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Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2018年第3期8卷 153-159页

作者： Zhijun Wang Bogdan Z.Olenyuk jean chen shih Jeffrey Wang Center for Advancement of Drug Research and Evaluation College of Pharmacy Western University of Health Sciences Department of Pharmaceutical Sciences College of Pharmacy Marshall B.Ketchum University Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy Department of Cell and Neurobiology Keck School of Medicine USC-Taiwan Center for Translational Research University of Southern California Department of Pharmaceutical Sciences College of Pharmacy Western University of Health Sciences

A high-performance liquid chromatography-electrospray ionization tandem mass spectrometric （HPLC- ESI-MS/MS） method was developed for the quantification of MHl148-clorgyline amide （NMl-amide）, a novel tumor-targeting monoamine oxidase A inhibitor, in mouse plasma. The method was validated in terms of sensitivity, precision, accuracy, recovery and stability and then applied to a pharmacokinetic study of NMl-amide in mice following intravenous administration. NMl-amide together with the internal standard （IS）, MHI-148, was extracted by protein precipitation using acetonitrile. Multiple reaction monitoring was used for quantification of NMl-amide by detecting m/z transition of 491.2-361.9, and 685.3-258.2 for NMl-amide and the IS, respectively. The lower limit of quantification （LLOQ） of the HPLC- MS/MS method for NMl-amide was 0.005 μg/mL and the linear calibration curve was acquired with R2〉 0.99 in the concentration range of 0.005-2μg/mL. The intra- and inter-day precisions of the assay were assessed by percentage of the coefficient of variations, which was within 9.8% at LLOQ and 14.0% for other quality control samples, whereas the mean accuracy ranged from 86.8% to 113.2%. The samples were stable under storage and experimental conditions. This method was successfully applied to a pharmacokinetic study in mice following intravenous administration of 5 mg/kg NMl-amide.

关键词： MH1148-clorgyline HPLC Mass spectrometry Pharmacokinetics

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Scanning transmission electron microscopy and atom probe tomography analysis of non-stoichiometry long-period-stacking-ordered structures in Mg-Ni-Y/Sm alloys

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Journal of Magnesium and Alloys 2024年第3期12卷 954-965页

作者： Yimeng chen Manuel Legrée jean-Louis Bobet Alexander Kvit CAMECA Instruments Inc MadisonWI 53711USA ICMCB Universitéde BordeauxPessacCEDEX 33608France NIAC&Materials Science Department University of WisconsinMadisonWI 53706USA

The long-period-stacking-ordered(LPSO)structure affects the mechanical,corrosion and hydrolysis properties of Mg *** current work employs high angle annular dark field-scanning transmission electron microscopy(HAADF-STEM)and atom probe tomography(APT)to investigate the structural and local chemical information of LPSO phases formed in Mg-Ni-Y/Sm ternary alloys after extended isothermal *** on the alloying elements and their concentrations,Mg-Ni-Y/Sm develops a two-phase LPSO+α-Mg structure in which the LPSO phase contains defects,hybrid LPSO structure,and Mg ***-STEM and APT indicate non-stoichiometric LPSO with incomplete Ni_(6)(Y/Sm)_(8) *** addition,the APT quantitatively determines the local composition of LPSO and confirms the presence of Ni within the Mg bonding *** results provide insight into a better understanding of the structure and hydrolysis properties of LPSO-Mg alloys.

关键词： Magnesium alloys Long-range ordering Atom probe tomography(APT) STEM HAADF Hydrolysis properties.

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Deep eutectic solvent-driven self-assembly of metal mercaptide complexes with enzyme-mimicking activities for detection of uric acid through one-step cascade catalytic reaction

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Green Chemical Engineering 2024年第1期5卷 75-84页

作者： jean Claude Munyemana Jia chen Xin Li Yangxia Han Hao Tang Hongdeng Qiu CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing100039China Department of Pharmacy Gansu Provincial HospitalLanzhou730000China

This work presents a generic strategy to create a series of metal mercaptides complexes via coordination selfassembly between transition metals(Mn,Cu,Co,Fe,and Ni)and cysteine(Cys)by forming the sulfur-metal *** strategy involves dissolving metal chlorides and Cys into deep eutectic solvents(DES),followed by the precipitation of metal mercaptides complexes(such as Cys-Mn)by adding water as an antisolvent,where DES serves as the solvent,shape directing,and capping agent,thereby preventing the formation of other metal ***,the prepared complexes possess both laccase and peroxidase-like properties,allowing the design of a technique for the detection of L-3,4-dihydroxyphenylalanine(L-DOPA)and uric acid,*** prepared Cys-Mn can linearly oxidize L-DOPA with its concentrations from 0.1 to 130μM and the detection limit was calculated to be 75.5 n ***,the Cys-Mn can mimic the activity of peroxidase towards oxidization of o-phenylenediamine at neutral p H,allowing single-step and one-pot cascade reactions for visual and fluorometric measurements of uric acid(UA)that could work in the range of 0.2-500μM UA with a detection limit of 0.06μM and 0.054μМ,*** assay was successful in detecting UA in serum and urine samples with relative standard deviation(RSD)ranging from 7.3%to 10.2%and 3.0%-8.5%respectively,suggesting that it may prove useful in medical diagnostic testing.

关键词： Metal-mercaptides Deep eutectic solvents Self-assembly Peroxidase-mimic catalyst Uric acid detection

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Application of novel constrained friction processing method to produce fine grained biomedical Mg-Zn-Ca alloy

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Journal of Magnesium and Alloys 2024年第2期12卷 516-529页

作者： Ting chen Banglong Fu Junjun Shen Uceu F.H.R.Suhuddin Björn Wiese Yuanding Huang Min Wang Jorge F.dos Santos jean Pierre Bergmann Benjamin Klusemann Solid State Materials Processing Institute of Material MechanicsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Functional Magnesium Materials Institute of Metallic BiomaterialsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Shanghai Key Laboratory of Materials Laser Processing and Modification Shanghai Jiao Tong UniversityDongchuan Road 800Shanghai 200240China Applied Materials and Manufacturing Energy and Environment DivisionPacific Northwest National LaboratoryPO Box 999RichlandWA 99352USA Production Technology Group Technisiche Universität IlmenauGustav-Kirchhoff-Platz 2Ilmenau 98693Germany Institute for Production Technology and Systems Leuphana University of LüneburgUniversitätsallee 1Lüneburg 21335Germany

In order to obtain Mg alloys with fine microstructures and high mechanical performances,a novel friction-based processing method,name as“constrained friction processing(CFP)”,was *** CFP,defect-free Mg-Zn-Ca rods with greatly refined grains and high mechanical properties were *** to the previous as-cast microstructure,the grain size was reduced from more than 1 mm to around 4μm within 3 s by a single process *** compressive yield strength was increased by 350%while the ultimate compressive strength by 53%.According to the established material flow behaviors by“tracer material”,the plastic material was transported by shear *** the base material to the rod,the material experienced three stages,*** by the tool,upward flow with additional tilt,followed by upward *** microstructural evolution was revealed by“stop-action”*** microstructural development at regions adjacent to the rod is mainly controlled by twinning,dynamic recrystallization(DRX)as well as particle stimulated nucleation,while that within the rod is related to DRX combined with grain growth.

关键词： Constrained friction processing Magnesium alloys Microstructure Mechanical properties Grain refinement Plastic deformation

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The efficacy of vitamin E in preventing arthrofibrosis after joint replacement

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Animal Models and Experimental Medicine 2024年第2期7卷 145-155页

作者： Yingfang Fan jean Yuh Sashank Lekkala Mehmet D.Asik Andrew Thomson Madeline McCanne Mark A.Randolph Antonia F.chen Ebru Oral Harris Orthopaedic Laboratory Department of Orthopaedic SurgeryMassachusetts General HospitalBostonMassachusettsUSA Department of Orthopaedic Surgery Harvard Medical SchoolBostonMassachusettsUSA Department of Surgery Harvard Medical SchoolBostonMassachusettsUSA Department of Orthopaedic Surgery Brigham and Women's HospitalBostonMassachusettsUSA

Background:Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint *** E is an antioxidant with potential anti-fibroblastic *** aim of this study was to establish an arthrofibrosis rat model after joint replacement and assess the effects of vitamin E supplementation on joint ***:We simulated knee replacement in 16 male Sprague–Dawley *** immobilized the surgical leg with a suture in full *** control groups were killed at 2 and 12 weeks(n=5 per group),and the test group was supplemented daily with vitamin E(0.2 mg/mL)in their drinking water for 12 weeks(n=6).We performed histological staining to investigate the presence and severity of *** staining andα2-macroglobulin(α2M)enzyme-linked immunosorbent assay(ELISA)were used to assess local and systemic *** weight bearing(total internal reflection)and range of motion(ROM)were collected for functional ***:The ROM and weight-bearing symmetry decreased after the procedure and recovered slowly with still significant deficit at the end of the study for both *** analysis confirmed fibrosis in both lateral and posterior periarticular *** E supplementation showed a moderate anti-inflammatory effect on the local and systemic *** vitamin E group exhibited significant improvement in ROM and weight-bearing symmetry at day 84 compared to the control ***:This model is viable for simulating arthrofibrosis after joint *** E may benefit postsurgical arthrofibrosis,and further studies are needed for dosing requirements.

关键词： arthrofibrosis range of motion total knee arthroplasty vitamin E

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21世纪全球新建水库编目:丰度、热点区及总蓄水量

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Science Bulletin 2024年第14期69卷 2179-2182页

作者：范晨雨宋春桥 Jida Wang Yongwei Sheng 蔺亚玲苑春雨 Md Safat Sikder jean-Francois Crétaux 刘凯陈探曾繁轩柯灵红 Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China University of Chinese Academy of Sciences Nanjing(UCASNJ)Nanjing 211135China Department of Geography and Geographic Information Science University of Illinois Urbana-ChampaignUrbana IL 61801USA Department of Geography and Geospatial Sciences Kansas State UniversityManhattan KS 66506USA Department of Geography University of CaliforniaLos Angeles CA 90095USA Laboratoire d’Études en Géophysique et Océanographie Spatiales(LEGOS) CNES-IRD-CNRS-UT3Universitéde ToulouseToulouse 31401France College of Hydrology and Water Resources Hohai UniversityNanjing 210098China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China

Dams and reservoirs play an essential role in regulating and managing water *** the middle of the 20th century,the growing demand for water and hydropower has led to an unprecedented boom in reservoir construction worldwide[1,2].Meanwhile,reservoir construction has also resulted in a variety of ecological and socioeconomic impacts[3–5].Reservoirs transform natural flow regimes into conditions favored by human *** associated flow regulations,especially in reservoirs constructed in recent decades(e.g.,after 2000)with greater seasonal variability[6,7],represent a strong human-induced alteration of the hydrologic *** reservoir construction continues to boom in many parts of the world,an up-to-date and openaccess inventory of reservoirs worldwide remains critically desired.

关键词： reservoir reservoirs alteration

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Surface oxidation of Ni-cermet electrodes by CO_(2) and H_(2)O and how to moderate it

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Journal of Energy Chemistry 2022年第4期31卷 300-308页

作者： Dingkai chen Mathias Barreau Thierry Dintzer Sylwia Turczyniak-Surdacka Fabrice Bournel jean-Jacques Gallet Spyridon Zafeiratos Institut de Chimie et Procédés pour l’Energie l’Environnement et la SantéUMR 7515 CNRS-UdS25 Rue Becquerel67087 StrasbourgFrance Faculty of Chemistry Biological and Chemical Research CentreUniversity of WarsawŻwirki i Wigury 10102-089 WarsawPoland Faculty of Chemistry University of WarsawPasteura 102-093Poland Laboratoire de Chimie Physique-Matière et Rayonnement Sorbonne UniversitéCampus CurieCNRS UMR 76144 place Jussieu75005 ParisFrance Synchrotron SOLEIL L’orme des MerisiersB.P.48Saint AubinGif-sur-Yvette Cedex 91192France

The oxidation of porous Ni-yttria-stabilized zirconia(YSZ)and Ni-gadolinia-doped ceria(GDC)ceramicmetal(cermet)electrodes in H_(2)O and CO_(2)atmospheres was studied by near-ambient pressure X-ray photoelectron spectroscopy(NAP-XPS).We show that the oxidation of nickel by the two gases is not similar,as is commonly believed,but it depends on the ceramic *** is vulnerable to oxidation in H_(2)O but it resists to CO_(2)in Ni-GDC,as compared to the Ni-YSZ *** by this observation we conceptualize and fabricate Ni-YSZ electrodes modified by ceria nanoparticles,which show significantly higher resistance to CO_(2)oxidation as compared with conventional Ni-YSZ *** preparation of tailormade cermet electrodes with identical bulk/mechanical characteristics but very different surface properties offers a promising fabrication strategy for high-performance and durability solid oxide electrolysis cells for CO_(2)conversion.

关键词： NAP-XPS CO_(2)electrolysis Nickel oxidation Solid oxide cells Ceria nanoparticles

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Urbanization reduces resource use efficiency of phytoplankton community by altering the environment and decreasing biodiversity

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Journal of Environmental Sciences 2022年第2期34卷 140-151页

作者： Yigang Yang Huihuang chen Mamun Abdullah Al jean Claude Ndayishimiye Jun R Yang Alain Isabwe Anqi Luo Jun Yang Aquatic EcoHealth Group Fujian Key Laboratory of Watershed EcologyKey Laboratory of Urban Environment and HealthInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Engineering Research Center of Ecology and Agricultural Use of Wetland(Ministry of Education) College of AgricultureYangtze UniversityJingzhou 434025China

Urbanization often exerts multiple effects on aquatic and terrestrial organisms,including changes in biodiversity,species composition and ecosystem ***,the impacts of urbanization on river phytoplankton in subtropical urbanizing watersheds remain largely ***,we explored the effects of urbanization on phytoplankton community structure(i.e.,biomass,community composition and diversity)and function(i.e.,resource use efficiency)in a subtropical river at watershed scale in southeast China over 6 years.A total of 318 phytoplankton species belonging into 120 genera and 7 phyla were identified from 108 *** biomass showed an increasing trend with increasing urbanization *** phytoplankton community shifted from Chlorophyta dominance in rural upstream waters to Bacillariophyta dominance in urbanized downstream ***,phytoplankton diversity and resource use efficiency(RUE=phytoplankton biomass/total phosphorus)were significantly decreased with increasing urbanization level from upstream to *** RUE exhibited a significant positive correlation with species richness,but a negative correlation with phytoplankton *** variation in environmental factors(turbidity,total nitrogen,NH_(4)^(+)-N,total phosphorus,PO_(4)^(3-)-P and percentage urbanized area)was significantly correlated with phytoplankton diversity and ***,our results revealed the influence of urbanization on phytoplankton community structure and ecosystem function was due to its altering the environmental ***,human-driven urbanization may play crucial roles in shaping the structure and function of phytoplankton communities in subtropical rivers,and the mechanism of this process can provide important information for freshwater sustainable uses,watershed management and conservation.

关键词： Plankton Community functioning Subtropical river Urbanization gradient Land use Watershed ecology

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An international multicentric phaseⅢrandomized controlled trial of time-acupoints-space acupuncture for the prevention of chemotherapy-induced fatigue in patients with early stage breast cancer:a study protocol

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Journal of Traditional Chinese Medicine 2022年第2期42卷 289-295页

作者： Saghachian Mahasti Barry Caroline Asselain Bernard LI Yunfen NIE Jianyun LIU Dequan chen Dedian chen Chunxin Laura Estevez LI Wenhui jean-Pierre Armand ZHU Miansheng JU Liya Institute Gustave Roussy ParisFrance Research Center of Epidemiology and public health ParisFrance Institute Curie of Paris ParisFrance Yunnan Cancer Hospital Third Affiliated Hospital of Kunming Medical UniversityKunmingChina PreciMed Platform Europe ParisFrance MD Anderson Cancer Hospital MadridSpain ARIATAS Association pour la Recherche et l’Information de l’Acupuncture Time-Acupoints-Space ParisFrance Yunnan Zhu's expert workstation National famous traditional Chinese medicine expert of Mian-Sheng ZHUKunmingChina

OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide(EC)followed by paclitaxel,as measured by the multidimensional fatigue inventory(MFI)over the previous week and Visual Analogue Scale measuring fatigue(VAS-F),and to evaluate the effects of ATAS on selfreported neuropathy pain,sleep,anxiety and ***:In this multicenter clinical trial,we have randomized patients into 3 groups:ATAS,Sham and nonacupuncture with an unequal randomization of 2∶1∶1.A cloud related electronical clinical report form and smartphone platform was established for data *** with a history of stageⅠ-Ⅲbreast cancer scheduled to receive adjuvant *** will be delivered once a week during chemotherapy with VAS-F *** order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture,an evaluation of immune profiling was incorporate in this ***:The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer *** induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life ***,we do not have effective pharmacological interventions *** clinical trials of acupuncture in preventing chemotherapyinduced fatigue in patients with early breast cancer have not been ***:The findings of the trial will allow us to determine the effects of acupuncture treatment *** will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments.

关键词： breast neoplasms chemotherapy adjuvant fatigue immunity clinical protocols time-acupoints-space acupuncture

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A Review of the Advances Made in Improving the Durability of Welded Wood against Water in Light of the Results of African Tropical Woods Welding

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Journal of Renewable Materials 2023年第3期11卷 1077-1099页

作者： jean Jalin Eyinga Biwôlé Achille Bernard Biwolé Antonio Pizzi Joseph Zobo Mfomo César Segovia Atangana Ateba Evariste Fedoung Fongnzossie Sahbi Ouertani Xinyi chen Bénoît Ndiwe DieudonnéAbessolo Pierre-jean Meausoone Laboratory of Forest Resources and Wood Valorization University of DoualaP.O.Box.2701DoualaCameroon Laboratory of Mechanics University of DoualaP.O.Box.2701DoualaCameroon CETELOR University of LorraineP.O.Box.21042EpinalFrance ENSTIB-LERMAB University of LorraineP.O.Box.21042EpinalFrance Laboratory of Energetics and Thermal and Mass Transfers El Manar University of TunisTunisTunisia

Wood plays a major role in the production of furniture and wooden ***,in this process,the massive use of adhesives and plural connectors remains a definite problem for health and the ***,wood welding is a breakthrough in this *** paper reviews the applications of wood welding in furniture and construction and then examines advances in improving the durability of welded wood against *** contribution also highlights the need to join African tropical woods using the rotational friction welding *** to our results,these woods present interesting chemical singularities,which could provide solutions to the water vulnerability of the welded ***,the use of such a joining method would first free the Cameroonian furniture industry from the chemical industry,secondly position it at the forefront of new eco-design trends and thirdly make it competitive with other countries in the Central African *** works enrich the long and rich bibliography on the technique of wood welding,which has long been conspicuous by its absence of tropical woods.

关键词： Wood welding tropical woods water vulnerability chemical singularities natural durability

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