Recent advances in cytokines:Therapeutic implications for inflammatory bowel diseases

作     者：Guillaume Bouguen Jean-Baptiste Chevaux Laurent Peyrin-Biroulet 

作者机构：Inserm UMR991Department of HepatoGastroenterologyUniversity Hospital of RennesPontchaillou35000 RennesFrance Inserm U954Department of Hepato-GastroenterologyUniversity Hospital of Nancy54511 Vandoeuvre-les-NancyFrance 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第5期

页      面：547-556页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Inflammatory bowel disease Ulcerative coli-tis Crohn's disease Cytokine Pathophysiology Biologi-cal therapy 

摘      要：Inflammatory bowel diseases （IBDs） are complex and chronic disabling conditions resulting from a dysregulated dialogue between intestinal microbiota and components of both the innate and adaptive immune systems. Cytokines are essential mediators between activated immune and non-immune cells, including epithelial and mes- enchymal cells. They are immunomodulatory peptides released by numerous cells and these have significant effects on immune function leading to the differentiation and survival of T cells. The physiology of IBD is becom- ing a very attractive field of research for development of new therapeutic agents. These include cytokines involved in intestinal immune inflammation. This review will focus on mechanisms of action of oytokines involved in IBD and new therapeutic opportunities for these diseases.