检索结果-南通市图书馆

Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

分子细胞生物学报:英文版 2011年第5期3卷 301-308页

作者： Mohamed Abu-Farha Sylvain Lanouette Fred Elisma Veronique Tremblay Jeffery Butson daniel Figeys jean-Francois Couture Ottawa Institute of Systems Biology Department of BiochemistryMicrobiology and ImmunologyUniversity of Ottawa451 Smyth RoadRoger-Guindon HallOttawaONK1H8M5Canada Biochemistry and Molecular Biology Unit Dasman Diabetes InstituteDasman 15462Kuwait

The SMYD(SET and MYND domain)family of lysine methyltransferases(KMTs)plays pivotal roles in various cellular processes,including gene expression regulation and DNA damage *** identified as genuine histone methyltransferases,specific members of this family have recently been shown to methylate non-histone proteins such as p53,VEGFR,and the retinoblastoma tumor suppressor(pRb).To gain further functional insights into this family of KMTs,we generated the protein interaction network for three different human SMYD proteins(SMYD2,SMYD3,and SMYD5).Characterization of each SMYD protein network revealed that they associate with both shared and unique sets of *** those,we found that HSP90 and several of its co-chaperones interact specifically with the tetratrico peptide repeat(TPR)-containing SMYD2 and ***,using proteomic and biochemical techniques,we provide evidence that SMYD2 methylates K209 and K615 on HSP90 nucleotide-binding and dimerization domains,*** addition,we found that each methylation site displays unique reactivity in regard to the presence of HSP90 co-chaperones,pH,and demethylation by the lysine amine oxidase LSD1,suggesting that alternative mechanisms control HSP90 methylation by ***,this study highlights the ability of SMYD proteins to form unique protein complexes that may underlie their various biological functions and the SMYD2-mediated methylation of the key molecular chaperone HSP90.

关键词： SMYD proteins HSP90 lysine methylation SET domain histone methylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Elderly patients with inflammatory bowel disease: Updated review of the therapeutic landscape

引用

World Journal of Gastroenterology 2019年第30期25卷 4158-4171页

作者： jean-Frédéric LeBlanc daniel Wiseman Peter L Lakatos Talat Bessissow Department of Adult Gastroenterology McGill University Health CentreMontrealQC H3G 1A4Canada Department of Medicine McGill University Health CentreMontrealQC H3G 1A4Canada 1^st Department of Medicine Semmelweis UniversityBudapest 1083Hungary

High-quality data remains scarce in terms of optimal management strategies in the elderly inflammatory bowel disease(IBD)***,available trials have been mostly retrospective,of small sample size,likely owing to underrepresentation of such a population in the major randomized controlled ***,in the last five years,there has been a steady increase in the number of published trials,helping clarify the estimated benefits and toxicity of the existing IBD *** the Everhov trial,prescription strategies were recorded over an average follow-up of 4.2 years.A minority of elderly IBD patients(1%-3%)were treated with biologics within the five years following diagnosis,whilst almost a quarter of these patients were receiving corticosteroid therapy at year five of follow-up,despite its multiple *** low use of biologic agents in real-life settings likely stems from limited data suggesting lower efficacy and higher *** minireview will aim to highlight current outcome measurements as it portends the elderly IBD patient,as well as summarize the available therapeutic strategies in view of a growing body of evidence.

关键词： Inflammatory bowel disease Elderly Outcomes Glucocorticoids Biological therapy Surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture

引用

Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： jean-daniel Malcor Emma J.Hunter Natalia Davidenko daniel V.Bax Ruth Cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUVECs),by inhibiting cell–collagen ***,we have improved crucial HUVEC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUVEC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Amplification of M2 response and switch in excita- tion-contraction coupling in bovine tracheal smooth muscle

引用

Acta Pharmacologica Sinica 1996年第1期 80-81页

作者： daniel Kwasi AMOAKO,关超然,jean-Pierre BOURREAU Department of Physiology Faculty of Medicine The University of Hong Kong Hong Kong Department of Physiology Faculty of Medicine The University of Hong Kong Hong Kong Department of Physiology Faculty of Medicine The University of Hong Kong Hong Kong

AIM: To assess whether internal Ca2+stores depletion could amplify M2response leading to a switch in coupling mode. METHOD: Isolated bovine tracheal smooth muscle strips were studied employing functional studies; using

关键词： tion-contraction coupling in bovine tracheal smooth muscle Amplification of M2 response and switch in excita

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hierarchical porous induced competent removal of low concentration azo dye molecules by generating a leachy crystalline structure H-MIL-53(Fe)

引用

Chinese Chemical Letters 2020年第10期31卷 2717-2720页

作者： Tao Feng jean Pierre Bavumiragira Mumbi Anne Wambui daniel Manaye Kabtamu Krisztina László Ying Wang Fengting Li State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Department of Physical Chemistry and Materials Science Budapest University of Technology and EconomicsH-1521 BudapestHungary

The development in technology of synthetic azo dyes,has led to excessive water resources *** n at lower concentration they can impart the quality of water and human ***,we have developed a novel synthesis strategy via introducing salicylic acid(SA)for the synthesis of a leachy crystalline material H-MIL-53(Fe)with hierarchical pores(HP)and exposed coordination unsaturated sites(CUS),which had higher surface area and larger pore volume than the as synthesized MIL-53(Fe).Due to these characteristics,H-MIL-53(Fe)was competent removal of orange G(OG,one of the frequently used azo dyes)with equilibrium in 300 min and the maximum adsorption capacity of 163.9 mg/*** adsorption mechanism of OG onto H-MIL-53(Fe)was mostly based on electrostatic attraction between CUS of HMIL-53(Fe)along with HP as active species to OG diffusion and *** comparing H-MIL-53(Fe)with other adsorbents for OG adsorption,it is undoubtedly that H-MIL-53(Fe)can be used as a promising adsorbent for OG removal from aqueous solutions.

关键词： H-MIL-53(Fe) Salicylic acid Leachy crystalline Adsorption Orange G removal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006

引用

World Journal of Gastroenterology 2008年第8期14卷 1237-1243页

作者： Francois Roman Karin Hawotte daniel Struck Anne-Marie Ternes jean-Yves Servais Vic Arendt Patrick Hoffman Robert Hemmer Thérèse Staub Carole Seguin-Devaux jean-Claude Schmit Retrovirology Laboratory CRP-Santé 84 rue Val fleuri L-1526 Luxembourg Centre Hospitalier de Luxembourg 4 rue Barblé L-1210 Luxembourg Centre Pénitentiaire de Luxembourg UmKuelebierg L-5299 Schrassig Luxembourg Retrovirology Laboratory CRP-Santé 84 rue Val fleuri L-1526 Luxembourg Centre Hospitalier de Luxembourg 4 rue Barblé L-1210 Luxembourg

AIM： To analyze the Hepatitis C virus （HCV） genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg.METHODS： Epidemiological information （gender, age and transmission risks） were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among whom 228 patients referred from prison. Genotyping using 5＇noncoding （5＇NC） sequencing was performed. We compared categorical data using the Fisher＇s exact F-test and odds ratios （OR） were calculated for evaluating association of HCV genotype and risk factors.RESULTS： The sex ratio was predominantly male （2.2） and individuals aged less than 40 years represented 49.6% of the population. Genotype 1 was predominant （53.4%） followed by genotype 3 （33%）. Among risk factors, intravenous drug usage （IVDU） was the most frequently reported （71.4%） followed by medical-related transmission （17.6%） including haemophilia, transfusion recipients and other nosocomial reasons. Genotype 3 was significantly associated to IVDU （OR = 4.84, P 〈 0.0001） whereas genotype 1 was significantly associated with a medical procedure （OR = 2.42, P 〈 0.001）. The HCV genotype distribution from inmate patients differed significantly from the rest of the population （Chi-square test with four degrees of freedom, P 〈 0.0001） with a higher frequency of genotype 3 （46.5% vs 27.5%） and a lower frequency of genotype 1 and 4 （44.7% vs 56.8% and 5.3% vs 9.6%, respectively）. IVDU was nearly exclusively reported as a risk factor in prison.CONCLUSION： We report the first description of the HCV genotype distribution in Luxembourg. The repartition is similar to other European counties, with one of the highest European prevalence rates of genotype 3 （33%）. Since serology screening became available in 2992, IVDU remains the most common way of HCV transmission in Luxembourg.

关键词： Hepatitis C virus Genotypes Luxembourg Risk factors Substance abuse Prisons

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of blood flow restriction without additional exercise on strength reductions and muscular atrophy following immobilization:A systematic review

引用

Journal of Sport and Health Science 2020年第2期9卷 152-159页

作者： Mikhail Santos Cerqueira Jose Diego Sales Do Nascimento daniel Germano Maciel jean Artur Mendonca Barboza Wouber Herickson De Brito Vieira Department of Physical Therapy Laboratory of Muscle PerformanceFederal University of Rio Grande do NorteNatalRio Grande do Norte 59072-970Brazil Department of Physical Therapy Neuromuscular Performance Analysis LaboratoryFederal University of Rio Grande do NorteNatalRio Grande do Norte 59072-970Brazil

Purpose:To investigate whether blood flow restriction(BFR) without concomitant exercise mitigated strength reduction and atrophy of thigh muscles in subjects under immobilization for lower ***:The following databases were searched:PubMed,CINAHL,PEDro,Web of Science,Central,and ***:The search identified 3 eligible studies,and the total sample in the identified studies consisted of 38 *** and isometric torque of the knee flexors and extensors was examined in 2 ***-sectional area of thigh muscles was evaluated in 1 study,and thigh girth was measured in 2 *** BFR protocol was 5 sets of 5 min of occlusion and 3 min of free flow,twice daily for approximately 2 *** a whole,the included studies indicate that BFR without exercise is able to minimize strength reduction and muscular atrophy after *** is crucial to emphasize,however,that the included studies showed a high risk of bias,especially regarding allocation concealment,blinding of outcome assessment,intention-to-treat analyses,and group similarity at ***:Although potentially useful,the high risk of bias presented by original stodies limits the indication of BFR without concomitant exercise as an effective countermeasure against strength reduction and atrophy mediated by immobilization.

关键词： Disuse Hypoxia Ischemia Muscle wasting Rehabilitation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Estimating impacts of emission specific characteristics on vehicle operation for quantifying air pollutant emissions and energy use

引用

Journal of Traffic and Transportation Engineering(English Edition) 2017年第3期4卷 215-229页

作者： K. S. Nesamani jean-daniel Saphores Michael G. McNally R. Jayakrishnan Institute of Transportation Studies University of California Irvine CA 92697 USA Department of Civil and Environmental Engineering University of California Irvine CA 92697 USA

This paper proposes and illustrates a methodology to predict the fraction of time motor vehicles spend in different operating conditions from readily observable variables called emission specific characteristics （ESC）. ESC describe salient characteristics of vehicles, roadway geometry, the roadside environment, traffic, and driving style （aggressive, normal, and calm）. The information generated by our methodology can then be entered in vehicular emission models that rely on vehicle specific power, i.e., comprehensive modal emissions model （CMEM）, international vehicle emissions （IVE）, or motor vehicle emission simulator （MOVES） to compute energy consumption and vehicular emissions for various air pollutants. After generating second-by-second vehicle trajectories from a calibrated micro-simulation model, the authors estimated structural equation models to examine the influence of link ESC on vehicle operation. Authors＇ results show that 67% of the link speed variance is explained by ESC. Overall, the roadway geometry exerts a greater influence on link speed than traffic characteristics, the roadside environment, and driving style. Moreover, the speed limit has the strongest influence on vehicle operation, followed by facility type and driving style. Better understanding the impact on vehicle operation of ESC could help metropolitan planning organizations （MPOs） and regional transportation au- thorities predict vehicle operations and reduce the environmental footprint of motor vehicles.

关键词： Vehicle operation Emission specific characteristics Structural equation modeling Micro-simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

27-gauge vitrectomy--an update on recent surgical outcomes

引用

Eye Science 2016年第4期31卷 211-213页

作者： daniel Su jean-Pierre Hubschman Stein Eye Institute University of California Los Angeles USA

The introduction of transconjunctival sutureless microincision vitrectomy surgery(MIVS)with 23-and25-gauge(23 and 25 G)instrumentation has virtually replaced the more antiquated 20-gauge equivalents,resulting in short... 详细信息

关键词：玻璃体手术切除术结膜

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mapping ideas from cyberspace to realspace: visualizing the spatial context of keywords from web page search results

引用

International Journal of Digital Earth 2014年第4期7卷 316-335页

作者： Ming-Hsiang Tsou Ick-Hoi Kim Sarah Wandersee daniel Lusher Li An Brian Spitzberg Dipak Gupta jean Mark Gawron Jennifer Smith Jiue-An Yang Su Yeon Han Department of Geography San Diego State UniversitySan DiegoCAUSA School of Communication San Diego State UniversitySan DiegoCAUSA Department of Political Science San Diego State UniversitySan DiegoCAUSA Department of Linguistics and Oriental Languages San Diego State UniversitySan DiegoCAUSA Department of Geography Pennsylvania State UniversityUniversity ParkPAUSA

We introduce a new method for visualizing and analyzing information landscapes of ideas and events posted on public web pages through customized web-search engines and *** research integrates GIScience and web-search engines to track and analyze public web pages and their web contents with associated spatial *** pages searched by clusters of keywords were mapped with real-world coordinates(by geolocating their Internet Protocol addresses).The resulting maps represent web information landscapes consisting of hundreds of populated web pages searched by selected *** creating a Spatial Web Automatic Reasoning and Mapping System prototype,researchers can visualize the spread of web pages associated with specific keywords,concepts,ideas,or news over time and *** maps may reveal important spatial relationships and spatial context associated with selected *** approach may provide a new research direction for geographers to study the diffusion of human thought and ideas.A better understanding of the spatial and temporal dynamics of the‘collective thinking of human beings’over the Internet may help us understand various innovation diffusion processes,human behaviors,and social movements around the world.

关键词： cyberspace web-search engines spatial context geolocation web information landscape innovation diffusion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：