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具有恐惧效应的生态流行病模型的稳定性分析与最优控制

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数学的实践与认识 2024年第6期54卷 151-160页

作者：胡皓宇张学兵张韵卓李顺杰南京信息工程大学数学与统计学院江苏南京210044 江苏省应用数学(南京信息工程大学)中心江苏省系统建模与数据分析国际合作联合实验室江苏南京210044

考虑了一个猎物种群具有疾病的生态流行病学模型,该模型考虑捕食者对猎物的恐惧效应,假设恐惧可以降低猎物的种群繁殖率,降低猎物种群的活动,从而降低疾病的传播率.首先讨论模型解的非负性和有界性,然后研究了非负平衡点的存在性和稳定... 详细信息

考虑了一个猎物种群具有疾病的生态流行病学模型,该模型考虑捕食者对猎物的恐惧效应,假设恐惧可以降低猎物的种群繁殖率,降低猎物种群的活动,从而降低疾病的传播率.首先讨论模型解的非负性和有界性,然后研究了非负平衡点的存在性和稳定性,最后讨论了模型的最优控制问题.

关键词：恐惧效应稳定性生态流行病最优控制

Calcium and Calmodulin-Mediated Regulation of Gene Expression in Plants

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Molecular Plant 2009年第1期2卷 13-21页

作者： Min Chul Kim Woo Sik Chung Dae-Jin yun Moo je Cho Division of Applied Life Science (BK21 Program) Plant Molecular Biology and Biotechnology Research Center and Environmental Biotechnology National Core Research Center Gyeongsang National University Jinju 660-701 Korea

Sessile plants have developed a very delicate system to sense diverse kinds of endogenous developmental cues and exogenous environmental stimuli by using a simple Ca^2＋ ion. Calmodulin （CAM） is the predominant Ca^2＋ sensor and plays a crucial role in decoding the Ca^2＋ signatures into proper cellular responses in various cellular compartments in eukaryotes. A growing body of evidence points to the importance of Ca^2＋ and CaM in the regulation of the transcriptional process during plant responses to endogenous and exogenous stimuli. Here, we review recent progress in the identification of transcriptional regulators modulated by Ca^2＋ and CaM and in the assessment of their functional significance during plant signal transduction in response to biotic and abiotic stresses and developmental cues.

关键词： Abiotic/environmental stress calcium signaling/transport gene expression.

The change of anterior segment parameters after cataract surgery in normal-tension glaucoma

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1239-1245页

作者： Wonseok Lee Hyoung Won Bae Chart yun Kim Gong je Seong Institute of Vision Research Department of OphthalmologYonsei University College of Medicine Seou103722 Korea

AIM： To investigate the change of anterior chamber angle morphology and intraocular pressure （lOP） reduction after cataract surgery in patients with normal-tension glaucoma （NTG） using swept-source optical coherence tomography （SS-OCT）. METHODS： This prospective, comparative, observational study recruited patients into two groups. Group 1 was the control group including normal subjects except those with cataracts （cataract group, n=67 eyes of 67 patients）, and group 2 was NTG group including patients who were diagnosed with NTG and cataracts （n=43 eyes of 43 patients）, which were treated with phacoemulsification and intraocular lens implantation. Before surgery, and at postoperative 1 and 6too, anterior chamber angles were evaluated by SS-OCT under dark conditions using three- dimensional angle analysis scan protocol. Angle opening distance （AOD）, angle recess area （ARA）, and trabecular- iris surface area （TISA） at four quadrants （temporal, nasal, superior, and inferior） were calculated automatically by SS-OGT, after the observer marked scleral spurs. RESULTS： A total of 106 patients （54 males and 52 females） were enrolled in the study. Angle parameters, AOD, ARA, and TISA were increased after surgery in both groups. However, changes of angle parameters were only significant in group 2. In group 2, preoperative lOP was 13.2＋2.9 mm Hg, and postoperative lOP at 1 and 6mo were 10.5＋3.0 and 10.7＋2.8 mm Hg, respectively. In group 1, preoperative lOP was 12.42.8 mm Hg, and postoperative lOP at 1 and 6mo were 11.6＋2.5 and 12.0＋2.8 mm Hg, respectively. After cataract surgery, angle parameters changed significantly while IOP significantly reduced and was maintained in group 2 （P〈0.001）. The changes in angle parameters （＆AOD500, ATISAS00 at temporal; ＆AOD500, S, RA500 at nasal） were linearly correlated with postoperative IOP changes. CONCLUSION： Cataract surgery may have improved antedor chamber angle parameters and decreased lOP in NTG patients.

关键词： normal-tension glaucoma cataract surgery intraocular pressure reduction swept-source optical coherence tomography angle parameters

贮藏温度对板栗果仁糖类物质含量和质地的影响

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粮食与油脂 2024年第9期37卷 63-69页

作者：黄秋伟龙凌云罗小杰金利刘功德毛立彦广西壮族自治区亚热带作物研究所广西南宁530001 农业农村部亚热带水果贮藏保鲜加工技术科研试验基地广西南宁530001 广西益香园食品有限公司广西河池547000 广西亚热带特色水果质量安全控制重点实验室广西南宁530001

为探究不同温度下板栗果仁在贮藏过程中糖类物质及质地的变化规律,以产自广西东兰县的野生板栗为试验材料,分析其在不同温度(25、8、4、-1℃)下贮藏45 d的理化品质和质构特性变化,并对理化指标和质构参数进行相关性和主成分分析。结果表... 详细信息

为探究不同温度下板栗果仁在贮藏过程中糖类物质及质地的变化规律,以产自广西东兰县的野生板栗为试验材料,分析其在不同温度(25、8、4、-1℃)下贮藏45 d的理化品质和质构特性变化,并对理化指标和质构参数进行相关性和主成分分析。结果表明:在0~45 d贮藏期内,-1℃贮藏的板栗果仁水分损失最少、硬度变化最小;在贮藏第40天时,-1℃贮藏的板栗果仁可溶性糖含量达到最高。相关性分析结果表明,在贮藏过程中,板栗果仁理化指标与其质构特性的相关性强弱依次为水分含量﹥可溶性糖含量﹥支链淀粉含量。主成分分析结果表明,第1主成分方差贡献率已超过50%,可作为评价板栗果仁贮藏品质的核心指标。

关键词：板栗贮藏温度糖类物质质地

基于ANSYS的柴油机发电机支架仿真优化设计

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农机化研究 2024年第10期46卷 264-268页

作者：黄有华赖云江西机电职业技术学院机械工程学院南昌330013 江西五十铃发动机有限公司技术中心南昌330200

发电机支架是柴油机以及油电混合动力发动机的主要部件。针对je4DDQ6B发动机在台架耐久试验中发生开裂、断裂的现象,对发电机支架系统进行了有限元模态分析计算、CAE仿真分析,并结合冲压的工艺特性,对结构进行了优化改进,全面解决了发... 详细信息

发电机支架是柴油机以及油电混合动力发动机的主要部件。针对je4DDQ6B发动机在台架耐久试验中发生开裂、断裂的现象,对发电机支架系统进行了有限元模态分析计算、CAE仿真分析,并结合冲压的工艺特性,对结构进行了优化改进,全面解决了发电机支架发生开裂、断裂失效的问题。

关键词：发电机支架有限元模态分析优化设计

Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice

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Bone Research 2019年第2期7卷 210-223页

作者： Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee jeong-Tae Koh Hong-In Shin je-Yong Choi yun Hyun Huh je-Hwang Ryu Department of Pharmacology and Dental Therapeutics School of DentistryChonnam National UniversityGwangju 61186Korea Research Center for Biomineralization Disorders School of DentistryChonnam National UniversityGwangju 61186Korea Department of Oral Pathology and IHBR School of DentistryKyungpook National UniversityDaegu 41940Korea Department of Biochemistry and Cell Biology BK21 Plus KNU Biomedical Convergence ProgramSkeletal Diseases Analysis CenterKorea Mouse Phenotyping Center (KMPC)School of MedicineKyungpook National UniversityDaegu 41944Korea School of Life Sciences Gwangju Institute of Science and TechnologyGwangju 61005Korea

Pathological bone loss is caused by an imbalance between bone formation and *** bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone ***,the relevant functions of HIF-2α are not well ***,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and *** vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of *** addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor *** performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this ***-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated ***,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis.

关键词： is RANKL its via

Deflection angle switching with a metasurface based on phase-change nanorods [Invited]

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Chinese Optics Letters 2018年第5期16卷 38-41页

作者： Chulsoo Choi Sun-je Kim jeong-Geun yun Jangwoon Sung Seung-Yeol Lee Byoungho Lee School of Electrical and Computer Engineering and Inter-University Semiconductor Research Center Seoul National University Gwanak-Gu Gwanakro 1 Seoul 08826 South Korea School of Electronics Engineering Kyungpook National University Daegu 41566 South Korea

We propose the active metasurface using phase-change material Ge2Sb2Te5（GST）, which has two distinct phases so called amorphous and crystalline phases, for an ultrathin light path switching device. By arranging multiple anisotropic GST nanorods, the gradient metasurface, which has opposite directions of phase gradients at the two distinct phases of GST, is demonstrated theoretically and numerically. As a result, in the case of normal incidence of circularly polarized light at the wavelength of 1650 nm, the cross-polarized light deflects to-55.6° at the amorphous phase and ＋55.6° at the crystalline phase with the signal-to-noise ratio above 10 dB.

关键词： Deflection angle switching with a metasurface based on phase-change nanorods GST

多囊卵巢综合征与骨密度因果关系的孟德尔随机化研究

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医药论坛杂志 2024年第3期45卷 225-228,233页

作者：姜中歌赵星浩翟梦洁杨秋云刘广芝郑州大学人民医院妇产科郑州1450003 河南省人民医院国际医疗中心郑州450003 河南大学河南省干细胞分化与调控重点实验室郑州450003

目的探究多囊卵巢综合征(polycystic ovary syndrome, PCOS)与骨密度(bone mineral density, BMD)之间的因果关系,从而为PCOS患者及时采取措施防治骨质疏松提供依据。方法基于公开发表的欧洲人群PCOS与全身BMD全基因组关联研究(genome... 详细信息

目的探究多囊卵巢综合征(polycystic ovary syndrome, PCOS)与骨密度(bone mineral density, BMD)之间的因果关系,从而为PCOS患者及时采取措施防治骨质疏松提供依据。方法基于公开发表的欧洲人群PCOS与全身BMD全基因组关联研究(genome-wide association study, GWAS)汇总数据,运用两样本孟德尔随机化(MR)探究PCOS与BMD之间的因果关联。采用与PCOS相关的遗传位点作为工具变量,使用逆方差加权法(IVW)作为主要分析方法进行MR分析,以比值比(OR)评价PCOS与全身BMD之间的因果关系;采用异质性检验、多效性检验和留一法进行敏感性分析,以评估分析结果的稳健性。结果共纳入68个单核苷酸多态性(SNP)作为工具变量,IVW法结果显示PCOS与全身BMD降低的风险相关(OR=1.010,95%CI:1.000~1.019,P=0.041)。敏感性分析结果稳健,SNP不存在水平多效性和异质性。结论 PCOS与全身BMD的降低存在因果关系,提示PCOS患者应密切关注BMD,及时采取预防骨质疏松的措施。

关键词：多囊卵巢综合征骨密度孟德尔随机化因果推断全基因组关联研究

Development of novel gene carrier using modified nano hydroxyapatite derived from equine bone for osteogenic differentiation of dental pulp stem cells

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Bioactive Materials 2021年第9期6卷 2742-2751页

作者： Myung Chul Lee Hoon Seonwoo Kyoung je Jang Shambhavi Pandey Jaewoon Lim Sangbae Park Jae Eun Kim yun-Hoon Choung Pankaj Garg Jong Hoon Chung Department of Biosystems&Biomaterials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea Department of Biosystems Engineering Seoul National UniversitySeoul08826Republic of Korea Department of Industrial Machinery Engineering Sunchon National University315 Maegok-dongSunchon57922Republic of Korea Interdisciplinary Program in IT-Bio Convergence System Sunchon National UniversitySuncheon57922Republic of Korea Division of Agro-system Engineering Gyeongsang National University501 Jinju-daeroJinju52828Republic of Korea Institute of Agriculture&Life Science Gyeongsang National UniversityJinju52828Republic of Korea Research Institute for Agriculture and Life Sciences Seoul National UniversitySeoul08826Republic of Korea Department of Otolaryngology Ajou University School of MedicineSuwon16499Republic of Korea Ajou University Graduate School of Medicine Bk21 Plus Research Center for Biomedical SciencesSuwon16499Republic of Korea BK21 Global Smart Farm Educational Research Center Seoul National UniversitySeoul08826Republic of Korea

Hydroxyapatite(HA)is a representative substance that induces bone *** research team extracted nanohydroxyapatite(EH)from natural resources,especially equine bones,and developed it as a molecular biological ***(PEI)was used to coat the EH to develop a gene *** verify that PEI is well coated in the EH,we first observed the morphology and dispersity of PEI-coated EH(pEH)by electron *** pEH particles were well distributed,while only the EH particles were not distributed and ***,the existence of nitrogen elements of PEI on the surface of the pEH was confirmed by EDS,calcium concentration measurement and fourier transform infrared spectroscopy(FT-IR).Additionally,the pEH was confirmed to have a more positive charge than the 25 kD PEI by comparing the zeta *** a result of pGL3 transfection,pEH was better able to transport genes to cells than 25 kD *** verification as a gene carrier for pEH,we induced osteogenic differentiation of DPSCs by loading the BMP-2 gene in pEH(BMP-2/pEH)and delivering it to the *** a result,it was confirmed that osteogenic differentiation was promoted by showing that the expression of osteopontin(OPN),osteocalcin(OCN),and runt-related transcription factor 2(RUNX2)was significantly increased in the group treated with BMP-2/*** conclusion,we have not only developed a novel nonviral gene carrier that is better performing and less toxic than 25 kD PEI by modifying natural HA(the agricultural byproduct)but also proved that bone differentiation can be effectively promoted by delivering BMP-2 with pEH to stem cells.

关键词： Nanocomposites Biomedical applications Hydroxyapatite Polyethyleneimine Gene carrier Osteogenic differentiation