes(NS3E) ISL-CNRS-UNISTRA UMR 3208French-German Research Institute of Saint-Louis5Rue Du General CassagnouB.P.7003468301Saint-LouisFrance Spinofrin SAS 20 Bis Rue Danjou92100BoulogneBillancourtFrance

Surface enhanced Raman spectroscopy(SERS) and confocal Raman microscopy are applied to investigate the structure and the molecular arrangement of sub-micron furosemide and polyvinylpyrrolidone(furosemide/PVP) particles produced by spray flash evaporation(SFE). Morphology, size and crystallinity of furosemide/PVP particles are analyzed by scanning electron microscopy(SEM) and X-ray powder diffraction(XRPD). Far-field Raman spectra and confocal far-field Raman maps of furosemide/PVP particles are interpreted based on the far-field Raman spectra of pure furosemide and PVP *** far-field Raman microscopy shows that furosemide/PVP particles feature an intermixture of furosemide and PVP molecules at the sub-micron scale. SERS and surface-enhanced confocal Raman microscopy(SECo RM) are performed on furosemide, PVP and furosemide/PVP composite particles sputtered with silver(40 nm). SERS and SECo RM maps reveal that furosemide/PVP particle surfaces mainly consist of PVP molecules. The combination of surface and bulk sensitive analyses reveal that furosemide/PVP sub-micron particles are formed by the agglomeration of primary furosemide nanocrystals embedded in a thin PVP matrix. Interestingly, both far-field Raman microscopy and SECo RM provide molecular information on a statistically-relevant amount of sub-micron particles in a single microscopic map;this combination is thus an effective and time-saving tool for investigating organic sub-micron composites.

关键词： SERS Confocal Raman microscopy Surface characterization Sub-micron particles Pharmaceutic composites

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Belt and Road Initiative ＆ Investment in Sustainable Development Field from China

Belt and Road Initiative ＆ Investment in Sustainable Develo...

引用

作者： jean-baptiste Blondaux 上海交通大学

学位级别：硕士

The principal aimed of this study was to show a correlation of Belt and Road Initiative and sustainable development for future years and additionally,tends to explain by which process,strategy Belt and Road Initiative works on to improve their *** master thesis methodology was based on qualitative research with four experts that gives their advice and opinions on the problematic during interview *** meet those experts in specific forums such as the forum of “Education for the Belt and Road Initiative,Our Shared Dream” The 8th International Educational Forum on the 03/04/2019 or at the Shanghai Expat Services Conferences on Green Technology in *** also complete our answer with quantitative research made by an online survey with 200 answers and also by two case analyses with one focusing on a BRI failure in Myanmar with a view to learning from past errors and the other case highlight a formula developed by researchers that shows the evolution of sustainable development score through Belt and Road Initiative,which could be interesting to implement as an official *** to our research,average sustainability through Belt and Road Initiative is low,but in constant positive ***,we could affirm a positive correlation between BRI and the SD field for future *** than that,from our quantitative research that has been done via an online survey with 200 answers,people trust and have faith in the ability of such a project to positively correlate with a sustainable development *** master thesis also highlights the desire of Chinese and Western European countries to financially involved themselves if the sustainable conditions are respected which represents a new pathway for the financial worlds to attract *** the other hand,this study is reinforced by qualitative research made by interviews with professional experts’ link to BRI and – or,sustainable development *** the case analysis and qualitative researc

关键词：

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Diallel analyses of soluble sugar content in cowpea (Vigna unguiculata ***.)

引用

The Crop Journal 2017年第6期5卷 553-559页

作者： Maina Antoine Nassourou Tchiagam jean baptiste Noubissié Yanou Nicolas Njintang Joseph Martin Bell Department of Biological Sciences Faculty of Science University of Ngaoundéré P.O. Box 454 Ngaoundéré Cameroon Department of Food Science and Nutrition ENSAI University of Ngaoundéré P.O. Box 455 Ngaoundéré Cameroon Genetics and Plant Breeding Unit Department of Plant Biology Faculty of Science University of Yaoundé I P.O. Box 812 Yaoundé Cameroon

The content of soluble sugar in cowpea(Vigna unguiculata L. Walp.) seeds is important for their acceptability to consumers. The objective of this study was to evaluate the genetic control of soluble sugar content in cowpea using diallel analysis. For this purpose,half-diallel crosses were made among seven diverse parents. The amount of total soluble sugar was estimated by the phenol sulfuric acid reagent method and reducing sugar were measured by the DNS(3,5-dinitrosalicylic acid) reagent method. The total soluble sugar ranged from 11.12(VYA) to 40.79 mg g^(-1)(IT93 K-693-2) with a mean of 22.31 mg g^(-1).Reducing soluble sugar showed a mean value of 9.11 mg g^(-1) and ranged from 13.61(TVx3236) to 4.98 mg g^(-1)(Lori niebe). Diallel analysis showed that both additive and non-additive gene effects were significant in the genetic control of these traits. However,dominance variance was greater than additive variance for soluble sugar. The traits were controlled mainly by an overdominance model, suggesting the advantage of delaying selection to later generations. Soluble sugar content was found to be highly heritable, with broad-sense heritability ranging from 0.987 to 0.976. Narrow-sense heritability ranged from0.154 to 0.422 and revealed the lower importance of additive variance. Parents and F_1 hybrids differed significantly on the basis of their general and specific combining abilities,respectively. Recessive alleles had positive effects on total soluble sugar and reducing soluble sugar. These results could help cowpea breeders improve the acceptability of cowpea seeds and cowpea-based foods by appropriate selection.

关键词： Cowpea Genetic improvement Diallel analysis Soluble sugar

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reciprocal interactions between gut microbiota and autophagy

引用

World Journal of Gastroenterology 2021年第48期27卷 8283-8301页

作者： Pierre Lapaquette jean-baptiste Bizeau Niyazi Acar Marie-Agnès Bringer UMR PAM A 02.102 University Bourgogne Franche-ComtéAgrosup DijonDijon 21000France Eye and Nutrition Research Group Centre des Sciences du Goût et de l'AlimentationAgroSup DijonCNRSINRAEUniversitéBourgogne Franche-ComtéDijon 21000France

A symbiotic relationship has set up between the gut microbiota and its host in the course of evolution,forming an interkingdom *** gut offers a favorable ecological niche for microbial communities,with the whole body and external factors(e.g.,diet or medications)contributing to modulating this ***,the gut microbiota is important for maintaining health by acting not only on the gut mucosa but also on other ***,failure in one or another of these two partners can lead to the breakdown in their symbiotic equilibrium and contribute to disease onset and/or *** microbial and host processes are devoted to facing up the stress that could alter the symbiosis,ensuring the resilience of the *** these processes,autophagy is a host catabolic process integrating a wide range of stress in order to maintain cell survival and *** cytoprotective mechanism,which is ubiquitous and operates at basal level in all tissues,can be rapidly down-or upregulated at the transcriptional,post-transcriptional,or post-translational levels,to respond to various stress *** of its sensitivity to all,metabolic-,immune-,and microbial-derived stimuli,autophagy is at the crossroad of the dialogue between changes occurring in the gut microbiota and the host *** this review,we first delineate the modulation of host autophagy by the gut microbiota locally in the gut and in peripheral ***,we describe the autophagy-related mechanisms affecting the gut *** conclude this review with the current challenges and an outlook toward the future interventions aiming at modulating host autophagy by targeting the gut microbiota.

关键词： Gut microbiota Autophagy Probiotic Brain Liver Muscle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：