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Distribution and Relation of Primes with Tesla Numbers 3, 6, and 9

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1021-1027页

作者： javier Mendoza-Navarrete Huetzin Perez Ismael Ojeda Victor Verdugo Gabriel Luna sandoval Ricardo Jimenez Garcia Jaime Alvarez Departametno de Matemá ticas CBTis 256 DGETI Cabo San Lucas M&#233xico DcI Departamento de Fisica Mé dica Universidad de Guanajuato Leon M&#233xico Divisió n de Ingenieria en Sistemas Computacionales Tecnol&#243gico Nacional de M&#233xico ITES Los Cabos Cabo San Lucas M&#233xico Departamento de Ingenieria Industrial en Manufactura Universidad Estatal de Sonora Navojoa M&#233xico Departamento de Elé ctrica-Electr&#243nica Tecnol&#243gico Nacional de M&#233xico Campus Mexicali Mexicali M&#233xico Guanajuato M&#233xico

This work presents a different approach to twin primes, an approach from the perspective of the Tesla numbers and gives a refresh and new observation of twin primes that could lead us to an answer to the Twin Prime conjecture problem. We expose a peculiar relation between twin primes and the generation of prime numbers with Tesla numbers. Tesla numbers seem to be present in so many domains like time, vibration and frequency [1], and the space between twin primes is not the exception. Let us say that twin primes are more than just prime numbers plus 2 or minus 2, and Tesla numbers are more involved with twin primes than we think, and hopefully, this approach give us a better understanding of the distribution of the twin pairs.

关键词： Tesla Numbers Prime Number Twin Prime Numbers Twin Pair

Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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cancer communications 2024年第3期44卷 443-447页

作者： Lucia chica-Redecillas sergio cuenca-Lopez Eduardo Andres-Leon Laura carmen Terron-camero Blanca cano-Gutierrez Jose Manuel cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis javier Martinez-Gonzalez Maria Jesus Alvarez-cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery service.University Hospital clínico san cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(Pc)comprises 5%-10%of all Pc *** increased risk of Pc in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(sNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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Acknowledgements

Advances in Polar science 2024年第1期35卷 142-142页

作者： carolina Acosta Hospitaleche javier N.Gelfo carolina Acosta Hospitaleche and javier N.Gelfo

Acknowledgement to reviewers for Vol.35 No.1 issue The editors of this special volume,along with the Editorial Board and Editorial Office of Advance in Polar science,wish to express deep gratitude for the time invested and the meticulous revisions carried out by Enrique Bostelmann(chile),Michael Burns(UsA),Rodolfo coria(Argentina),Jun Ebersole(UsA),Jürgen Kriwet(Austria),Guillermo M.López(Argentina),James Parham(UsA),Juan saad(Argentina),Leonardo salgado(Argentina),sergio soto Acuña(chile),Washington Jones(Uruguay)and seven anonymous reviewers from Argentina,china,Germany,Poland,and UsA.

关键词： knowledge invested saa

colorectal peritoneal metastases:Optimal management review

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World Journal of Gastroenterology 2019年第27期25卷 3484-3502页

作者： Juan Manuel sánchez-Hidalgo Lidia Rodríguez-Ortiz Alvaro Arjona-sánchez sebastián Rufián-Pena Angela casado-Adam Antonio cosano-Alvarez javier Briceno-Delgado Department of General and Digestive surgery Reina Sofia University HospitalCordoba 14004Spain

The peritoneum is a common site of dissemination for colorrectal cancer, with a poorer prognosis than other sites of metastases. In the last two decades, it has been considered as a locoregional disease progression and treated as such with curative intention treatments. cytoreductive surgery(cRs) and hyperthermic intraperitoneal chemotherapy(HIPEc) is the actual reference treatment for these patients as better survival results have been reached as compared to systemic chemotherapy alone, but its therapeutic efficacy is still under debate. Actual guidelines recommend that the management of colorectal cancer with peritoneal metastases should be led by a multidisciplinary team carried out in experienced centers and consider cRs + HIPEc for selected patients. Accumulative evidence in the last three years suggests that this is a curative treatment that may improve patients disease-free survival, decrease the risk of recurrence, and does not increase the risk of treatment-related mortality. In this review we aim to gather the latest results from referral centers and opinions from experts about the effectiveness and feasibility of cRs + HIPEc for treating peritoneal disease from colorectal malignancies.

关键词： Peritoneal metastases colorectal cancer cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal carcinomatosis

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Foreword

Advances in Polar science 2024年第1期34卷 2-2页

作者： javier N.Gelfo carolina Acosta Hospitaleche

Motivated by the spirit ignited during the I Provincial scientific congress on Antarctica in the city of Ushuaia,in Tierra del Fuego,Antártida e Islas del Atlántico sur Province,Argentina,convened in October 2022,we proudly introduce this special volume entitled“Past and present climatic change in Antarctica:geological proxies and biological processes”.

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Wireless capsule endoscopy: Perspectives beyond gastrointestinal bleeding

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World Journal of Gastroenterology 2014年第42期20卷 15664-15673页

作者： Eduardo Redondo-cerezo Antonio Damián sánchez-capilla Paloma De La Torre-Rubio javier De Teresa Endoscopy Unit Department of Gastroenterology University Hospital Virgen de Las Nieves Department of Gastroenterology University Hospital Virgen de Las Nieves

Wireless capsule endoscopy(cE) is a technology developed for the endoscopic exploration of the small bowel. The first capsule model was approved by the Food and Drug Administration in 2001, and its first and essential indication was occult gastrointestinal(GI) bleeding. Over subsequent years, this technology has been refined to provide superior resolution, increased battery life, and capabilities to view different parts of the GI tract. Indeed, cases for which cE proved useful have increased significantly over the last few years, with new indications for the small bowel and technical improvements that have expanded its use to other parts of the GI tract, including the esophagus and colon. The main challenges in the development of cE are new devices with the ability to provide therapy, air inflation for a better vision of the small bowel, biopsy sampling systems attached to the capsule and the possibility to guide and move the capsule with an external motion control. In this article we review the current and new indications of cE, and the evolving technological changes shaping this technology, which has a promising potential in the coming future of gastroenterology.

关键词： Wireless capsule endoscopy Obscure gastrointestinal bleeding small bowel tumors colon capsule endoscopy Esophageal capsule endoscopy

The Nikola Tesla constant and Its Relation to the circumference Inscribed in a square

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Journal of Applied Mathematics and Physics 2024年第1期12卷 277-283页

作者： javier Mendoza Navarrete José Ismael Ojeda campaña Huetzin Perez Gabriel Luna-sandoval Victor Verdugo Ricardo Jiménez Garcia Departamento de Matemáticas CBTis 256 DGETI Cabo San Lucas México División de Ingeniería en sistemas computacionales Tecnológico Nacional de México/ITES de Los Cabos Cabo San Lucas México DcI Departamento de Física Médica Universidad de Guanajuato León México Departamento de Ingeniería Industrial en Manufactura Universidad Estatal de Sonora Navojoa México Departamento de Eléctrica-Electrónica Tecnológico Nacional de México Campus Mexicali Mexicali México

This research work relates the surface of a square and the area circumscribed by a circle, resulting in a value called Nikola Tesla constant. This constant starts with the calculation of the areas of the square and the inscribed circle, giving a ratio of 9/40 and from which a residual area of the area proportions of the geometric figures described is obtained. Plotting smooth curves, particularly those in round shapes, can be represented efficiently with the use of Nikola Tesla constant, reducing complex mathematical calculus.

关键词： Tesla Numbers Prime Number circle Binary Area

Animal models used to study direct peripheral nerve repair: a systematic review

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Neural Regeneration Research 2020年第3期15卷 491-502页

作者： Francisco javier Vela Guadalupe Martínez-chacón Alberto Ballestín JoséLuis campos Francisco Miguel sánchez-Margallo Elena Abellán Department of Microsurgery Jesús Usón Minimally Invasive Surgery CentreCáceresSpain scientific Director Jesús Usón Minimally Invasive Surgery CentreCáceresSpain

Objective:Peripheral nerve repair is required after traumatic *** common condition represents a major public health problem *** after nerve repair depends on several factors,including the severity of the injury,the nerve involved,and the surgeon’s technical *** the precise microsurgical repair of nerve lesions,adequate functional recovery is not always achieved and,therefore,the regeneration process and surgical techniques are still being ***-clinical animal models are essential for this research and,for this reason,the focus of the present systematic review(according to the PRIsMA statement)was to analyze the different animal models used in pre-clinical peripheral nerve repair *** sources:Original articles,published in English from 2000 to 2018,were collected using the Web of science,scopus,and PubMed *** selection:Only preclinical trials on direct nerve repair were included in this *** articles were evaluated by the first two authors,in accordance with predefined data *** measures:The primary outcomes included functional motor abilities,daily activity and regeneration *** outcomes included coaptation technique and animal ***:This review yielded 267 articles,of which,after completion of the screening,49 studies were *** were 1425 animals in those 49 studies,being rats,mice,guinea pigs,rabbits,cats and dogs the different pre-clinical *** nerves used were classified into three groups:head and neck(11),forelimb(8)and hindlimb(30).The techniques used to perform the coaptation were:microsuture(46),glue(12),laser(8)and mechanical(2).The follow-up examinations were histology(43),electrophysiological analysis(24)and behavioral observation(22).conclusion:The most widely used animal model in the study of peripheral nerve repair is the *** animal models are also used but the cost-benefit of the rat model provides several strengths over the ***

关键词： nerve microsurgery peripheral nerve regeneration repair reconstruction direct nerve repair animal model coaptation PRIsMA systematic review

Patient safety in the Use of Mechanical Restraints: Regulatory compliance among Hospitals in the city of Buenos Aires and Proposal for Its Improvement

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Open Journal of Emergency Medicine 2024年第2期12卷 33-39页

作者： Martín javier Mazzoglio y Nabar sergio Giordano Edgardo Knopoff Lorena Onofrio Oscar Agustín Porta Romina Rodríguez Emergency service Torcuato de Alvear Psychiatric Emergency Hospital Buenos Aires Argentina Department of Psychiatry and Mental Health Faculty of Medicine University of Buenos Aires Buenos Aires Argentina

Introduction: Mechanical or physical restraint is an exceptional therapeutic resource to immobilize a subject and thus guarantee the safety of the patient and/or third parties in the face of high-risk behaviors, but it entails multiple crossings (bioethical, philosophical, medical, psychological, legal). Framed in the so-called “safety culture” developed by the WHO, based on the Protocol for its implementation of the cABA and attentive to its frequent use in cABA by different hospital services (medical clinic, geriatrics, intensive care and medical guards) we consider it necessary its study in terms of compliance with the risks it entails and its management. Objectives: Identify regulatory compliance with the GcABA Mechanical restraint (MR) Protocol from a patient safety perspective, as well as describe the clinical and medicolegal aspects, and propose the usefulness of a tool for its management and control. Methodology: Observational, descriptive, transversal and prospective work through the analysis of clinical Records with indication of MR using a rubric-type form. 177 cases were analyzed between september-November 2023 from three hospitals of the Government of the city of Buenos Aires, statistical parameters were applied and graphs were made. Results: Only 12.99% complied with the Protocol. In the mental health specialized hospital compliance was almost 5 times greater than in the general one, and in the emergency services compliance was 12 times greater than in Inpatient services. We found that the start or end time of MR was not recorded and only 43% described the causes/justifications for the indication (mostly in Emergency and specialized hospitals), with the MR average time being shorter in Emergency. conclusions: Only 1.3 out of 10 patients reliably completed the Protocol and it was mostly in the mental health specialized hospital and the emergency services. The results show non-compliance behavior in the application and management of the risk that the use

关键词： Mechanical containment Patient safety Injuries in custody Buenos Aires city check List