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A multifaceted approach towards understanding the peculiar behavior of(α)-hydroxyiminophosphonates

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Organic Chemistry Frontiers 2022年第1期9卷 173-182页

作者： Thomas Toupy Christopher Kune Kristof Van Hecke loïc Quinton jean-Christophe M.Monbaliu Center for Integrated Technology and Organic Synthesis MolSys Research UnitUniversity of LiègeB-4000 Liège(Sart Tilman)Belgium Mass Spectrometry Laboratory MolSys Research UnitUniversity of LiègeB-4000 Liège(Sart Tilman)Belgium XStruct Department of ChemistryGhent UniversityKrijgslaan 281-S3B-9000 GhentBelgium

The peculiar isomer-selective reduction of(α)-hydroxyiminophosphonates(oxime isomers)into(α)-hydroxyaminophosphonate(hydroxylamine)derivatives is presented.A library of 16(α)-hydroxyiminophosphonates is prepared and studied via a unique multifaceted approach involving the interplay of NMR,XRD,MS,IM-MS and computational chemistry *** combination of NMR,XRD and HPLC enables the seamless separation,identification and quantification of the oxime isomers(E/Z).Tandem MS(MS/MS)enables the determination of the fragmentation patterns for both *** energy breakdown curves highlight the order of apparition of the fragments as well as their related energy of fragmentation,demonstrating that the strength of the C–P bond in the Z isomers is much weaker than in the E *** chemistry demonstrates that favorable protonation site is isomer-dependent with the phosphonate moiety being the favorable protonation site for the E isomers,while protonation occurs preferentially on the amino moiety for Z isomers regardless of the phosphite *** combination of these various methods led an unprecedented level of characterization of oxime isomers,providing a better uderstanding of the isomer-dependent behavior of(α)-hydroxyiminophosphonates.

关键词： isomers phosphonate moiety

The Rice RMR1 Associates with a Distinct Prevacuolar Compartment for the Protein Storage Vacuole Pathway

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Molecular Plant 2011年第5期4卷 854-868页

作者： Yun Shen Junqi Wang Yu Ding Sze Wan lo Guillaume Gouzerh jean-Marc Neuhau Liwen Jiang School of Life Sciences Centre for Cell and Developmental Biology The Chinese University of Hong Kong Shatin New Territories Hong Kong China Laboratory of Cell and Molecular Biology University of Neuchatel CH-2000 Neuchatel Switzerland

Transport of vacuolar proteins from Golgi apparatus or trans-Golgi network （TGN） to vacuoles is a receptor-mediated process via an intermediate membrane-bound prevacuolar compartment （PVC） in plant cells. Both vacuolar sorting receptor （VSR） and receptor homology region-transmembrane domain-RING-H2 （RMR） proteins have been shown to function in transporting storage proteins to protein storage vacuole （PSV）, but little is known about the nature of the PVC for the PSV pathway. Here, we use the rice RMR1 （OsRMR1） as a probe to study the PSV pathway in plants. Immunogold electron microscopy （EM） with specific OsRMR1 antibodies showed that OsRMR1 proteins were found in the Golgi apparatus, TGN, and a distinct organelle with characteristics of PVC in both rice culture cells and developing rice seeds, as well as the protein body type II （PBII） or PSV in developing rice seeds. This organelle, also found in both tobacco BY-2 and Arabidopsis suspension cultured cells, is morphologically distinct from the VSR-positive multivesicular lytic PVC or multivesicular body （MVB） and thus represent a PVC for the PSV pathway that we name storage PVC （sPVC）. Further in vivo and in vitro interaction studies using truncated OsRMR1 proteins secreted into the culture media of transgenic BY-2 suspension cells demonstrated that OsRMR1 functions as a sorting receptor in transporting vicilin-like storage proteins.

关键词： PSV RMR storage PVC sorting receptor transport pathway.

Depleted uranium oxide supported nickel catalyst for autothermal CO_(2)methanation in non-adiabatic reactor under induction heating

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Journal of Energy Chemistry 2023年第10期85卷 310-323,I0010页

作者： Lai Truong-Phuoc jean-Mario Nhut loïc Vidal Cuong Duong-Viet Sécou Sall Corinne Petit Christophe Sutter Mehdi Arab Alex Jourdan Cuong Pham-Huu Institute of Chemistry and Processes for Energy Environment and Health(ICPEES)ECPMUMR 7515 CNRS-University of Strasbourg25 rue Becquerel67087 Strasbourg Cedex 02France BlackLeaf SAS 210 rue Geiler de Kaysersberg67400 IllkirchFrance Institute of Materials Science of Mulhouse IS2MUMR 7361Universitéde Haute-AlsaceCNRS15rue Jean Starcky-BP 248868057 MulhouseFrance ORANO Tricastin Direction de La Recherche&DéveloppementSite du TRICASTIN BP 1626701 Pierrelatte CedexFrance

Undoped nickel-based catalysts supported on depleted uranium oxide allow one to carry out CO_(2)methanation process under extremely low reaction temperature under atmospheric pressure and powered by a contactless induction *** adjusting the reaction conditions,the catalyst is able to perform CO_(2)methanation reaction under autothermal process operated inside a non-adiabatic reactor,without any external energy *** autothermal process is possible thanks to the high apparent density of the UO_x which allows one to confine the reaction heat in a small catalyst volume in order to confine the exothermicity of the reaction inside the catalyst and to operate the reaction at equilibrium heat in-heat *** autothermal operation mode allows one to significantly reduce the complexity of the process compared to that operated using adiabatic reactor,where complete insulation is required to prevent heat disequilibrium,in order to reduce as much as possible,the heat exchange with the external *** catalyst displays an extremely high stability as a function of time on stream as no apparent *** is expected that such new catalyst with unprecedented catalytic performance could open new era in the field of heterogeneous catalysis where traditional supports show their limitations to operate catalytic processes under severe reaction conditions.

关键词： CO_(2)methanation Auto-methanation Induction heating Depleted uranium oxide Electrification process Operando DRIFTS

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A 3D Numerical Study of lo_2/GH_2 Supercritical Combustion in the ONERA-Mascotte Test-rig Configuration

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Journal of Thermal Science 2016年第1期25卷 97-108页

作者： Abdelkrim Benmansour Abdelkrim Liazid Pierre-Olivier logerais jean-Félix Durastanti Laboratory LTE ENP-OranBP 1523 El Mnaouer 31000Oran Algeria Universite de Paris-Est CERTESIUT de Senartrue Georges Charpak77567 LieusaintFrance

Cryogenic propellants lox/H2 are used at very high pressure in rocket engine combustion. The description of the combustion process in such application is very complex due essentially to the supercritical regime. Ideal gas law becomes invalid. In order to try to capture the average characteristics of this combustion process, numerical computations are performed using a model based on a one-phase multi-component approach. Such work requires fluid properties and a correct definition of the mixture behavior generally described by cubic equations of state with appropriated thermodynamic relations validated against the NIST data. In this study we consider an alternative way to get the effect of real gas by testing the volume-weighted-mixing-law with association of the component transport properties using directly the NIST library data fitting including the supercritical regime range. The numerical simulations are carried out using 3D RANS approach associated with two tested turbulence models, the standard k-Epsilon model and the realizable k-Epsilon one. The combustion model is also associated with two chemical reaction mechanisms. The first one is a one-step generic chemical reaction and the second one is a two-step chemical reaction. The obtained results like temperature profiles, recirculation zones, visible flame lengths and distributions of OH species are discussed.

关键词： Rocket engine non-premixed combustion supercritical regime H2-O2 flame transport properties

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Study of the Activation Process of a 2 m3 Pilot Biodigester on a Microfarm Site

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Journal of Agricultural Chemistry and Environment 2023年第4期12卷 397-413页

作者： jean-Baptiste Mansaly Djicknoum Diouf Bruno Pirou Elhadji Mba Bamdo Diakhaby Seynabou lo Amadou Seidou Maïga Diène Ndiaye Laboratoire Environnement Ingénierie Télécommunications et Energies Renouvelables Université Gaston Berger de Saint-Louis Saint-Louis Sénégal Centre de coopération Internationale en Recherche Agronomique pour le Développement Montpellier France Laboratoire Régional de Saint lo.is et UFR-2S Université Gaston Berger Saint Louis Sénégal

A domestic balloon-type digester with 1200 liters of substrate and a 700-litre gas reserve was installed at the Université Gaston Berger pilot farm, which has 4 cows. After an initial load of 1000 L of water, 90 L of bovine rumen and 145 L of cow dung, the functional parameters of the reaction medium, i.e., temperature, pH, salinity and conductimetry, were regularly monitored at a rate of 3 tests per day until the thirtieth day, corresponding to the flame test and the start of analysis and daily loading of the biodigester. The analysis of the biogas obtained after the flame test showed us the considerable contribution of bovine hindquarters to the CH4 fraction, which reached 72.2% from the start of the production phase. As anaerobic digestion is both a complex and multiparametric process, microbiological analysis revealed the presence of several strains of bacteria in the substrate used. Among the most abundant were Escherichia coli, Klebsiella spp, non-fermentative Gram-negative bacilli and Enterococcus sp. However, the bacterial strain that interests us most in anaerobic digestion is the non-fermentative Gram-negative family. We see the identification and temporal monitoring of these families of bacteria as a major step forward in the control of anaerobic fermentation processes in the Sahelian context and in Senegal in particular.

关键词： Pilot Digester Activation Bovine Belly Conductimetry Salinity Microbiology Analysis

ENABLING CROP DIVERSIFICATION TO SUPPORT TRANSITIONS TOWARD MORE SUSTAINABLE EUROPEAN AGRIFOOD SYSTEMS

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Frontiers of Agricultural Science and Engineering 2021年第3期8卷 474-480页

作者： Antoine MESSEAN loïc VIGUIER Lise PARESYS jean-Noel AUBERTOT Stefano CANALI Pietro IANNETTA Eric JUSTES Alison KARLEY Beatrix KEILloR Laura KEMPER Frédéric MUEL Barbara PANCINO Didier STILMANT Christine WATSON Helga WILLER Raul ZORNOZA French National Institute for Agriculture Food and Environment(INRAE)Eco-InnovF-78850 Thiverval-GrignonFrance French National Institute for Agriculture Food and Environment(INRAE)UMR AGIRToulouseFrance Council for Agricultural Research and Economics-Research Centre for Agriculture and Environment(CREA-AA) 00184 RomeItaly The James Hutton Institute InvergowrieDundeeDD25DAUK French Agricultural Research Centre for International Development(CIRAD) Persyst DepartmentF-34398 MontpellierFrance Research Institute of Organic Agriculture(FiBL) 5070 FrickSwitzerland Terres Inovia F-78850 Thiverval-GrignonFrance University of Tuscia Department of EconomicsEngineeringSociety and Business Organization01100 ViterboItaly Wallon Agricultural Research Centre(CRA-W) Sustainabilitysystems and prospectives DepartmentB-6800 LibramontBelgium Scotland’s Rural College(SRUC) Craibstone EstateAberdeen AB219YAUK Technical University of Cartagena Department of Agricultural EngineeringCartagenaSpain

European cropping systems are often characterized by short rotations or even monocropping,leading to environmental issues such as soil degradation,water eutrophication,and air pollution including greenhouse gas emissions,that contribute to climate change and biodiversity *** use of diversification practices(i.e.,intercropping,multiple cropping including cover cropping and rotation extension),may help enhance agrobiodiversity and deliver ecosystem services while developing new value *** its benefits,crop diversification is hindered by various technical,organizational,and institutional barriers along value chains(input industries,farms,trading and processing industries,retailers,and consumers)and within sociotechnical systems(policy,research,education,regulation and advisory).Six EU-funded research projects have joined forces to boost crop diversification by creating the European Crop Diversification Cluster(CDC).This Cluster aggregates research,innovation,commercial and citizen-focused partnerships to identify and remove barriers across the agrifood system and thus enables the uptake of diversification measures by all European value-chain *** CDC will produce a typology of barriers,develop tools to accompany actors in their transition,harmonize the use of multicriteria assessment indicators,prepare policy recommendations and pave the way for a long-term network on crop diversification.

关键词： crop rotation lock-in intercropping multiple cropping networking

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Hypoglycemic and hypocholesterolemic activities of the aqueous preparation of Kalanchoe pinnata leaves in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2015年第1期5卷 3-9页

作者： Nikhil Menon jean Sparks Felix Omoruyi Department of Life Sciences Texas A&M University-Corpus Christi

Objective:To evaluate the hypoglycemic and hypocholesterolemic activities of the aqueous preparation of Kalanchoe pinnata(***) leaves in streplozotocin-induced diabetic ***:Diabetes mellitus was induced in rats by a single administration of streptozotocin(60 mg/Kg).Diabetic rats were then treated with aqueous *** for 30 *** glucose,*** composition,liver and kidney function indices,inflammatory markers,and key enzymes of hepatic carbohydrate and lipid metabolism were ***:The untreated and treated diabetic groups lost weight and consumed less food compared to the normal *** noted 37.9%decrease in fasting blood glucose in the treated diabetic group compared to 13.2%and 17.0%increases in normal and untreated diabetic groups *** cholesterol and triglyceride levels were significantly(Plo the normal *** alkaline phosphatase and hepatic pyruvate kinase activities were significantly(Plood glucose and cholesterol level suggests that the aqueous *** preparation consumption may be beneficial in the management of diabetes *** observed adverse effect on alkaline phosphatase activity may be due to the combined effect of streptozotocin-induced diabetes and *** preparation administration.

关键词： Kalanchoe pinnata Diabetes Streptozotocin Hypoglycemic Hypocholesterolemic

Impact of time to diagnosis on the occurrence of cardiogenic shock in MIS‑C post‑COVID-19 infection

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world Journal of Pediatrics 2023年第6期19卷 595-604页

作者： Said Bichali Mathilde Bonnet Marie‑Emilie Lampin jean‑Benoit Baudelet Heloise Reumaux Olivia Domanski Thameur Rakza Alexandre Delarue Morgan Recher Jerome Soquet Francois Dubos Stephane Leteurtre Ali Houeijeh Francois Godart Pediatric Cardiology Univ.LilleCHU Lille2 Avenue Oscar Lambret59000 LilleFrance Pediatric Intensive Care Univ.LilleCHU Lille59000 LilleFrance ULR 2694‑Metrics:Evaluation des Technologies de Sante et des Pratiques Medicales Univ.Lille59000 LilleFrance Pediatric Rhumatology Univ.LilleCHU Lille59000 LilleFrance Cardiac Surgery Univ.LilleCHU Lille59000 LilleFrance Pediatric Emergency Univ.LilleCHU Lille59000 LilleFrance

Background In multisystem inflammatory syndrome in children(MIS-C),diagnostic delay could be associated with *** study aims to measure the time to diagnosis in MIS-C,assess its impact on the occurrence of cardiogenic shock,and specify its *** A single-center prospective cohort observational study was conducted between May 2020 and July 2022 at a tertiary care *** meeting the world Health Organization MIS-C criteria were included.A long time to diagnosis was defined as six days or *** on time to diagnosis were collected by two independent *** primary outcome was the occurrence of cardiogenic *** regression and receiver operating characteristic curve analysis were used for outcomes,and a Cox proportional hazards model was used for *** Totally 60 children were assessed for inclusion,and 31 were finally analyzed[52%males,median age 8.8(5.7-10.7)years].The median time to diagnosis was 5.3(4.2-6.2)*** univariable analysis,age above the median,time to diagnosis,high C-reactive protein,and high N-terminal pro-B-type natriuretic peptide(NT-proBNP)were associated with cardiogenic shock[odds ratio(OR)6.13(1.02-36.9),2.79(1.15-6.74),2.08(1.05-4.12),and 1.70(1.04-2.78),respectively].In multivariable analysis,time to diagnosis≥6 days was associated with cardiogenic shock[adjusted OR(aOR)21.2(1.98-227)].Time to diagnosis≥6 days had a sensitivity of 89% and a specificity of 77% in predicting cardiogenic shock;the addition of age>8 years and NT-proBNP at diagnosis≥11,254 ng/L increased the specificity to 91%.Independent determinants of short time to diagnosis were age<8.8 years[aHR 0.34(0.13-0.88)],short distance to tertiary care hospital[aHR 0.27(0.08-0.92)],and the late period of the COVID-19 pandemic[aHR 2.48(1.05-5.85)].Conclusions Time to diagnosis≥6 days was independently associated with cardiogenic shock in *** diagnosis and treatment are crucial to avoid the use of inotropes and

关键词： COVID-19 Delay in diagnosis Heart failure MIS-C SARS-CoV-2

Attitudes and Practices of Senegalese Dentists towards Hepatitis B

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Open Journal of Epidemiology 2017年第4期7卷 317-325页

作者： Massamba Diouf jean-Claude Guinan Amadou Dieng Mbatio Diop Aida Kanouté Abou Dramane Sanghare Ndeye Amina Diop Daouda Cisse Cheikh Mamadou Mbacke lo Daouda Faye Public Health Service Department of Dentistry Cheikh Anta Diop University Dakar Senegal Public Health Service Faculty of Dentistry Felix H Boigny University Abidjan C&ocirc te d’Ivoire Service of Dentistry Health Office Dakar Senegal

Introduction: Hepatitis B is an infectious viral disease that causes inflammation of the liver. It is transmitted through body secretions and fluids, including genital secretions, saliva and blood. The objective of this study was to assess the attitudes and practices of dental surgeons in the face infection of Hepatitis B. Methods: This was a descriptive, cross-sectional a sample of 171 dental surgeons. Probabilistic multi-stage, stratified, and systematic sampling was used. Using a questionnaire, we gathered variables related to the attitudes and practices of dentists with respect to Hep B. Results: Nearly 22% of dentists were not vaccinated against hepatitis B virus;Compliance with the use of gloves, glasses, professional clothing, and hygiene in dental offices was not systematic. Blood exposure accidents (BEA) were common, with nearly 13% suffering from needle stick injuries, 10% from eye splashes and about 6% from sharp instruments. The majority of the actions to be taken in the event of (BEA) were disinfection in the event of sticks or injuries (52.1%) and rinsing in the event of eye splashes (66.7%). Conclusion: Dentists should be educated and informed about the need for vaccination and hygiene, sterilization, and good behaviour in case of exposure to blood.

关键词： Attitudes Practices Hepatitis B Dentist Senegal