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Saponins as adipokines modulator: A possible therapeutic intervention for type 2 diabetes

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World Journal of Diabetes 2017年第7期8卷 337-345页

作者： Olusola Olalekan Elekofehinti Oluwamodupe Cecilia Ejelonu jean paul Kamdem Oluwaseun Benedicta Akinlosotu Isaac Gbadura Adanlawo Department of Biochemistry University of Ado-Ekiti Department of Biochemistry Adekunle Ajasin University Departamento de Ciências Biológicas Universidade Regional do Cariri-URCA Campus Pimenta Department of Biochemistry Federal University of TechnologyAkure

Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we sum-marized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents.

关键词： Adipokines Adipose tissue Insulin resistance Antidiabetic Obesity

Discours prononcéàl′occasion du 5e anniversaire de la coopé-ration et de la communication culturelles entre la France et l′Universitéde wuhan

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法国研究 1985年第4期 7-8页

作者： jean-paul Réau

Monsieur le président,Messieur les Directeurs,Mesdames,Messieurs,Chers Amis,L′Ambassadeur de France ayant étéappelé pour consultation par *** DUMAS,Ministre des Relations Extérieures,l′honneur m′échoitde le r... 详细信息

关键词：外物

Virtual brain twins: from basic neuroscience to clinical use

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National Science Review 2024年第5期11卷 72-86页

作者： Huifang E.Wang paul Triebkorn Martin Breyton Borana Dollomaja jean-Didier Lemarechal Spase Petkoski Pierpaolo Sorrentino Damien Depannemaecker Meysam Hashemi Viktor K.Jirsa Aix Marseille Université Institut National de la Santéet de la Recherche Médicale Institut de Neurosciences des Systèmes(INS) UMR1106 Service de Pharmacologie Clinique et Pharmacosurveillance AP–HM

Virtual brain twins are personalized, generative and adaptive brain models based on data from an individual's brain for scientific and clinical use. After a description of the key elements of virtual brain twins,we present the standard model for personalized whole-brain network models. The personalization is accomplished using a subject's brain imaging data by three means:(1) assemble cortical and subcortical areas in the subject-specific brain space;(2) directly map connectivity into the brain models, which can be generalized to other parameters; and(3) estimate relevant parameters through model inversion, typically using probabilistic machine learning. We present the use of personalized whole-brain network models in healthy ageing and five clinical diseases: epilepsy, Alzheimer's disease, multiple sclerosis, Parkinson's disease and psychiatric disorders. Specifically, we introduce spatial masks for relevant parameters and demonstrate their use based on the physiological and pathophysiological hypotheses. Finally, we pinpoint the key challenges and future directions.

关键词： virtual brain twin personalized modeling inference neuroscience brain disorder

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消泡剂对超滤膜的影响

食品与发酵工业 2007年第5期33卷 51-53页

作者： jean-paul Lecomte 道康宁公司上海200001

膜污垢已成为作为分离和净化系统的超滤膜的主要缺陷。有关膜污垢的原因和理论，以及系统优化、污垢对膜寿命的影响。等研究已广泛开展。特别是人们发现，消泡剂可导致显著的膜污垢。本论文旨在讨论消泡剂膜污垢问题，研究膜污垢产生的... 详细信息

膜污垢已成为作为分离和净化系统的超滤膜的主要缺陷。有关膜污垢的原因和理论，以及系统优化、污垢对膜寿命的影响。等研究已广泛开展。特别是人们发现，消泡剂可导致显著的膜污垢。本论文旨在讨论消泡剂膜污垢问题，研究膜污垢产生的主要原因，并介绍了用于超滤顺流工艺的无污垢消泡剂的开发。

关键词：超滤膜消泡剂净化系统污垢膜寿命原因分离

Hybridisation on coral reefs and the conservation of evolutionary novelty

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Current Zoology 2015年第1期61卷 132-145页

作者： Zoe T. RICHARDS jean-paul A. HOBBS Department of Aquatic Zoology Western Australian Museum Welshpool WA 6015 Australia Department of Environment and Agriculture Curtin University Bentley WA 6845 Australia

Hybridisation was traditionally considered rare on coral reefs. However, a rapid increase in hybrid studies over the last 20 years has revealed that hybridisation on coral reefs is common and widespread. In this review, we summarise the growing body of evidence arising from studies on stony corals and reef fishes to verify the occurrence of hybridisatiori, and we examine the influence hybridisation has had on the enormous level of biodiversity present on coral reefs. We discuss the challenges of dis- tinguishing hybridisation from alternative hypotheses （e.g. incomplete lineage sorting）. This review also explores the evolutio- nary consequences of hybridisation, which range from increasing genetic diversity and the production of novel lineages that may outperform the parent species, to reverse speciation and extinction by genetic swamping. Instances of hybridisation can be natural or occur as a result of human impacts （e.g. habitat degradation） and distinguishing between these two very different causal me- chanisms is important for management. Currently, the legislative status of hybrids is unclear and hybrids are rarely protected in conservation programs. Failing to adequately manage hybridisation and hybrid lineages may lead to potential losses of evolutio- nary novelty, declines in phylogenetic diversity or species extinctions. To conserve existing coral reef biodiversity, and the processes that generate biodiversity, conservation policies must be re-defined and instances of hybridisation must be assessed and managed on a case-by-case basis [Current Zoology 61 （1）： 132 145, 2015].

关键词： Coral Reefs Stony Corals Reef Fish Hybridisation Evolutionary Novelty Extinction

转换酶抑制剂培哚普利拉非激肽酶依赖性地加强由激肽引起的内皮依赖性血管松弛(英文)

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Acta Pharmacologica Sinica 2002年第3期23卷 15-19页

作者： jean Vivien MOMBOULI,Kevin D BALLARD,paul M VANHOUTTE University of Marien Ngouabi Brazzaville Republic of Congo Center for Experimental Therapeutics Baylor College of Medicine Houston Texas USA Institut de Recherches Internationales Servier 92415 Courbevoie Cedex France

The present study examined whether or not the resistance to degradation of bradykinin analogs affects the kinin-potentiating action of the inhibitor of converting enzyme, perindoprilat. METHODS: Hydrolysis of [Hyp3,Tyr(Me)8]-bradykinin by ACE present in isolated canine coronary arteries was assessed by determination of peptide metabolites using electrospray mass spectrometry, and compared to that of bradykinin. Contractions and relaxations of isolated rings of coronary arteries, with and without endothelium, were recorded as changes in isometric force. RESULTS: After a 30 min incubation, most of the bradykinin was degraded by the arteries, while less than 10 % of [Hyp3 Tyr(Me)8]-bradykinin was hydrolysed. In organ chambers, [Hyp3, Tyr(Me)8]-bradykinin like bradykinin caused relaxations of isolated canine coronary arteries with endothelium that could be attributed to both NO and endothelium-derived hyperpolarizing factor (EDHF). Perindoprilat caused a comparable leftward shift in the concentration-relaxa

关键词：缓激肽受体一氧化氮内皮血管紧张素转换酶抑制药肽基-二肽酶A

Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog

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Cancer Biology & Medicine 2017年第2期14卷 109-120页

作者： Armel Herve Nwabo Kamdje paul Takam Kamga Richard Tagne Simo Lorella Vecchio paul Faustin Seke Etet jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera Department of Biomedical Sciences University of Ngaoundere Laboratory University of Verona Department of Basic Health SciencesCollege of Applied Medical SciencesQassim University Faculty of Science University of Poitiers Department of Biochemistry College of MedicineUniversity of Saskatchewan

Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed.

关键词： Cancer metastasis developmental pathways Notch Wnt Hedgehog therapeutic targets

Geochemistry and zircon U–Pb ages of the Paleoproterozoic ultramafic rocks of the Mbi Valley, Boali area, Central African Republic

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Acta Geochimica 2022年第3期41卷 515-535页

作者： Evine Laure Njiosseu Tanko Prince Emilien Danguene Philomene Nga Essomba Tsoungui Sylvestre Ganno Jonas Didero Takodjou Wambo Bertin Guy Takam Tchoupe Gus Djibril Kouankap Nono Timoleon Ngnotue Boniface Kankeu jean Biandja jean paul Nzenti Department of Earth Sciences University of DschangP.O.Box 67DschangCameroon Department of Earth Sciences University of BanguiP.O.Box 908BanguiCentral African Republic Department of Mining Engineering and Mineral Processing School of Mines and Petroleum IndustriesUniversity of MarouaP.O.Box 08Kaélé-MarouaCameroon Department of Earth Sciences University of YaoundéIP.O.Box 812YaoundéCameroon Department of Geology HTTCUniversity of BamendaP.O.Box 39BambiliBamendaCameroon Institute for Geological and Mining Researches(IGMR) P.O.Box 4110YaoundéCameroon

This paper investigates the geochemistry of bulk rock and infers the petrogenesis of ultramafic rocks in the Boali Precambrian terrane in Mbi Valley,in the North of the Central African Republic(CAR).The studied rocks comprise coarse primary olivine and orthopyroxene relics(dominant phase),magnesio-hornblende,magnetite,and ***-rock analysis indicates low SiO_(2)(average of 43.14 wt%)and high MgO(19.84–26.98 wt%)contents and their Mg number(Mg#)ranges from 74 to ***(526–865 ppm),Cr(1500–3680 ppm)***(Na_(2)O-K_(2)O)-FeO-MgO)and ACM(Al_(2)O_(3)-CaO-MgO)ternary diagrams have revealed that the studied samples correspond to arc-related ultramafic ***-normalized REE plots display an increasing trend from La to Sm(CeN/SmN:0.74–1.81),weak negative to no Eu(Eu/Eu*=0.72–1.05)and strong negative Ce(Ce/Ce*=0.33–0.98)*** mantle normalized of multi-element diagrams exhibit LREE enrichment and large ion lithophile elements(LILE)relative to high field strength elements(HFSE),and notable negative anomalies in *** suggests the generation of the parent melt by slab dehydration and wedge melting *** addition,incompatible trace element composition and ratios assumed that the source magma had an enhanced mantle source associated with a prominent influence of continental *** of mantle wedge by plate-dehydrated,LILE-rich fluids and the incorporation of sediments derived from subduction explain the enhancement of the *** major and trace element compositions jointly with the tectonic reconstruction of this region and LA-ICP-MS U–Pb data on zircon constrain the emplacement age at ca.2099 Ma in a continental margin arc setting involving subduction of an oceanic plate beneath the continental lithosphere,dehydration of the slab and mantle wedge *** result intimate that the remnants of Paleoproterozoic oceanic crust or subduction event and subsequent basins closure extended from

关键词： Atlantic supercontinent Central African Republic Ultramafic cumulate LILE-enriched fluids Arc setting

Oculoplastic publication trends in general ophthalmology journals

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1852-1856页

作者： jean-paul Dray Nur Khatib Eric Souied Peerooz Saeed Guy Ben Simon Juliana Gildener-Leapman Ofira Zloto Department of Ophthalmology Centre Hospitalier Intercommunal de CreteilCreteil 94000France Orbital Center Department of OphthalmologyAmsterdam University Medical CentersAmsterdam 1105the Netherlands Goldschleger Eye Institute Sheba Medical CenterAffiliated to the Sackler Faculty of MedicineTel Aviv UniversityTel Aviv6997801Israel Meir Medical Center Kfar Saba 4428164Israel

AIM: To examine the publication trend of oculoplastic articles throughout the last decade in general ophthalmology ***: A review of all abstracts published between Januar y 2010 to December 2019 in general, clinical ophthalmic journals was conducted. Articles that were categorized as original articles in general and clinical journals were included in the ***: Totally 10 281 abstracts were included. Of them 465(4.5%) were oculoplastic publications. The mean number of annual-publications was 46.5 and the mean annual-rate of oculoplastic publications was 4.51%. A significant decreasing trend in the number of oculoplastic publication in the last decade was found(P<0.01, R^(2)=0.770). However, there was no significant change in the annual-rate of oculoplastic publications during the last decade(P=0.191, R2=0.203). From the 465 oculoplastic articles: 179(38.5%) were articles about eyelid diseases, 160(34.40%) were about orbit diseases, 92(19.80%) were about lacrimal diseases and 34(7.30%) were about thyroid eye disease(TED). A significant decreasing trends in the number of orbital and eyelids publications were found(P<0.01, P<0.01). However, there were no significant changes in the annual-rate of orbital, eyelids, TED and lacrimal-diseases publications throughout the last ***: Oculoplastic subspecialty deals with a wide range of pathologies in different ages. However, less than 5% of the articles in general, clinical, high impact factor ophthalmology journals are about oculoplastic diseases. One of the best way for ophthalmologists from different subspecilties, nowadays, to be updated, is to read highimpact-factor, general ophthalmology journals. Therefore, it is important that those journals will include articles about breakthroughs in oculoplastic.

关键词： oculoplastic publications journals general articles ophthalmology