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Contribution at the Study of Neuroprotective Properties of Neuroglobin during Severe Chronic Glaucoma

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World Journal of Neuroscience 2020年第1期10卷 42-67页

作者： jean fidèle nnang essone Tatiana Harly Mba Aki Angue Mounir Belmalih Rosalie Nkiéma Ludmila Betty Eke Ndouo Emmanuel Anyunzoghe Nathan Ekegue Félix Ovono Abessolo Department of Physiology Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Physiological Functional Exploration and Physical Medicine Services Owendo University Hospital Center Owendo Libreville Gabon Department of Ophthalmology Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Mother-Child University Hospital Center Libreville Gabon Department of Biochemistry-Chemistry Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Department of Epidemiology Biostatistics and Medical Informatics Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Faculty of Pharmacy University of Health Sciences Owendo Libreville Gabon

Introduction: The mechanisms of overexpression of neuroglobin in patients with severe glaucoma (CG+) remain hypothetical. Objective: To study the anti-apoptotic, anti-hypoxic and anti-oxidant properties of neuroglobin in CG+. Population and Methods: The visual field, as well as plasma dosage of neuroglobin (CmNgb, ng/ml), hypoxia inductible factor-1alpha (CmHIF-1α, pg/ml), glutathione peroxidase (CmGpx, pg/ml), and cytochrome C oxidase (CmCyt C, pg/ml) were carried out in 45 CG+ and 45 controls (CG-). The chi-2 test compared the proportions, and Spearman’s test studied the correlations between quantitative variables (p Results: CmNgb was 4.1 in CG+, versus 2.3 in CG- (p = 1.52 × 10-5). CmGpx was 1144.7 in CG+, versus 752.8 in GC- (p = 0.0199). CmHIF-1α was 4.1 in CG+, versus 3.5 in CG- (p = 0.4530). CmCyt C was 2303.26 in CG+, versus 1750.44 in CG- (p = 0.0450). In CG+, there was a correlation between CmNgb and CmGpx (r = 0.417;p = 0.004), CmNgb and CmHIF-1α (r = 0.644;p = 1.8 × 10-6), and between CmHIF-1α and CmGpx (r = 0.447;p = 0.002), CmHIF-1α and CmCyt C (r = 0.371;p = 0.012). None correlation was found between CmNgb and CmCyt C (r = 0.126;p = 0.370), as well as CmGpx and CmCyt C (r = 0.102;p = 0.505). Conclusion: The variations of apoptosis, hypoxic, and oxidative stress biomarkers were found between CG+ and CG-, as well as their correlations, suggesting that neuroglobin overexpression is related to its anti-apoptotic, anti-oxidative, and anti-hypoxic properties.

关键词： Chronic Severe Glaucoma Neuroglobin Neuroprotective-Properties

Body Composition in Sickle Cell Disease Patients in the Steady State

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Open Journal of Molecular and Integrative Physiology 2024年第2期14卷 31-38页

作者： Mame Saloum Coly Mouhamadou Mansour Diagne jean fidele nnang essone Abdou Khadir Sow Salimata Diagne Houndjo Maimouna Toure Aïssatou Seck Awa Ba Abdoulaye Ba Abdoulaye Samb Moussa Seck Saliou Diop Mor Diaw Fatou Bintou Sar Arame Mbengue Laboratory of Physiology and Functional Explorations UFR of Health Sciences Iba Der Thiam University Thies Senegal Laboratory of Physiology and Functional Explorations FMPO Cheikh Anta DIOP University Dakar Senegal Department of Fundamental Sciences FMSS/USS Libreville Gabon Laboratory of Physiology UFR of Health Alioune DIOP University Bambey Senegal National Center of Blood Transfusion Dakar Senegal

Introduction: Previous studies in sickle cell disease (SCD) patients have demonstrated low muscle mass (MM) and high fat mass (FM) percentages compared to individuals with normal hemoglobin. The relationship between the evolutions of body composition (BC) parameters in the active SCD population is not well elucidated. The aim of the present study was to assess the body composition in active adult SCD patients in sub-Saharan Africa during the inter-critical period. Methodology: We conducted a descriptive and analytical cross-sectional study over an 8-month period. Eighteen SCD patients (sex ratio = 1) reported regular physical activity (RPA) corresponding to level 3 (RPA of moderate intensity) of the 4-level Saltin-Grimby physical activity scale were recruited. Anthropometric and BC parameters such as BMI, percentage FM and percentage MM were evaluated using an impedance meter. Results: The study population had a mean age of 26 ± 7 years and a mean BMI of 20.5 ± 1.9 kg/m2. We found a significantly higher percentage of FM in women compared to the men (25.6% ± 10.2% vs 11.1% ± 2.1%;p = 0.001). For the proportion of MM, all the women had a normal percentage. The men mostly had high levels of MM compared with reference norms. Men had significantly greater MM percentages than women (45.4% ± 1.8% vs. 26.5% ± 1.4%;p Conclusion: RPA appears to have positive effects on BC in active population with SCD, and a greater-than-expected effect was observed on MM in male patients. Promoting regular, adapted physical activity would be a promising way of improving BC parameters and quality of life in the SCD population. Further studies with larger cohorts will be needed to better substantiate these results.

关键词： Sickle Cell Disease Body Composition Physical Activity

Submicroscopic Plasmodial Infection May lead to Severe Malaria in Children

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Journal of Life Sciences 2014年第2期8卷 120-127页

作者： Berthe Amelie Iroungou jean Claude Biteghe Bi essone Fabrice Kassa Dieudonne Nkoghe jean-LouisMege Fousseyni S Toure Ndouo Centre International de Recherches Medicales de Franceville (CIRMF) BP 769 Franceville Gabon Ecole Doctorale Regionale de Recherche en Infectiologie Tropicale BP 876 Franceville Gabon Unite de Recherche des Maladies Infectieuses Tropicales Emergentes URMITE-IRD198 CNRS UMR7278 INSERM U1095 Faculte de Medecine 13385 Marseille Cedex 05 France

Malaria is one of the leading causes of consultation in African pediatric hospitals. In Gabon, malaria transmission is perennial. Plasmodium falciparum, responsible for the most severe form of the disease, represents more than 95% of all species. In P. falciparum infection, the hyperparasitemia accounts among the main criteria of disease severity. However, in many endemic countries, a significant decrease of malaria burden accompanying with the diminution of parasite load in infected individuals has been demonstrated. The objective of the study was to analyze the occurrence of febrile syndrome in childhood and investigate whether the acute febrile illness could be associated with P. falciparum submicroscopic infection. A cross-sectional study was carried out during January to March 2013 in Franceville. A total of 203 acute febrile children were enrolled. A clinical examination and biomedical analysis including parasitological diagnosis by microscope were carried out in all the patients and PCR on microscope negative ones. Of 203 children recruited for febrile syndrome, 111 have been diagnosed positive for P. falciparum infection, 73 （35.9%） by microscope （ME） and 38 （18.71%） by PCR （submicroscopic infection = SM1） with an overall prevalence of 54.68%. Of the 11 1 P. falciparum infected individuals and according to the WHO criteria, 35 （31.53%） children showed a clinical picture of severe malaria against 76 （68.47%） others classified as uncomplicated malaria. The overall prevalence rates were therefore estimated as 17.24 （35/203） for severe cases and 37.43% （76/203） for uncomplicated ones. Clinically, these severe malaria cases （27 ME＋ and 8 PCR＋） were mainly composed of 85.71% of anaemic patients （30/35）, 71.14% of prostrated individuals （25/35） and 57.14% of children with clinical icterus （20/35）. However, only two cases of severe anaemia were observed, the remaining others cases were moderate （10） and mild anaemia （18）. More interestingly, eight submicroscopic inf

关键词： Plasmodiumfalciparum PCR Severe Malaria.

Diagnostic and Prognostic Interests of Plasmatic Neuroglobin during Stroke in Adult at the Acute Phase

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World Journal of Neuroscience 2019年第2期9卷 52-70页

作者： J. F. nnang essone C. Allognon R. Nkiema S. R. Aubin Igombé P. Nzoghe Nguema F. Ovono Abessolo E. Anyunzok E. Ngou Milama Department of Physiology Faculty of Medicine and Health Sciences of Libreville and Department of Emergency Resuscitation Anesthesia of Angondjé University Hospital Center Libreville Gabon Department of Cardiology University Hospital Angondjé Libreville Gabon Department of Chemistry-Biochemistry Faculty of Medicine and Health Sciences University of Health Sciences Libreville Gabon Department of Anesthesia Emergency Resuscitation of Owendo University Hospital Libreville Gabon Department of Mathematics and Biostatistics Faculty of Medicine and Health Sciences University of Health Sciences Li-breville Gabon

Introduction: Neuroglobin (Ngb) owes its name to its preferred location in the nervous system. Its plasma concentration increases during cerebral ischemia. However, the interest of its dosage in the diagnosis and the prognosis of the strokes in the adult is not defined. Objectives: To determine if plasmatic Ngb can be used as a diagnostic biomarker and prognostic for stroke in adults at the acute phase. Population and Methods: This was a prospective study in 69 people, including 39 suspected stroke (Cerebral ischemia or CI, Intracerebral hemorrhage or ICH) and 30 healthy volunteers (controls). The plasma concentration of Ngb (CmNgb in ng/ml) of the patients was determined at admission day (d1), at the third day (d3) and seventh day (d7). CmNgbtaken at d1 was compared between patients and controls. Its evolution over time, as well as its relation with the clinical parameters, including the Glasgow coma scale and the short-term mortality in stroke subjects was analyzed by the Mann and Whitney tests and the Wilcoxon test (p Results: At d1, the CmNgb of all types of stroke was 3.140 ± 2.700 ng/ml, and did not differ significantly from controls (0.303 ± 0.114 ng/ml, p = 0.070). On the other hand, it was higher in CI victims (5.800 ± 0.720 ng/ml) than in ICH (1.750 ± 0,090 ng/ml) (p = 0.030). It then decreased on d3 in CI victims (2.600 ± 0.112 ng/ml) and ICH (0.420 ± 0.211 ng/ml), returning to normal on d7 (0.420 ± 0.200 ng/ml for CI’s, p = 0.001, and 0.360 ± 0.300 ng/ml for ICH, p = 0.002). There was a relationship between CmNgb, delay of occurrence of the first symptoms of the stroke (3.140 ± 2.700 ng/ml before the 6th hour, and 0.643 ± 0.244 ng/ml after the 6th hour (p = 0.003) and the volume of the hematoma (p = 0.0027). None relationship existed between CmNgb, Glasgow coma scale (p = 0.427) and short-term mortality (CmNgb = 3.95 ng/ml in survivors versus 2.65 ng/ml in deceased p = 0.060). Conclusion: This study shows that the plasma concentration of Neuroglobin is h

关键词： Neuroglobin Stroke Diagnosis Prognosis

Uterine Reperfusion Ischemia and Use of Elastic Tourniquet

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Journal of Biosciences and Medicines 2019年第2期7卷 98-119页

作者： J. F. nnang essone F. Ovono Abessolo A. Tsagoulela G. Edjo Nkhilli P. Assoumou J. A. Bang Ntamack E. Anyunzok U. Minkobame J. F. Meye E. Ngou Milama Department of Physiology Faculty of Medicine and Health Sciences Libreville Gabon Department of Anesthesia Resuscitation Emergencies University Hospital Center of Owendo Owendo Gabon Department of Chemistry-Biochemistry Faculty of Medicine and Health Sciences Libreville Gabon Anesthesia Resuscitation Service Army Training Hospital Libreville Gabon Department of Gynecology and Obstetrics Faculty of Medicine and Health Sciences Libreville Gabon Department of Mathematic and Biostatistic Faculty of Medicine and Health Sciences Libreville Gabon

Introduction: In humans, it has not been established that the use of elastic tourniquet (ET) during myomectomies, whose delivery times do not exceed 90 minutes, which is responsible for ischemia reperfusion (I/R) systemic. Objectives: To study the plasma variations of markers of I/R during myomectomies performed with ET, whose exposure time does not exceed 90 minutes. Population and methods: Plasma créatinin phosphokinase kinase (CPK) and gluthatione peroxydase (GPX) levels of patients with ET myoma (M + G +, n = 19), taken before, during and after exposure, were compared to those of women operated on myoma without tourniquet (M + G -, n = 15), carriers of unoperated myomas (M + G0, n = 20) and controls (M0G0, n = 18). The duration of exposure of the ET was determined, and perioperative variations of GPX, Ca2+, K+ and CPK between M + G + and others groups were analyzed (p Results: The average duration of exposure of the ET was 51.56 ± 14.12 [30 - 88] min. In M + G +, prior to insertion, CPK was 71.64, GPX 3.537, Ca2+ 3.000, K+ 3.934, and did not vary from those of M + G - (CPK = 59.354, GPX = 3.205, Ca2+ = 2.525, K+ = 3.788), M + G0 (CPK = 71.640, GPX = 2.759, Ca2+ = 3.004, K+ = 3.934) and M0G0 (CPK = 57.2, GPX = 2.306, Ca2+ = 2.879, K+ = 3.705). Conversely, during the posture (CPK = 95.665, GPX = 3.645, Ca2+ = 3.642, K+ = 4.757) and after the release of the ET (CPK = 135.443, GPX = 3.694, Ca2+ = 3.892, K+ = 5.322), these rates were higher among the M + G + compared to the M + G0 and M0G0, but did not differ from those of the M + G - during (CPK = 91.270, GPX = 3.413, Ca2+ = 3.068, K+ = 4.257) and after release (CPK = 137.776, GPX = 3.632, Ca2+ = 3.148, K+ = 5.075). Conclusion: The plasmatic concentration of ischemia (CPK, K+) and reperfusion (GPX, Ca2+) biomarkers does not differ between M + G + and M + G -, but is elevated relatively to controls (M0G0), but also to M + G0’s group. These results show that, for exposure times not exceeding 90 minutes, the elastic to

关键词： Ischemia Reperfusion Uterus Elastic Tourniquet

Is There a Relationship between Endotheline-1, Vascular Cell Adhesion Molecule-1 and the Arterial Hypotension Observed during Spinal Anesthesia?

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Journal of Biosciences and Medicines 2021年第1期9卷 64-85页

作者： J. F. nnang essone K. Nzé Pascal G. Edjo Nkhilli N. Ekegue Diaw Mor C. P. Akagha Kondé P. Nzoghe Nguéma E. Anyunzok E. R. Obame C. Allognon B. Nguéma Asseko F. Ovono Abessolo E. Ngou Milama Department of Physiology Faculty of Medicine and Health Sciences of Libreville (USS) Libreville Gabon Department of Anesthesia and Emergency Resuscitation The University Hospital of Owendo Libreville Gabon Department of Anesthesia and Emergency Resuscitation The Mother Child University Hospital Center Libreville Gabon Department of Anesthesia and Resuscitation The Army Instruction Hospital Libreville Gabon Laboratory of Biology and Physiological Functional Explorations UCAD Dakar Senegal Department of Medicine The University Hospital of Libreville Libreville Gabon Department of Epidemiology Biostatistics and Medical Mathematics USS Libreville Gabon Department of Surgery The University Hospital of Libreville Libreville Gabon Department of Chemistry-Biochemistry Faculty of Medicine and Health Sciences USS Libreville Gabon

Introduction: The involvement of the endothelial dysfunction (ED) in arterial hypotension (AHPT) post of spinal anesthesia (SA) has not been established. Objective: To determine if there is a relationship between ED and AHPT observed during the 1st 15 minutes after SA. Population and Methods: The study concerned 40 people who were to benefit from a programmed herniorrhaphy under SA and 40 controls (SA-). The correlations between mean plasma concentrations of endothelin-1 (CmET-1, pg/ml) and Vascular Cell Adhesion Molecule-1 (CmVCAM-1, pg/ml) taken from SA+ one hour before (H0), then 15 minutes after the SA (H15) and the mean arterial pression (AMP, mmHg) with heart rate (bpm) were analyzed (p Results: CmET-1 and CmVCAM-1 of SA- were 1.07 and 3.34, respectively, compared to 1.12 (p = 0.735) and 3.57 (p = 0.862) in SA+ at H0 and H15. In SA+, at H15, CmET-1 was 1.13 (p = 0.823) and CmVCAM-1 was 3.57 (p = 0.257). In SA-, a negative correlation existed between CmET-1 and CmVCAM-1 (r = -0.438;p = 0.005). Conversely, in SA+, whether at H0 (r = -0.31;p = 0.051) or at H15 (r = 0.024;p = 0.883), no correlation existed between CmET-1 and CmVCAM-1, nor between MAP and ED markers (r = 0.111;p = 0.325). Conclusion: These results show that there is no relationship between the AHPT which occurs during the first fifteen minutes post SA, CmVCAM-1 and CmET-1. Moreover, these data suggest that ED is not involved in AHPT post SA.

关键词： Endothelin-1 VCAM-1 Hypotension Endothelial Dysfunction Spinal Anesthesia